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Auris, Nasus, Larynx

Tsutomu Ueda, Kazunori Kubota, Noriyuki Shiroma, Shogo Maeda, Hiromi Furuie, Takayuki Taruya, Takao Hamamoto, Sachio Takeno
BACKGROUND: Extra-axial chordomas are exceedingly rare malignant tumours. Herein, we present the first case of an extra-axial chordoma in the gingivae. METHODS AND RESULTS: A 21-year-old man presented with a suspected chordoma in the upper right gingiva. Diagnosis was difficult; however, owing to strong expression of the chordoma marker brachyury, extra-axial chordoma was ultimately diagnosed. The tumour was completely resected without performing a facial incision...
March 20, 2019: Auris, Nasus, Larynx
Taliye Cakabay, Selin Üstün Bezgin, Mahmut Cem Tarakcioglu, Murat Kocyigit, Bilge Serin Keskinege, Safiye Giran Örtekin, Mustafa Ozdemir
OBJECTIVE: In this study, we aimed to evaluate the diagnoses of the infants who were admitted to our outpatient clinic with the complaint of pulling on the ear and to identify the related factors which may contribute to the diagnosis. METHODS: This prospective study included a total of 102 infants who were admitted to our hospital with the complaint of tugging and pulling on, touching, and rubbing the ears on the shoulder or pillow and shaking the head between July 2016 and July 2017...
March 18, 2019: Auris, Nasus, Larynx
Nao Takahashi, Kaori Mori, Hironori Baba, Takanobu Sasaki, Masaaki Ohno, Fumio Ikarashi, Naotaka Aizawa, Kunihiro Sato, Akio Tsuchiya, Hideyuki Hanazawa, Masahiko Tomita, Yamato Kubota, Yuka Morita, Kuniyuki Takahashi, Arata Horii
No abstract text is available yet for this article.
March 14, 2019: Auris, Nasus, Larynx
Vincent Pitiot, Ruben Hermann, Aurélie Coudert, Eric Truy
We report two patients presenting with delayed complicationsafter Vibrant SounBridge® middle ear implant surgery: in both cases, a revision surgery was performed and lysis of the long process of the incus was highlighted. A re-assembly of the clip around the remaining long process of the incus was performed, associated with hydroxyapatite bone cement application, on the clip and the incudo-stapedial joint. Both patients had a satisfying result, with a mean follow up of 12 months.
March 13, 2019: Auris, Nasus, Larynx
Naoki Nishio, Yasushi Fujimoto, Mariko Hiramatsu, Takashi Maruo, Hidenori Tsuzuki, Nobuaki Mukoyama, Sayaka Yokoi, Akihisa Wada, Madoka Kaneko Furukawa, Masaki Furukawa, Michihiko Sone
OBJECTIVE: The purpose of this study was to evaluate the usefulness of ultrasound (US) volume measurement of the cervical lymph nodes for diagnosing nodal metastasis in patients with head and neck cancer using a node-by-node comparison. METHODS: Thirty-four consecutive patients with head and neck cancer from one tertiary university hospital were prospectively enrolled from 2012 to 2017. Patients with histologically proven squamous cell primary tumors in the head and neck region scheduled to undergo a therapeutic neck dissection were eligible...
March 8, 2019: Auris, Nasus, Larynx
Akihito Arai, Satomi Ozawa, Shota Kinoshita, Kanako Yoshimura, Junichi Mitsuda, Sumiyo Saburi, Daichi Mori, Mari Takenaka, Takahiro Tsujikawa, Eiichi Konishi, Shigeru Hirano
Secondary carcinogenesis within the irradiation range is one of the most severe problems in cancer survivors. A 60-year-old woman developed hypopharyngeal carcinoma, and she received radical surgery and postoperative radiotherapy. Eight years later, brown pigmentation and induration were observed in the left subaural region. Fine-needle aspiration biopsy revealed malignancy and the parotid tumor was diagnosed as recurrence of hypopharyngeal carcinoma. Neoadjuvant chemotherapy followed by radical parotidectomy was performed...
March 5, 2019: Auris, Nasus, Larynx
Kengo Tamari, Hiroko Takeuchi, Masayoshi Kobayashi, Kazuhiko Takeuchi, Takashi Kurahashi, Tetsuro Yamamoto
OBJECTIVE: The electrical properties of olfactory cells (OCs) are typically examined using animals such as newts, mice, and frogs, with few studies on human OCs. This study investigated the electrical properties of human cells from olfactory epithelium (hCOEs) obtained from subjects of olfactory epithelium showing no clinical symptoms during endoscopic sinus surgery. METHODS: hCOEs were isolated by collagenase treatment for whole-cell patch clamp recording. The identity of the cells was confirmed by immunohistochemistry with an antibody against olfactory maker protein...
