journal
https://read.qxmd.com/read/38492357/endobronchial-solitary-fibrous-tumors-an-enigma-for-diagnosis
#21
Fátima Ramalhosa, Federica Pezzuto, Francesco Fortarezza, Gianluca Canu, Davide Biondini, Eleonora Faccioli, Roberta Polverosi, Chiara Giraudo, Fiorella Calabrese
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms constituting less than 2% of all soft tissue tumors. They typically originate in the thoracic cavity, mainly in the pleura, but can also occur in other various sites such as lung parenchyma, pericardium, and bronchus. In this study, a 49-year-old non-smoking female with a history of allergies presented to our pulmonary clinic with a chronic cough. An explorative bronchoscopy revealed an intrabronchial mass in the left superior bronchi, and a 68 Ga-DOTATOC positron emission computed tomography suggested a carcinoid tumor...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38471291/peripheral-t-cell-lymphoma-initially-presenting-in-lung-biopsies-a-diagnostic-challenge
#22
JOURNAL ARTICLE
Lu He, Xianzheng Gao, Fanqing Meng, Jieyu Chen, Qianyun Shi, Linyue Zhao, Jun Yang, Qiang Zhou, Hongyan Wu, Wencai Li, Zhiwen Li
BACKGROUND: Primary or secondary pulmonary involvement by peripheral T cell lymphoma (PTCL) is rare and difficult to diagnose particularly via lung biopsies. METHODS: 22 cases of PTCL diagnosed initially in lung biopsies between January 2006 and November 2020 were retrospectively reviewed followed at Nanjing Drum Tower Hospital and the First Affiliated Hospital of Zhengzhou University, respectively, including clinical manifestations, baseline biochemical indexes, images, histological findings and other available ancillary studies such as immunostaining, Epstein-Barr virus encoded RNA (EBER) in situ hybridization and T-cell receptor rearrangement analysis upon diagnosis...
March 2, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452586/prognostic-value-of-genome-wide-methylation-in-acute-on-chronic-hepatitis-b-liver-failure
#23
JOURNAL ARTICLE
Haiming Li, Shuai Gao, Jieru Yang, Ying Zhang, Xuefei, Yuchen Fan, Kai Wang
AIM: Methylation status of genome varies between pre-acute-on-chronic hepatitis B liver failure (pre-ACHBLF), acute-on-chronic hepatitis B liver failure (ACHBLF), and chronic hepatitis B patients. This study aimed to find better prognostic indicators for acute-on-chronic liver failure. METHODS: The level of global genome methylation in peripheral blood mononuclear cells (PBMCs) was detected. The overall genome methylation rate was determined using MethylFlash™ Methylated DNA Quantification Kit(Colorimetric)...
March 2, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452583/sirt7-a-potential-prognostic-marker-and-therapeutic-target-in-gallbladder-cancer
#24
JOURNAL ARTICLE
Bo Xu, Xiaojing Cai, Guohao Cai, Guoyu Huang
Gallbladder cancer (GBC) is a highly aggressive malignancy with limited treatment options and poor prognosis. In this study, we aimed to investigate the role of SIRT7, a member of the sirtuin family, in GBC and its potential as a prognostic marker and therapeutic target. Through immunohistochemistry analysis of GBC tissue samples, we observed elevated levels of SIRT7, which were correlated with worse clinicopathological parameters and shorter overall survival in GBC patients. Additionally, through cellular and animal experiments, we have discovered that interfering with SIRT7 can effectively suppress the proliferation, migration, and invasive capabilities of GBC cells...
