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Irish Journal of Medical Science

Ali Seven, Esin Yalinbas, Suna Kabil Kucur, Emel Kocak, Ozben Isiklar, Beril Yuksel, Hakan Timur, Mehmet Erbakirci, Nadi Keskin
AIM: To evaluate maternal and cord blood irisin levels in pregnant women with gestational diabetes mellitus (GDM) and in obese pregnant women without GDM. METHODS: The study included 109 patients, with 34 patients in the GDM group, 40 in the obese non-GDM group, and 35 in the control group. Maternal serum irisin levels at the time of delivery were measured by an enzyme-linked immunosorbent assay kit. The correlation of serum irisin levels with metabolic parameters and anthropometric measurements was analyzed...
May 17, 2019: Irish Journal of Medical Science
Seán C Maguire, Mohamed Elnagar, Afia Nazar, Stephen J Sheehan
INTRODUCTION: Prompt carotid endarterectomy for stroke prevention remains an essential component of treatment for symptomatic carotid stenosis. There exist a number of techniques, most commonly, access via a longitudinal arteriotomy for conventional carotid endarterectomy (CCEA), but eversion endarterectomy (ECEA) may also be used. Neither has been definitively proven as superior. We outline the experience in our institution of these two approaches. METHODS: All patients who had surgery over a 7-year period (2009-2015) under a single consultant vascular surgeon were included in this analysis...
May 17, 2019: Irish Journal of Medical Science
Atakan Tanacan, Erdem Fadiloglu, Gonca Ozten, Ali Can Gunes, Gokcen Orgul, Mehmet Sinan Beksac
BACKGROUND AND AIM: To share our experience with the management of pregnancies in women with myasthenia gravis (MG) in a tertiary center. METHODS: The study retrospectively evaluated 27 pregnancies in 12 patients. The pregnancies were divided into 3 groups on the basis of the clinical course of MG during pregnancy: improvement (n = 7), disease-stable (n = 9), and deterioration (n = 11). The groups were compared with respect to patient characteristics, clinical features, and obstetric outcomes...
May 9, 2019: Irish Journal of Medical Science
Karla A Lee, Guhan Rangaswamy, Naomi A Lavan, Mary Dunne, Conor D Collins, Cormac Small, Pierre Thirion
BACKGROUND: Radiotherapy (RT) is a key treatment modality in the curative treatment of patients with non-small cell lung cancer (NSCLC). Incorrect definition of the gross, or clinical, target volume is a common source of error which can lead to a reduced probability of tumour control. OBJECTIVE: This was a pilot and a phase II study. The pilot evaluated the technical feasibility of integrating positron emission tomography-computed tomography (PET-CT) fusion. The primary outcome of the phase II study was to evaluate the safety of PET-CT scan-based RT by evaluating the rate of loco-regional recurrence outside the PET-CT planning target volume (PTV) but within conventional 3-D PTV...
May 6, 2019: Irish Journal of Medical Science
R L Geary, L R Corrigan, D N Carney, M J Higgins
BACKGROUND: The overall survival of patients with localised osteosarcoma has dramatically improved with the introduction of multidrug chemotherapeutic regimens into the treatment paradigm. However, despite optimal treatment, all-cause mortality remains higher among osteosarcoma survivors than in the general population. The development of second malignant neoplasms contributes to this higher mortality rate. CASE SERIES: We present three cases of patients definitively treated for osteosarcoma who subsequently developed a second malignant neoplasm...
May 3, 2019: Irish Journal of Medical Science
Emily Greenan, Marisa Salim, Daniel Nicholas Coakley, Mark James
AIM: To determine whether geodemographic factors, specifically age, gender or commuting distance, affect the attendance rates of patients referred to a Diabetic Retinopathy Treatment (DRT) Centre from the Irish National Diabetic Retinal Screening (DRS) Programme. METHODS: A retrospective analysis of the first 1200 patients who were referred for ophthalmic assessment between November 2013 and June 2015 to Cork University Hospital's (CUH) DRT clinic from the DRS was completed...
