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Journals International Journal of Pharm...

International Journal of Pharmaceutics

https://read.qxmd.com/read/38527922/corrigendum-to-ifn-%C3%AE-gene-loaded-human-umbilical-mesenchymal-stromal-cells-targeting-therapy-for-graft-versus-host-disease-int-j-pharm-592-2021-120058
#1
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
No abstract text is available yet for this article.
March 25, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38531434/an-enhanced-cardio-protective-effect-of-nanoparticles-loaded-with-active-components-from-polygonum-orientale-l-against-isoproterenol-induced-myocardial-ischemia-in-rats
#2
JOURNAL ARTICLE
Jincheng Jing, Shumei Fang, Yueting Li, Wenting Liu, Cong Wang, Yanyu Lan, Yonglin Wang, Chang Yang
In this study, nanoparticles loaded with active components from Polygonum orientale L. (PO), a traditional Chinese herb known for its anti-myocardial ischemic properties, were investigated for cardio-protective properties. Specifically, OVQ-Nanoparticles (OVQ-NPs) with Orientin (Ori), Vitexin (Vit), and Quercetin (Que) was obtained by double emulsion-solvent evaporation method. The OVQ-NPs exhibited a spherical shape, with a uniform size distribution of 136.77 ± 3.88 nm and a stable ζ-potential of -13...
March 24, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38531433/difucosin-diclofenac-sodium-salt-loaded-fucoidan-sericin-nanoparticles-for-the-management-of-chronic-inflammatory-diseases
#3
JOURNAL ARTICLE
Agnese Gagliardi, Emanuela Chiarella, Silvia Voci, Nicola Ambrosio, Marilena Celano, Maria Cristina Salvatici, Donato Cosco
The current investigation emphasizes the use of fucoidan and sericin as dual-role biomaterials for obtaining novel nanohybrid systems for the delivery of diclofenac sodium (DS) and the potential treatment of chronic inflammatory diseases. The innovative formulations containing 4 mg/ml of fucoidan and 3 mg/ml of sericin showed an average diameter of about 200 nm, a low polydispersity index (0.17) and a negative surface charge. The hybrid nanosystems demonstrated high stability at various pHs and temperatures, as well as in both saline and glucose solutions...
March 24, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527566/development-of-a-hydrogel-containing-bisabolol-loaded-nanocapsules-for-the-treatment-of-atopic-dermatitis-in-a-balb-c-mice-model
#4
JOURNAL ARTICLE
Homa Karami, Mohammad Reza Niavand, Rasool Haddadi, Alireza Noriyan, Seyed Yaser Vafaei
α-Bisabolol (αBIS), a plant-derived compound with anti-inflammatory properties, is potentially a therapeutic agent for Atopic dermatitis. However, its poor water solubility and photoinstability limit its topical application. Therefore, the present study, aimed to develop cationic polymeric nanocapsules of αBIS to improve its skin delivery, photostability, and therapeutic efficacy. The αBIS- loaded nanocapsules were prepared using the solvent displacement technique. A Box-Behnken (BB) design was employed to statistically optimize formulation variables and αBIS- loaded nanocapsules characterized by particle size, surface charge and encapsulation efficiency...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527565/ultrasound-imaging-guided-targeted-sonodynamic-therapy-enhanced-by-magnetophoretically-controlled-magnetic-microbubbles
#5
JOURNAL ARTICLE
Yao Zhu, Gulzira Arkin, Tianzhen He, Fengjuan Guo, Ling Zhang, Yu Wu, Paras N Prasad, Zhongjian Xie
Sonodynamic therapy (SDT) utilizes ultrasonic excitation of a sensitizer to generate reactive oxygen species (ROS) to destroy tumor. Two dimensional (2D) black phosphorus (BP) is an emerging sonosensitizer that can promote ROS production to be used in SDT but it alone lacks active targeting effect and showed low therapy efficiency. In this study, a stable dispersion of integrated micro-nanoplatform consisting of BP nanosheets loaded and Fe3 O4 nanoparticles (NPs) connected microbubbles was introduced for ultrasound imaging guided and magnetic field directed precision SDT of breast cancer...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527564/fabrication-optimization-and-evaluation-of-lyophilized-lacidipine-loaded-fatty-based-nanovesicles-as-orally-fast-disintegrating-sponge-delivery-system
#6
JOURNAL ARTICLE
Rania Moataz El-Dahmy, Ahmed Hassen Elshafeey, Yasmin Ahmed El-Feky
Lacidipine (LCD) is a potent antihypertensive agent. Fatty-based nanovesicles (FNVs) were designed to improve LCD low solubility and bioavailability. LCD-FNVs were formulated according to different proportions of cetyl alcohol, cremophor®RH40, and oleic acid adopting Box-Behnken Design. The optimized LCD-FNVs, composed of cetyl alcohol 48.4 mg, cremophor®RH40 120 mg, and oleic acid 40 mg, showed minimum vesicle size (124.8 nm), maximum entrapment efficiency % (91.04 %) and zeta potential (-36...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527563/formulation-and-evaluation-of-inhaled-sildenafil-loaded-plga-microparticles-for-treatment-of-pulmonary-arterial-hypertension-pah-a-novel-high-drug-loaded-formulation-and-scalable-process-via-hot-melt-extrusion-technology-part-%C3%A2
