journal
https://read.qxmd.com/read/37776622/associations-between-perfluoroalkyl-substances-and-the-severity-of-non-alcoholic-fatty-liver-disease
#1
JOURNAL ARTICLE
Norma David, Jean-Philippe Antignac, Marine Roux, Philippe Marchand, Sophie Michalak, Fréderic Oberti, Isabelle Fouchard, Adrien Lannes, Odile Blanchet, Paul Cales, Etienne B Blanc, Jérôme Boursier, Clémence M Canivet
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide and the determinants driving its severity remain to be elucidated. Perfluoroalkyl substances (PFAS) are synthetic chemical compounds. They are used in commonplace products and persistent in water, soil and the human body. In vitro and animal studies suggest a pathogenic role for PFAS in metabolic diseases such as NAFLD. OBJECTIVES: We aimed to evaluate the association between NAFLD severity and serum PFAS concentrations in humans...
September 27, 2023: Environment International
https://read.qxmd.com/read/37776620/greenness-and-excess-deaths-from-heat-in-323-latin-american-cities-do-associations-vary-according-to-climate-zone-or-green-space-configuration
#2
JOURNAL ARTICLE
Leah H Schinasi, Maryia Bakhtsiyarava, Brisa N Sanchez, Josiah L Kephart, Yang Ju, Sarav Arunachalam, Nelson Gouveia, Waleska Teixeira Caiaffa, Marie S O'Neill, Iryna Dronova, Ana V Diez Roux, Daniel A Rodriguez
Green vegetation may protect against heat-related death by improving thermal comfort. Few studies have investigated associations of green vegetation with heat-related mortality in Latin America or whether associations are modified by the spatial configuration of green vegetation. We used data from 323 Latin American cities and meta-regression models to estimate associations between city-level greenness, quantified using population-weighted normalized difference vegetation index values and modeled as three-level categorical terms, and excess deaths from heat (heat excess death fractions [heat EDFs])...
September 25, 2023: Environment International
https://read.qxmd.com/read/37774458/adverse-developmental-impacts-in-progeny-of-zebrafish-exposed-to-the-agricultural-herbicide-atrazine-during-embryogenesis
#3
JOURNAL ARTICLE
Janiel K Ahkin Chin Tai, Katharine A Horzmann, Thomas L Jenkins, Isabelle N Akoro, Sydney Stradtman, Uma K Aryal, Jennifer L Freeman
Atrazine (ATZ) is an herbicide commonly used on crops in the Midwestern US and other select global regions. The US Environmental Protection Agency ATZ regulatory limit is 3 parts per billion (ppb; µg/L), but this limit is often exceeded. ATZ has a long half-life, is a common contaminant of drinking water sources, and is indicated as an endocrine disrupting chemical in multiple species. The zebrafish was used to test the hypothesis that an embryonic parental ATZ exposure alters protein levels leading to modifications in morphology and behavior in developing progeny...
September 24, 2023: Environment International
https://read.qxmd.com/read/37758599/a-vision-for-safer-food-contact-materials-public-health-concerns-as-drivers-for-improved-testing
#4
JOURNAL ARTICLE
Jane Muncke, Anna-Maria Andersson, Thomas Backhaus, Scott M Belcher, Justin M Boucher, Bethanie Carney Almroth, Terrence J Collins, Birgit Geueke, Ksenia J Groh, Jerrold J Heindel, Frank A von Hippel, Juliette Legler, Maricel V Maffini, Olwenn V Martin, John Peterson Myers, Angel Nadal, Cristina Nerin, Ana M Soto, Leonardo Trasande, Laura N Vandenberg, Martin Wagner, Lisa Zimmermann, R Thomas Zoeller, Martin Scheringer
Food contact materials (FCMs) and food contact articles are ubiquitous in today's globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases...
