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Early Human Development

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https://read.qxmd.com/read/31377564/poorer-outcomes-of-all-low-birth-weight-groups-at-age-10-missouri-statewide-case-control-study
#1
Laura S Hillman, Linda S Day, Howard J Hoffman, Joseph W Stockbauer
BACKGROUND: In 1989-1991, a population-based cohort of every Missouri birth weighing < 1500 g was identified over a 16-month period. Infants born moderately low birth weight (MLBW, 1500-2499 g) and normal birth weight (NBW, ≥ 2500 g), were matched to < 1500 g infants by delivery date, race, maternal age, and residence. AIMS: To compare outcomes of extremely low birth weight (ELBW, < 1000 g), very low birth weight (VLBW, 1000-1499 g), and MLBW, to NBW infants at age 10...
August 1, 2019: Early Human Development
https://read.qxmd.com/read/31374456/the-impact-of-neonatal-posthemorrhagic-hydrocephalus-of-prematurity-on-family-function-at-preschool-age
#2
Netanel Agajany, Moran Gigi, Jessica Ross, Jonathan Roth, Rina Eshel, Shlomi Constantini, Haim Bassan
AIMS: To determine the impact on families (IOF) of former preterm infants (gestational age < 32 weeks) after posthemorrhagic hydrocephalus requiring shunt (PHH-S), and to identify risk factors of family dysfunction. STUDY DESIGN: 38 preterm infants with PHH-S were matched for gestational age, birthweight, and gender with preterm infants with normal cranial ultrasonography. IOF questionnaire was administered at 5.7 ± 2 years (higher IOF score indicates worse impact)...
July 30, 2019: Early Human Development
https://read.qxmd.com/read/31374455/erythropoietin-treatment-is-associated-with-a-reduction-in-moderate-to-severe-bronchopulmonary-dysplasia-in-preterm-infants-a-regional-retrospective-study
#3
Kim Chi T Bui, Romina Kim, Afshan Abbasi, Marielle Nguyen, Maria Fe Villosis, Qiaoling Chen
Erythropoietin treatment is associated with a reduction in moderate to severe bronchopulmonary dysplasia in preterm infants. A regional retrospective study. OBJECTIVE: To determine whether premature infants treated with erythropoietin (Epo) in the neonatal period for anemia had a lower incidence of bronchopulmonary dysplasia (BPD), defined as oxygen need at 36 weeks postmenstrual age, and lower rehospitalization rates in the first year of life than infants not exposed. METHODS: Retrospective study of a population of infants born at 23 to 32 weeks gestational age, between January 2009 and December 2014, with birthweight ≤1500 g...
July 30, 2019: Early Human Development
https://read.qxmd.com/read/31374454/omphalocele-at-school-age-what-do-parents-report-a-call-for-long-term-follow-up-of-complex-omphalocele-patients
#4
Annelieke Hijkoop, André B Rietman, René M H Wijnen, Dick Tibboel, Titia E Cohen-Overbeek, Joost van Rosmalen, Hanneke IJsselstijn
OBJECTIVE: Many children with omphalocele experience morbidity in early life, which could affect long-term outcomes. We determined parent-reported outcomes in school-aged children treated for minor or giant omphalocele. STUDY DESIGN: We sent paper questionnaires to the parents of all children treated for omphalocele in 2000-2012. Giant omphalocele was defined as defect diameter ≥ 5 cm with liver protruding. Motor function (MABC-2 Checklist) was compared with Dutch reference data; cognition (PedsPCF), health status (PedsQL), quality of life (DUX-25) and behavior (Strengths and Difficulties Questionnaire; SDQ) were compared with those of controls (two per child) matched for age, gender and maternal education level...
July 30, 2019: Early Human Development
https://read.qxmd.com/read/31362253/biomarkers-of-neonatal-stress-assessment-a-prospective-study
#5
H Rouatbi, S Zigabe, E Gkiougki, L Vranken, C Van Linthout, M-C Seghaye
INTRODUCTION: Early diagnosis of perinatal asphyxia, the major cause of neonatal mortality and morbidity, might be improved by the detection of neonatal stress biomarkers such as cardiac troponin (CTn)T, CTnI, NT-Terminal-pro-Brain Natriuretic Peptide (NT-pro-BNP), copeptin, and high sensitivity C-reactive protein (hs-CRP). However, reference values in neonates are lacking. The objective of our study was therefore to establish a reference range of these biomarkers in healthy full term newborns and to analyze the influence of delivery mode on their cord blood concentrations...
