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International Journal of Artificial Organs

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https://read.qxmd.com/read/30744504/expansion-of-mouse-hematopoietic-stem-progenitor-cells-in-three-dimensional-cocultures-on-growth-suppressed-stromal-cell-layer
#1
Hirotoshi Miyoshi, Chiaki Sato, Yuichiro Shimizu, Misa Morita
With the aim of establishing an effective method to expand hematopoietic stem/progenitor cells for application in hematopoietic stem cell transplantation, we performed ex vivo expansion of hematopoietic stem/progenitor cells derived from mouse fetal liver cells in three-dimensional cocultures with stromal cells. In these cocultures, stromal cells were first cultured within three-dimensional scaffolds to form stromal layers and then fetal liver cells containing hematopoietic cells were seeded on these scaffolds to expand the hematopoietic cells over the 2 weeks of coculture in a serum-containing medium without the addition of cytokines...
February 12, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30681018/the-positive-influence-of-psychological-intervention-on-the-level-of-anxiety-and-depression-in-dialysis-patients-a-pilot-study
#2
Kamilla Bargiel-Matusiewicz, Agnieszka Łyś, Paulina Stelmachowska
Medical progress in dialysis therapy made it possible to treat patients with the end-stage renal disease for many years. But at the other side it may lead to profound changes in everyday life and may induce depression and anxiety. The research presented in this article explores the influence of psychological interventions on anxiety and depression levels in patients undergoing dialysis therapy. The experimental design included two experimental groups: cognitive intervention and cognitive/narrative intervention and one control group (standard treatment)...
January 25, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30654706/risk-factors-for-adverse-outcomes-after-left-ventricular-assist-device-implantation-and-extracorporeal-cardiopulmonary-resuscitation
#3
Edis Ljajikj, Armin Zittermann, Andreas Koster, Masatoshi Hata, Jochen Börgermann, Michael Schönbrodt, Kavous Hakim Meibodi, Jan F Gummert, Michiel Morshuis
Left ventricular assist device implantation following extracorporeal cardiopulmonary resuscitation has been associated with ambivalent results. In a series of patients who underwent left ventricular assist device implantation after extracorporeal cardiopulmonary resuscitation, we investigated whether the outcome can be predicted by preoperative risk factors or established risk scores. Primary endpoint was a composite of mortality and severe neurological disabling over 1 year of follow-up. To assess predictors of the primary endpoint, we performed univariate and multivariable Cox regression analyses...
January 17, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30638133/a-pilot-study-investigating-the-effect-of-pedalling-exercise-during-dialysis-on-6-min-walking-test-and-hand-grip-and-pinch-strength
#4
Manasi Desai, Ahmed Mohamed, Andrew Davenport
INTRODUCTION: Haemodialysis patients are at an increased risk of sarcopenia. Physical inactivity is now recognised as a major cause of muscle wasting in haemodialysis patients. It is unclear as to what and how much exercise is required to show benefit. We therefore performed a pilot study of cycling during haemodialysis. METHODS: Patients underwent a progressive submaximal individualised cycling exercise, 3× a week during haemodialysis for 4 months using bed-cycle ergometers...
January 14, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30638121/antibody-mediated-rejection-after-cardiac-transplant-treatment-with-immunoadsorption-intravenous-immunoglobulin-and-anti-thymocyte-globulin
#5
Nihat Firat Sipahi, Diyar Saeed, Hisaki Makimoto, Arash Mehdiani, Payam Akhyari, Hannan Dalyanoglu, Petra Reinecke, Artur Lichtenberg, Udo Boeken
Antibody-mediated rejection of allograft is a poorly understood problem after cardiac transplantation that complicates the postoperative course and impairs the graft function and overall survival. Although plasmapheresis and intravenous immunoglobulins have been used as standard therapies for years, there is no consensus about antibody-mediated rejection therapy and most transplantation centers have their own protocols. We describe herein a successful treatment for an acute antibody-mediated rejection of cardiac allograft combining immunoadsorption, intravenous immunoglobulins, and anti-thymocyte globulin, which manifested with polymorphic ventricular tachycardia and right ventricular dysfunction...
