Journals International Journal of Artif...

International Journal of Artificial Organs
Aili Wang, Yumiao Wang, Wanbing Liu, Li Liu, Jianye Zhou
OBJECTIVE: We aimed to elucidate the effects of the micro-structure of the pyrolytic carbon for artificial heart valves on its hydrodynamic performance. METHODS: Bileaflet mechanical valves of GKS 23 and 29 A were randomly selected. According to ISO5840, mean transvalvular pressure (MPG), regurgitation fraction (RF), and effective orifice area (EOA) of valve were assessed. Then, parallel-groove pattern was constructed by laser etching on leaflet surface, and the valves were subjected again to the same test...
September 12, 2023: International Journal of Artificial Organs
Sarah M Beargie, Lindsey Tolbert, Robert K Tunney, Zachary L Cox, Wu Gong, Sandip Zalawadiya
More than 50% of heart failure (HF) patients require diuretic therapy after left ventricular assist device (LVAD). Although few data related to diuretic response (DR) exist in stage D patients, tubular sodium reabsorption may be clinically prognostic independent of estimated glomerular filtration rate (eGFR) and proteinuria within this cohort. We aimed to characterize DR serially before and after LVAD implantation in a stage D population. We conducted a prospective, observational cohort study of HF patients receiving diuretics with plans to undergo LVAD implantation...
August 30, 2023: International Journal of Artificial Organs
Suresh Sankarasubbaiyan, Kamal D Shah, Vikram Vuppula, Vivekanand Jha
Hemodialysis is the commonest kidney replacement therapy (KRT) globally and rapidly growing in developing countries, while in developed countries it is reaching a plateau. The penetration of hemodialysis (HD) varies widely among countries and is largely influenced by socioeconomics, healthcare financing, particularly by government, local infrastructure, healthcare workforce, health system characteristics, and affordability of the population. Biomedical equipment, consumables, disposables, and labor are major cost drivers of KRT...
August 28, 2023: International Journal of Artificial Organs
Phillip Weeks, Kelly Dunton, Brian Gulbis, Marwan Jumean, Lisa Janowiak, Igor Banjac, Rajko Radovancevic, Igor Gregoric, Biswajit Kar
After the initiation of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) for hemodynamic support, patients often require vasopressor and inotropic medications to support their blood pressure and cardiac contractility. The vasoactive-inotropic score (VIS) is a standardized calculation of vasopressor and inotrope equivalence, which uses coefficients for each medication to calculate a total value. This study evaluated the association between the 30-day survival of patients receiving V-A ECMO support and the VIS calculated 24 h after ECMO cannulation (VIS24)...
August 25, 2023: International Journal of Artificial Organs
Oliver Sommerfeld, Caroline Neumann, Jan Becker, Christian von Loeffelholz, Johannes Roth, Andreas Kortgen, Michael Bauer, Christoph Sponholz
BACKGROUND: Besides standard medical therapy and critical care monitoring, extracorporeal liver support may provide a therapeutic option in patients with liver failure. However, little is known about detoxification capabilities, efficacy, and efficiency among different devices. METHODS: Retrospective single-center analysis of patients treated with extracorporeal albumin dialysis. Generalized Estimating Equations with robust variance estimator were used to account for repeated measurements of several cycles and devices per patient...
August 23, 2023: International Journal of Artificial Organs
Karlijn Verkerk, Lara Ca Pladet, Christiaan L Meuwese, Dirk W Donker, Lennie Pg Derde, Olaf L Cremer
Infectious complications are common during extracorporeal membrane oxygenation (ECMO) and may negatively impact outcomes. However, there is considerable variation in the reported rates of incidence, which hampers the use of infections as a quality benchmark for ECMO centers. To assess the contributing role of poor interrater agreement, three independent raters reviewed medical records from all intensive care unit (ICU) patients who received ECMO for >24 h in our tertiary center between October 2019 and October 2021 for suspected episodes of infection, which were rated based on their date of onset and presumed site/diagnosis...
August 19, 2023: International Journal of Artificial Organs
Gonzalo Ramírez-Guerrero, Thiago Reis, Matteo Marcello, Massimo de Cal, Claudio Ronco
No abstract text is available yet for this article.
August 17, 2023: International Journal of Artificial Organs
Andrzej Breborowicz
BACKGROUND: Treatment of anemia in peritoneal dialysis patients often requires intravenous iron supplementation. Iron diffuses into the peritoneal cavity and is injurious to the peritoneum. We studied how intermittent exposure to iron changes the properties of the senescent peritoneal mesothelial cells (MC). METHODS: Replicative senescence was induced in MC in control medium (Con) or in control medium with intermittent exposure to iron isomaltoside 15 µg/dL (Con-IIS)...
