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Drug Development and Industrial Pharmacy | Page 2

Nilutpal Sharma Bora, Bhaskar Mazumder, Pompy Patowary, Sumit Kishor, Yangchen Doma Bhutia, Pronobesh Chattopadhyay, Sanjai Kumar Dwivedi
The present study is aimed at the development of a sunscreen cream for use in high altitude areas which have been found to possess superior sun protection factor (SPF) along with remarkable antioxidant activity. The topical formulation is a standard oil-in-water emulsion of a combination of United States Food and Drug Administration (US FDA) approved ultraviolet filters; along with melatonin and pumpkin seed oil. The in-silico optimized formulation was characterized using established methods and the stability study was carried out as per International Conference on Harmonization guidelines...
May 22, 2019: Drug Development and Industrial Pharmacy
Anne Trivino, Ashwini Gumireddy, Fan Meng, Dev Prasad, Harsh Chauhan
The major goal of this research was to successfully formulate solid dispersion (SD) of the poorly soluble anticancer drug flutamide (FLT) using various hydrophilic polymers. Furthermore, to get more insight into SD, solid-state studies (miscibility and molecular interaction) were correlated with solution study (precipitation inhibition, dissolution). Hydrophilic polymers like PVP K90, HPMC, Eudragit EPO, and PEG 8000 were used at different drug-to-polymer w/w ratios. Solid-state miscibility studies were carried out using modulated differential scanning calorimetry (MDSC)...
May 21, 2019: Drug Development and Industrial Pharmacy
Sunny Raina, Ashish Mungantiwar, Supriya Halde, Nancy Pandita
The purpose of the study was to develop and validate a high performance liquid chromatography method which can be further applied to understand the mechanism, kinetics, isotherm and thermodynamics of bile acid adsorption onto bile acid sequestrants. To investigate these properties a high performance liquid chromatography method was developed using peerless C-8 (150 x 4.6 mm, 5µm) column with a detection wavelength of 200 nm and run time of about 12.5 minutes. Bile salts Glycocholic acid (GC), Glycochenodeoxycholic acid (GCDC) and Taurodeoxycholic acid (TDC), were used and Colesevelam Hydrochloride was employed as bile acid sequestrant...
May 20, 2019: Drug Development and Industrial Pharmacy
Rie Shimamura, Tatsuo Koide, Hiroshi Hisada, Motoki Inoue, Toshiro Fukami, Noriko Katori, Yukihiro Goda
The purpose of this study was to investigate the quantification performance of transmission Raman spectroscopy with univariate analysis. Model dosage forms containing acetaminophen and an excipient, lactose monohydrate, were prepared. Raman spectra of the tablets were obtained using the modes of transmission, backscattering micro-spectroscopy, and wide area illumination. Calibration curves for quantification of acetaminophen in the tablets were created using peak heights of the Raman spectra. Of the three modes of measurement, the quantitative results by transmission had the highest correlation with those by conventional UV-Vis methods...
May 20, 2019: Drug Development and Industrial Pharmacy
Ghada E Yassin, Marwa H S Dawoud, Reham Wasfi, Ahmed Maher, Ahmed M Fayez
Platelet-rich plasma (PRP) accelerates wound healing, as it is an excellent source of growth factors. PRP was separated from whole human blood by centrifugation. PRP powder and wafers were prepared by lyophilization, with the wafers prepared using sodium carboxymethylcellulose (Na CMC). The PRP wafers showed porous structures, as indicated by scanning electron microscopy (SEM) images, and the ability of the wafer to absorb exudates and thus promote wound healing was tested with the hydration capacity test. The platelet count was tested and indicated that the presence of PRP in the wafers had no effect on the platelet count...
May 17, 2019: Drug Development and Industrial Pharmacy
S Bernal-Chávez, M G Nava-Arzaluz, R I Y Quiroz-Segoviano, A Ganem-Rondero
In general, the systems intended for the treatment and recovery of wounds, seek to act as a coating for the damaged area, maintaining an adequate level of humidity, reducing pain, and preventing the invasion and proliferation of microorganisms. Although many of the systems that are currently on the market meet the purposes mentioned above, with the arrival of nanotechnology, it has sought to improve the performance of these coatings. The variety of nano-systems that have been proposed is very extensive, including the use of very different materials (natural or synthetic) ranging from polymers or lipids to systems derived from microorganisms...
