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Journals Clinical and Investigative Med...

Clinical and Investigative Medicine. Médecine Clinique et Experimentale

https://read.qxmd.com/read/38330184/changes-to-cim-are-on-the-way
#1
EDITORIAL
Robert Bortolussi
No abstract text is available yet for this article.
December 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/38330183/efficacy-and-safety-of-glucocorticoid-in-the-treatment-of-acute-respiratory-distress-syndrome-caused-by-covid-19-a-systematic-review-and-meta-analysis
#2
REVIEW
Xiangyang Jiang, Changyun Zhao, Weihang Hu, Difan Lu, Changqin Chen, Shijin Gong, Jing Yan, Wenchao Mao
BACKGROUND: Glucocorticoids are often used to treat acute respiratory distress syndrome (ARDS) and novel coronavirus disease 2019 (COVID-19). However, the efficacy and safety of glucocorticoids in the treatment of ARDS caused by COVID-19 are still controversial; therefore, we conducted this meta-analysis of the literature on this topic. METHODS: Four databases (PubMed, EMBASE, Cochrane Library, and Web of Science) were searched from the establishment of the databases to August 16, 2023...
December 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/38330182/hats-off-to-the-cim-reviewers-of-2023
#3
JOURNAL ARTICLE
Robert Bortolussi
No abstract text is available yet for this article.
December 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37769276/ccl2-promotes-novel-coronavirus-mediated-inflammatory-responses-in-macrophages
#4
JOURNAL ARTICLE
Fang Ding, Muwei Dai, Xichun Kang, Xin Zhang, Li Li, Lei Zhao, Ping Jiang, Huixia Gao, Huimin Yan
PURPOSE: The hyperinflammatory response is one of the main complications associated with novel coronavirus disease 2019 (COVID-19), and there is no effective treatment for cytokine storm. Therefore, it is important to investigate the key genes associated with severity of the disease. METHODS: In this study, we used a microarray data set to analyze the key genes associated with severe illness in patients with COVID-19. The proportion of immune cells was determined using the CIBERSORT algorithm...
September 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37769275/knowledge-mapping-of-inflammasome-and-pyroptosis-in-stroke-a-bibliometric-analysis-2007-2023
#5
JOURNAL ARTICLE
Mingfen Wu, Aning Sun, Hailun Jiang, Yinan Zhang, Zhigang Zhao, Bin Zhu
BACKGROUND: Stroke is a major contributor to disability and death worldwide. Studies have demonstrated that inflammasome/pyroptosis and its mediated inflammatory response are important factors aggravating brain injury after stroke. We aimed to investigate and map the knowledge structure and global trends on inflam- masome/pyroptosis in stroke. METHODS: All relevant documents were obtained from the Web of Science on 5 June 2023. Bibliometric visualization diagrams were created using VOSviewer and CiteSpace...
September 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37769274/h19-promoter-dna-methylation-is-lower-among-early-abortion-patients-undergoing-ivf-embryo-transfer
#6
JOURNAL ARTICLE
Lei Han, Xianghui Zhang, Xiaohan Wu, Huishu Xu, Baolin Zhang, Yiwei Pang, Peihui Ding, Caiying Zhang, Yanlin Wang, Jiajia An
BACKGROUND: H19 is the first long noncoding RNA (lncRNA) found to be associated with gene imprinting. It is highly expressed in the embryonic stage and may have important regulatory effects on human embryonic development. We investigated the differences between the levels of H19 promoter DNA methylation in the chorionic villi of patients who experienced spontaneous abortion (SA) following in vitro fertilization embryo transfer (IVF-ET) and those of patients with a normal early pregnancy (NEP)...
September 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37769273/fall-2023-clinician-investigator-trainee-association-of-canada-citac
#7
JOURNAL ARTICLE
Melissa S Phuong, Robert X Lao, Salonee V Patel, Amelia T Yuan, Wenxuan Wang
This has been a great first half of the year for CITAC-ACCFC (Clinician Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada)! We are looking forward to our new members joining us in the fall and welcoming back our previous members after the summer.
September 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37769272/overview-of-the-the-clinician-investigator-trainees-research-presented-at-the-2022-csci-citac-joint-meeting
#8
JOURNAL ARTICLE
Valera Castanov, Shubham Soni, Melissa S Phuong, Zaid A M Al-Azzawi, Andrew Mazzanti, Salonee Patel, Yujin Suk, Wenxuan Wang, Amelia T Yuan
The 2022 Annual Joint Meeting (AJM) and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de recherches clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada (CITAC/ACCFC) was held in Montréal, November 13-14, 2022. The theme of this year's AJM was "Strength in Perseverance" and focused on highlighting clinician-investigator trainee achievements and resilience in research engagement through recent challenging and unprecedented times...
