Nourhan M Abdelmaksoud, Hesham A El-Mahdy, Ahmed Ismail, Elsayed G E Elsakka, Ahmed A El-Husseiny, Emad Gamil Khidr, Esraa M Ali, Mohammed Helmy Rashed, Fatma El-Saeed El-Demerdash, Ahmed S Doghish
Endometrial cancer (EC) is the 2nd common cancer in females after breast cancer. Besides, it's the most common among gynecological cancers. Several epigenetic factors such as miRNAs have been reported to affect EC aspects including initiation, progression, angiogenesis, and resistance to therapy. miRNAs could regulate the expression of various genes involved in EC pathogenesis. This effect is attributed to miRNAs' effects in proliferation, apoptosis, cell cycle, angiogenesis, invasion, and metastasis. miRNAs also influence crucial EC-related mechanistic pathways such as JAK/STAT axis, EGFR, TGF-β signaling, and P53...
March 11, 2023: Pathology, Research and Practice