Drug Development and Industrial Pharmacy | Page 2

Magdy I Mohamed, Abdulaziz M Al-Mahallawi, Sami M Awadalla
In an attempt to improve the low oral bioavailability of Diacerein (DCN), the combination of a ternary solid dispersion and an asymmetric osmotic pump system had been designed to enhance solubility and to control DCN delivery. Ternary DCN solid dispersion was prepared by melting fusion method using surfactant polymers, and carrier (Pluronic® PF127, Solutol® HS15, and PEG 35K) and this DCN solid dispersion powder with the proper amount of excipients were compressed and coated with Opadry® CA to develop a Semi-Permeable and Asymmetric Osmotic Pump tablets...
April 20, 2020: Drug Development and Industrial Pharmacy
Mozhgan Aghajanzadeh, Ehsan Naderi, Mostafa Zamani, Ali Sharafi, Mahmoud Naseri, Hossein Danafar
In The present project, a variety of MnFe2 O4 (Mn) and Cr2 Fe6 O12 (Cr)-based nanocarriers (NCs) were synthesized as photosensitizer and NCs for delivery of chemotherapeutic curcumin (CUR) and provide a new structure for Photodynamic Therapy (PDT). For determining efficiency of NCs release study, MTT assay, lethal dose test and hemolysis assay were carried out. The release study showed the release of CUR from NCs was pH-dependent, but, every NCs had its own behavior for releasing the drug. The data acquired from the release study showed the CUR release from Mn can reach to over 90% at acidic media instead of 41% at neutral media...
April 17, 2020: Drug Development and Industrial Pharmacy
Yunjie Xia, Long Li, Xiaowu Huang, Zengming Wang, Hui Zhang, Jing Gao, Yimeng Du, Wen Chen, Aiping Zheng
The purpose of this study was to investigate the nasal absorption rate and nasal mucosal toxicity of thermosensitive ketamine in situ gels containing various absorption enhancers. The optimal composition ratio for the gel matrix was determined to be 17.2% Poloxamer 407 and 2% Poloxamer 188, as this combination resulted in solutions with a gelation point within the range found in the nasal cavity. Ketamine gels containing the tested enhancers, namely ethylenediaminetetraacetic acid disodium salt, hydroxypropyl-β-cyclodextrin, propylene glycol, or Tween-80, were compared with enhancer-free counterparts to determine the absorption of the drug, in vivo by measuring its plasma levels in rats and in vitro using a Franz diffusion cell...
April 15, 2020: Drug Development and Industrial Pharmacy
Hiroshi Ueno, Yu Takahashi, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
It is estimated that 80% of the world's population consumes caffeine from beverages and food every day. The traditional form of caffeine intake is oral, but more recently people have been inhaling caffeine using nasal sprays. However, the effects of caffeine inhalation are not well understood. The purpose of this study was to determine whether caffeine inhalation affects mouse behavior. To test this, we compared spontaneous activity of mice following inhalation and intraperitoneal administration of caffeine...
April 15, 2020: Drug Development and Industrial Pharmacy
Eva Faulhammer, Julia Kruisz, Otto Scheibelhofer, Jakob Rehrl, Andreas Witschnigg, Johannes G Khinast
We studied three lactose-based formulations in terms of bulk powder properties and capsule-filling behavior in a tamping pin capsule filling system, to which several mechanical adaptions were made for process optimization in light of future continuous production. The model formulations were thoroughly characterized and filled into size 1 capsules according a well-defined design of experiments (DoE). Overall, the three entirely different formulations were successfully filled within the selected design space...
April 15, 2020: Drug Development and Industrial Pharmacy
Sachin Bhusari, Irfan Ansari, Avinash Chaudhary
The aim of present study is to develop Darunavir pro-liposome powder for oral delivery. Darunavir-loaded oral pro-liposome powder (OPP) was prepared by a solvent evaporation technique with varying independent variables at three different levels. Based on different levels pro-liposome powder formulation was optimized by using Box-Behnken design. The formulations were analyzed for its size distribution, entrapment efficiency and surface morphology. Optimized pro-liposome batch A was evaluated for physical parameter, morphological parameters, entrapment efficiency, followed by in vitro, ex- vivo and in-vivo studies...