March 2, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38447489/the-detailed-histopathological-characteristics-of-ovarian-fibroma-compared-with-thecoma-granulosa-cell-tumor-and-sclerosing-stromal-tumor
#25
JOURNAL ARTICLE
Mousa Mobarki, Alexandra Papoudou-Bai, Shaqraa Musawi, Michel Péoc'h, Georgia Karpathiou
BACKGROUND: Ovarian fibromas are benign tumors that can present peculiar morphological features not studied sufficiently. MATERIAL AND METHODS: In this retrospective study, 75 consecutive cases of ovarian fibroma were morphologically compared with 46 thecomas, 16 granulosa cell tumors, and 5 sclerosing stroma tumors for the following factors: the growth pattern as diffuse or nodular, the presence of hyaline plaques, necrosis, keloid-like sclerosis, calcifications, cystic degeneration, fibrous or edematous stroma, prominent vascularity, lutein cells, cellularity, scant or abundant cytoplasm, prominent cell membranes, nuclear grooves, atypia, and mitotic activity...
March 2, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38508996/patient-derived-melanoma-models
#26
REVIEW
Franziska Karras, Manfred Kunz
Melanoma is a very aggressive, rapidly metastasizing tumor that has been studied intensively in the past regarding the underlying genetic and molecular mechanisms. More recently developed treatment modalities have improved response rates and overall survival of patients. However, the majority of patients suffer from secondary treatment resistance, which requires in depth analyses of the underlying mechanisms. Here, melanoma models based on patients-derived material may play an important role. Consequently, a plethora of different experimental techniques have been developed in the past years...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38490099/cancer-stem-cells-the-important-role-of-cd-markers-signaling-pathways-and-micrornas
#27
REVIEW
Amir Gholamzad, Niloofar Khakpour, Elaheh Mohandesi Khosroshahi, Saba Asadi, Zeinab Khazaei Koohpar, Arash Matinahmadi, Ali Jebali, Mohsen Rashidi, Mehrdad Hashemi, Farzaneh Hasani Sadi, Mehrdad Gholamzad
For the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and liver...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452585/beyond-the-genome-malat1-s-role-in-advancing-urologic-cancer-care
#28
REVIEW
Mohd Imran, Abida, Lina Eltaib, Muhammad Irfan Siddique, Mehnaz Kamal, Syed Mohammed Basheeruddin Asdaq, Neelam Singla, Marwan Al-Hajeili, Fatemah Abdulaziz Alhakami, Ahmed Farhan AlQarni, Altaf A Abdulkhaliq, Ali A Rabaan
Urologic cancers (UCs), which include bladder, kidney, and prostate tumors, account for almost a quarter of all malignancies. Long non-coding RNAs (lncRNAs) are tissue-specific RNAs that influence cell growth, death, and division. LncRNAs are dysregulated in UCs, and their abnormal expression may allow them to be used in cancer detection, outlook, and therapy. With the identification of several novel lncRNAs and significant exploration of their functions in various illnesses, particularly cancer, the study of lncRNAs has evolved into a new obsession...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38442448/noncoding-rnas-as-therapeutic-targets-in-autophagy-related-diabetic-cardiomyopathy
#29
REVIEW
Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Saad Alqarni, Sami M Magam, Muhammad Nawaz, Sameer Shaikh, Ahmed Al Otaibi, Najat Masood, Kareem M Younes
Diabetic cardiomyopathy, a multifaceted complication of diabetes mellitus, remains a major challenge in clinical management due to its intricate pathophysiology. Emerging evidence underscores the pivotal role of autophagy dysregulation in the progression of diabetic cardiomyopathy, providing a novel avenue for therapeutic intervention. Noncoding RNAs (ncRNAs), a diverse class of regulatory molecules, have recently emerged as promising candidates for targeted therapeutic strategies. The exploration of various classes of ncRNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) reveal their intricate regulatory networks in modulating autophagy and influencing the pathophysiological processes associated with diabetic cardiomyopathy...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38484655/a-comprehensive-review-of-lncrna-crnde-in-cancer-progression-and-pathology-with-a-specific-glance-at-the-epithelial-mesenchymal-transition-emt-process
#30
REVIEW
Saade Abdalkareem Jasim, Sulieman Ibraheem Shelash Al-Hawary, Ahmed Hjazi, Irfan Ahmad, Irwanjot Kaur, Wesam R Kadhum, Adnan Taan Alkhafaji, Pallavi Ghildiyal, Mohammed Abed Jawad, Salim B Alsaadi
It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we briefly overview its biological action and related cancer-related pathways...
