Journals International Journal of Artif...

International Journal of Artificial Organs
Mohamed Abdelaty, Adham Mohamed, Mohamed O Saad, Hassan Mitwally, Mohamad M Alkadi, Ahmed Hashim, Hassan Al Malki, Husain S Ali, Ahmed Soliman Mohamed, Emad Mustafa, Abdulaziz Alalawi, Moustafa Elshafei, Muftah Othman, Mohamad Khatib, Abdul-Salam Ibrahim
INTRODUCTION: Severe COVID-19 is associated with a dysregulated immune response that usually leads to cytokine release syndrome. This study aimed to compare the use of extracorporeal blood purification therapy (Oxiris® ) versus standard continuous renal replacement therapy (CRRT) in critically-ill patients with severe COVID-19. METHODS: This was a national, multicenter, retrospective study of patients with COVID-19 admitted to the intensive care unit (ICU) between March and October 2020 who required CRRT...
December 2023: International Journal of Artificial Organs
Yael Lichter, Amir Gal Oz, Uri Carmi, Nimrod Adi, Asaph Nini, Yoel Angel, Andrey Nevo, Daniel Aviram, Itay Moshkovits, Noam Goder, Dekel Stavi
BACKGROUND: The exposure of blood to the artificial circuit during extracorporeal membrane oxygenation (ECMO) can induce an inflammatory response. C-reactive protein (CRP) is a commonly used biomarker of systemic inflammation. METHODS: In this retrospective observational study, we analyzed results of daily plasma CRP measurements in 110 critically ill patients, treated with ECMO. We compared CRP levels during the first 5 days of ECMO operation, between different groups of patients according to ECMO configurations, Coronavirus disease 2019 (COVID-19) status, and mechanical ventilation parameters...
November 29, 2023: International Journal of Artificial Organs
Hilal Peker Ozturk, Simel Ayyıldız
OBJECTIVES: To manage the mandibular traumas, for the expression of the complex anatomy or pathology in education of health sciences related branches, a model of the traumatized mandible is indispensable. For these, different 3D-print-technologies can be used. The aim of this study is, to measure how close these 3D-printed-models are to human-mandible (trueness) and the effectiveness of CT and CBCT at this point. STUDY DESIGN: One-dry-human-mandible and 10-models manufactured by five different 3D-printers in four different-kinds of additive-manufacturing technology (Fused-Deposition-Modeling (FDM), Stereolithography (SLA), Binder-jetting (BJ), Polyjet (PJ)) were used, five-anatomic-landmarks and eight-distances were measured and evaluated...
November 19, 2023: International Journal of Artificial Organs
Shuya Shida, Kenichi Tsushima, Masahiro Osa, Daniel L Timms, Toru Masuzawa
Severe left ventricular failure can progress to right ventricular failure, necessitating alternatives to heart transplantation, such as total artificial heart (TAH) treatment. Conventional TAHs encounter challenges associated with miniaturization and hemocompatibility owing to their reliance on mechanical valves and bearings. A magnetically levitated TAH (IB-Heart) was developed, utilizing a magnetic bearing. The IB-Heart features a distinctive biventricular shunt channel situated between the flow paths of the left and right centrifugal blood pumps, simplifying and miniaturizing its control system...
October 31, 2023: International Journal of Artificial Organs
Aili Wang, De Wang, Yumiao Wang, Bixuan Liu, Haiyang Wei, Yibo Wang, Jianye Zhou
OBJECTIVES: To evaluate the effects of combined treatment with tannic acid and ferric ions on the biomechanical and anti-calcification properties of glutaraldehyde-fixed bovine jugular veins after xenografting. METHODS: Two-point bending test and uniaxial tensile test were used to evaluate the flexural and biomechanical properties; Subcutaneous implantation in rat and right ventricular outflow tract reconstruction of sheep were used to evaluate the anti-calcification effects; The performance of the graft in sheep models was evaluated every month after the surgery with echocardiography examination...
October 31, 2023: International Journal of Artificial Organs
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October 31, 2023: International Journal of Artificial Organs
Meghan Unes, Kento Kurashima, Yasar Caliskan, Edward Portz, Ajay Jain, Mustafa Nazzal
In recent years, normothermic machine perfusion (NMP) has emerged in conversation surrounding organ preservation and transplantation techniques with the goal of improving patient and clinical outcomes. This is in great attempt to address the rate of non-utilization and the shortage of available organs in kidney transplantation. This focus in mind, normothermic perfusion presents itself as a potential tool to mimic physiological conditions and improve current preservation methods, such as static cold storage...