#7
JOURNAL ARTICLE
Mashan Almutairi, Amr Hefnawy, Ahmed Almotairy, Ahmed Alobaida, Mohammed Alyahya, Abdulmajeed Althobaiti, Ahmed Adel Ali Youssef, Rasha M Elkanayati, Eman A Ashour, Hugh D C Smyth, Michael A Repka
In recent years, several techniques were employed to develop a local sustained pulmonary delivery of sildenafil citrate (SC) as an alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). Most of these methods, however, need to be improved due to limitations of scalability, low yield production, low drug loading, and stability issues. In this study, we report the use of hot-melt extrusion (HME) as a scalable process for making Poly (lactic-co-glycolic acid) (PLGA) microparticles with high SC load...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38522491/surface-modification-of-hollow-gold-nanoparticles-conducted-by-incorporating-cancer-cell-membrane-and-as1411-aptamer-aiming-to-achieve-a-dual-targeted-therapy-for-colorectal-cancer
#8
JOURNAL ARTICLE
Sepideh Hassibian, Seyed Mohammad Taghdisi, Zahra Jamshidi, Ali Samie, Morteza Alinezhad Nameghi, Mersedeh Shayan, Naser Farrokhi, Mona Alibolandi, Mohammad Ramezani, Seyed Mohsen Dehnavi, Khalil Abnous
Due to its inherent membrane structure, a nanostructure enveloped by an active cell membrane possesses distinctive characteristics such as prolonged presence in the bloodstream, precise identification capabilities, and evasion of immune responses. This research involved the production of biomimetic nanoparticles, specifically hollow gold nanoparticles (HGNPs) loaded with methotrexate (MTX), which were further coated with cancer cell membrane. These nanoparticles were then adorned with AS1411 aptamer to serve as a targeting agent (Apt-CCM-HG@MTX)...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38522490/synergism-of-polysaccharide-polymers-in-antihistamine-eye-drops-influence-on-physicochemical-properties-and-in-vivo-efficacy
#9
JOURNAL ARTICLE
Anđelka Račić, Bisera Jurišić Dukovski, Jasmina Lovrić, Vladimir Dobričić, Sonja Vučen, Ana Micov, Radica Stepanović-Petrović, Maja Tomić, Uroš Pecikoza, Jelena Bajac, Danina Krajišnik
The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient, containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between ketotifen and polymers...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38522489/numerical-study-of-drop-dynamics-for-inkjet-based-3d-printing-of-pharmaceutical-tablets
#10
JOURNAL ARTICLE
Tanu Mehta, Hossain Aziz, Koyel Sen, Venkatraman Nagarajan, Anson W K Ma, Bodhisattwa Chaudhuri
Interest in 3D printing has been growing rapidly especially in pharmaceutical industry due to its multiple advantages such as manufacturing versatility, personalization of medicine, scalability, and cost effectiveness. Inkjet based 3D printing gained special attention after FDA's approval of Spritam® manufactured by Aprecia pharmaceuticals in 2015. The precision and printing efficiency of 3D printing is strongly influenced by the dynamics of ink/binder jetting, which further depends on the ink's fluid properties...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38521692/withdrawal-notice-to-gastroretentive-fibrous-dosage-forms-for-prolonged-delivery-of-sparingly-soluble-tyrosine-kinase-inhibitors-part-2-experimental-validation-of-the-models-of-expansion-mechanical-strength-and-in-vitro-drug-release-int-j-pharm-653-2024-123429
#11
https://read.qxmd.com/read/38521691/withdrawal-notice-to-gastroretentive-fibrous-dosage-forms-for-prolonged-delivery-of-sparingly-soluble-tyrosine-kinase-inhibitors-part-4-experimental-validation-of-the-models-of-in-vivo-expansion-gastric-residence-time-and-drug-concentration-in-blood-int-j-pharm
#12
https://read.qxmd.com/read/38521690/withdrawal-notice-to-gastroretentive-fibrous-dosage-forms-for-prolonged-delivery-of-sparingly-soluble-tyrosine-kinase-inhibitors-part-3-theoretical-models-of-in-vivo-expansion-gastric-residence-time-and-drug-concentration-in-blood-int-j-pharm-653-2024-123478
#13
https://read.qxmd.com/read/38521689/withdrawal-notice-to-gastroretentive-fibrous-dosage-forms-for-prolonged-delivery-of-sparingly-soluble-tyrosine-kinase-inhibitors-part-1-dosage-form-design-and-models-of-expansion-post-expansion-mechanical-strength-and-drug-release-int-j-pharm-653-2024-123428
#14
https://read.qxmd.com/read/38521376/zinc-caproate-ecofriendly-synthesis-structural-characterization-and-antibacterial-action
#15
JOURNAL ARTICLE
Jilong Xu, Hanzhen Qiao, Liping Gan, Peng Wang, Jinrong Wang, Yaoming Cui, Jiale Zhou, Qingyu Liu, Yue Jiang, Huadong Zhang, Kunfan Yang
