Jiesheng Rong, Rui Pu, Hongru Sun, Yupeng Liu, Tian Tian, Haoran Bi, Tingting Xia, Lei Zhang, Yuanyuan Zhang, Yashuang Zhao, Lin Zhu
BACKGROUND: Aberrant promoter methylation of CpG islands plays an important role in carcinogenesis. However, the association between the DNA methylation of JAK-STAT pathway-related genes in peripheral blood leukocytes and colorectal cancer (CRC) susceptibility remains unclear. METHODS: We conducted a case-control study of 403 patients with CRC and 419 cancer free controls, and the DNA methylation levels of JAK2, STAT1, STAT3, and SOCS3 in peripheral blood samples from all subjects were assessed using a methylation-sensitive high-resolution melting (MS-HRM) analysis...
March 11, 2023: Gene