September 22, 2023: Environment International
https://read.qxmd.com/read/37757619/particle-lung-deposited-surface-area-ldsa-al-size-distributions-in-different-urban-environments-and-geographical-regions-towards-understanding-of-the-pm-2-5-dose-response
#5
JOURNAL ARTICLE
Teemu Lepistö, Henna Lintusaari, Anna Oudin, Luis M F Barreira, Jarkko V Niemi, Panu Karjalainen, Laura Salo, Ville Silvonen, Lassi Markkula, Jussi Hoivala, Petteri Marjanen, Sampsa Martikainen, Minna Aurela, Felipe Reyes Reyes, Pedro Oyola, Heino Kuuluvainen, Hanna E Manninen, Roel P F Schins, Michal Vojtisek-Lom, Jakub Ondracek, Jan Topinka, Hilkka Timonen, Pasi Jalava, Sanna Saarikoski, Topi Rönkkö
Recent studies indicate that monitoring only fine particulate matter (PM2.5 ) may not be enough to understand and tackle the health risk caused by particulate pollution. Health effects per unit PM2.5 seem to increase in countries with low PM2.5 , but also near local pollution sources (e.g., traffic) within cities. The aim of this study is to understand the differences in the characteristics of lung-depositing particles in different geographical regions and urban environments. Particle lung deposited surface area (LDSAal ) concentrations and size distributions, along with PM2...
September 20, 2023: Environment International
https://read.qxmd.com/read/37751662/deleterious-functional-consequences-of-perfluoroalkyl-substances-accumulation-into-the-myelin-sheath
#6
JOURNAL ARTICLE
L Butruille, P Jubin, E Martin, M S Aigrot, M Lhomme, J B Fini, B Demeneix, B Stankoff, C Lubetzki, B Zalc, S Remaud
Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential increased risk of neurological disorders in adulthood. Here we questioned whether exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) could alter myelin formation and regeneration. First, we show that PFOS, and to a lesser extent PFOA, accumulated into the myelin sheath of postnatal day 21 (p21) mice, whose mothers were exposed to either PFOA or PFOS (20 mg/L) via drinking water during late gestation and lactation, suggesting that accumulation of PFOS into the myelin could interfere with myelin formation and function...
September 20, 2023: Environment International
https://read.qxmd.com/read/37748372/testing-the-effectiveness-of-household-fuel-conservation-strategies-policy-implications-for-increasing-the-affordability-of-exclusive-clean-cooking
#7
JOURNAL ARTICLE
Kendra N Williams, Katarina Kamenar, Josiah L Kephart, Marilu Chiang, Stella M Hartinger, William Checkley
BACKGROUND: Exclusive clean fuel use is essential for realizing health and other benefits but is often unaffordable. Decreasing household-level fuel needs could make exclusive clean fuel use more affordable, but there is a lack of knowledge on the amount of fuel savings that could be achieved through fuel conservation behaviors relevant to rural settings in low- and middle-income countries. METHODS: Within a trial in Peru, we trained a random half of intervention participants, who had previously received a liquefied petroleum gas (LPG) stove and were purchasing their own fuel, on fuel conservation strategies...
September 20, 2023: Environment International
https://read.qxmd.com/read/37742460/multi-omics-analysis-reveals-hepatic-lipid-metabolism-profiles-and-serum-lipid-biomarkers-upon-indoor-relevant-voc-exposure
#8
JOURNAL ARTICLE
Gan Miao, Yu Wang, Baoqiang Wang, Hongyan Yu, Jing Liu, Ruonan Pan, Chengying Zhou, Jie Ning, Yuxin Zheng, Rong Zhang, Xiaoting Jin
As a widespread indoor air pollutant, volatile organic compound (VOC) caused various adverse health effects, especial the damage to liver, which has become a growing public concern. However, the current toxic data are intrinsically restricted in the single or major VOC species. Limited knowledge is available regarding toxic effects, biomarkers and underlying mechanisms of real indoor VOC-caused liver damage. Herein, an indoor relevant VOC exposure model was established to evaluate the hepatic adverse outcomes...
