Junko Fujiyoshi, Hirosuke Inoue, Toru Sawano, Yuichi Mushimoto, Yoshitomo Motomura, Kei Nishiyama, Noriyuki Kaku, Hazumu Nagata, Kenichiro Yamamura, Masataka Ishimura, Yuhki Koga, Masayuki Ochiai, Yasunari Sakai, Tatsuro Tajiri, Shouichi Ohga
INTRODUCTION: To establish actionable neonatal screening during the first month of life, we investigated critical diseases in seemingly healthy newborns discharged from birth hospitals. METHODS: This retrospective study enrolled previously healthy full-term infants who visited our hospital, a tertiary hospital in Japan, from home between 5 and 28 days after birth from 2009 to 2018. Infants with known perinatal or congenital diseases, positive newborn screening results, or accidental injuries were excluded...
September 26, 2023: Early Human Development
Sudeepta K Basu, Kushal J Kapse, Jonathan Murnick, Subechhya Pradhan, Emma Spoehr, Anqing Zhang, Nickie Andescavage, Gustavo Nino, Adre J du Plessis, Catherine Limperopoulos
BACKGROUND: Bronchopulmonary dysplasia (BPD) is associated with cognitive-behavioral deficits in very preterm (VPT) infants, often in the absence of structural brain injury. Advanced GABA-editing techniques like Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) can quantify in-vivo gamma-aminobutyric acid (GABA+, with macromolecules) and glutamate (Glx, with glutamine) concentrations to investigate for neurophysiologic perturbations in the developing brain of VPT infants. OBJECTIVE: To investigate the relationship between the severity of BPD and basal-ganglia GABA+ and Glx concentrations in VPT infants...
September 21, 2023: Early Human Development
Hai-Bo Huang, Matthew Hicks, Qian-Shen Zhang, Man Joe Watt, Fang Lin, Xue-Qin Wan, Po-Yin Cheung
BACKGROUND: Very preterm infants of <29 weeks' gestation are at high risk for adverse neurodevelopment due to multiple risk factors in the early stages of life. There is little information regarding the associative effects of risk factors in early life, neonatal morbidities and subsequent neurodevelopmental outcomes. AIMS: Investigate the association of early neurodevelopmental outcomes, neonatal complications and the risk factors in the early hours of life in a cohort of preterm infants <29 weeks' gestational age...
September 13, 2023: Early Human Development
Fatih İşleyen, İstemi Han Çelik, Nihal Demirel, Nihan Özel Erçel, Dilek Ulubaş Işık, Ahmet Yağmur Baş
BACKGROUND: Transcutaneous bilirubin (TCB) measurement is a simple, painless, and time-saving alternative for the assessment of TSB (total serum bilirubin) levels. However, TCB measurements obtained during phototherapy can yield inaccurate results. We evaluated the effectiveness of TCB measurements obtained from protected skin areas in patients who underwent phototherapy. METHODS: This prospective study included neonates delivered at a gestational age of ≥340/7 weeks...
September 12, 2023: Early Human Development
Oguz Kaya, Nevzat Gonder, Dilsad Arisoy Demir, Ibrahim Halil Demir, Ozlem Akay
BACKGROUND: Developmental dysplasia of the hip (DDH) encompasses a range of hip disorders, from dysplasia to dislocation. One key factor is sex, with women being four to eight times more susceptible to DDH than men. However, there have been no studies investigating the second-to-fourth digit ratio (2D:4D), a biomarker of prenatal sex steroid exposure, in DDH patients. This study aimed to explore whether there is an association between the 2D:4D ratio and DDH. METHODS: Digital calipers were used to measure the second and fourth finger lengths of 250 patients treated for DDH and 200 patients in the healthy control group between January 2020 and January 2023...
September 4, 2023: Early Human Development
Karen VanHaltren, Ruth K Armstrong, Julia K Gunn-Charlton
BACKGROUND: Neonates requiring early surgical intervention for major non-cardiac congenital anomalies are at high risk of adverse neurodevelopmental outcomes. Early recognition of potential neuro-developmental delay is critical to facilitate access to early childhood intervention services and therefore maximise the functional capabilities of these children. AIMS: This study aims to compare Bayley's Scales of Infant and Toddler Development (BSID-3) and the Paediatric Evaluation of Disability Inventory (PEDI) as early screening tools in predicting neuro-developmental disability across multiple domains...
