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Journal of Endocrinological Investigation

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https://read.qxmd.com/read/30778906/the-representation-of-a-goiter-by-renaissance-painter-moretto-da-brescia
#1
Francesco Trinca, Michele Augusto Riva
Alessandro Bonvicino (c. 1498-1554), commonly known as Il Moretto da Brescia, was an Italian Renaissance painter. In his "The Adoration of Shepherds" (1539-1540), a shepherd shows a bi-lobar goiter. The painter was active in a geographical area, where inhabitants often suffered from endemic goiter due to dietary iodine deficiency and could have influenced Moretto.
February 18, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30762200/effects-of-pcsk9-inhibitors-on-ldl-cholesterol-cardiovascular-morbidity-and-all-cause-mortality-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
I Dicembrini, S Giannini, B Ragghianti, E Mannucci, M Monami
BACKGROUND AND AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors determine a wide reduction of LDL cholesterol, greater than other lipid-lowering agents. The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity and all-cause mortality. METHODS AND RESULTS: A Medline and Clinicaltrials.gov search for eligible studies until December 1, 2017, was performed. All randomized trials (> 12 weeks) comparing PCSK-9 inhibitors with placebo or active drugs were retrieved...
February 14, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30742257/functional-hypothalamic-and-drug-induced-amenorrhea-an-overview
#3
REVIEW
A Lania, L Gianotti, I Gagliardi, M Bondanelli, W Vena, M R Ambrosio
BACKGROUND: Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation not due to identifiable organic causes and with adverse health consequences. The identification of women with this disorder or the precocious identification of women at risk is based on the knowledge of lifestyle risk factors or behaviors such as stress, weight loss, and excessive physical exercise that are known to negatively impact gonadal axis activity. METHODS: In this overview, we described the most common forms of FHA, in particular stress-induced amenorrhea and overtraining-induced amenorrhea...
February 11, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30730039/the-clinical-enigma-of-the-flea-catcher-by-georges-de-la-tour-a-pregnant-sinner-with-pre-eclampsia-or-a-hypothyroid-girl
#4
F Trimarchi, E Martino, L Bartalena
No abstract text is available yet for this article.
February 7, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30719623/can-combination-of-glucocorticoids-with-other-immunosoppressive-drugs-reduce-the-cumulative-dose-of-glucocorticoids-for-moderate-to-severe-and-active-graves-orbitopathy
#5
LETTER
M L Tanda, E Piantanida, E Masiello, C Cusini, L Bartalena
No abstract text is available yet for this article.
February 4, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30712220/correction-to-in-memory-of-professor-domenico-andreani
#6
(no author information available yet)
Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed.
February 2, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30712219/iodine-supplementation-in-women-of-reproductive-age-a-survey-of-clinical-practice-among-italian-gynecologists-and-midwives
#7
LETTER
M L Tanda, C Cusini, A Colombo, P Premoli, S Rosetti, A Cromi, E Piantanida, L Bartalena
No abstract text is available yet for this article.
February 2, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30707410/thyroid-hormone-resistance-from-newborns-to-adults-a-spanish-experience
#8
A Vela, G Pérez-Nanclares, I Ríos, I Rica, N Portillo, L Castaño
OBJECTIVE: Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagnosis in a Spanish cohort of patients with genetically confirmed RTH β, with ages ranging from newborns to adults. METHODS: Retrospective multicenter study of 28 patients who were genetically confirmed as RTH β...
February 1, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30701438/relationship-between-surrogate-estimates-and-direct-measurement-of-insulin-resistance-in-women-with-polycystic-ovary-syndrome
#9
M H Dahan, F Abbasi, G Reaven
PURPOSE: To evaluate the relationship between surrogate estimates of insulin resistance and a direct measurement of insulin-mediated glucose uptake women with and without PCOS. METHODS: Retrospective cohort study of 75 PCOS and 118 controls. Fasting plasma glucose and insulin concentrations, insulin resistance as determined by the insulin suppression test, calculation of multiple surrogate estimates of insulin resistance, total and free testosterone concentrations, and correlations between the direct measure and surrogate estimates of insulin resistance were evaluated...
January 30, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30684245/next-generation-sequencing-identifies-novel-mitochondrial-variants-in-pituitary-adenomas
#10
K Németh, O Darvasi, I Likó, N Szücs, S Czirják, L Reiniger, B Szabó, P A Kurucz, L Krokker, P Igaz, A Patócs, H Butz
PURPOSE: Disrupted mitochondrial functions and genetic variants of mitochondrial DNA (mtDNA) have been observed in different human neoplasms. Next-generation sequencing (NGS) can be used to detect even low heteroplasmy-level mtDNA variants. We aimed to investigate the mitochondrial genome in pituitary adenomas by NGS. METHODS: We analysed 11 growth hormone producing and 33 non-functioning [22 gonadotroph and 11 hormone immunonegative] pituitary adenomas using VariantPro™ Mitochondrion Panel on Illumina MiSeq instrument...