September 20, 2023: Environment International
https://read.qxmd.com/read/37741006/temporal-trends-in-microplastic-accumulation-in-placentas-from-pregnancies-in-hawai-i
#9
JOURNAL ARTICLE
Rodrigo Barbano Weingrill, Men-Jean Lee, Paula Benny, Jonathan Riel, Kevin Saiki, Jacob Garcia, Lais Farias Azevedo de Magalhaes Oliveira, Eduardo Jorge da Silva Fonseca, Samuel Teixeira de Souza, Flavio de Oliveira Silva D'Amato, Ueslen Rocha Silva, Mariana Lima Dutra, Aldilane Lays Xavier Marques, Alexandre Urban Borbely, Johann Urschitz
Microplastics are created for commercial use, are shed from textiles, or result from the breakdown of larger plastic items. Recent reports have shown that microplastics accumulate in human tissues and may have adverse health consequences. Currently, there are no standardized environmental monitoring systems to track microplastic accumulation within human tissues. Using Raman spectroscopy, we investigated the temporal exposures to plastic pollution in Hawai'i and noted a significant increase in the accumulation of microplastics in discarded placentas over the past 15 years, with changes in the size and chemical composition of the polymers...
September 20, 2023: Environment International
https://read.qxmd.com/read/37748373/mechanism-of-thyroid-hormone-and-its-structurally-similar-contaminant-bisphenol-s-exposure-on-retinoid-metabolism-in-zebrafish-larval-eyes
#10
JOURNAL ARTICLE
Liguo Qiu, Shuhui Wei, Yunsheng Wang, Rui Zhang, Shaoguo Ru, Xiaona Zhang
The photoreceptor necessitates the retinoids metabolism processes in visual cycle pathway to regenerate visual pigments and sustain vision. Bisphenol S (BPS), with similar structure of thyroid hormone (TH), was reported to impair the light-sensing function of zebrafish larvae via disturbing TH-thyroid hormone receptor β (TRβ) signaling pathway. However, it remains unknown whether TRβ could modulate the toxicity of BPS on retinoid metabolism in visual cycle. This study showed that BPS diminished the optokinetic response of zebrafish larvae and had a stimulative effect on all-trans-retinoic acid (atRA) metabolism, like exogenous T3 exposure...
September 19, 2023: Environment International
https://read.qxmd.com/read/37738696/significant-impacts-of-river-inputs-on-the-distributions-and-transports-of-mercury-and-methylmercury-in-nearshore-and-open-seas-simulation-based-on-field-surveys-and-mass-balance-modeling
#11
JOURNAL ARTICLE
Chenghao Yu, Huiming Lin, Junming Guo, Mao Peng, Maodian Liu, Yindong Tong, Yifan Lu, Xuejun Wang, Xiangliang Pan
Rivers are important sources of Hg for adjacent seas, and seafood from nearshore waters is a major source of Hg exposure for humans. There is thus a key scientific concern regarding how much riverine Hg inputs influence Hg loads in nearshore waters as well as how far the impact range can extend from the river to the open sea. In addition, it is important to understand the influence of anthropogenic hydro-facilities and activities on Hg levels in downstream seas. Because of the concise mass exchange pattern between the seas and the previously demonstrated intensive Hg inputs under anthropogenic regulation from the Yellow River, the Bohai and Yellow Seas, which are key fishery and marine breeding areas for China, are an ideal research area for exploring the impacts of riverine Hg on nearshore and adjacent open seas...
September 19, 2023: Environment International
https://read.qxmd.com/read/37738697/liquid-crystal-monomers-in-ventilation-and-air-conditioning-dust-indoor-characteristics-sources-analysis-and-toxicity-assessment
#12
JOURNAL ARTICLE
Qianqian Jin, Yinzheng Fan, Yichun Lu, Yuting Zhan, Jiaji Sun, Danyang Tao, Yuhe He
Indoor dust contaminated with liquid crystal monomers (LCMs) released from various commercial liquid crystal display (LCD) screens may pose environmental health risks to humans. This study aimed to investigate the occurrence of 64 LCMs in ventilation and air conditioning filters (VACF) dust, characterize their composition profiles, potential sources, and associations with indoor characteristics, and assess their in vitro toxicity using the human lung bronchial epithelial cells (BEAS-2B). A total of 31 LCMs with concentrations (ΣLCMs) ranging from 43...