Disease-causing microorganisms such as Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are among the primary contributors to morbidity and mortality of diarrhea in humans. Considering the challenges associated with antibiotic use, including antimicrobial resistance, this study aimed to develop a novel zinc-based agent for bacterial inactivation. To this end, zinc caproate (ZnCA) was synthesized using caproic acid (CA) and zinc oxide (ZnO) in anhydrous ethanol via the solvothermal method. Structural characterization techniques, including Fourier-transform infrared spectroscopy, single crystal X-ray diffraction analysis, and nuclear magnetic resonance spectroscopy, revealed the bidentate bridging coordination of zinc atoms with CA...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38521375/development-of-a-self-microemulsifying-drug-delivery-system-to-deliver-delamanid-via-a-pressurized-metered-dose-inhaler-for-treatment-of-multi-drug-resistant-pulmonary-tuberculosis
#16
JOURNAL ARTICLE
Himanshu Paliwal, Titpawan Nakpheng, Pijush Kumar Paul, K Prem Ananth, Teerapol Srichana
Tuberculosis (TB) is a serious health issue that contributes to millions of deaths throughout the world and increases the threat of serious pulmonary infections in patients with respiratory illness. Delamanid is a novel drug approved in 2014 to deal with multi-drug resistant TB (MDR-TB). Despite its high efficiency in TB treatment, delamanid poses delivery challenges due to poor water solubility leading to inadequate absorption upon oral administration. This study involves the development of novel formulation-based pressurized metered dose inhalers (pMDIs) containing self-microemulsifying mixtures of delamanid for efficient delivery to the lungs...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38521374/biodegradable-zwitterionic-polymer-cloaked-defective-metal-organic-frameworks-for-ferroptosis-inducing-cancer-therapy
#17
JOURNAL ARTICLE
Minghua Zhang, Xianxian Yao, Jian Xu, Jiaying Song, Shuting Mai, Weichu Zhu, Yichen Zhang, Liangliang Zhu, Wuli Yang
Ferroptosis inhibits tumor growth by iron-dependently accumulating lipid peroxides (LPO) to a lethal extent, which can result from iron overload and glutathione peroxidase 4 (GPX4) inactivation. In this study, we developed biodegradable zwitterionic polymer-cloaked atorvastatin (ATV)-loaded ferric metal-organic frameworks (Fe-MOFs) for cancer treatment. Fe-MOFs served as nanoplatforms to co-deliver ferrous ions and ATV to cancer cells; the zwitterionic polymer membrane extended the circulation time of the nanoparticles and increased their accumulation at tumor sites...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38518872/harnessing-the-potential-of-fatty-acid-surfactant-based-micellar-gel-for-enhanced-topical-delivery-of-apremilast-in-psoriasis-treatment
#18
JOURNAL ARTICLE
Arun Sontakke, Sayali Dighe, Reena Sharma, Vivek Yadav, Sanyog Jain
Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier system presents a novel option to increase the efficacy of the topical treatment of APR. The current investigation deals with the development of fatty acid-surfactant conjugate-based hybrid mixed micellar gel (HMMG) for the topical delivery of APR. The developed micelles exhibited an average size of 83...
March 20, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38518871/co-delivery-of-paclitaxel-atovaquone-quercetin-to-regulate-energy-metabolism-to-reverse-multidrug-resistance-in-ovarian-cancer-by-plga-peg-nanoparticles
#19
JOURNAL ARTICLE
Qingyu Lu, Wenhao Gao, Zhenzhen Chen, Zhihong Liu, Jie Wang, Lingjun Zeng, Xiaomu Hu, Enqin Zheng, Qian Zhang, Hongtao Song
Ovarian cancer is a malignant tumor that seriously endangers the lives of women, with chemotherapy being the primary clinical treatment. However, chemotherapy encounters the problem of generating multidrug resistance (MDR), mainly due to drug efflux induced by P-glycoprotein (P-gp), which decreases intracellular accumulation of chemotherapeutic drugs. The drugs efflux mediated by P-gp requires adenosine triphosphate (ATP) hydrolysis to provide energy. Therefore, modulating energy metabolism pathways and inhibiting ATP production may be a potential strategy to reverse MDR...
March 20, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38518870/how-spray-drying-processing-and-solution-composition-can-affect-the-mabs-stability-in-reconstituted-solutions-for-subcutaneous-injections-part-i-contribution-of-processing-stresses-against-composition
#20
JOURNAL ARTICLE
Carla M Barcelo, Vasco Filipe, Mostafa Nakach, Maria Inês Ré
Spray drying is increasingly being applied to process biopharmaceuticals, particularly monoclonal antibodies (mAbs). However, due to their protein nature, mAbs are susceptible to degradation when subjected to various stresses during a drying process. Despite extensive research in this domain, identifying the appropriate formulation composition and spray drying conditions remains a complex challenge, requiring further studies to enhance the understanding on how process and formulation parameters impact mAb stability in reconstituted solutions...
March 20, 2024: International Journal of Pharmaceutics
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