April 15, 2020: Drug Development and Industrial Pharmacy
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April 14, 2020: Drug Development and Industrial Pharmacy
A Alper Öztürk, Evrim Yenilmez, Behiye Şenel, Hülya Tuba Kıyan, Umay Merve Güven
Objective: The effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loaded NPs with different molecular weight (Mw ) PLGA and investigate the effect of Mw on NP character. One of the most important objectives is to provide a high anti-inflammatory effect with a low dose and the anti-inflammatory efficacy of the selected optimal formulation is to be determined by in vivo Hen's Egg Test on Chorioallantoic Membrane (HET-CAM) analysis that a new, popular and in vivo animal experiment alternative method...
April 13, 2020: Drug Development and Industrial Pharmacy
Dina Fathalla, Ehab A Fouad, Ghareb M Soliman
Objective: Glaucoma is a leading cause of irreversible blindness worldwide. Whereas latanoprost is one of the most effective drugs in glaucoma treatment, its eye drops need frequent application leading to lack of patient adherence. This study aimed to develop a patient-friendly niosome-in-gel system for the sustained ocular delivery of latanoprost. Methods: Niosomes were prepared by the reverse-phase evaporation technique and optimized for different formulation parameters, such as cholesterol/surfactant and drug/surfactant ratios...
April 13, 2020: Drug Development and Industrial Pharmacy
Waleed M Khattab, Esmat E Zein El-Dein, Sanaa A El-Gizawy
Objective : This study aims to detect the enhancement in oral bioavailability of a poorly water-soluble antihypertensive drug Olmesartan Medoxomil (OM) due to formulation of lyophilized oily-core nanocapsules. Significance : A comparative pharmacokinetics study in rats was conducted for oily-core polymeric nanocapsules (ONC) after formulation and lyophilization against market tablet product to show the significant improvement in oral absorption of OM. Materials and methods : OM loaded ONC were prepared using poly-Ɛ-caprolactone (0...
April 10, 2020: Drug Development and Industrial Pharmacy
Rabab A Mahmoud, Amal K Hussein, Ghada A Nasef, Heba F Mansour
The aim of the present work was to develop a promising drug delivery system of oxiconazole nitrate-loaded solid lipid nanoparticles (SLNs) topical gel to enhance the drug effectiveness for the treatment of Tinea infection. SLNs were prepared by emulsification-solvent evaporation method. Particle size and entrapment efficiency of the prepared SLNs were investigated. An appropriate formulation was selected and examined for morphology and physicochemical characterization adopting Scanning electron microscope and Differential scanning colorimetry...
April 8, 2020: Drug Development and Industrial Pharmacy
Mahmoud H Teaima, Ahmed M El Mohamady, Mohamed A El-Nabarawi, Amir I Mohamed
Ondansetron HCl is a (5-HT3) serotonin receptor antagonist, used as anti-emetic drug in combination with anticancer agents. Conventional dosage forms have poor bioavailability and patient compliance. These problems can be reduced by the use of nasal niosomal thermo reversible in situ gelling system; Niosomes were formulated using various surfactants (Span 60, Span 80, Tween 20 and Tween 80) in different ratios using thin film hydration technique. Niosomes were evaluated for particle size, zeta potential, Transmission Electron Microscopy (TEM) imaging, drug entrapment efficiency and in-vitro drug release...
April 6, 2020: Drug Development and Industrial Pharmacy
Fahima M Hashim, Fathy I Abd Allah, Rania S Abdel-Rashid, Abdelsabour A Hassan
Objective The development of nanosuspension for targeted delivery of glibenclamide as hypoglycemic agent to the lung in an inhaler dosage form. Method Glibenclamide nanosuspension formulations were prepared using Box-Behnken design to investigate the effect of independent factors on the dependent variables, Fourier-transform Infra-Red spectroscopy, Differential Scanning Calorimetry, evaluation of glibenclamide nanosuspension inhaler and in vivo hypoglycemic efficacy were performed to determine glibenclamide nanosuspension inhaler effect...
April 6, 2020: Drug Development and Industrial Pharmacy
Ahmed A H Abdellatif
Even so, the metal nanoparticles (Metal NPs) have attractive optical and biomedical applications, the translation of metal NPs into the clinical practice remains a challenge due to their severe accumulation in the body. Active targeting to renal podocytes opens the door for enhancing kidney targeting and clearance. The goal of this study was to asses the excretion of larger particle size through kidney podocyte via active targeting. To reach this goal, PEGylated quantum dots (QDs) were coated with vapreotide (VAP) for selectively reaching somatostatin receptors (sstrs) expressed in the podocyte...