September 18, 2023: Environment International
https://read.qxmd.com/read/37774459/the-association-of-long-term-exposure-to-criteria-air-pollutants-fine-particulate-matter-components-and-airborne-trace-metals-with-late-life-brain-amyloid-burden-in-the-atherosclerosis-risk-in-communities-aric-study
#13
JOURNAL ARTICLE
Erin E Bennett, Ziwei Song, Katie M Lynch, Chelsea Liu, Emma K Stapp, Xiaohui Xu, Eun Sug Park, Qi Ying, Richard L Smith, James D Stewart, Eric A Whitsel, Thomas H Mosley, Dean F Wong, Duanping Liao, Jeff D Yanosky, Adam A Szpiro, Joel D Kaufman, Rebecca F Gottesman, Melinda C Power
BACKGROUND: Studies suggest associations between long-term ambient air pollution exposure and outcomes related to Alzheimer's disease (AD). Whether a link exists between pollutants and brain amyloid accumulation, a biomarker of AD, is unclear. We assessed whether long-term air pollutant exposures are associated with late-life brain amyloid deposition in Atherosclerosis Risk in Communities (ARIC) study participants. METHODS: We used a chemical transport model with data fusion to estimate ambient concentrations of PM2...
September 17, 2023: Environment International
https://read.qxmd.com/read/37769447/dual-hit-glyphosate-exposure-at-noael-level-negatively-impacts-birth-and-glia-behavioural-measures-in-heterozygous-shank3-mutants
#14
JOURNAL ARTICLE
Sophie Sakkaki, Noemie Cresto, Raphaël Chancel, Maé Jaulmes, Emma Zub, Marine Blaquière, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
The omnipresence of environmental contaminants represents a health danger with ramifications for adverse neurological trajectories. Here, we tested the dual-hit hypothesis that continuous exposure to non-observable adverse effect level (NOAEL) glyphosate from pre-natal to adulthood represents a risk factor for neurological-associated adaptations when in the presence of the heterozygote or homozygote mutation of the Shank3 synaptic gene. Ultrasound analysis of pregnant dams revealed patterns of pre-natal mortality with effects dependent on wild-type, Shank3ΔC/+ , or Shank3ΔC/ΔC genotypes exposed to NOAEL glyphosate (GLY) compared to unexposed conditions...
September 17, 2023: Environment International
https://read.qxmd.com/read/37741004/tuning-electronic-structure-of-the-carbon-skeleton-to-accelerate-electron-transfer-for-promoting-the-capture-of-gold
#15
JOURNAL ARTICLE
Dewei Li, Xianxin Luo, Penghui Shao, Zhu Meng, Ziwei Yao, Liming Yang, Jiachuang Shao, Hao Dong, Li Zhang, Lingrong Zeng, Xubiao Luo
The efficient and selective recovery of gold from secondary sources is key to sustainable development. However, the complexity of the recovery environment can significantly complicate the compositions of utilized sorbents. Here, we report a straw-derived mesoporous carbon as an inexpensive support material. This mesoporous carbon is modified by anions (sulfur modulation, C-S-180) to improve its electron-transfer efficiency and tune the electronic structure of its skeleton toward enhanced gold reduction. The high surface area of C-S-180 (989...
September 17, 2023: Environment International
https://read.qxmd.com/read/37776621/solar-periodate-triggered-rapid-inactivation-of-microcystis-aeruginosa-by-interrupting-the-calvin-benson-cycle
#16
JOURNAL ARTICLE
Chengsong Ye, Chenlan Chen, Kaiting Zhang, Xu Wu, Wei-Feng Cai, Mingbao Feng, Xin Yu
Frequent outbreak of cyanobacteria is a serious problem for drinking water treatment. The microcystins released from Microcystis aeruginosa (M. aeruginosa) could cause irreversible damage to human health. Catalyst-free solar/periodate (PI) system has recently presented great potential for bacterial inactivation, whereas the application potential and underlying mechanisms of the effective M. aeruginosa control remain unclear. Our work delineated the key role of ROS that inactivating/harmless disposing M. aeruginosa in the simulated sunlight (SSL)/PI system...