October 28, 2023: International Journal of Artificial Organs
Ning An, Haishan Zhou, Xianhui Li, Xinyin Yu, Haijuan Yang, Liping Zhai, Yuhua Huang, Cuiwei Yao
OBJECTIVE: To investigate the effects of low-calcium and standard-calcium dialysate in patients with chronic kidney disease on peritoneal dialysis, and find out which dialysate has less vascular calcification effect. METHODS: A total of 141 patients who had undergone peritoneal dialysis (PD) for 2 years in the PD centre from January 2012 to December 2017 were included and divided into two groups according to the calcium concentration of the PD fluid used...
October 25, 2023: International Journal of Artificial Organs
Wei Wei, Tianhao Wang, Jian Li, Jianheng Liu, Keya Mao, Chun'ang Pan, Hui Li, Yongfei Zhao
OBJECTIVE: To analyze the biomechanical effects of proximal iatrogenic muscle-ligaments complex (MLC) damage on adjacent segments following posterior lumbar interbody fusion (PLIF) by finite element (FE) analysis. METHODS: The multifidus muscle force was loaded in the validated intact lumbosacral finite element model. Based on whether undergoing PLIF or the proximal MLC damage, three models were established. Range of motion (ROM) and the maximum von Mises (VM) stress of adjacent segments were analyzed, as well as the average muscle force and work capacity in four loading directions...
October 21, 2023: International Journal of Artificial Organs
Luca Soliveri, Michela Bozzetto, Paolo Brambilla, Anna Caroli, Andrea Remuzzi
The mechanisms underlying vascular stenosis formation in the arteriovenous fistula (AVF) for hemodialysis (HD) remain mostly unknown. Several computational fluid dynamics (CFD) studies have suggested a potential role for unsteady flow in inducing intimal hyperplasia and AVF stenosis, but the majority of these observations have been limited to a single time point after surgical creation. The aim of the present study was to investigate the relation between hemodynamic conditions and AVF vascular remodeling through a CFD longitudinal study...
September 27, 2023: International Journal of Artificial Organs
Joachim Kron, Stefanie Broszeit, John Volkenandt, Til Leimbach, Susanne Kron
The ratio of blood volume to extracellular volume is approximately one to three under physiological conditions and also in stable chronic hemodialysis patients. Recently, it was found that this ratio remains unchanged during hemodialysis despite ultrafiltration. This would signify that the higher the ratio, the lower the refilling and vice versa. To test this hypothesis, treatment data of a previous study were re-analyzed. In 79 stable chronic hemodialysis patients, the refilling fraction was 0.749 ± 0...
September 25, 2023: International Journal of Artificial Organs
Aili Wang, Yumiao Wang, Wanbing Liu, Li Liu, Jianye Zhou
OBJECTIVE: We aimed to elucidate the effects of the micro-structure of the pyrolytic carbon for artificial heart valves on its hydrodynamic performance. METHODS: Bileaflet mechanical valves of GKS 23 and 29 A were randomly selected. According to ISO5840, mean transvalvular pressure (MPG), regurgitation fraction (RF), and effective orifice area (EOA) of valve were assessed. Then, parallel-groove pattern was constructed by laser etching on leaflet surface, and the valves were subjected again to the same test...
September 12, 2023: International Journal of Artificial Organs
Oliver Sommerfeld, Caroline Neumann, Jan Becker, Christian von Loeffelholz, Johannes Roth, Andreas Kortgen, Michael Bauer, Christoph Sponholz
BACKGROUND: Besides standard medical therapy and critical care monitoring, extracorporeal liver support may provide a therapeutic option in patients with liver failure. However, little is known about detoxification capabilities, efficacy, and efficiency among different devices. METHODS: Retrospective single-center analysis of patients treated with extracorporeal albumin dialysis. Generalized Estimating Equations with robust variance estimator were used to account for repeated measurements of several cycles and devices per patient...
