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International Journal of Pharmaceutics

https://read.qxmd.com/read/38986968/development-of-ph-sensitive-hydrogel-for-advanced-wound-healing-graft-copolymerization-of-locust-bean-gum-with-acrylamide-and-acrylic-acid
#1
JOURNAL ARTICLE
Alka, Priya Singh, Ravi Raj Pal, Nidhi Mishra, Neelu Singh, Abhishek Verma, Shubhini A Saraf
Wounds pose a formidable challenge in healthcare, necessitating the exploration of innovative tissue-healing solutions. Traditional wound dressings exhibit drawbacks, causing tissue damage and impeding natural healing. Using a Microwave (MW)-)-assisted technique, we envisaged a novel hydrogel (Hg) scaffold to address these challenges. This hydrogel scaffold was created by synthesizing a pH-responsive crosslinked material, specifically locust bean gum-grafted-poly(acrylamide-co-acrylic acid) [LBG-g-poly(AAm-co-AAc)], to enable sustained release of c-phycocyanin (C-Pc)...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986967/the-effects-of-bioactive-glass-hydrogel-coated-with-hyaluronic-acid-pluronic-f-127-conjugates-containing-silver-nanoparticles-to-accelerate-healing-of-infected-wounds
#2
JOURNAL ARTICLE
Reza Fayaz, Mohammad Reza Farahpour, Zohreh Ghazi Tabatabaei
Antimicrobial resistance has forced researchers to produce new dressings for the treatment of infected wounds. Tissue engineering based on biomaterials is used to accelerate the wound healing process. The purpose of this study was to examine the effects of bioactive glass (BG) hydrogel coated with hyaluronic acid (HA)-Pluronic F-127 (PLF-127) conjugates containing silver nanoparticles (AgNPs) for healing the infected wounds. HA/BG, PL&HA/BG and PL&HA/BG-AgNPs formulations were designed and their properties were evaluated for application in the wound healing process...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986966/red-blood-cells-based-nanotheranostics-a-smart-biomimetic-approach-for-fighting-against-cancer
#3
REVIEW
Ranjita Misra, Naomi Sanjana Sharath
The technique of engineering drug delivery vehicles continues to develop, which bring enhancements in working more efficiently and minimizing side effects to make it more effective and safer. The intense capability of therapeutic agents to remain undamaged in a harsh extracellular environment is helpful to the success of drug development efforts. With this in mind, alterations of biopharmaceuticals with enhanced stability and decreased immunogenicity have been an increasingly active focus of such efforts. Red blood cells (RBCs), also known as erythrocytes have undergone extensive scrutiny as potential vehicles for drug delivery due to their remarkable attributes over the years of research...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986965/breaking-barriers-innovative-approaches-for-skin-delivery-of-rna-therapeutics
#4
JOURNAL ARTICLE
Gowtham Subramanian, Kamaladasan Kalidasan, Shan Quah, Han Qi Chou Gavin, Justin Chan, Matthias G Wacker, Prabha Sampath
RNA therapeutics represent a rapidly expanding platform with game-changing prospects in personalized medicine. The disruptive potential of this technology will overhaul the standard of care with reference to both primary and specialty care. To date, RNA therapeutics have mostly been delivered parenterally via injection, but topical administration followed by intradermal or transdermal delivery represents an attractive method that is convenient to patients and minimally invasive. The skin barrier, particularly the lipid-rich stratum corneum, presents a significant hurdle to the uptake of large, charged oligonucleotide drugs...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986964/a-systematic-comparison-of-four-pharmacopoeial-methods-for-measuring-powder-flowability
#5
JOURNAL ARTICLE
Weeraya Tharanon, Yiwang Guo, Jomjai Peerapattana, Changquan Calvin Sun
Powder flow is one of the crucial factors affecting several pharmaceutical manufacturing processes. Problems due to insufficient powder flow reduce production process efficiency and cause suboptimum product quality. The U.S. Pharmacopoeia has specified four methods to evaluate the flowability of pharmaceutical powders, including angle of repose (AoR), compressibility index (CI) and Hausner ratio (HR), Flow through an orifice, and shear cell. Comparison within and between those methods with 21 powders (covering a wide range of flowability) was performed in this study...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986963/integration-of-mucus-and-its-impact-within-in-vitro-setups-for-inhaled-drugs-and-formulations-identifying-the-limits-of-simple-vs-complex-methodologies-when-studying-drug-dissolution-and-permeability