July 27, 2019: Early Human Development
https://read.qxmd.com/read/31357084/therapeutic-hypothermia-and-n-pass-results-from-implementation-in-a-level-3-nicu
#6
Inger Louise Üner, Tove Johansen, Julie Dahle, Mette Persson, Tom Stiris, Jannicke Hanne Andresen
BACKGROUND: Neonates that have been subjected to perinatal asphyxia and fulfill criteria for therapeutic hypothermia are cooled to 33.5 °C for 72 h. There is no consensus regarding sedation and analgesic use during hypothermia, but there is evidence supporting the importance of pain relief and adequate sedation. There is a need for assessment of the neonates need for pain relief and sedation, and for adjustments of medication to ensure adequate treatment. There are many different scoring tools available...
July 26, 2019: Early Human Development
https://read.qxmd.com/read/31352221/autonomic-signatures-of-late-preterm-early-term-and-full-term-neonates-during-early-postnatal-life
#7
Nina Burtchen, Michael M Myers, Maristella Lucchini, Maria Ordonez Retamar, Daianna Rodriguez, William P Fifer
BACKGROUND: Late preterm and early term births account for ~25% of live births. Infants born prior to term are at significantly higher risk for subsequent morbidity and mortality. AIMS: Determine autonomic regulation differences in infants (35-40 weeks gestation) during sleep at birth and one-month after delivery. STUDY DESIGN: Consecutive enrollment until at least 20 infants per group: 75 late preterm (35-36 weeks gestation), 110 early term (37-38 weeks), and 130 full term (39-40 weeks)...
July 25, 2019: Early Human Development
https://read.qxmd.com/read/31352220/second-to-fourth-digit-ratio-2d-4d-in-women-with-carpal-tunnel-syndrome
#8
Anna Kasielska-Trojan, Aneta Sitek, Bogusław Antoszewski
BACKGROUND: Carpal tunnel syndrome (CTS), a median nerve compressive neuropathy at the wrist, is the most common entrapment nerve disorder. Sex is an important risk factor of CTS as this condition is to five times more common in women than in men (sex-hormone dependent). There are no studies concerning 2D:4D (biomarker of prenatal sex steroids exposure) in patients with CTS. AIM: Here we consider the relationship between 2D:4D and CTS in women. STUDY DESIGN AND METHODS: The study involved 90 female participants (40 with a severe CTS (the mean age - 52...
July 25, 2019: Early Human Development
https://read.qxmd.com/read/31330463/enamel-neonatal-line-thickness-in-deciduous-teeth-of-australian-children-from-known-maternal-health-and-pregnancy-conditions
#9
Alison M Behie, Justyna J Miszkiewicz
BACKGROUND: Physiological disruptions to early human development have implications for health and disease in later life. Limited research has explored how prenatal factors influence dental development in children of mothers with known pregnancy conditions. Enamel in human deciduous teeth begins forming in utero and is highly susceptible to physiological upsets experienced perinatally. The moment of birth itself is marked in deciduous enamel by the Neonatal Line (NNL) as a baby transitions from the uterine to external environment...
July 19, 2019: Early Human Development
https://read.qxmd.com/read/31330462/the-association-between-2d-4d-ratio-and-aggression-in-children-and-adolescents-cross-cultural-and-gender-differences
#10
M Butovskaya, V Burkova, D Karelin, V Filatova
BACKGROUND: Two recent meta-analyses have suggested the association between digit ratio (2D:4D) and aggression is weak. This conclusion has been criticised because the meta-analyses conflate forms of aggression that show strong sex differences with those that do not, and most studies have considered post-pubertal participants. AIMS: We test the influence of 2D:4D and ethnicity in the expression of aggression in children and adolescents in four ethnic groups of European and African origin...
