David Walk, Katharine Nicholson, Eduardo Locatelli, James Chan, Eric A Macklin, Valerie Ferment, Georgios Manousakis, Marianne Chase, Mariah Connolly, Derek Dagostino, Meghan Hall, Joseph Ostrow, Lindsay Pothier, Cassandra Lieberman, Dario Gelevski, Rebecca Randall, Alexander V Sherman, Erin Steinhart, Daniela Grasso Walker, Jason Walker, Hong Yu, Anne-Marie Wills, Michael A Schwarzschild, Anna L Beukenhorst, Jukka-Pekka Onnela, James D Berry, Merit E Cudkowicz, Sabrina Paganoni
INTRODUCTION/AIMS: Higher urate levels are associated with improved ALS survival in retrospective studies, however whether raising urate levels confers a survival advantage is unknown. In the Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (SURE-ALS) trial, inosine raised serum urate and was safe and well-tolerated. The SURE-ALS2 trial was designed to assess longer term safety. Functional outcomes and a smartphone application were also explored. METHODS: Participants were randomized 2:1 to inosine (n=14) or placebo (n=9) for 20 weeks, titrated to serum urate of 7-8 mg/dL...
February 25, 2023: Muscle & Nerve