September 2023: International Journal of Artificial Organs
Fernanda Albuquerque da Silva, Marcia Tereza Silva Martins, Gabriel Brayan Gutiérrez-Peredo, Angiolina Campos Kraychete, Carolina Cartaxo Penalva, Marcelo Barreto Lopes, Cacia Mendes Matos, Antonio Alberto Lopes
BACKGROUND AND OBJECTIVE: Some studies on maintenance hemodialysis (MHD) patients report a longer survival, albeit with poorer health-related quality of life (HRQoL), and more depression symptoms in women than in men. Whether these gender differences vary with age is uncertain. We tested the associations of gender with mortality, depression symptoms, and HRQoL in MHD patients of different age groups. METHODS: We used data from 1504 adult MHD patients enrolled in the PROHEMO, a prospective cohort in Salvador, Brazil...
September 2023: International Journal of Artificial Organs
Junxian Xu, Lijun Tian, Xudong Han
Near-fatal asthma (NFA) can lead to severe hypercapnia and sudden cardiac arrest; however, it can be reversed by extracorporeal membrane oxygenation (ECMO). We report a case of a 37-year-old male diagnosed with NFA. After fluid rehydaration, spasmolysis, and treatment with glucocorticoid and mechanical ventilation, the patient's condition improved temporarily. However, his condition worsened rapidly, and the patient presented with progressive respiratory distress, a sharp increase in airway pressure, decreased tidal volume, and barotrauma...
September 2023: International Journal of Artificial Organs
Sarah M Beargie, Lindsey Tolbert, Robert K Tunney, Zachary L Cox, Wu Gong, Sandip Zalawadiya
More than 50% of heart failure (HF) patients require diuretic therapy after left ventricular assist device (LVAD). Although few data related to diuretic response (DR) exist in stage D patients, tubular sodium reabsorption may be clinically prognostic independent of estimated glomerular filtration rate (eGFR) and proteinuria within this cohort. We aimed to characterize DR serially before and after LVAD implantation in a stage D population. We conducted a prospective, observational cohort study of HF patients receiving diuretics with plans to undergo LVAD implantation...
August 30, 2023: International Journal of Artificial Organs
Phillip Weeks, Kelly Dunton, Brian Gulbis, Marwan Jumean, Lisa Janowiak, Igor Banjac, Rajko Radovancevic, Igor Gregoric, Biswajit Kar
After the initiation of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) for hemodynamic support, patients often require vasopressor and inotropic medications to support their blood pressure and cardiac contractility. The vasoactive-inotropic score (VIS) is a standardized calculation of vasopressor and inotrope equivalence, which uses coefficients for each medication to calculate a total value. This study evaluated the association between the 30-day survival of patients receiving V-A ECMO support and the VIS calculated 24 h after ECMO cannulation (VIS24)...
August 25, 2023: International Journal of Artificial Organs
Karlijn Verkerk, Lara Ca Pladet, Christiaan L Meuwese, Dirk W Donker, Lennie Pg Derde, Olaf L Cremer
Infectious complications are common during extracorporeal membrane oxygenation (ECMO) and may negatively impact outcomes. However, there is considerable variation in the reported rates of incidence, which hampers the use of infections as a quality benchmark for ECMO centers. To assess the contributing role of poor interrater agreement, three independent raters reviewed medical records from all intensive care unit (ICU) patients who received ECMO for >24 h in our tertiary center between October 2019 and October 2021 for suspected episodes of infection, which were rated based on their date of onset and presumed site/diagnosis...
August 19, 2023: International Journal of Artificial Organs
Andrzej Breborowicz
BACKGROUND: Treatment of anemia in peritoneal dialysis patients often requires intravenous iron supplementation. Iron diffuses into the peritoneal cavity and is injurious to the peritoneum. We studied how intermittent exposure to iron changes the properties of the senescent peritoneal mesothelial cells (MC). METHODS: Replicative senescence was induced in MC in control medium (Con) or in control medium with intermittent exposure to iron isomaltoside 15 µg/dL (Con-IIS)...
August 11, 2023: International Journal of Artificial Organs
Jose Lopez, Justin Mark, Waseem Wahood, Nader Lamaa, Mauricio Danckers
BACKGROUND: The newer Left Ventricular Assist Device (LVAD), the HeartMate 3 (HM3), was initially approved by the Food and Drug Administration in 2017. We aimed to describe the temporal trends of in-hospital stroke and mortality among patients who underwent LVAD placement between 2017 and 2019. METHODS: The National Inpatient Sample was queried from 2017 to 2019 to identify all adults with heart failure and reduced ejection fraction (HFrEF) who underwent LVAD implantation using the International Classification of Diseases 10th Revision codes...
June 30, 2023: International Journal of Artificial Organs
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