July 19, 2019: Early Human Development
https://read.qxmd.com/read/31319353/maternal-urinary-tract-infection-during-pregnancy-and-long-term-infectious-morbidity-of-the-offspring
#11
Ram Cohen, Gil Gutvirtz, Tamar Wainstock, Eyal Sheiner
BACKGROUND: Urinary tract infection (UTI) is a common bacterial infection in pregnant women and is associated with adverse perinatal outcomes. We sought to investigate the long-term infectious outcomes of children to mothers who were diagnosed with UTI during their pregnancy. METHODS: A population-based cohort analysis was conducted at a single tertiary medical center. The study included all singleton deliveries between the years 1991-2014, comparing offspring born to mothers diagnosed with UTI during their pregnancy with those born to non-exposed mothers...
July 15, 2019: Early Human Development
https://read.qxmd.com/read/31310860/the-association-of-the-cerebral-oxygenation-during-neonatal-sepsis-with-the-bayley-iii-scale-of-infant-and-toddler-development-index-scores-at-18-24-months-of-age
#12
Dimitrios Rallis, Paraskevi Karagianni, Evanthia Goutsiou, Vasiliki Soubasi-Griva, Jayanta Banerjee, Christos Tsakalidis
BACKGROUND: Neonatal sepsis has been associated with poor neurodevelopmental outcome, however the evidence regarding the exact mechanism of the inflammation to the developing neonatal brain are inconclusive. AIMS: To investigate association between cerebral oxygenation during neonatal sepsis and neurodevelopmental outcome. STUDY DESIGN: Follow-up assessment of a previously described prospective case-control study. SUBJECTS: A cohort of late preterm (34-37 weeks' gestation) and preterm (<34 weeks' gestation) infants with sepsis and healthy controls, evaluated at 18-24 months of corrected gestational age with Bayley-III Scales for Infant and Toddler Development (BSID-III)...
July 13, 2019: Early Human Development
https://read.qxmd.com/read/31302388/fronto-central-slow-cortical-activity-is-attenuated-during-phasic-events-in-rapid-eye-movement-sleep-at-full-term-birth
#13
Kimberley Whitehead, Maria Slobodina, Judith Meek, Lorenzo Fabrizi
Delta and theta power across fronto-central regions is lower during phasic (saccadic eye movements) than tonic rapid eye movement (active) sleep in full-term infants (n = 15). This indicates that the behavioural-electrophysiological pillars of rapid eye movement sleep micro-architecture are in place at birth.
July 11, 2019: Early Human Development
https://read.qxmd.com/read/31302387/postoperative-pain-in-small-for-gestational-age-infants-after-hernia-repair-orchidopexy-and-urethral-reconstruction-surgery-a-pilot-study
#14
Stephanie C Schüssler, Franziska Kußmann, Fabian B Fahlbusch, Tino Münster, Karin Hirsch, Roman Carbon, Sven Albrecht, Jörg Dötsch, Wolfgang Rascher
BACKGROUND: Small-for-gestational-age (SGA) birth bears an enhanced risk of developing hypertension, obesity, insulin resistance and mental health disorders in later life as a consequence of adaptive processes in utero. Only a small number of studies on pain perception in SGA infants exist. These are indicative of a blunted stress response to pain in SGA newborns. AIM: We initiated a pilot study investigating differences in postoperative pain perception between SGA and appropriate-for-gestational-age (AGA) infants...
July 11, 2019: Early Human Development
https://read.qxmd.com/read/31299551/the-psychometric-properties-of-the-ages-and-stages-questionnaires-3-in-arabic-cross-sectional-observational-study
#15
Lama Charafeddine, Alia Dani, Lina Kurdahi Badr, Durriyah Sinno, Hani Tamim, Joanne Khoury, Fatima Nasser, Maha Makki
BACKGROUND: Screening for developmental delay is recommended for pediatricians, yet validated screening tools in Arabic are scarce. AIMS: Assess the reliability, validity, sensitivity and specificity of the Arabic ASQ-3 in detecting developmental delays in children aged 4-33 months. STUDY DESIGN: Cross-sectional observational study. SUBJECTS: A sample of 491 children from all Lebanese governorates from five age groups (4, 10, 18, 27 and 33 months)...