April 6, 2020: Drug Development and Industrial Pharmacy
Mengyang Liu, Manisha Sharma, Guo-Liang Lu, Naibo Yin, Murad Al Gailani, Sree Sreebhavan, Jingyuan Wen
Objectives: L-Glutathione (GSH) is an endogenous tripeptide with super antioxidant properties. In this study, preformulation parameters of GSH and its degradation products were fully investigated. Significance: To date, no experimental preformulation data is available for GSH. Therefore, to the author's knowledge, this is the first study to experimentally determine the preformulation parameters of GSH, which can be considered more reliable for further studies. Methods: An HPLC method for GSH was optimized and validated to accurately quantify the GSH amount in solution, used to investigate GSH's solubility and Log P...
April 6, 2020: Drug Development and Industrial Pharmacy
Guigang Li, Lingjuan Xu, Menglin Jiang, Xianggen Wu
The aim was to reveal the characteristic profiles of the marketed levofloxacin eye drops (5 mg/ml) and levofloxacin eye gel (3 mg/g) from the pharmacokinetics and pharmacodynamics views of rabbits' eyes. A mild and a heavy bacterial keratitis models in rabbits were established. Different regimens of levofloxacin eye drops and eye gel, including phosphate buffer solution (the PBS group), the 4-Sol +1-Gel group (rabbits were treated with 4 doses of levofloxacin eye drops and 1 dose levofloxacin eye gel per day), the 3-Sol +1-Gel group (3 doses drops and 1 dose gel), the 4-Sol group (4 doses drops), the 4-Gel group (4 doses gel), the 3-Sol group (3 doses drops), and the 3-Gel group (3 doses gel), were applied to evaluate their efficacies...
April 1, 2020: Drug Development and Industrial Pharmacy
Veronika Debevec, Tijana Stanić Ljubin, Žiga Jeraj, Tanja Rozman Peterka, Borut Bratuž, Dušan Gašperlin, Stanko Srčič, Matej Horvat
The objective of this study is to present a practical example of a scale-independent design space development using a step-wise approach. A detailed description of the development process with a systematic outline of the main steps is provided. Design space is developed for film coating of tablets with moisture protective polyvinyl alcohol (PVA) based coating. The impact of scale-independent coating process parameters on the properties of film-coated tablets (FCT), i.e. water activity and film coating protection ability, and consequently on product long-term stability is explored...
April 1, 2020: Drug Development and Industrial Pharmacy
Md Habban Akhter, Sandeep Kumar, Shibli Nomani
Objective: In vitro , optimization, characterization and cytotoxic studies of NAR NPs to against pancreatic cancer. Method: The sonication tailored NARG loaded poly (lactide-co-glycolic acid) (PLGA) nanoparticle (NPs) was fabricated for potential cytotoxic effect against pancreatic cancer. NARG NPs were prepared by emulsion-diffusion evaporation technique applying Box Behnken experimental design based on 3-level and 3-factors. The effect of independent variables surfactant concentration (X1 ), polymer concentration (X2 ) and sonication time (X3 ) were studied on responses particle size (Y1 ), and drug release % (Y2 )...
March 25, 2020: Drug Development and Industrial Pharmacy
Samar Murjan, Sara Saeedi, Mohammad Reza Nabid
Linear and star-like redox-sensitive amphiphilic block copolymers have been studied as anticancer drug delivery systems. However, few reports directly compared the properties of those two structures especially when they are used as nanocarriers for antitumor drugs. To address this, a novel star-like copolymer and its linear counterpart were synthesized with a hydrophobic/redox-responsive/hydrophilic structure. The overall molecular weight of the star-shaped copolymer was nearly equal to that of the linear counterpart...
March 24, 2020: Drug Development and Industrial Pharmacy
Swathi H P, Anusha Matadh V, Sarasija Suresh, Jhimli Paul Guin, Narasimha Murthy S, Paranjothy Kanni, Lalit Varshney, Shivakumar H N
Soluble Microneedles (MNs) of four different hydrophilic polymers namely Sodium Carboxymethyl Cellulose ( CMC), Polyvinylpyrrolidone (PVP) K30, PVP K90 and Sodium Hyaluronate (HU) were fabricated by mold casting technique. When exposed to gamma radiation, a dose of 25 Kilogray (kGy) was found to render the microneedle (MN) sterile. However, CMC was found to form MN with poor mechanical properties whereas PVP K30 MNs were drastically deformed upon exposure to applied dose as observed in bright field microscopy...
March 24, 2020: Drug Development and Industrial Pharmacy
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