Heybet Kerem Polat, Sedat Ünal, Eren Aytekin, Nasıf Fatih Karakuyu, Esra Pezik, Muhammet Kerim Haydar, Nihat Kurt, Osman Doğan, Behzad Mokhtare
OBJECTIVE: In the current research, lornoxicam-loaded in situ gels were developed, and their potential usage in ocular inflammation was evaluated. SIGNIFICANCE: Lornoxicam cyclodextrin complex prepared with hydroxypropyl methylcellulose and poloxamer P407 because of the low viscosity of in situ gels to provide easy application. However, washing and removing it from the ocular surface becomes difficult due to the gelation formation with heat. METHODS: A three-level factorial experimental design was used to evaluate the effects of poloxamer 407 concentration, polymer type, and polymer concentration on viscosity, pH, gelation capacity, gelation time, and gelation temperature, which were considered the optimal indicators of lornoxicam-containing formulations...
October 3, 2023: Drug Development and Industrial Pharmacy