E Varaldo, M Sibilla, F Bioletto, D Cuboni, N Prencipe, C Bona, M Ferrari, F Viglino, L S Aversa, S Grottoli, E Ghigo, V Gasco, A M Berton
PURPOSE: The precise effects of non-steroidal anti-inflammatory drugs on the neuroendocrine hydro-electrolytic regulation are not precisely understood. The aim of this pilot study was to evaluate, in healthy subjects, the neuroendocrine response of the antidiuretic system to intravenous diclofenac infusion. METHODS: For this single-blinded, cross-over study, we recruited 12 healthy subjects (50% women). Test sessions were divided into three observation times (pre-test; test; 48 h post-test), which were repeated equally on two different occasions, with the administration of diclofenac (75 mg in saline solution 0...
May 27, 2023: Journal of Endocrinological Investigation