#6
JOURNAL ARTICLE
Snezana Radivojev, Lukas Kargl, Joana T Pinto, Magda Swedrowska, Maria Malmlöf, Claudia Meindl, Ben Forbes, Per Gerde, Amrit Paudel, Eleonore Fröhlich
Traditionally, developing inhaled drug formulations relied on trial and error, yet recent technological advancements have deepened the understanding of 'inhalation biopharmaceutics' i.e. the processes that occur to influence the rate and extent of drug exposure in the lungs. This knowledge has led to the development of new in vitro models that predict the in vivo behavior of drugs, facilitating the enhancement of existing formulation and the development of novel ones. Our prior research examined how simulated lung fluid (SLF) affects the solubility of inhaled drugs...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38986962/indocyanine-green-j-aggregate-ija-theranostics-challenges-and-opportunities
#7
JOURNAL ARTICLE
Hamoud Alotaibi, Taher Hatahet, Wafa' T Al-Jamal
Indocyanine green is an FDA-approved fluorescent imaging dye used for determining cardiac output, hepatic function, liver blood flow, and retinal perfusion. It has been investigated preclinically in photoacoustic imaging and photothermal therapy (PTT); however, ICG photodegradation limits its biomedical applications. An aggregated form of ICG, known as J-aggregate (IJA), exhibits superior photoacoustic signals and thermal stability than the monomeric ICG. Nevertheless, IJA still suffers from low stability in the biological milieu, and short in vivo blood circulation...
July 8, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38977165/assessment-of-subcutaneously-administered-insulins-using-in-vitro-release-cartridge-medium-composition-and-albumin-binding
#8
JOURNAL ARTICLE
Frederik Bock, Nadia Zivlaei, Anna Thu Hoai Nguyen, Susan Weng Larsen, Xujin Lu, Jesper Østergaard
Biotherapeutics is the fastest growing class of drugs administered by subcutaneous injection. In vitro release testing mimicking physiological conditions at the injection site may guide formulation development and improve biopredictive capabilities. Here, anin vitrorelease cartridge (IVR cartridge) comprising a porous agarose matrix emulating subcutaneous tissue was explored. The objective was to assess effects of medium composition and incorporation of human serum albumin into the matrix. Drug disappearance was assessed for solution, suspension and in situ precipitating insulin products (Actrapid, Levemir, Tresiba, Mixtard 30, Insulatard, Lantus) using the flow-based cartridge...
July 6, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38977164/liposomal-quercetin-a-promising-strategy-to-combat-hepatic-insulin-resistance-and-inflammation-in-type-2-diabetes-mellitus
#9
JOURNAL ARTICLE
Sónia Rocha, M Luísa Corvo, Marisa Freitas, Eduarda Fernandes
In type 2 diabetes mellitus, hepatic insulin resistance is intricately associated with oxidative stress and inflammation. Nonetheless, the lack of therapeutic interventions directly targeting hepatic dysfunction represents a notable gap in current treatment options. Flavonoids have been explored due to their potential anti-diabetic effects. However, these compounds are associated with low bioavailability and high metabolization. In the present study, four flavonoids, kaempferol, quercetin, kaempferol-7-O-glucoside and quercetin-7-O-glucoside, were studied in a cellular model of hepatic insulin resistance using HepG2 cells...
July 6, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38977163/a-dual-prodrug-nanogel-combining-vorinostat-and-pyropheophorbide-a-for-a-high-efficient-photochemotherapy
#10
JOURNAL ARTICLE
Weiwei Jiang, Yuwei Cheng, Lei Hou, Ying Huang, Sizhen Wang, Yunchang Zhang, Tao Jiang, Feng Yang, Zhiqiang Ma
The challenges posed by intractable relapse and metastasis in cancer treatment have led to the development of various forms of photodynamic therapy (PDT). However, traditional drug delivery systems, such as virus vectors, liposomes, and polymers, often suffer from issues like desynchronized drug release, carrier instability, and drug leakage during circulation. To address these problems, we have developed a dual-prodrug nanogel (PVBN) consisting of Pyro (Pyropheophorbide a) and SAHA (Vorinostat) bound to BSA (Bovine Serum Albumin), which facilitates synchronous and spontaneous drug release in situ within the lysosome...