January 14, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30638104/a-new-hydrophilic-polysulfone-hemodialysis-membrane-can-prevent-platelet-neutrophil-interactions-and-successive-neutrophil-activation
#6
Yoko Koga, Hiroyuki Meguro, Hiroaki Fujieda, Yoshiyuki Ueno, Keishi Miwa, Mie Kainoh
PURPOSE: Microaggregates have often been observed during hemodialysis and are clearly associated with complications of hemodialysis therapy. In this study, we aimed to clarify the effects of two polysulfone membranes, with different abilities to activate blood cells, on the formation of these microaggregates; we also investigated their molecular mechanisms. METHODS: Human whole blood was circulated through a mini-module dialyzer using the membranes in vitro; platelet-neutrophil complexes in blood were determined by flow cytometry...
January 14, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30638101/clinical-effects-of-hemoadsorption-with-cytosorb-%C3%A2-in-patients-with-severe-acute-pancreatitis-a-case-series
#7
Dana Tomescu, Mihai Popescu, Corina David, Simona Dima
Hemoadsorption using CytoSorb® has recently gained attention as a new therapy aimed at modulating the inflammatory response syndrome in critically ill patients. The aim of our study was to assess the clinical effects of CytoSorb in patients with severe acute pancreatitis. We prospectively included 12 patients admitted to the intensive care unit for severe acute pancreatitis. After inclusion, continuous venovenous hemodiafiltration in conjunction with CytoSorb was applied. Clinical data, number of organ dysfunctions, paraclinical data, and vasopressor support were collected before and after the treatment...
January 14, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30630389/ventricular-assist-device-in-a-patient-with-congenitally-corrected-transposition-of-the-great-arteries-and-situs-inversus-totalis
#8
Radi Wieloch, Nihat Firat Sipahi, Udo Boeken, Alexander Albert, Payam Akhyari, Ralf Westenfeld, Artur Lichtenberg, Diyar Saeed
Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%-0.9% of newborns, less than 1% of them have congenitally corrected transposition of the great arteries. Meanwhile, the incidence of situs inversus totalis is about 0.01%. This is a case report of a patient with congenitally corrected transposition of the great arteries and situs inversus totalis who was supported with a ventricular assist device, resulting in a challenging clinical scenario...
January 10, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30630379/numerical-investigation-of-the-influence-of-a-bearing-shaft-structure-in-an-axial-blood-pump-on-the-potential-for-device-thrombosis
#9
Guang-Mao Liu, Dong-Hai Jin, Hai-Bo Chen, Jian-Feng Hou, Yan Zhang, Han-Song Sun, Jian-Ye Zhou, Sheng-Shou Hu, Xing-Min Gui
Adverse events caused by flow-induced thrombus formation around the bearing/shaft of an axial blood pump remain a serious problem for axial blood pumps. Moreover, excessive anticoagulation with thrombosis around the bearing potentially increases the risk of postoperative gastrointestinal bleeding. The purpose of this study is to analyze the influence of the bearing structure on the thrombosis potential of an axial blood pump. The bearing/shaft structure was embedded into an axial blood pump numerical model...
January 10, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30621486/mechanical-circulatory-support-60-years-of-evolving-knowledge
#10
Amedeo Terzi
Since the 1950s when the first devices for mechanical circulatory support were developed, there has been an impressive evolution of their technology. The first pioneering pumps were used to rescue acute complications after cardiac surgery. Advances in technology, increased knowledge of flow dynamics, and a more appropriate selection of the patients who actually need this support have contributed to significantly improve the benefits of this therapy. Today, mechanical circulatory support is an essential tool for the treatment of advanced heart failure...