August 31, 2023: Early Human Development
Giulia Purpura, Simona Fumagalli, Renata Nacinovich, Anna Riva, Sara Ornaghi, Marzia Serafini, Antonella Nespoli
BACKGROUND: Infancy is a complex period of human life, in which environmental experiences have a fundamental role for neurodevelopment. Although conditions of social and sensory deprivation are uncommon in high income countries, the Covid-19 pandemic abruptly modified this condition, by depriving people of their social stimuli of daily life. AIM: To understand the impact of this deprivation on infants' behaviour, we investigated the short-term effects of isolation and use of individual protective systems by mothers during the first two weeks of life...
August 30, 2023: Early Human Development
Nicole Chapman-Hatchett, Nia Chittenden, Fahad M S Arattu Thodika, Emma E Williams, Christopher Harris, Theodore Dassios, Anusha Arasu, Kathryn Johnson, Anne Greenough
BACKGROUND: Infants born at the threshold of viability have a high risk of mortality and morbidity. The British Association of Perinatal Medicine (BAPM) provided updated guidance in 2019 advising a risk-based approach to balancing decisions about active versus redirected care at birth. AIMS: To determine survival and morbidity of infants born between 22 and 24 completed weeks of gestation. To develop a scoring system to categorise infants at birth according to risk for mortality or severe adverse outcome...
August 27, 2023: Early Human Development
Güllü Aydın Yağcıoğlu, İpek Alemdaroğlu Gürbüz, Semra Topuz, Öznur Yılmaz
BACKGROUND: Patients with Duchenne Muscular Dystrophy (DMD) have gait disorders. Therefore, specific gait assessment tools are needed. AIMS: The aim of this study was to develop a gait assessment instrument for DMD patients (DMD-GAS), and investigate its validity and reliability. STUDY DESIGN: The scale was developed considering the expert opinions which included 10 physiotherapists who had experience in the management of patients with DMD, and the Content Validity Index (CVI) was calculated...
August 23, 2023: Early Human Development
Massimo Di Pietro, Nunzia Decembrino, Miriam Gallo Afflitto, Emilio Malerba, Teresio Avitabile, Livio Marco Franco, Antonio Longo, Pasqua Betta
OBJECTIVE: To evaluate Retinopathy of Prematurity (ROP) rate and risk factors in a large cohort of preterm newborns. METHODS: Single center retrospective study. All preterm inborn hospitalized at the Neonatal Intensive Care Unit of the Policlinico of Catania from January 1, 2009 till December 31, 2018, were included. ROP stage and location, treatments required, maternal and infant risk factors were evaluated. RESULTS: Medical records of 898 preterms were retrospectively examined (mean gestational age 32...
August 19, 2023: Early Human Development
Nathani Cristina da Silva, Luciana Pinato, Erlane M Ribeiro, Celia Maria Giacheti
BACKGROUND: The characterization of the phenotype of children with congenital Zika virus syndrome (CZS) is an ongoing process, since many characteristics can only be described with the advancing age of children providing some insights into the long-term sequelae. AIMS: To describe emerging findings on the impact of CZS on language development in children with CZS in a 4-year longitudinal study. METHODS AND PROCEDURES: 39 boys and 44 girls with CZS were allocated into four groups according to age ranging from 12 to 36 months...
August 9, 2023: Early Human Development
Christian Daniele, Leslie V Farland, Ki Park, Peter F Schnatz, Aladdin H Shadyab, Marcia L Stefanick, Jean Wactawski-Wende, Robert A Wild, Cassandra N Spracklen
BACKGROUND: Advancements in medical technology and pharmacologic interventions have drastically improved survival of infants born preterm and low birth weight, but knowledge regarding the long-term health impacts of these individuals is limited and inconsistent. AIM: To investigate whether an individual's birthweight or history of being born preterm increases the risk of an adverse reproductive outcome. STUDY DESIGN: Nested case-control study within the Women's Health Initiative...
August 3, 2023: Early Human Development
Tuomas Koskela, Judith Meek, Angela Huertas-Ceballos, Giles S Kendall, Kimberley Whitehead
BACKGROUND: In healthy preterm infants, cortical burst rate and temporal dynamics predict important measures such as brain growth. We hypothesised that in preterm infants with germinal matrix-intraventricular haemorrhage (GM-IVH), cortical bursting could provide prognostic information. AIMS: We determined how cortical bursting was influenced by the injury, and whether this was related to developmental outcome. STUDY DESIGN: Single-centre retrospective cohort study at University College London Hospitals, UK...