September 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37379166/video-education-program-for-proper-use-of-inhalation-devices-in-elderly-copd-patients
#9
JOURNAL ARTICLE
Hong Zhu, Shouquan Qin, Meng Wu
PURPOSE: This research investigated the utility of a QR code-based video pharmaceutical education program to guide the proper use of the inhalation device in elderly chronic obstructive pulmonary disease (COPD) patients. METHODS: The patients were recruited for this prospective study during a COPD hospitalization, with 96 patients in the control group (CG) receiving conventional hospital care and 93 patients in the intervention group (IG) receiving QR code-based video pharmaceutical education from hospitalization to six months after discharge to improve proper utilization of inhalation technology The outcome measures used to assess the effectiveness of the education program were the COPD Assessment Test (CAT), inhaler use accuracy, inhaler technique score, Beliefs about Medicines Questionnaire (BMQ) score and patient satisfaction...
June 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37379165/risk-due-to-elevated-uric-acid-levels-in-children-with-henoch-schonlein-purpura
#10
JOURNAL ARTICLE
Xiucui Han, Pengfei Xu
PURPOSE: To compare uric acid levels in children with Henoch-Schonlein purpura (HSP)without nephritis and with renal damage, and at different pathological grades. METHODS: A total of 451 children were enrolled in this study, including 64 with HSP without nephritis and 387 HSP with kidney damage. Age, gender, uric acid, urea, creatinine and cystatin C levels were reviewed. Pathological findings of those with renal impairment were also reviewed. RESULTS: Among the HSP children with renal damage, 44 were grade I, 167 were grade II and 176 were grade III...
June 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37379164/interview-with-csci-joe-doupe-young-investigator-awardee-dr-amy-metcalfe
#11
JOURNAL ARTICLE
Zaid Al-Azzawi, Amy Metcalfe
Dr. Amy Metcalfe is an Associate Professor in the Departments of Obstetrics and Gynecology, Medicine, and Community Health Sciences at the University of Calgary. She is also the Maternal and Child Health Program Director with the Alberta Children's Hospital Research Institute. Dr. Metcalfe's training is a perinatal epidemiologist whose research broadly focuses on the management of chronic illness during pregnancy, and how events in pregnancy impact women's health and wellbeing throughout the life course. Current major projects include co-leading the P3 Cohort study (https://p3cohort...
June 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/37379163/young-investigator-interview-with-csci-distinguished-scientist-awardee-dr-caroline-quach-thanh
#12
JOURNAL ARTICLE
Valera Castanov, Caroline Quach
Dr. Caroline Quach-Thanh is a Professor in the Departments of Microbiology, Infectious Diseases and Immunology and of Pediatrics at University of Montreal. She is in charge of Infection Prevention and Control at CHU Sainte-Justine where she works as a pediatric infectious diseases specialist and medical microbiologist. Dr. Quach is a clinician-scientist and the Canada Research Chair, Tier 1 in Infection Prevention and Control. In 2022, Dr. Quach-Thanh received the Distinguished Scientist Award 2022 from the Canadian Society for Clinical Investigation...