July 9, 2019: Early Human Development
https://read.qxmd.com/read/31299550/differences-in-early-auditory-exposure-across-neonatal-environments
#16
Lara Liszka, Joan Smith, Amit Mathur, Bradley L Schlaggar, Graham Colditz, Roberta Pineda
BACKGROUND: To date, no study has compared preterm and full term auditory environments. AIM: To define differences in auditory exposure for preterm infants at term equivalent age in the neonatal intensive care unit (NICU) compared to auditory exposure in hospital rooms on a labor and delivery ward after full term birth. STUDY DESIGN: Ninety-eight infants (48 preterm infants born 28 weeks gestation in the NICU at term equivalent age and 50 full term infants in a hospital room on the labor and delivery ward within 4 days of birth) had auditory exposure measured over a single 16-hour period using the Language Environment Acquisition (LENA) device...
July 9, 2019: Early Human Development
https://read.qxmd.com/read/31295648/meconium-aspiration-syndrome-incidence-and-outcomes-using-discharge-data
#17
Patrick D Thornton, Richard T Campbell, Mulubrhan F Mogos, Carrie S Klima, Johanna Parsson, Minna Strid
BACKGROUND: Meconium aspiration syndrome (MAS) is a leading cause of morbidity and mortality among term, otherwise healthy newborns, yet population studies are rare. Definitions, outcomes and International Classification of Diseases (ICD) codes are heterogenous, complicating estimates of incidence, outcomes and risks. AIMS: To measure population incidence, risks and outcomes of MAS by ICD codes. STUDY DESIGN: Retrospective population study...
July 8, 2019: Early Human Development
https://read.qxmd.com/read/31284129/the-association-between-digit-ratio-2d-4d-and-overweight-or-obesity-among-chinese-children-and-adolescents-a-cross-sectional-study
#18
Lu Wu, Rongying Yao, Yifei Zhang, Yuan Wang, Ting Li, Manman Chen, Wenming Liu, Hui Han, Linda Bi, Lianguo Fu
BACKGROUND: The aim of this study was to analyze the relationship between 2D:4D and childhood overweight or obesity, which might indirectly show the role of prenatal hormone in childhood overweight or obesity. METHODS: Using stratified cluster sampling approach, a school-based cross-sectional investigation was undertaken among 687 children and adolescents aged 8-15 years. Each participant's index finger (2D) and ring finger (4D) length, height, weight, testosterone, and estradiol levels were measured, and their dietary behaviors, physical and sedentary activities were also surveyed...
July 5, 2019: Early Human Development
https://read.qxmd.com/read/31271995/preterm-children-with-suspected-cerebral-palsy-at-19-months-corrected-age-in-the-canadian-neonatal-follow-up-network
#19
Anne Synnes, Jenna Gillone, Annette Majnemer, Abhay Lodha, Dianne Creighton, Diane Moddemann, Prakesh S Shah
BACKGROUND: The ability to definitively diagnose cerebral palsy (CP) at 18-24 months is unknown. AIMS: To describe very preterm children who, at 19 months, have suspected CP defined as neither having a definitive diagnosis of CP nor no CP and compare them with children with and without CP. STUDY DESIGN AND METHODS: Longitudinal national cohort study of births <29 weeks' gestation with linked Canadian Neonatal Network and Canadian Neonatal Follow-up Network data with 19 month assessments and 3-year questionnaires (Ages and Stages-3 and Health Status Classification System-Preschool)...
July 1, 2019: Early Human Development
https://read.qxmd.com/read/31265946/extended-course-of-prednisolone-in-infants-with-severe-bronchopulmonary-dysplasia
#20
Alaina Linafelter, Alain Cuna, Cynthia Liu, Anastasia Quigley, William E Truog, Venkatesh Sampath, Alexandra Oschman
BACKGROUND: There are few published data on the efficacy and safety of prednisolone in preterm infants with bronchopulmonary dysplasia (BPD). AIMS: To describe the use of chronic prednisolone therapy in a population of infants with severe BPD, examine potential benefits on respiratory status, and document potential effects on growth. STUDY DESIGN: Single-center retrospective cohort study. SUBJECTS: Preterm infants who had received ≥30 days of prednisolone for the treatment of severe BPD...
June 29, 2019: Early Human Development
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