August 2, 2023: Early Human Development
Kamile Uzun Akkaya, Rabia Eraslan, Nurcan Hanedan, Eray Esra Onal, Esin Koc, Bulent Elbasan
BACKGROUND: Hyperbilirubinemia is a clinical picture frequently occurring in the neonatal period and may negatively affect the development of infants. AIMS: To evaluate term infants with hyperbilirubinemia in terms of both motor development and sensory processing skills and to compare them with their healthy peers without hyperbilirubinemia. STUDY DESIGN: A cross-sectional study. SUBJECTS: Children born at term, aged 10-18 months, with and without a history of hyperbilirubinemia were included in the study...
August 2, 2023: Early Human Development
Michelle Baczynski, Bonny Jasani, Charmaine De Castro, Carlo Dani, Nimish V Subhedar, Praveen Chandrasekharan, Satyan Lakshminrusimha, Patrick J McNamara, Adrianne R Bischoff, Amish Jain
PURPOSE: To investigate whether immediate response to inhaled nitric oxide (iNO) therapy is associated with reduced mortality in preterm infants with hypoxemic respiratory failure (HRF) and pulmonary hypertension (PH). METHODS: A systematic review and meta-analysis of observational studies was conducted to examine the association between immediate response (improved oxygenation ≤6 h) compared to non-response, and all-cause mortality among preterm infants <34 weeks gestational age without congenital anomalies or genetic disorders who received iNO treatment...
August 2, 2023: Early Human Development
Raheleh Faramarzi, Azadeh Darabi, Maryam Emad Zadeh, Gholamali Maamouri, Reyhane Rezvani
OBJECTIVE: This retrospective cohort study aimed to evaluate neurodevelopmental outcomes of preterm infants (≤ 34 weeks gestational age) in the NICU. METHODS: This retrospective cohort study included 89 preterm infants admitted to the NICU of Ghaem hospital, Mashhad, between 2016 and 2020. Data on neonatal and maternal factors were collected. By recalling the mentioned infants in 2021, the neurodevelopmental outcomes were assessed using the Bayley Scales of Infant and Toddler Development...
July 27, 2023: Early Human Development
Marina Butovskaya, Yulia Adam, Valery Batsevich, Todd K Shackelford, Bernhard Fink
BACKGROUND: In Mongolian-origin ethnic groups digit ratio (2D:4D; a proxy for prenatal sex-steroids) is sexually dimorphic (males < females), as reported for other ethnicities. Most studies measured 2D:4D from soft tissue (directly from the digits, or indirectly from hand scans), or from radiographs. Evidence on the correspondence of 2D:4D measurements from soft tissue with measurements from radiographic images is scarce and has not been reported for a Mongolian-origin sample. In addition, previous research has not considered relationships between 2D:4D and measures of skeletal maturity...
July 27, 2023: Early Human Development
Aisling Smith, Rachel Mullaly, Orla Franklin, Afif El-Khuffash
BACKGROUND & AIM: Almost all randomised controlled trials use a Patent Ductus Arteriosus (PDA) diameter ≥ 1.5 mm as the primary criterion to ascribe haemodynamic significance to the PDA. The aim of this study was to evaluate if calculation of a PDA Severity Score (PDAsc) possessed superior intra- and inter-rater reproducibility when compared with the measurement of PDA diameter alone. METHODS: This cross-sectional study assessed echocardiograms performed on infants <30 weeks gestation at 36 to 72 h of age between July 2020 and December 2022 to calculate the PDAsc...
July 26, 2023: Early Human Development
Aida Ravarian, Nahid Rahmani, Farin Soleimani, Firoozeh Sajedi, Mehdi Noroozi, Suzann K Campbell, Mohammad A Mohseni-Bandpei
BACKGROUND: The Test of Infant Motor Performance (TIMP) is an appropriate tool used to measure infant motor performance in many countries and due to the importance of the TIMP in the early diagnosis of infants with developmental delay, the production of a reliable translation of the TIMP in Iran is necessary. AIMS: This study was designed to evaluate the validity and reliability of the Persian version of the TIMP and cross-cultural adaptation of the TIMP to Persian...
July 22, 2023: Early Human Development
Judith A Ten Barge, Madhvi Moelchand, Monique van Dijk, Sinno H P Simons, Joost van Rosmalen, Erica L T van den Akker, Dick Tibboel, Gerbrich E van den Bosch
BACKGROUND: Infants admitted to the intensive care unit experience numerous early-life stressors, which may have long-term effects on hypothalamic-pituitary-adrenal axis functioning. AIMS: To determine the effects of intensive care treatment and related exposure to stress, pain, and opioids in infancy on cortisol levels in childhood and adolescence. STUDY DESIGN: Cross-sectional study. SUBJECTS: Children and adolescents aged 8 to 18 years with a history of intensive care treatment in infancy and healthy controls...
July 16, 2023: Early Human Development
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