July 6, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972524/quaternized-oxidized-sodium-alginate-injectable-hydrogel-with-high-antimicrobial-and-hemostatic-efficacy-promotes-diabetic-wound-healing
#11
JOURNAL ARTICLE
Shuang Ma, Kecheng Chen, Qiteng Ding, Shuai Zhang, Yang Lu, Taojing Yu, Chuanbo Ding, Wencong Liu, Shuang Liu
In this paper, a hydrogel material with efficient antibacterial, hemostatic, self-healing, and injectable properties was designed for the treatment of diabetic wounds. Firstly, quaternary ammonium salts were grafted with oxidized sodium alginate, and quaternized oxidized sodium alginate (QOSA) was synthesized. Due to the introduction of quaternary ammonium group it has antibacterial and hemostatic effects, at the same time, due to the presence of aldehyde group it can be reacted with carboxymethyl chitosan (CMCS) to form a hydrogel through the Schiff base reaction...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972523/hydroxytyrosol-permeability-comparisons-and-strategies-to-improve-hydroxytyrosol-stability-in-formulations
#12
JOURNAL ARTICLE
Mengmeng Feng, Yize Li, Yanfei Jiang, Chunyue Zhao
There has been a growing interest in hydroxytyrosol (HT) due to its powerful antioxidant and free-radical scavenging properties when added to formulations such as pharmaceuticals and cosmetics. To study the stability and transdermal properties of hydrogels and creams (HT-based formulations), a high-performance liquid chromatography method was developed for determining HT. In the Franz diffusion cell system, both hydrogel and cream show a rapid and similar penetration profile through the Bama miniature pig skin...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972522/a-multi-scale-numerical-study-of-monoclonal-antibodies-uptake-by-initial-lymphatics-after-subcutaneous-injection
#13
JOURNAL ARTICLE
Chenji Li, Xiaoxu Zhong, Ehsan Rahimi, Arezoo M Ardekani
This paper studies the transport of monoclonal antibodies through skin tissue and initial lymphatics, which impacts the pharmacokinetics of monoclonal antibodies. Our model integrates a macroscale representation of the entire skin tissue with a mesoscale model that focuses on the papillary dermis layer. Our results indicate that it takes hours for the drugs to disperse from the injection site to the papillary dermis before entering the initial lymphatics. Additionally, we observe an inhomogeneous drug distribution in the interstitial space of the papillary dermis, with higher drug concentrations near initial lymphatics and lower concentrations near blood capillaries...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972521/smart-laser-sintering-deep-learning-powered-powder-bed-fusion-3d-printing-in-precision-medicine
#14
JOURNAL ARTICLE
Youssef Abdalla, Martin Ferianc, Atheer Awad, Jeesu Kim, Moe Elbadawi, Abdul W Basit, Mine Orlu, Miguel Rodrigues
Medicines remain ineffective for over 50% of patients due to conventional mass production methods with fixed drug dosages. Three-dimensional (3D) printing, specifically selective laser sintering (SLS), offers a potential solution to this challenge, allowing the manufacturing of small, personalized batches of medication. Despite its simplicity and suitability for upscaling to large-scale production, SLS was not designed for pharmaceutical manufacturing and necessitates a time-consuming, trial-and-error adaptation process...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972520/anti-egfr-immunoliposomes-for-cabazitaxel-delivery-from-formulation-development-to-in-vivo-evaluation-in-prostate-cancer-xenograft-model
#15
JOURNAL ARTICLE
Ana Carolina Cruz de Sousa, Elias da Silva Santos, Thais da Silva Moreira, Maria Gabriela Araújo Mendes, Bruno Rodrigues Arruda, Celina de Jesus Guimarães, José de Brito Vieira Neto, Yara Santiago de Oliveira, Alejandro Pedro Ayala, Mac Dionys Rodrigues da Costa, Tiago Lima Sampaio, Ana Paula Negreiros Nunes Alves, Cláudia Pessoa, Raquel Petrilli, Josimar O Eloy
Liposomes functionalized with monoclonal antibodies offer targeted therapy for cancer, boasting advantages like sustained drug release, enhanced stability, passive accumulation in tumors, and interaction with overexpressed receptors on cancer cells. This study aimed to develop and characterize anti-EGFR immunoliposomes loaded with cabazitaxel and assess their properties against prostate cancer in vitro and in vivo. Using a Box-Behnken design, a formulation with soy phosphatidylcholine, 10% cholesterol, and a 1:20 drug-lipid ratio yielded nanometric particle size, low polydispersity and high drug encapsulation...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972519/targeted-ph-responsive-biomimetic-nanoparticle-mediated-starvation-enhanced-chemodynamic-therapy-combined-with-chemotherapy-for-ovarian-cancer-treatment