April 18, 2019: Irish Journal of Medical Science
Gavin Sugrue, Matthew T Crockett, Alan Byrne, Rod Mcloughlin, Susan Maguire, Paddy Gilligan, Eoin C Kavanagh, Stephen J Eustace
BACKGROUND: The increased strength and conditioning of elite athletes has led to greater potential for high impact injuries. With increasing concerns for player welfare, the decision to return to play after sustaining an on-field injury is complex. AIM: Review of a 5-year experience of a pitch side radiology unit (PSRU) at a large international sports stadium. METHODS: X-rays were acquired in a purpose built pitch side radiology unit (PSRU) within a large international sports stadium (Aviva Stadium) using a mobile digital X-ray unit...
April 17, 2019: Irish Journal of Medical Science
Roberta Rowntree, Larkin Feeney
BACKGROUND: Gaming is a growing area and there are conflicting reports on its harms and benefits. There is also increasing interest in the use of gaming clinically. AIMS: This research aims to enhance our understanding of video and smartphone game use, and perceptions, among outpatients attending an Irish general adult mental health service. METHODS: An anonymised, opportunistic survey of outpatients attending an Irish general adult mental health service was completed...
April 17, 2019: Irish Journal of Medical Science
Christina Fleming
BACKGROUND: There is contradictory evidence regarding the merits of restricted versus liberal perioperative intravenous (IV) fluid administration in bowel surgery. This study sought to audit perioperative fluid management in elective colectomy in Ireland and to analyse the impact of such on operative outcomes. METHODS: A national surgical trainee collaborative audit of perioperative fluid management was performed. Data from each site was collected prospectively over a selected 3-week period within a pre-defined 2-month block...
April 13, 2019: Irish Journal of Medical Science
James Sweeney, Dimitrios Adamis, Luqman Helmi, Alastair J D Macdonald
BACKGROUND: Routine clinical outcome monitoring (RCOM) is the standardised gathering of measures of clinical outcomes in everyday practice. HoNOS (Health of the Nation Outcome Scales) is a tool used in RCOM. AIMS: To examine (a) agreement between HoNOS and Global Assessment of Functioning (GAF), (b) HoNOS changes over time/attendance and (c) clinical parameters affecting HoNOS scores. METHODS: Data from outpatient clinics were collected at each contact over 2 years until June 2016 including: gender, age, diagnosis (ICD-10) and HoNOS scores...
April 12, 2019: Irish Journal of Medical Science
Stephen E Langabeer
No abstract text is available yet for this article.
April 11, 2019: Irish Journal of Medical Science
Raymond O'Connor, Jane O'Doherty, Andrew O'Regan
No abstract text is available yet for this article.
April 4, 2019: Irish Journal of Medical Science
Joshua De Marchi, Florin Remus Sferle, Dermot Hehir
BACKGROUND: Symptomatic ventral herniation is a common clinical presentation. The treatment, whether elective or as an emergency, can be difficult and a variety of surgical repairs are utilised. Intraperitoneal onlay mesh (IPOM) involves the placement of a reinforcing prosthesis, usually supported by primary closure of the defect. Intra-abdominal adhesions have been highlighted as a potential complication in utilising this form of mesh placement. Several methods of laparoscopic mesh placement outside of the peritoneal cavity are gaining prominence as potential alternatives to IPOM...
April 4, 2019: Irish Journal of Medical Science
Bobby D O'Leary, Gerard J Agnew, Myra Fitzpatrick, Ann M Hanly
INTRODUCTION: Traditionally, the pelvic floor has been described as three separate compartments and problems in each compartment were managed separately. A more contemporary approach is to identify the entire pelvic floor as a single dynamic compartment. Multidisciplinary pelvic floor clinics such as ours with the support of physiotherapy, clinical nurse specialists, urodynamics, and endo-anal ultrasound are uncommon. The aim of this study was to assess patient satisfaction with a joint colorectal and urogynaecology clinic...