February 27, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38461693/progress-in-long-non-coding-rnas-as-prognostic-factors-of-papillary-thyroid-carcinoma
#31
REVIEW
Hao-Nan Zhu, Dong-Liang Song, Si-Nan Zhang, Zhao-Jie Zheng, Xing-Yu Chen, Xin Jin
Papillary thyroid carcinoma (PTC) is generally recognized as a slow-growing tumor. However, a small subset of patients may still experience relapse or metastasis shortly after therapy, leading to a poor prognosis and raising concerns about excessive medical treatment. One major challenge lies in the inadequacy of effective biomarkers for accurate risk stratification. Long non-coding RNAs (lncRNAs), which are closely related to malignant characteristics and poor prognosis, play a significant role in the genesis and development of PTC through various pathways...
February 27, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38460244/laparoscopic-retroperitoneal-lymphadenectomy-for-ovarian-mixed-germ-cell-tumor-in-a-patient-with-situs-inversus-totalis-reporting-the-first-case-worldwide-with-literature-review-and-in-silico-analysis
#32
Ahmed Shoukry Hafez, Mohammed Mamdouh Asar, Sayed Farid, Ahmed Abdelsamad, Nadia M Hamdy
BACKGROUND: Situs inversus totalis (SIT) is a rare autosomal recessive inheritance at which the abdomino-thoracic organs are mirror-image transposed. Germ cell tumors originate from the primitive germ cell of the ovary and testis. CASE REPORT PRESENTATION: A rare association between malignant ovarian mixed germ cell tumor and SIT was presented in a 32-years-old Egyptian female, successfully treated with laparoscopic total abdominal hysterectomy, right salpingo-oophorectomy, and retroperitoneal lymphadenectomy (laparoscopic retroperitoneal lymphadenectomy) of both sides...
February 27, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38422911/long-noncoding-rna-linc00675-drives-malignancy-in-acute-myeloid-leukemia-via-the-mir-6809-cdk6-axis
#33
JOURNAL ARTICLE
Xinyi Long, Huinan Jiang, Zhuogang Liu, Jing Liu, Rong Hu
Hematological malignancies such as acute myeloid leukemia (AML) have a low cure rate and a high recurrence rate. Long noncoding RNAs (LNCs) are essential regulators of tumorigenesis and progression. The role of lncRNA LINC00675 in AML has rarely been reported. This study revealed elevated LINC00675 expression in AML that promotes proliferation and inhibits apoptosis. Mechanistically, LINC00675 combines with miR-6809 to promote the expression of CDK6 in vitro and in vivo. Immune-checkpoint genes were expressed more highly in LINC00675-high patients...
February 27, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452587/harnessing-the-supremacy-of-meg3-lncrna-to-defeat-gastrointestinal-malignancies
#34
REVIEW
H H Rashwan, A M Taher, H A Hassan, A A Awaji, C J Kiriacos, R A Assal, R A Youness
Evidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gastrointestinal cancers such as colorectal cancer, gall bladder cancer, pancreatic cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, gastrointestinal stromal tumors and most importantly, hepatocellular carcinoma...
February 23, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452584/exploring-ncrna-mediated-pathways-in-sepsis-induced-pyroptosis
#35
REVIEW
Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal, Pooja Bansal, Harpreet Kaur, Mahamedha Deorari, Haider Ali, Moyad Shahwan, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Hairsh Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Sepsis, a potentially fatal illness caused by an improper host response to infection, remains a serious problem in the world of healthcare. In recent years, the role of ncRNA has emerged as a pivotal aspect in the intricate landscape of cellular regulation. The exploration of ncRNA-mediated regulatory networks reveals their profound influence on key molecular pathways orchestrating pyroptotic responses during septic conditions. Through a comprehensive analysis of current literature, we navigate the diverse classes of ncRNAs, including miRNAs, lncRNAs, and circRNAs, elucidating their roles as both facilitators and inhibitors in the modulation of pyroptotic processes...