January 8, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30614343/first-successful-hemoadsorption-using-cytosorb%C3%A2-in-a-septic-pediatric-patient-in-kazakhstan-a-case-report
#11
Askhat Saparov, Vitaliy Sazonov, Zaure Tobylbaeva, Samat Isakov, Almat Bekpan, Darkhan Autalipov, Bakhyt Muratbekova, Zhazira Manaybekova, Vitaliy Anikin
PURPOSE: For the first time in Kazakhstan, we have used a combined extracorporeal support, by including the CytoSorb system in a continuous veno-venous hemofiltration system in an 8-month-old patient with a body weight of 5600 g. RESULTS: The CytoSorb therapy session resulted in a reduction of inflammation markers IL-6, S100, procalcitonin, and C-reactive protein. Simultaneously, the level of transaminases, creatine kinase, and troponin were normalized, by the end of the session patient hemodynamics were stable and there was no need for vasopressors, acid-base balance was maintained, and the patient was weaned from mechanical ventilation to spontaneous breathing...
January 7, 2019: International Journal of Artificial Organs
https://read.qxmd.com/read/30585116/amnion-derived-mesenchymal-stem-cells-improve-viability-of-endothelial-cells-exposed-to-shear-stress-in-eptfe-grafts
#12
Dagmar Pfeiffer, Karin Wankhammer, Christina Stefanitsch, Kerstin Hingerl, Berthold Huppertz, Gottfried Dohr, Gernot Desoye, Ingrid Lang
PURPOSE: Blood vessel reconstruction is an increasing need of patients suffering from cardiovascular diseases. For the development of microvascular prostheses, efficient endothelialization is mandatory to prevent graft occlusion. Here, we assessed the impact of amnion-derived mesenchymal stem/stromal cells (hAMSC), known for their important angiogenic potential, on the integrity and stability of endothelial cells exposed to shear stress in vascular grafts. METHODS: Human placental endothelial cells (hPEC) were cultured at the inner surface of an expanded polytetrafluoroethylene (ePTFE) graft positioned within a bioreactor and exposed to a minimal shear stress of 0...
December 26, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30585115/mechanical-shear-stress-and-leukocyte-phenotype-and-function-implications-for-ventricular-assist-device-development-and-use
#13
Gemma Radley, Sabrina Ali, Ina Laura Pieper, Catherine A Thornton
Heart failure remains a disease of ever increasing prevalence in the modern world. Patients with end-stage heart failure are being referred increasingly for mechanical circulatory support. Mechanical circulatory support can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. It is also used during cardiopulmonary bypass surgery to maintain circulation while operating on the heart. While mechanical circulatory support can stabilise heart failure and improve quality of life, complications such as infection and thrombosis remain a common risk...
December 26, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30580668/it-keeps-on-turning-effects-of-prolonged-long-term-left-ventricular-assist-device-support-as-a-bridge-to-heart-transplantation
#14
Bastian Schmack, Leonie Grossekettler, Mohamed Zeriouh, Alexander Weymann, Prashant Mohite, Achim Koch, Arjang Ruhparwar, Andre Ruediger Simon, Anton Sabashnikov, Aron Frederik Popov
OBJECTIVES: Increasing incidence of end-stage heart failure has moved the therapy with left ventricular assist devices to the forefront of surgical treatment. Moreover, continuous sophistication in this technology has resulted in increasing proportion of patients on prolonged support. Early and late complications after left ventricular assist device as a bridge to transplantation and present factors associated with long-term support and long-term outcomes of patients supported for at least 1 year were compared...
December 24, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30556439/transient-power-elevation-during-iron-dextran-infusion-in-a-patient-with-a-continuous-flow-left-ventricular-assist-device
#15
Paulino A Alvarez, Nicole Byram, J Brad Williams, Miriam Jacob, Marinela Kreiss, Kiyotaka Fukamachi, Nader Moazami
Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. We subsequently studied the effects of iron dextran infusion in an in vitro LVAD mock circulatory loop. The observed increase in flow and power was most likely due to drug-patient interaction rather than drug-LVAD interaction...