May 17, 2019: Drug Development and Industrial Pharmacy
Edit Benke, Árpád Farkas, Imre Balásházy, Piroska Szabó-Révész, Rita Ambrus
OBJECTIVE: The aim was to study the stability of dry powder inhaler (DPI) formulations containing antibiotic with different preparation ways -carrier-based, carrier-free, and novel combined formulation - and thereby to compare their physicochemical and in vitro-in silico aerodynamical properties before and after storage. SIGNIFICANCE: Presenting a novel combined technology in the field of DPI formulation including the carrier-based and carrier-free methods, it is the most important reason to introduce this stable formulation for the further development of DPIs...
May 17, 2019: Drug Development and Industrial Pharmacy
Jeetendra Prasad Kushwaha, Debjani Baidya, Sharvil Patil
Harmine (HM), a phytoconstituent has wide range of pharmacological activities including antimicrobial, antifungal, antioxidative and anticancer. HM has shown promising anticancer activity against liver cancer cells. However, poor aqueous solubility, multidrug pump P-gp efflux, extensive in vivo metabolism and rapid elimination due to glucuronidation/sulfation limits clinical utility of HM. In order to overcome the drawbacks of HM, the current work reports preparation of HM loaded galactosylated pluronic F-68 (PF68)-Gelucire® 44/14(GL44) mixed micelles (HM-MM)...
May 16, 2019: Drug Development and Industrial Pharmacy
Rajalakshmi Rukmangathen, Indira Muzib Yallamalli, Prasanna Raju Yalavarthi
CONTEXT: High lipophilicity and extensive hepatic metabolism limits the oral application of risperidone in the treatment of CNS disorders. OBJECTIVE: To process risperidone (RS) loaded chitosan nanoparticles (CS-NPs) for intranasal administration in the management of schizophrenia. MATERIALS AND METHODS: RS loaded CS-NPs were prepared by ionic gelation of chitosan with tripolyphosphate and stabilized by tween 80/poloxamer 188. The CS-NPs were characterized by FTIR, DSC, particle size, zeta potential and surface morphology...
May 16, 2019: Drug Development and Industrial Pharmacy
Yogita Tyagi, N V Satheesh Madhav
BACKGROUND: Depression is one of the most frequent psychiatric and potentially life-threatening disorders. This research work can offers a potential for delivery of selegiline moiety via ocular route in bio-nanosuspension mode for the effective management of depression after preclinical performance screening. RESEARCH DESIGN AND METHODS: The selegiline loaded Bio-nanosuspension was prepared using novel bio-retardant isolated from fruit pulp of Manilkara zapota (Sapodilla) by sonication solvent evaporation method with different ratios (0...
May 14, 2019: Drug Development and Industrial Pharmacy
Jie Shao, Mong-Jen Chen, Philip J Kuehl, Guenther Hochhaus
Peptide YY(3-36) (PYY(3-36) ) is an endogenous appetite suppressing peptide. The present research was to perform pharmacokinetic/pharmacodynamic (PK/PD) analysis for predicting the concentration- and response-time profiles of PYY(3-36) after systemic and pulmonary delivery in mice, with the goal of suggesting a potential pulmonary dosing regimen in humans. A PK/PD model was developed to describe PYY(3-36) plasma concentration - and relative food intake rate ratio (as % of control) - time profiles after intraperitoneal and subcutaneous administration, and inhalation in mice...
April 30, 2019: Drug Development and Industrial Pharmacy
Mohammad A M Momin, Shubhra Sinha, Ian G Tucker, Shyamal C Das
This study aimed to develop a combination dry powder formulation of ethionamide and moxifloxacin HCl as this combination is synergistic against drug-resistant Mycobacterium tuberculosis (Mtb). L-leucine (20% w/w) was added in the formulations to maximize the process yield. Moxifloxacin HCl and/or ethionamide powders with/without L-leucine were produced using a Buchi Mini Spray-dryer. A next generation impactor (NGI) was used to determine the in vitro aerosolization efficiency. The powders were also characterized for other physicochemical properties and cytotoxicity...
April 24, 2019: Drug Development and Industrial Pharmacy
Alaa M Ali, Ahmed S Abo Dena, Magdi H Yacoub, Ibrahim M El-Sherbiny
Dry powder inhalers (DPIs) are considered a main drug delivery system through pulmonary route. The main objective of this work is to study the flow of differently shaped microparticles in order to find the optimum shape of drug particles that will demonstrate the best flow to the deep lung. The flowability of particles in air or any fluid depends particularly on the drag force which is defined as the resistance of the fluid molecules to the particle flow. One of the most important parameters that affect the drag force is the particles' shape...