February 23, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38452582/emerging-role-of-tumor-suppressing-micrornas-as-therapeutics-in-managing-non-small-cell-lung-cancer
#36
REVIEW
Shubham Singh, Sangeeta Saxena, Himani Sharma, Keshav Raj Paudel, Amlan Chakraborty, Ronan MacLoughlin, Brian G Oliver, Gaurav Gupta, Poonam Negi, Sachin Kumar Singh, Kamal Dua
Lung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of key genes such as EGFR, Wnt/β-catenin signaling, ALK, MET, K-Ras and p53 and downstream signaling pathways associated with tumor growth, differentiation, and survival...
February 23, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38432050/unraveling-igfbp3-mediated-m6a-modification-in-fracture-healing
#37
JOURNAL ARTICLE
Aining Lai, Junjian Sun, Zhiyuan Dai, Long Guo, Degang Tao, Haitang Li, Bin Chen, Rong Zhou
BACKGROUND: This study investigates the role of IGFBP3-mediated m6A modification in regulating the miR-23a-3p/SMAD5 axis and its impact on fracture healing, aiming to provide insights into potential therapeutic targets. METHODS: Utilizing fracture-related datasets, we identified m6A modification-related mRNA and predicted miR-23a-3p as a regulator of SMAD5. We established a mouse fracture healing model and conducted experiments, including Micro-CT, RT-qPCR, Alizarin Red staining, and Alkaline phosphatase (ALP) staining, to assess gene expression and osteogenic differentiation...
February 22, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38430814/unlocking-the-potential-of-exosomes-in-cancer-research-a-paradigm-shift-in-diagnosis-treatment-and-prevention
#38
REVIEW
Saloomeh Khoushab, Mina Hobabi Aghmiuni, Negin Esfandiari, Mohammad Reza Roudaki Sarvandani, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Mehrdad Hashemi
Exosomes, which are tiny particles released by cells, have the ability to transport various molecules, including proteins, lipids, and genetic material containing non-coding RNAs (ncRNAs). They are associated with processes like cancer metastasis, immunity, and tissue repair. Clinical trials have shown exosomes to be effective in treating cancer, inflammation, and chronic diseases. Mesenchymal stem cells (MSCs) and dendritic cells (DCs) are common sources of exosome production. Exosomes have therapeutic potential due to their ability to deliver cargo, modulate the immune system, and promote tissue regeneration...
February 20, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38458087/two-effective-factors-in-cancer-investigating-the-effect-of-ncrnas-in-cancer-and-also-the-effect-of-nanotherapy-in-its-treatment
#39
REVIEW
Raed Obaid Saleh, Hariadi Yuseran, Sofiene Mansouri, Anaheed Hussein Kareem, Maha Noori Shakir, Mohammed Qasim Alasheqi, Nabiyeva Naima Akhmedovna, Sheraliyeva Intizor Dilmurodovna, Ahmed Alawadi, Ali Alsalamy
Cancer remains one of the most pressing health challenges globally, necessitating ongoing research into innovative therapeutic approaches. This article explores two critical factors influencing cancer: ncRNAs and nanotherapy. The role of ncRNAs, including microRNAs and long non-coding RNAs, in cancer pathogenesis, progression, and treatment resistance is elucidated. Additionally, the potential of nanotherapy, leveraging nanoscale materials for targeted drug delivery and enhanced therapeutic efficacy, is investigated...
February 17, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38422912/prediction-of-the-binding-location-between-the-nuclear-inhibitor-of-dna-binding-and-differentiation-2-id2-and-hspa5
#40
JOURNAL ARTICLE
Abdo A Elfiky
Glucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along with molecular dynamics simulation...
February 17, 2024: Pathology, Research and Practice
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