June 28, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36966390/predictors-of-adherence-to-short-course-probiotics-among-children-with-gastroenteritis-who-are-enrolled-in-a-clinical-trial
#13
JOURNAL ARTICLE
Katrina F Hurley, Eleanor A Fitzpatrick, Jianling Xie, Sarah Urquhart, Ken J Farion, Serge Gouin, Suzanne Schuh, Naveen Poonai, Stephen Freedman
BACKGROUND: To improve our understanding of adherence to discharge medications in the ED and within research trials, we sought to quantify medication adherence and identify predictors thereof in children with acute gastroenteritis (AGE). METHODS: We conducted a secondary analysis of a randomized trial of twice daily probiotic for 5 days. The population included previously healthy children aged 3-47 months with AGE. The primary outcome was patient-reported adherence to the treatment regimen, defined a priori as having received >70% of the prescribed doses...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36966389/efficacy-of-mesenchymal-stem-cell-therapy-on-lupus-nephritis-and-renal-function-in-systemic-lupus-erythematosus-a-meta-analysis
#14
JOURNAL ARTICLE
Yang Xia, Hua Ye, Kejia Li, Bairu Shi, Xian Sun, Jiajun Wu
PURPOSE: The purpose of this meta-analysis is to determine the efficacy of mesenchymal stromal/stem cell (MSC) transplantation therapy on lupus nephritis (LN) and renal function of patients with systemic lupus erythematosus (SLE). METHODS: Articles that reported the data of MSC therapy on the renal function as well as disease activity of LN in patients with SLE were searched in PubMed, Web of Science, Embase and the Cochrane Library. Mean difference for disease activity and laboratory parameters were pooled to evaluate the efficacy of MSC, and incidence was pooled for clinical remission, death and severe adverse event...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36966388/gender-disparities-in-academic-outcomes-among-graduates-of-a-canadian-md-phd-program
#15
JOURNAL ARTICLE
Joan Miguel Romero, Mark Sorin, Matthew Dankner, Heather Whittaker, April Rose, Jacquetta Trasler, Mark J Eisenberg
PURPOSE: Women have traditionally been underrepresented in MD and MD-PhD training programs. Here, we describe the changing demographics of an MD-PhD Program over three distinct time intervals. METHODS: We designed a 64-question survey and sent it to 47 graduates of the McGill University MD-PhD program in Montréal, Québec, Canada, since its inception in 1985. We also sent a 23-question survey to the 24 students of the program in 2021. The surveys included questions related to demographics, physician-scientist training, research metrics, as well as academic and personal considerations...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36966387/spring-2023-clinician-investigator-trainee-association-of-canada-citac
#16
JOURNAL ARTICLE
Melissa Phuong, Robert Lao, Yujin Suk, Wenxuan Wang, Amelia Yuan
Over the past year, the leadership of the Clinician Investigator Trainee Association of Canada (CITAC), alongside our MD+ trainees, had the opportunity to further develop and implement our strategic plan in response to the evolving medical landscape. We have dedicated our efforts to the progression towards a post-pandemic environment, have taken advantage of the lessons learned during the coronavirus disease 2019 (COVID-19) health crisis and have focused on enhancing in-person career development opportunities for our members...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36966386/hydrocortisone-combined-with-vitamin-c-and-thiamine-in-the-treatment-of-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#17
JOURNAL ARTICLE
Difan Lu, Wenchao Mao
BACKGROUND: This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock. METHODS: PubMed, EMBASE and Web of Science were searched (establishment of the database to October 31, 2022). The meta-analysis included randomized controlled trials (RCTs); comparing the efficacy of HVT regimen and placebo in the treatment of sepsis/septic shock. The Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias...
March 26, 2023: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36586104/value-of-anteroposterior-to-transverse-ratio-in-ultrasonic-diagnosis-of-thyroid-nodule-in-different-locations
#18
JOURNAL ARTICLE
Hai-Ning Zheng, Wei Wang Md Wang, Xiao-Qing Wang Md Wang, Wen-Jing Song, Wen-Jing Song, Rui Zhao, Meng Li, Chao-Yang Wen Md Wen
To investigate the value of anteroposterior-to-transverse ratio (ATR) and the effect on features of nodules in ultrasound (US) diagnosis of thyroid nodules in different locations.  Methods: The nodules were divided into three groups according to the different nodule location: isthmus group; upper and lower poles of bilobed thyroid group; and the middle of the bilobed thyroid group. The diameters of the nodules were recorded, and ATR of the nodule was calculated on the transverse and longitudinal sections...
December 31, 2022: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36586103/changes-in-vector-astigmatism-after-superotemporal-versus-temporal-clear-corneal-incision-cataract-surgery
#19
JOURNAL ARTICLE
Zhennan Zhao, Qi Fan, Yongxiang Jiang, Yi Lu
PURPOSE: To investigate vector and refractive astigmatism changes after superotemporal versus temporal clear corneal incision cataract surgery. METHODS: Patients were diagnosed with age-related cataract with corneal astigmatism < 1.5 diopters (D) and were divided into two groups: superotemporal incision (R group) and temporal incision (L group). Uncorrected visual acuity, manifest refraction, corneal topography, anterior segment optical coherence tomography was performed pre- and six months postoperatively...
December 31, 2022: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/36586102/analysis-of-the-association-between-sh2b1-chr16-28884655-and-type-2-diabetes
#20
JOURNAL ARTICLE
Jingjin Liu, Renjun Cao, Dewei Li, Fang Miao, Ping An Yang, Hui He, Han Yu, Xiang Zhang, Jie Qin, Yanlan Yang
PURPOSE: To determine correlation between genetic susceptibility of type 2 diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene polymorphism in a diabetic population.  Methods: A total of 111 T2DM patients (DM group) and 34 healthy controls (NC group) from Shanxi Provincial People's Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using the Sanger sequencing method, and the relationship between SH2B1 gene polymorphism and diabetes was analyzed...
December 31, 2022: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
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