December 16, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30545255/in-vitro-removal-of-anti-infective-agents-by-a-novel-cytokine-adsorbent-system
#16
Christina König, Anka C Röhr, Otto R Frey, Alexander Brinkmann, Jason A Roberts, Dominic Wichmann, Stephan Braune, Stefan Kluge, Axel Nierhaus
OBJECTIVES: The aim of this study is to describe the in vitro adsorption of anti-infective drugs onto an extracorporeal cytokine adsorber. METHODS: Various anti-infective drugs (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared in normal saline 0.9% and human albumin 5%, and pumped through a cytokine cartridge (CytoSorb® ; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at a flow rate of 1.2 L/h for 1.5 h. In addition, meropenem and ciprofloxacin were dissolved in reconstituted blood and run through a CytoSorb cartridge, which was integrated into a continuous renal replacement therapy circuit with a flow rate of 2 L/h for 18 h...
December 13, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30537880/bloodstream-infections-during-post-cardiotomy-extracorporeal-membrane-oxygenation-incidence-risk-factors-and-outcomes
#17
Simona Silvetti, Marco Ranucci, Valeria Pistuddi, Giuseppe Isgrò, Andrea Ballotta, Laurenzia Ferraris, Mauro Cotza
INTRODUCTION: Veno-arterial extracorporeal membrane oxygenation after heart surgery is a relatively common procedure. It is easily applicable but associated with a number of complications, including bloodstream infections. The aim of this study is to determine the current rate and the risk factors related to bloodstream infections acquired during post-cardiotomy veno-arterial extracorporeal membrane oxygenation. METHODS: Single-center retrospective study. From the overall population receiving any kind of extracorporeal membrane oxygenation from March 2013 through December 2017, the post-cardiotomy patient population was extracted, with a final sample of 92 veno-arterial extracorporeal membrane oxygenations...
December 11, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30537876/patient-specific-design-process-and-evaluation-of-a-hip-prosthesis-femoral-stem
#18
Osama Abdelaal, Saied Darwish, Hassan El-Hofy, Yoshio Saito
INTRODUCTION: There are several commercially available hip implant systems. However, for some cases, custom implant designed based on patient-specific anatomy can offer the patient the best available implant solution. Currently, there is a growing trend toward personalization of medical implants involving additive manufacturing into orthopedic medical implants' manufacturing. METHODS: This article introduces a systematic design methodology of femoral stem prosthesis based on patient's computer tomography data...
December 11, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30520328/development-of-exercise-related-values-in-heart-failure-patients-supported-with-a-left-ventricular-assist-device
#19
Thomas Schmidt, Birna Bjarnason-Wehrens, Stephanie Mommertz, Sebastian Schulte-Eistrup, Detlev Willemsen, Jürgen Sindermann, Hans-Georg Predel, Nils Reiss
Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27.5, 100% HeartWare) underwent the following diagnostic tests during cardiac rehabilitation and during two subsequent ambulatory visits: 6-min walking test, handgrip strength test, cardiopulmonary exercise test and Minnesota Living with Heart Failure questionnaire...
December 6, 2018: International Journal of Artificial Organs
https://read.qxmd.com/read/30486706/antithrombotic-properties-of-hemofilter-coated-with-polymer-having-a-hydrophilic-blood-contacting-layer
#20
Masashi Tagaya, Kazunobu Hara, Shunsuke Takahashi, Saki Nagoshi, Hiroki Handa, Shinya Okano, Takuo Murataka
OBJECTIVE: Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter. METHODS: Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin-antithrombin complex every 40 min, for a total of 240 min of recirculation...
November 29, 2018: International Journal of Artificial Organs
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