August 11, 2023: International Journal of Artificial Organs
Fernanda Albuquerque da Silva, Marcia Tereza Silva Martins, Gabriel Brayan Gutiérrez-Peredo, Angiolina Campos Kraychete, Carolina Cartaxo Penalva, Marcelo Barreto Lopes, Cacia Mendes Matos, Antonio Alberto Lopes
BACKGROUND AND OBJECTIVE: Some studies on maintenance hemodialysis (MHD) patients report a longer survival, albeit with poorer health-related quality of life (HRQoL), and more depression symptoms in women than in men. Whether these gender differences vary with age is uncertain. We tested the associations of gender with mortality, depression symptoms, and HRQoL in MHD patients of different age groups. METHODS: We used data from 1504 adult MHD patients enrolled in the PROHEMO, a prospective cohort in Salvador, Brazil...
July 9, 2023: International Journal of Artificial Organs
Jose Lopez, Justin Mark, Waseem Wahood, Nader Lamaa, Mauricio Danckers
BACKGROUND: The newer Left Ventricular Assist Device (LVAD), the HeartMate 3 (HM3), was initially approved by the Food and Drug Administration in 2017. We aimed to describe the temporal trends of in-hospital stroke and mortality among patients who underwent LVAD placement between 2017 and 2019. METHODS: The National Inpatient Sample was queried from 2017 to 2019 to identify all adults with heart failure and reduced ejection fraction (HFrEF) who underwent LVAD implantation using the International Classification of Diseases 10th Revision codes...
June 30, 2023: International Journal of Artificial Organs
Kun Zhang, Chunxia Liu, Heling Zhao
OBJECTIVE: Although continuous renal replacement therapy (CRRT) is common, unplanned interruptions often limit its usefulness. Unplanned interruption refers to the forced interruption of blood purification treatment, the failure to complete blood purification treatment goals or the failure to meet blood purification schedule times. This study aimed to evaluate the effect of haematocrit and activated partial thromboplastin time (APTT) on the incidence of unplanned interruptions in critical patients with CRRT...
June 27, 2023: International Journal of Artificial Organs
Junxian Xu, Lijun Tian, Xudong Han
Near-fatal asthma (NFA) can lead to severe hypercapnia and sudden cardiac arrest; however, it can be reversed by extracorporeal membrane oxygenation (ECMO). We report a case of a 37-year-old male diagnosed with NFA. After fluid rehydaration, spasmolysis, and treatment with glucocorticoid and mechanical ventilation, the patient's condition improved temporarily. However, his condition worsened rapidly, and the patient presented with progressive respiratory distress, a sharp increase in airway pressure, decreased tidal volume, and barotrauma...
September 2023: International Journal of Artificial Organs
Soner Yavas, Umit Kervan, Mehmet Karahan, Sinan Sabit Kocabeyoglu, Dogan Emre Sert, Ozgur Ersoy, Burcu Demirkan, Ahmet Temizhan, Mehmet Ali Ozatik
BACKGROUND: The aim of the study is to compare the results of patients who had moderate or severe tricuspid insufficiency (TI) at the time of left ventricular assist device (LVAD) implantation that did not undergo intervention. METHODS: Between October 2013 and December 2019, 144 patients who did not undergo tricuspid valve repair (TVR) during LVAD implantation in our department were included in the study. The patients were divided into two groups according to the TI grade; Group 1: 106 patients (73...
June 19, 2023: International Journal of Artificial Organs
John Kenneth Leypoldt, Mauro Pietribiasi, Malgorzata Debowska, Monika Wieliczko, Malgorzata Twardowska-Kawalec, Jolanta Malyszko, Jacek Waniewski
BACKGROUND: The hydrogen ion (H+ ) mobilisation model has been previously shown to accurately describe blood bicarbonate (HCO3 ) kinetics during haemodialysis (HD) when the dialysate bicarbonate concentration ([HCO3 ]) is constant throughout the treatment. This study evaluated the ability of the H+ mobilization model to describe blood HCO3 kinetics during HD treatments with a time-dependent dialysate [HCO3 ]. METHODS: Data from a recent clinical study where blood [HCO3 ] was measured at the beginning of and every hour during 4-h treatments in 20 chronic, thrice-weekly HD patients with a constant (Treatment A), decreasing (Treatment B) and increasing (Treatment C) dialysate [HCO3 ] were evaluated...
