Anna Kasielska-Trojan, John T Manning, Marek Kałuża, Ewa Głowacka, Bogusław Antoszewski
BACKGROUND: It is thought that digit ratios (2D:4D) are a correlate of 1st trimester maternal and foetal sex steroids. Here we consider the relationship of 2D:4D to the former. METHOD: Digit lengths were directly measured with a calliper at infant age 13 months. Measures of T and E were obtained from mother's blood at 6-8 weeks, 10-11 weeks and 1st trimester means were calculated. RESULTS: There were 69 mother-infant pairs (33 boys)...
June 15, 2024: Early Human Development
Anna Markkula, Riikka Pyhälä-Neuvonen, Suvi Stolt
BACKGROUND: Preterm children have a higher risk for linguistic delays than full-term infants but are rarely provided with language intervention at an early age. Knowledge on early language interventions targeted to preterm children is scarce, and efficacy of the interventions is rarely reported. AIM: This systematic review aims to identify interventions for preterm children aged 0-3 years with at least one language outcome. Efficacy of the interventions and quality of the study reports were evaluated...
June 9, 2024: Early Human Development
Lisa Horn, Sonja Windhager, Nina Juricka, Thomas Bugnyar, Jorg J M Massen, Gabriela Markova
BACKGROUND AND AIMS: Prosocial behavior such as helping and sharing develops early in childhood. Yet very few studies have investigated physiological and relational factors shaping prosociality among children. Here, we systematically examined the role of prenatal androgen exposure alongside prestige, dominance, and friendship in 3-6-year-old preschoolers' prosocial sharing with familiar peers. METHODS: We tested a sample of 65 children, predominately of European descent...
June 6, 2024: Early Human Development
Diana Rodrigues, Kirti Joshi, Sayli Rajadhyaksha, Ramesh V Debur
PURPOSE: The study aimed at scoring Indian preterm infants at three months corrected age on the TIMP and then comparing the scores to the United States age-based population scores. METHODS: After obtaining Ethical clearance, participants meeting the inclusion criteria of 53 infants whose parents consented were screened and recruited (N = 47) at a tertiary care hospital. The TIMP was then administered at three months of corrected age. RESULTS: Data obtained from 47 infants born preterm (Male = 33, Female = 14) at three months corrected age with mean gestational age (34...
June 4, 2024: Early Human Development
Carla L Avena-Zampieri, Theodore Dassios, Anna Milan, Rui Santos, Vanessa Kyriakopoulou, Daniel Cromb, Megan Hall, Alexia Egloff, Matthew McGovern, Alena Uus, Jana Hutter, Kelly Payette, Mary Rutherford, Anne Greenough, Lisa Story
BACKGROUND: Neonatal chest-Xray (CXR)s are commonly performed as a first line investigation for the evaluation of respiratory complications. Although lung area derived from CXRs correlates well with functional assessments of the neonatal lung, it is not currently utilised in clinical practice, partly due to the lack of reference ranges for CXR-derived lung area in healthy neonates. Advanced MR techniques now enable direct evaluation of both fetal pulmonary volume and area. This study therefore aims to generate reference ranges for pulmonary volume and area in uncomplicated pregnancies, evaluate the correlation between prenatal pulmonary volume and area, as well as to assess the agreement between antenatal MRI-derived and neonatal CXR-derived pulmonary area in a cohort of fetuses that delivered shortly after the antenatal MRI investigation...
May 24, 2024: Early Human Development
Peter Korček, Zbyněk Straňák
BACKGROUND: Probiotic prophylaxis has been suggested to reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in very preterm newborns. However, choosing the optimal probiotic is difficult due to variations in strain-specific effects and interactions facilitated by the use of combination species. AIMS: To compare clinical outcomes of very preterm infants receiving multi or single-species probiotics. STUDY DESIGN: Retrospective, single-center, cohort study...