March 5, 2019: Auris, Nasus, Larynx
Seiichiro Makihara, Shin Kariya, Tomoyuki Naito, Kensuke Uraguchi, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Kazunori Nishizaki
OBJECTIVE: The treatment of all forms of sinonasal inverted papilloma (IP) is a complete, wide, local resection. The main surgical purpose is to remove all diseased mucosa and mucoperiosteum, together with a cuff of normal-looking mucosa at the attachment site, followed by drilling and/or coagulation. Our aim is to present our experiences in endoscopic surgical management of IP by using attachment-oriented excision. METHODS: We present 20 cases of sinonasal IP. The data collected includes the histopathological diagnosis, staging, extension of the tumor, tumor attachment site, approach to surgery, serum squamous cell carcinoma antigen (SCCA) level, and recurrences...
March 1, 2019: Auris, Nasus, Larynx
Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hirotaka Shinomiya, Masanori Teshima, Yasutaka Kojima, Ken-Ichi Nibu
Papillary thyroid carcinoma (PTC) occasionally invades tracheal cartilages. We adapted a reconstructive procedure "modified spiral tracheoplasty" to extensive tracheal defect after resection of locally advanced thyroid cancer. Extensive window resection of tracheal wall was performed in a 72-year-old woman and a 48-year-old man with PTC invading intraluminal trachea. Remaining stumps of trachea were separated from the esophageal wall and were rotated by 90 degrees in opposite directions. Posterior and lateral walls were anastomosed and tracheocutaneous fistula was created to prevent postoperative airway obstruction...
February 28, 2019: Auris, Nasus, Larynx
Masao Noda, Miyako Hatano, Tsuyoshi Hattori, Mika Takarada-Iemata, Tomohiro Shinozaki, Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori
OBJECTIVE: Microglia are highly specialized tissue macrophages in the central nervous system. Their activation in the auditory system has been reported in adult hearing loss models, but their status in the developing auditory system is less understood. Therefore, we investigated microglial status in the cochlear nucleus (CN) during normal developing periods and after exposing rats to amikacin, a potent ototoxin, around the time of hearing onset. METHODS: To develop the deafness model, rats were administered with a daily intraperitoneal injection of amikacin (500 mg/kg) from postnatal day 7 (P7) to P15...
February 28, 2019: Auris, Nasus, Larynx
Takeshi Hori, Kazuma Sugahara, Junko Tsuda, Yoshinobu Hirose, Makoto Hashimoto, Yousuke Takemoto, Shunsuke Tarumoto, Hiroshi Yamashita
OBJECTIVE: Tsumura Suzuki Obese Diabetes (TSOD) mice exhibit early age-associated hearing loss. Histopathological analysis of these mice shows narrowing of capillaries in the stria vascularis and chronic reduction of blood flow in the cochlea. In this study, we investigated the effect of oral administration of a herbal medicine or calorie restriction on hearing in TSOD mice. METHODS: TSOD mice were divided into 4 groups: CR (calorie restriction), BF and DS (treated with the herbal medicines, Bofutsushosan and Daisaikoto, respectively), and the control group...
February 21, 2019: Auris, Nasus, Larynx
Sachie Arima, Shigefumi Koike, Maki Fujinaga, Takenao Mihara, Shintaro Sato, Motohiko Suzuki, Shingo Murakami, Meiho Nakayama
OBJECTIVE: Since reports on surgical results for pediatric obstructive sleep apnea (OSA) in Japan are insufficient for debate, this study aimed to evaluate the feature of Japanese OSA children and surgical result and document whether is obesity and affecting factor similar to non-Asian countries. METHODS: This is a retrospective study. A total of 242 children with OSA at the Department of Otolaryngology and the Good Sleep Center, Nagoya City University Hospital and the Toyohashi Mates Sleep Disorders Center were included in the study...
February 21, 2019: Auris, Nasus, Larynx
Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Akinori Kakigi, Naoki Otsuki, Ken-Ichi Nibu
OBJECTIVE: The purpose of this study was to clarify the impact of superficial parotidectomy and postoperative radiotherapy (PORT) for the surgical treatment of early stage squamous cell carcinoma (SCC) in external auditory canal (EAC). MATERIALS AND METHODS: Thirty-seven patients with T1 (n = 14) or T2 (n = 19) SCC in EAC treated between 2000 and 2016 at Kobe University Hospital were enrolled in this study. Thirty-three patients were operated with sleeve resection or lateral temporal bone resection...