June 8, 2023: International Journal of Artificial Organs
Emmanuel Tasos, Joao Sequeira, Paul Lincoln, Stephen Pettit, Sai Bhagra
Patients with implantable left ventricular assist devices (LVAD) are at risk of ventricular arrhythmias but these may be hemodynamically tolerated. An electrocardiogram (ECG) is essential to determine whether an LVAD-supported patient is experiencing a ventricular arrhythmia. Access to 12 lead ECG is predominantly in healthcare facilities. Implantable LVAD also cause significant electromagnetic interference leading to artefacts on ECG. We report a patient on Heartmate 3 LVAD with a diagnostic quality 6 lead ECG obtained with an AliveCor device during an episode of sustained palpitations...
June 6, 2023: International Journal of Artificial Organs
Mirac Berke Topcu Ersöz, Emre Mumcu, Esra Nur Avukat, Canan Akay, Suat Pat, Demet Erdönmez
BACKGROUND: The purpose of this study was to analyze the anti-adherent activity of nano-coatings deposited by Thermionic Vacuum Arc plasma on C. albicans ATCC 10231 biofilm. MATERIALS AND METHODS: A total of 80 disc-shaped (2 × 10 mm) polymethymethacrylate samples were prepared and divided into four groups with 10 samples in each group (Control, ZnO, SnO2 , Ag) ( n  = 10). Using thermionic vacuum arc plasma, they were coated with ZnO, SnO2 , and Ag...
June 2, 2023: International Journal of Artificial Organs
Zhen Hu, Junnan Xu, Yanyan Gong, Chenfu Gan, Tin Jiang, Xiaoling Wu, Yanyun Jiang, Tiantian Xiong, Jiayu Deng, Yiqun Zhong, Menglin Zou, Laimin Luo
OBJECTIVE: To investigate non-anticoagulant factors that affect blood coagulation in the extracorporeal circulation (ECC) circuit of regional citrate anticoagulation (RCA) protocol for hemodialysis (HD). METHOD: The clinical characteristics of patients undergoing an individualized RCA protocol for HD between February 2021 and March 2022 were collected; Coagulation scores, pressures in various parts of the ECC circuit, the incidence of coagulation, and citrate concentrations in the ECC circuit during treatment were determined, and non-anticoagulant factors affecting coagulation in the ECC circuit were analyzed...
June 2023: International Journal of Artificial Organs
Bo Soo Kim, Steven P Keller, Jeffrey M Dodd-O
When COVID-19 ARDS abolishes pulmonary function, VV-ECMO can provide gas exchange. If oxygenation remains insufficient despite maximal VV-ECMO support, the addition of esmolol has been proposed. Conflict exists, however, as to the oxygenation level which should trigger beta-blocker initiation. We evaluated the effect of esmolol therapy on oxygenation and oxygen delivery in patients with negligible native lung function and various degrees of hypoxemia despite maximal VV-ECMO support. We found that, in COVID-19 patients with negligible pulmonary gas exchange, the generalized use of esmolol administration to raise arterial oxygenation by slowing heart rate and thereby match native cardiac output to maximal attainable VV ECMO flows actually reduces systemic oxygen delivery in many cases...
June 2023: International Journal of Artificial Organs
Massimo Capoccia, Dirk M Maybauer, Joseph M Brewer, Marc O Maybauer
We sought to review the role of extracorporeal membrane oxygenation (ECMO) for the management of burn and smoke inhalation injury in the adult patient population. Therefore, we conducted a systematic search of the literature according to specific combination of key words to ascertain the effectiveness of this support strategy. A total of 26 articles were filtered out of 269 and considered suitable for this study. The PICOS approach and PRISMA flow chart were followed for the purposes of our review. Although there is growing evidence supporting the role of ECMO as an option for burn injury in the adult patient population, this strategy should be considered if a likely successful outcome is expected...
June 2023: International Journal of Artificial Organs
Xu Mei, Qiubo Jiang, Nana Huan, Haidong He, Liudi Zhang
The incidence of clinical complication gastrointestinal bleeding has been proved as consequence of von Willebrand factor (VWF) damage after mechanical circulatory support in clinic. Many studies have been conducted to evaluate VWF damage, of which the most studied influencing factors are mechanical factors such as shear stress. However, in addition to mechanical factors, VWF damage may also be affected by interface factors. To address this issue, a roller pump circulation platform was established to investigate the effect of material surface micron-scale structures distribution on VWF damage in flow state...
June 2023: International Journal of Artificial Organs
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