May 22, 2024: Early Human Development
Saaz Mantri, An-Chiao Cheng, Kelley Saia, Hira Shrestha, Rachel Amgott, Jonathan Bressler, Martha M Werler, Ginny Carter, Hendree E Jones, Elisha M Wachman
BACKGROUND: Naltrexone is a medication used to treat both opioid and alcohol use disorder with limited experience in pregnant individuals, particularly in comparison to more commonly utilized treatments such as buprenorphine-naloxone. The long-term outcomes of infants exposed to naltrexone has not been previously examined. AIMS: To compare the neurobehavioral outcomes of naltrexone versus buprenorphine-naloxone exposed infants. STUDY DESIGN: Multi-centered prospective cohort study...
May 21, 2024: Early Human Development
Dilek Ulubas Isik, Istemi Han Celik, Fatih Isleyen, Fatma Pinar Tabanli, Esay Kiran Yenice
No abstract text is available yet for this article.
May 21, 2024: Early Human Development
Nour Rebai, Enrico Lopriore, Vincent Bekker, Femke Slaghekke, Michiel H D Schoenaker, Sophie G Groene
Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality in preterm neonates, yet its pathophysiology remains unclear. The aim of this study is to evaluate risk factors for NEC using an identical twin model. In this case-control study, all monochorionic twin pairs born in our center in 2002-2020 were retrospectively reviewed for NEC. Potential risk factors for NEC were studied. For within-pair comparison, outcomes were compared between affected and unaffected twins. Within-pair analyses showed that the twin with NEC had a lower birth weight compared to its unaffected co-twin (1100 (913-1364) vs...
May 21, 2024: Early Human Development
Gustavo Rocha, Rita Calejo, Vanessa Arnet, Filipa Flôr de Lima, Gonçalo Cassiano, Isabel Diogo, Joana Mesquita, Gabriela Mimoso, Elisa Proença, Carmen Carvalho, Constança Gouvêa Pinto, Anabela Salazar, Marta Aguiar, Albina Silva, Almerinda Barroso, Conceição Quintas
BACKGROUND: Our objective was to determine whether the use of two or more courses of low-dose systemic dexamethasone for extubation of ventilator-dependent preterm infants after the first week of life, as proposed in the DART study, is associated with greater neurodevelopmental harm at two years of corrected age, compared to a single course. METHODS: Retrospective review at seven level III neonatal intensive care units. Preterm infants who underwent only one course of systemic dexamethasone for extubation were grouped into DART-1; those who underwent two or more courses were grouped into DART-2...
May 20, 2024: Early Human Development
Anniina Väliaho, Liisa Lehtonen, Anna Axelin, Riikka Korja
BACKGROUND: The survival of the smallest and most immature preterm infants, born at 23-24 weeks of gestation, has improved significantly. While there is a substantial amount of research on the neurocognitive and social outcomes of extremely premature birth, little is known about the survivors' subjective experience of being born preterm and its effect on later life. AIMS: The purpose was to study the subjective experiences of school-aged children born at 23-24 weeks of gestation, in order to understand their perspectives on how being born extremely early had affected their life...
May 19, 2024: Early Human Development
Gianluca Malatesta, Daniele Marzoli, Chiara Lucafò, Anita D'Anselmo, Teresiana Azzilonna, Giulia Prete, Luca Tommasi
The left-cradling bias (i.e., the motor asymmetry for cradling infants on the left side) has often been associated to the right-hemispheric social-emotional specialization, and it has often been reported to be stronger in females than in males. In this study we explored the effects of sexual orientation and gender identity on this lateral bias by means of a web-based investigation in a sample of adults (485 biological females and 196 biological males) recruited through LGBTQIA+ networks and general university forums...
May 18, 2024: Early Human Development
Eirik Nestaas, Lisa Bjarkø, Torvid Kiserud, Guttorm Haugen, Drude Fugelseth
No abstract text is available yet for this article.