February 21, 2019: Auris, Nasus, Larynx
Seon-Lin Kim, Sung-Dong Kim, Han-Seul Na, Jae-Wook Kim, Keun-Ik Yi, Sue-Jean Mun, Kyu-Sup Cho
OBJECTIVE: The blocking of airflow into sinonasal cavity may decrease postoperative crusting and the development of adhesions. The purpose of this study was to investigate the efficacy of cotton ball packing in patients following endoscopic sinus surgery (ESS). METHODS: Thirty nine patients with chronic rhinosinusitis requiring the same extent of ESS were included. As a part of postoperative care, the patients were instructed to perform a nasal saline irrigation and apply a nasal spray in each nostril, and then informed to put a cotton ball in a one side of nostril, and the other side was kept to be empty as a control...
February 16, 2019: Auris, Nasus, Larynx
Masaru Miyazaki, Mikiko Aoki, Kaori Koga, Makoto Hamasaki, Yoshikazu Sugiyama, Kensuke Midorikawa, Daisuke Hamatake, Michio Masaki, Yasushi Takamatsu, Akinori Iwasaki, Toshifumi Sakata, Toshitaka Nagao, Kazuki Nabeshima
Adenoid cystic carcinoma (AdCC) with high-grade transformation (AdCC-HGT) is rare, and AdCC-HGT with spindle cell component is particularly rare. The patient was a 65-year-old man with a 5 cm sized swelling of the right submandibular gland. Submandibular sialoadenectomy was performed. Histopathological findings mainly showed conventional AdCC, and minorly showed two other components: (1) the pleomorphic component, a proliferation of atypical pleomorphic epithelial cells forming solid or small clusters and accompanied by necrosis; (2) the spindle cell component, containing atypical spindle cells invading the stroma...
February 15, 2019: Auris, Nasus, Larynx
Thomas Guenzel, Stephan Hoch, Niels Heinze, Thomas Wilhelm, Christian Gueldner, Achim Franzen, Annekathrin Coordes, Anja Lieder, Susanne Wiegand
OBJECTIVE: To demonstrate the safety and efficiency of holmium laser-assisted lithotripsy during sialendoscopy of the submandibular gland using a retrospective, interventional consecutive case series. METHODS: We performed 374 sialendoscopies between 2008 and 2015 and evaluated all patients regarding clinical symptoms, clinical findings, therapy and outcome. We performed 109 procedures of holmium laser-assisted lithotripsy in 64 patients whose sialoliths measured 5 mm or more in diameter...
February 11, 2019: Auris, Nasus, Larynx
Koji Araki, Masayuki Tomifuji, Kosuke Uno, Hiroshi Suzuki, Yuya Tanaka, Shingo Tanaka, Eiko Kimura, Akihiro Shiotani
OBJECTIVE: The fiber-guided carbon dioxide (CO2 ) laser is a useful device for laryngopharyngeal surgery. The flexible CO2 wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO2 flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO2 TNFLS) is not permitted in Japan. This feasibility study aimed to assess the value and the safety of an in-office CO2 TNFLS procedure. METHODS: Patients with small laryngopharyngeal diseases were enrolled from June 2015...
February 11, 2019: Auris, Nasus, Larynx
Seiichiro Makihara, Shin Kariya, Mai Noujima-Harada, Nobuya Ohara, Tomoyuki Naito, Junya Matsumoto, Yohei Noda, Mitsuhiro Okano, Tadashi Yoshino, Kazunori Nishizaki
As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. After withdrawal of MTX, the multiple bilateral pulmonary nodules and bilateral cervical lymphadenopathy disappeared without chemotherapy in both cases...
February 7, 2019: Auris, Nasus, Larynx
Akinobu Kakigi, Teruhiko Okada, Taizo Takeda, Natsumi Uehara, Ken-Ichi Nibu
Objective The endocytosis of cationized feritin (CF) via a clathrin-mediated pathway is regulated by a signaling network. Marginal cells showed the active endocytosis of CF via a clathrin-mediated pathway. The internalization of receptors through this clathrin-mediated pathway is an important regulatory event in signal transduction. Numerous kinases are involved in endocytosis, and each endocytic route is subjected to high-order regulation by cellular signaling mechanisms. In this study, we investigated whether ROCK and MLCK signaling cascades and G-proteins regulate the endocytosis of CF in marginal cells of the stria vascularis...
February 7, 2019: Auris, Nasus, Larynx
Hiroshi Hosoi, Tadashi Nishimura, Ryota Shimokura, Tadashi Kitahara
It has been long considered that air and bone are the two major mediators that conduct sounds to the inner ear. In 2004, Hosoi found that vibration of aural cartilage, generated by placing gently a transducer on it, could create audible sound with the same level of clarity as air- and bone-conduction sound. He thus proposed the term "cartilage conduction" for this concept. This research identified a third mediator for sound conduction to the inner ear. Hosoi also proposed the development of novel communication devices, such as hearing aids, telephones, etc...
February 1, 2019: Auris, Nasus, Larynx
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