January 25, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30674011/alterations-in-the-intestinal-microbiota-of-patients-with-severe-and-active-graves-orbitopathy-a-cross-sectional-study
#11
T-T Shi, Z Xin, L Hua, R-X Zhao, Y-L Yang, H Wang, S Zhang, W Liu, R-R Xie
BACKGROUND: The intestinal microbiota was linked to autoimmune diseases. Graves' orbitopathy (GO) is an autoimmune disease that is usually associated with Graves' disease. However, information on the microbiome of GO patients is yet lacking. OBJECTIVES: To investigate whether GO patients differ from healthy controls in the fecal microbiota. DESIGN: A cross-sectional study. SETTING: 33 patients with severe and active GO and 32 healthy controls of Han nationality were enrolled between March 2017 and March 2018...
January 23, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30674010/therapeutic-effects-of-the-selective-farnesoid-x-receptor-agonist-obeticholic-acid-in-a-monocrotaline-induced-pulmonary-hypertension-rat-model
#12
P Comeglio, S Filippi, E Sarchielli, A Morelli, I Cellai, C Corno, L Adorini, G B Vannelli, M Maggi, L Vignozzi
BACKGROUND: Activation of the farnesoid X receptor (FXR), a member of the nuclear receptor steroid superfamily, leads to anti-inflammatory and anti-fibrotic effects in several tissues, including the lung. We have recently demonstrated a protective effect of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) in rat models of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) and bleomycin-induced pulmonary fibrosis. The aim of the present study was to investigate whether the positive effects of OCA treatment could be exerted also in established MCT-induced PAH, i...
January 23, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30674009/epicardial-adipose-tissue-is-a-predictor-of-decreased-kidney-function-and-coronary-artery-calcification-in-youth-and-early-adult-onset-type-2-diabetes-mellitus
#13
M Reinhardt, T R Cushman, M S Thearle, J Krakoff
PURPOSE: To examine the association of epicardial and pericardial fat volume (EFV, PFV) with cardiovascular risk factors and kidney function in Native Americans of southwestern heritage with youth and early adult onset type 2 diabetes mellitus (T2DM) versus healthy controls. METHODS: Using computed tomography, we quantified EFV and PFV in 149 Native Americans (92 women, 57 men), 95 of which had T2DM (38 diagnosed prior to age 20 years). Duration of T2DM, mean carotid arterial mass (AM), coronary artery calcification (CAC), IL-6, and estimated glomerular filtration rate eGFRcr(CKD-EPI) were measured...
January 23, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30666528/gender-difference-in-authorship-of-clinical-practice-guidelines-and-position-statements-in-endocrinology
#14
LETTER
A Mantovani, F Sartori
No abstract text is available yet for this article.
January 21, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30635826/bilateral-inferior-petrosal-sinus-sampling-in-adrenocorticotropin-dependent-hypercortisolism-always-never-or-sometimes
#15
M Losa, A Allora, P Panni, C Righi, P Mortini
No abstract text is available yet for this article.
January 11, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30628046/local-ablative-therapy-of-oligoprogressive-tki-treated-thyroid-cancer
#16
REVIEW
T Porcelli, F Sessa, C Luongo, D Salvatore
Metastatic cancer patients generally respond well to treatment with tyrosine kinase inhibitors (TKIs). However, TKI resistance occurs in almost all cases and often leads to a change in treatment. Recent guidelines, including thyroid cancer, raised the possibility of locally treating TKI-resistant oligoprogressive disease, i.e., one or a few progressing lesions in an otherwise treatment-responsive metastatic cancer, thereby obviating the need to change the ongoing TKI. To determine the benefits of this intervention, we reviewed studies on the use of LAT for TKI-treated oligoprogressive cancers...
January 9, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30628045/a-lute-player-peasant-with-nodular-goiter-by-bartolomeo-passarotti-1529-1592
#17
F Trimarchi
No abstract text is available yet for this article.
January 9, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30623304/hypothalamic-pituitary-adrenal-axis-function-in-traumatic-spinal-cord-injury-related-neuropathic-pain-a-case-control-study
#18
E Cuce, H Demir, I Cuce, F Bayram
PURPOSE: This study aimed to investigate the hypothalamic-pituitary-adrenal (HPA) axis in spinal cord injury (SCI)-related neuropathic pain (NP) using dynamic adrenocorticotropic hormone (ACTH) stimulation tests. METHODS: This case-control study was conducted with 22 patients diagnosed with traumatic chronic spinal cord injury (15 with and 7 without neuropathic pain) and ten age- and sex-matched healthy control subjects. Collected data included socio-demographic variables, SCI characteristics, and level of NP using a numeric rating scale (NRS) and the Leeds Assessment of Neuropathic Symptoms and Signs pain scale (LANSS)...
January 9, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30618029/the-mediterranean-diet-of-an-italian-worker-of-the-sixteenth-century-portrayed-by-annibale-carracci-1560-1609
#19
F Trimarchi, D Cucinotta
No abstract text is available yet for this article.
January 8, 2019: Journal of Endocrinological Investigation
https://read.qxmd.com/read/30612306/mystical-marriage-of-saint-catherine-by-paolo-veronese-1528-1588
#20
D Lazzeri, F Nicoli
No abstract text is available yet for this article.
January 5, 2019: Journal of Endocrinological Investigation
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