September 16, 2023: Environment International
https://read.qxmd.com/read/37769446/the-use-of-gas-chromatography-combined-with-chemical-and-sensory-analysis-to-evaluate-nuisance-odours-in-the-air-and-water-environment
#17
REVIEW
James E Hayes, Radosław J Barczak, Irwin Mel Suffet, Richard M Stuetz
Varieties of gas chromatography (GC) combined with chemical detection (CD) and sensory analysis at the odour detection port (ODP) for the evaluation of environmental odorants has steadily increased in application and sophistication; this has given rise to a plethora of techniques that cater to specific tasks. With this diversity of approaches in mind, there is a need to assess the critical points at which these approaches differ, as well as likely risks and factors that may affect them. These critical points explained within this review include sample preparation, GC separation techniques (with associated co-elution risks), how the elute is separated between CD and sensory analysis, the type of CD, the type of sensory analysis (with particular attention paid to its factors and guidelines), integrative data techniques, as well as how that data may be used...
September 16, 2023: Environment International
https://read.qxmd.com/read/37741005/unveiling-the-novel-role-of-ryegrass-rhizospheric-metabolites-in-benzo-a-pyrene-biodegradation
#18
JOURNAL ARTICLE
Xuan Zhao, Jibing Li, Dayi Zhang, Longfei Jiang, Yujie Wang, Beibei Hu, Shuang Wang, Yeliang Dai, Chunling Luo, Gan Zhang
Rhizoremediation is a promising remediation technology for the removal of soil persistent organic pollutants (POPs), especially benzo[a]pyrene (BaP). However, our understanding of the associations among rhizospheric soil metabolites, functional microorganisms, and POPs degradation in different plant growth stages is limited. We combined stable-isotope probing (SIP), high-throughput sequencing, and metabolomics to analyze changes in rhizospheric soil metabolites, functional microbes, and BaP biodegradation in the early growth stages (tillering, jointing) and later stage (booting) of ryegrass...
September 16, 2023: Environment International
https://read.qxmd.com/read/37741007/serum-concentrations-of-per-and-polyfluoroalkyl-substances-and-risk-of-renal-cell-carcinoma-in-the-multiethnic-cohort-study
#19
JOURNAL ARTICLE
Jongeun Rhee, Vicky C Chang, Iona Cheng, Antonia M Calafat, Julianne Cook Botelho, Joseph J Shearer, Joshua N Sampson, Veronica Wendy Setiawan, Lynne R Wilkens, Debra T Silverman, Mark P Purdue, Jonathan N Hofmann
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent organic pollutants detectable in the serum of most U.S. adults. We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993-2001. To extend our investigations to a larger and more racially and ethnically diverse population, we conducted a nested case-control study of serum PFAS concentrations and RCC within the Multiethnic Cohort Study...
September 14, 2023: Environment International
https://read.qxmd.com/read/37734144/the-impact-of-heat-exposures-on-biomarkers-of-aki-and-plasma-metabolome-among-agricultural-and-non-agricultural-workers
#20
JOURNAL ARTICLE
Roxana C Chicas, Yilin Wang, E Jennifer Weil, Lisa Elon, Nezahualcoyotl Xiuhtecutli, Madelyn C Houser, Dean P Jones, Jeff M Sands, Vicki Hertzberg, Linda McCauley, Donghai Liang
BACKGROUND: Agricultural workers are consistently exposed to elevated heat exposures and vulnerable to acute kidney injury. The underlying pathophysiology and detailed molecular mechanisms of AKI among agricultural workers, and the disproportionate burden of HRI and heat stress exposure are not well understood, especially at the level of cellular metabolism. OBJECTIVE: The aim of this study was to examine the impact of heat exposures on renal biomarkers and on the human metabolome via untargeted high-resolution metabolomics among agricultural and non-agricultural workers...
September 14, 2023: Environment International
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