May 18, 2024: Early Human Development
Alexandrea L Craft, Marie Camerota, Cynthia Loncar, Brian S Carter, Jennifer Check, Jennifer B Helderman, Julie A Hofheimer, Elisabeth C McGowan, Charles R Neal, T Michael O'Shea, Steven L Pastyrnak, Lynne M Smith, Lynne M Dansereau, Sheri A DellaGrotta, Carmen Marsit, Barry M Lester
OBJECTIVE: Understand how high-risk infants' development changes over time. Examine whether NICU Network Neurobehavioral Scale (NNNS) profiles are associated with decrements in developmental outcomes between ages 2 and 3 years in infants born very preterm. STUDY DESIGN: The Neonatal Outcomes for Very preterm Infants (NOVI) cohort is a multisite prospective study of 704 preterm infants born <30 weeks' gestation across nine university and VON affiliated NICUs...
May 14, 2024: Early Human Development
Naiara Franco Baroni, Mariana Rinaldi Carvalho, Izabela da Silva Santos, Ana Vitória Lanzoni Chaves, Daniela Elias Goulart de Andrade Miranda, Lívia Castro Crivellenti, Daniela Saes Sartorelli
BACKGROUND: The excess neonatal adiposity is considered a risk factor for the development of childhood obesity and the birth weight is a marker of health throughout life. AIMS: To evaluate the effect of a lifestyle intervention conducted among pregnant women with overweight on neonatal adiposity and birth weight. METHODS: A total of 350 pregnant women were recruited and randomly allocated into the control (CG) and intervention (IG) groups...
May 12, 2024: Early Human Development
Marina Butovskaya, Yulia Adam, Valery Batsevich, Todd K Shackelford, Bernhard Fink
BACKGROUND: Digit ratio (2D:4D) - the relative lengths of the index and ring finger - is sexually dimorphic (male < female), possibly because of the sex-differentiated impact of prenatal androgenization on fetal development in the 1st trimester. The sex difference remains stable with age and has been reported in children, adolescents, and adults from industrialized and non-industrialized societies. Handgrip strength (HGS) also is sexually dimorphic (males > females) and correlates negatively with 2D:4D...
May 8, 2024: Early Human Development
Lynn Bitar, Barbara S Stonestreet, Yow-Pin Lim, Joseph Qiu, Xiaodi Chen, Imran N Mir, Lina F Chalak
BACKGROUND: Inter-alpha inhibitor proteins (IAIPs) are structurally related proteins found in the systemic circulation with immunomodulatory anti-inflammatory properties. Reduced levels are found in inflammatory related conditions including sepsis and necrotizing enterocolitis, and in neonatal rodents after exposure to hypoxia ischemia. In the current study, cord blood IAIP levels were measured in neonates with and without exposure to hypoxic-ischemic encephalopathy (HIE). METHODS: This is a prospective cohort study including infants born ≥36 weeks over a one-year period...
May 7, 2024: Early Human Development
Glenn Weisfeld
No abstract text is available yet for this article.
May 4, 2024: Early Human Development
Hila Segal
The commentary delves into the implications of "assortative parenting" and "assortative cross-parenting," as introduced by N. L. Segal, and situates these concepts within the framework of current research. It addresses the joys and complexities of raising twins, highlighting how their concurrent development stages can amplify parental favoritism and heighten the challenge of addressing each twin's unique needs. This interplay provides a rich context to investigate assortative parenting practices. Additionally, this paper contemplates the broader picture of twin studies, particularly how the care of monozygotic twins (who share 100 % of their genes) and dizygotic twins (who share 50 % of their genes, on average) may reveal the intertwined nature of genetics and environment in parenting strategies...
May 3, 2024: Early Human Development
Mary S Tarsha, Darcia Narvaez
BACKGROUND: The Evolved Developmental Niche (EDN) is a millions-year-old developmental system that matches the maturational schedule of the offspring, optimizing health. Every animal has a developmental niche. AIMS: Humanity has fallen away from providing its EDN. Does it matter? STUDY DESIGN: Several components of humanity's EDN were reviewed (breastfeeding, positive touch, allomothers, responsive care, free play) in relation to cardiac vagal nerve regulation, a signal of healthy development...
May 3, 2024: Early Human Development
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