#16
JOURNAL ARTICLE
Mingzhu Ye, Roumei Ye, Yun Wang, Mengyu Guo, Maoshu Zhu, Fengyue Yin, Yubo Wang, Xiaoqin Lai, Yu Wang, Zhongqun Qi, Jinling Wang, Dengyue Chen
In recent years, the use of arsenic trioxide (ATO) in the context of ovarian cancer chemotherapy has attracted significant attention. However, ATO's limited biocompatibility and the occurrence of severe toxic side effects hinder its clinical application. A nanoparticle (NP) drug delivery system using ATO as a therapeutic agent is reported in this study. Achieving a synergistic effect by combining starvation therapy, chemodynamic therapy, and chemotherapy for the treatment of ovarian cancer was the ultimate goal of this system...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38972518/exploring-the-influence-of-hydrogen-bond-donor-groups-on-the-microstructure-and-intermolecular-interactions-of-amorphous-solid-dispersions-containing-diflunisal-structural-analogues
#17
JOURNAL ARTICLE
Lennert Cools, Elien Derveaux, Felien Reniers, Wim Dehaen, Peter Adriaensens, Guy Van den Mooter
Drug-polymer intermolecular interactions, and H-bonds specifically, play an important role in the stabilization process of a compound in an amorphous solid dispersion (ASD). However, it is still difficult to predict whether or not interactions will form and what the strength of those interactions would be, based on the structure of drug and polymer. Therefore, in this study, structural analogues of diflunisal (DIF) were synthesized and incorporated in ASDs with poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA) as a stabilizing polymer...
July 5, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38971512/irinotecan-loaded-magnetite-silica-core-shell-systems-for-colorectal-cancer-treatment
#18
JOURNAL ARTICLE
Cristina Chircov, Mihai-Cătălin Petcu, Bogdan Stefan Vasile, Bogdan Purcăreanu, Adrian Ionut Nicoară, Ovidiu Cristian Oprea, Roxana Cristina Popescu
Colorectal cancer represents a worldwide spread type of cancer and it is regarded as one of the leading death causes, along with lung, breast, and prostate cancers. Since conventional surgical resection and chemotherapy proved limited efficiency, the use of alternative drug delivery systems that ensure the controlled release of cytostatic agents possess immense potential for treatment. In this regard, the present study aimed to develop and evaluate the efficiency of a series of irinotecan-loaded magnetite-silica core-shell systems...
July 4, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38971511/development-of-monoclonal-antibodies-in-tablet-form-a-new-approach-for-local-delivery
#19
JOURNAL ARTICLE
Julie Auffray, Hassana Hsein, Nicolas Biteau, Christophe Velours, Thierry Noel, Pierre Tchoreloff
Among the various pharmaceutical forms, tablets offer numerous advantages, like ease of administration, cost-effectiveness in production, and better stability of biomolecules. Beyond these benefits, the tablet form opens up possibilities for alternative routes for the local delivery of biopharmaceuticals such as oral or vaginal administration, thereby expanding the therapeutic applications of these biomolecules and overcoming the inconvenients associated with parenteral administration. However, to date there is limited information on the feasibility of developing biomolecules in the tablet form...
July 4, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38971510/nano-co-delivery-of-doxorubicin-and-plumbagin-achieves-synergistic-chemotherapy-of-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Chenyu Cao, Yifei Li, Fangzhou Shi, Shanshan Jiang, Yutong Li, Leilei Yang, Xinyi Zhou, Yuqiong Gao, Feiyan Tang, Huan Li, Shulan Han, Zhuo Yu, Yifang Zou, Jianfeng Guo
Doxorubicin (DOX) is a chemotherapy drug used for hepatocellular carcinoma (HCC) treatment, but its effectiveness can be dramatically dampened by cancer cell chemoresistance. Signal transducer and activator of transcription 3 (STAT3) is implicated with drug resistance in a range of cancers (e.g., HCC), and the STAT3 inhibition can reverse the resistance of cancer cells to chemotherapeutic drugs. In the present study, a combination regimen to improve the efficiency of DOX was provided via the STAT3 blockade using plumbagin (PLB)...
July 4, 2024: International Journal of Pharmaceutics
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