April 21, 2019: Drug Development and Industrial Pharmacy
Mohd Abul Kalam, Sultan Alshehri, Aws Alshamsan, Musaed Alkholief, Raisuddin Ali, Faiyaz Shakeel
Gemfibrozil (GEM) is cholesterol-lowering agent which is being proposed as poorly water soluble drug (PWSD). Temperature based solubility values of GEM are not yet available in literature or any pharmacopoeia/monograph. Hence, the present studies were carried out to determine the solubility of PWSD GEM (as mole fraction) in various pharmaceutically used solvents such as "water (H2 O), methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO) and Transcutol® (THP)" at the temperatures ranging from "T = 298...
April 17, 2019: Drug Development and Industrial Pharmacy
Hong-Hai Li, Xian-Xu Song, Bo Liu, Wen-Ping Yang
PURPOSE: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors, however its functional implication on gastric carcinoma is currently undetermined. Based on this, this study designed to assess the functional role of it on human gastric carcinoma and underlying mechanism of action. METHODS: Cell Counting Kit-8 (CCK-8) assay, transwell assay, and flow cytometry were used to assess capabilities of SGC-7901 cell proliferation, invasion/migration, and apoptosis, respectively...
April 17, 2019: Drug Development and Industrial Pharmacy
Qiuxuan Yang, Qilong Wang, Yingshu Feng, Qiuyu Wei, Congyong Sun, Caleb Kesse Firempong, Michael Adu-Frimpong, Ran Li, Rui Bao, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu
The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess the diverse pharmacological activities. However, its poor aqueous solubility usually lead to low bioavailability, and further clinical applications will be greatly discounted. The current study aimed to formulate a 6-shogaol-loaded-Self Microemulsifying Drug Delivery System (SMEDDS) to amend low aqueous solubility and bioavailability orally as well as potentiate the hyperuricemic activity of the 6-shogaol...
April 16, 2019: Drug Development and Industrial Pharmacy
Mohammad A M Momin, Ian G Tucker, Shyamal C Das
The purpose of this study was to investigate the influence of storage humidity on in vitro aerosolization and physicochemical properties of co-spray dried powders of kanamycin with rifampicin. The powders were stored for one-month in an open Petri dish at different relative humidities (RHs) (15%, 43% and 75%) and 25 ± 2 °C. The in vitro aerosolization (fine particle fraction, FPF) of the powders was determined by a next generation impactor (NGI). The moisture content, particle morphology and crystallinity of the powders were determined by Karl Fischer titration, scanning electron microscopy and X-ray powder diffractometry, respectively...
April 16, 2019: Drug Development and Industrial Pharmacy
Ludmylla Cunha, Susana Rodrigues, Ana M Rosa da Costa, Leonor Faleiro, Francesca Buttini, Ana Grenha
The direct delivery of antibiotics to the lung has been considered an effective approach to treat pulmonary tuberculosis, which represents approximately 80% of total cases. In this sense, this work aimed at producing inhalable chitosan microparticles simultaneously associating isoniazid and rifabutin, for an application in pulmonary tuberculosis therapy. Spray-dried chitosan microparticles were obtained with adequate flow properties for deep lung delivery (aerodynamic diameter of 4 µm) and high drug association efficiencies (93% for isoniazid and 99% for rifabutin)...
April 16, 2019: Drug Development and Industrial Pharmacy
Mohammad A Altamimi, Mohsin Kaz, Mshaan Hadi Albgomi, Abdul Ahad, Mohammad Raish
The purpose of this work is to develop novel lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) as carriers for transdermal delivery of curcumin. SNEDDS containing black seed oil, medium chain mono- and diglycerides and surfactants, were prepared as curcumin delivery vehicles. Their formation spontaneity, morphology, droplet size, and drug loading were evaluated. Gel preparation containing two of the SNEDDS formulations were used in the carrageenan induced paw edema to evaluate the anti-inflammatory effect...
April 15, 2019: Drug Development and Industrial Pharmacy
Yelda Komesli, Ali Burak Ozkaya, Bekir Ugur Ergur, Levent Kirilmaz, Ercument Karasulu
Olmesartan Medoxomil (OM) is a hydrophobic antihypertensive drug with low bioavailability (26%) and is known to have adverse effects such as celiac disease and enteropathy. The purpose of this study was to develop SMEDDS to increase bioavailability and decrease potential side effects of OM. Hydrophilic lipophilic balance was calculated by testing solubility of OM in different oils, surfactants and cosurfactants to obtain the most suitable combination of SMEDDS. Pseudoternary phase diagram was used to select the better oil/water formulation of SMEDDS...
April 15, 2019: Drug Development and Industrial Pharmacy
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