April 3, 2019: Irish Journal of Medical Science
John R Kelly, Mary Cosgrove, Cian Judd, Kathy Scott, Aoibheann Mc Loughlin, Veronica O'Keane
BACKGROUND: Depression is the leading contributor to the burden of disease worldwide. Stigma and negative attitudes to depression can act as barriers to treatment and to social inclusion. Understanding attitudes to depression and treatment has implications for individual outcomes and societal mental health. AIMS: To explore public attitudes to, and management of depression, including lifestyle factors, medication, and psychotherapy. METHODS: A nationally representative online population survey of Irish adults was conducted by RED C...
April 2, 2019: Irish Journal of Medical Science
Oratile Kgosidialwa, Amar Agha
Post-traumatic hypopituitarism (PTHP) is an important and relatively common complication of TBI (traumatic brain injury). A number of studies have shown that this clinical phenomenon can occur soon after TBI (acute) or later in the chronic phase. Patients with moderate to severe TBI are at a particular risk of developing PTHP. In the acute setting, it is important to monitor patients for hypoadrenalism as this confers a high risk for morbidity and even mortality. The gonadotrophin, growth hormone and TSH deficiencies are better defined in the chronic phase...
April 1, 2019: Irish Journal of Medical Science
Brian O'Doherty, Jane Dorman, Karen McGrath, Kevin Kelly, David Molony, Seán Lacey, Sarah Whelan, Simon Schmid, Shane Sullivan
AIMS: Indacaterol/glycopyrronium (IND/GLY) 110/50 μg is a once-daily (o.d.) fixed-dose combination of long-acting β2 -agonist/long-acting muscarinic antagonist approved in over 90 countries, including Ireland, for the management of COPD. The present study was conducted to evaluate health status of COPD patients, initiated on IND/GLY 110/50 μg o.d., using the Clinical COPD Questionnaire (CCQ) tool in a real-world primary care setting in Ireland. METHODS: This was a real-world, prospective, open-label study...
March 28, 2019: Irish Journal of Medical Science
Sarah Walsh, Aoife O'Neill, Ailish Hannigan, Dominic Harmon
BACKGROUND: Little is known about the influence of patient-perceived healthcare provider empathy on patient satisfaction in the setting of a hospital pain clinic consultation. The objective of this research was to examine the relationship between patient-rated physician empathy and patient satisfaction after a single new pain clinic consultation. METHODS: After institutional ethics committee approval, a sample of 140 adult patients completed a two-page questionnaire, directly after a pain clinic consultation...
March 27, 2019: Irish Journal of Medical Science
Cillian Clancy, Patrick Jordan, Paul F Ridgway
INTRODUCTION: Increasing awareness and regulatory body attention is directed towards the insertion of synthetic material for a variety of surgical procedures. This review aims to assess current evidence regarding systemic and auto-immune effects of polypropylene mesh insertion in hernia repair. METHODS: The electronic literature on systemic and auto-immune effects associated with mesh insertion was examined. RESULTS: Foreign body reaction following mesh implantation initiates an acute inflammatory cellular response...
March 27, 2019: Irish Journal of Medical Science
Li Tao, Xu Xiaodong, Meng Qiang, Li Jiao, Zhao Xu
BACKGROUND: The purpose of this study is to investigate whether the preoperative comprehensive geriatric assessment (CGA) would predict postoperative delirium (POD) in elderly patients with hip fracture. METHODS: This is an observational study, performed in a tertiary hospital from June 2014 to May 2018, which enrolled patients with hip fracture aged over 65 years. The comprehensive geriatric assessment for recruited patients was carried out before surgery. POD was recorded prospectively until discharge...
March 26, 2019: Irish Journal of Medical Science
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