Sexually Transmitted Diseases

We found that tetracycline resistance associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline PEP may select for resistance to other antimicrobials.

BACKGROUND: Intimate partner violence (IPV) has been a concern among men who have sex with men (MSM), but less attention has been paid to the factors associated with this population in China. AIMS: We investigate the prevalence of and factors associated with IPV victimhood among MSM in Guangzhou, China. METHODS: MSM were recruited from May to November 2017, and data were collected using an anonymous electronic questionnaire. Chi-squared tests and non-conditional logistic regressions were used to explore the factors associated with IPV victimhood...

BACKGROUND: As a potential indicator of equity in research partnerships, we conducted a bibliometric analysis of author affiliations and author order in publications about sub-Saharan Africa published in the journal Sexually Transmitted Diseases. METHODS: We identified articles in the journal Sexually Transmitted Diseases that were about sub-Saharan Africa and published from 2011 to 2020. Medical Subject Heading (MeSH) terms in PubMed were used to identity articles about sub-Saharan Africa...

BACKGROUND: National guidelines recommend sexually active women under the age of 25 be screened annually for chlamydia. Our objective was to estimate the chlamydia screening rate of sexually active women aged 16-24 years from 2011-2020. METHODS: We analyzed the chlamydia screening rates among sexually active women aged 16-24 from 2011-2020 using the chlamydia measures in the Healthcare Effectiveness Data and Information Set (HEDIS) dataset. The annual national chlamydia screening rates was further stratified by census region and by patient age...

BACKGROUND: In the United States, annual screening for rectal gonorrhea and chlamydia is only recommended for men who report receptive anal sex (RAS), but other behaviors (e.g., rimming) may lead to rectal GC/CT acquisition. METHODS: We enrolled individuals assigned male sex at birth who reported sex with men and denied RAS in the past 2 years or reported RAS 1-2 years ago but were tested and treated since last RAS. Participants enrolled in-person at the Sexual Health Clinic in Seattle, Washington (December 2019-July 2022) or online (July 2021-March 2022)...

BACKGROUND: Pre-Exposure Prophylaxis (PrEP) for HIV is disproportionately under prescribed to women. Centers for Disease Control and Prevention (CDC) guidelines identify a group of women at risk of HIV acquisition who should be offered PrEP, but opportunities remain to improve patient awareness of and provider counseling about PrEP, and to expand service delivery of PrEP. METHODS: Using nationally representative data from the 2017-2019 National Survey of Family Growth, we compared women with (n = 689) and without (n = 5,452) CDC indications for PrEP on measures of PrEP awareness, counseling by a provider, and interaction with the health care system...

BACKGROUND: The primary objective of this study was to assess utilization of sexual health services at a university's student health and wellness center and to determine whether the presence of a dedicated sexual health clinic (SHC) associated with different utilization patterns for sexual health services when compared to primary care clinics. METHODS: This was a retrospective chart review of patients presenting to the University of Alabama at Birmingham's (UAB) Student Health and Wellness Center for sexual health services between January 2015 and June 2019...

Using data from the HPV Infection in Men cohort study, we demonstrate HPV 16 methylation associations with persistent oral HPV infection, the obligate precursor to oropharyngeal cancer (OPC). HPV16 persistence was significantly associated with methylation of HPV16 L2 CpG-4268 (Wilcoxon p = 0.04), and methylation of HPV16 E2 CpG-Pos-4 (Wilcoxon p = 0.04).

BACKGROUND: CDC recommends that the decision to provide STI/HIV testing and presumptive treatment to patients who report sexual assault and abuse (SAA) be made on an individual basis. METHODS: The 2019 CMS national Medicaid dataset was used. SAA visits were identified by ICD-10-CM (O9A4 for pregnancy-related sexual abuse, T74.2 for confirmed sexual abuse, and Z04.4 for alleged rape). The initial SAA visit was defined as the patient's first SAA-related visit. Medical services were identified by ICD-10-CM codes, CPT codes, and NDC codes...

Trichomoniasis is the most common non-viral sexually transmitted infection.1 For patients with resistance to standard treatment with 5-nitroimidazoles, alternative therapies are limited. We present a case of a 34-year-old woman with multi-drug resistant trichomoniasis who was successfully treated with 600 mg intravaginal boric acid twice daily for 3 months.

Mpox vaccination is recommended for persons exposed to or at risk for mpox. About 25% of an online sample of MSM with presumed mpox exposure were vaccinated (≥1 dose). Vaccination was higher among younger MSM and MSM concerned about mpox or reporting sexual risk behaviors. Incorporating mpox vaccination into routine sexual health care and increasing 2-dose vaccination uptake is essential to preventing mpox acquisition, improving MSM sexual health, and averting future mpox outbreaks.

BACKGROUND: This study evaluated the clinical laboratory capacity for the diagnosis of Chlamydia trachomatis (CT) in China, in order to provide recommendations to improve the diagnostic capacity and quality of this clinically important sexually transmitted disease. METHODS: An electronic questionnaire-based cross-sectional survey study was conducted by the National Center for STD Control among different types of healthcare facilities in China from July to December 2021...

BACKGROUND: Rapid linkage to HIV medical care, ideally within seven days of a person's diagnosis with HIV infection, is a vital strategy of the Ending the HIV Epidemic (EHE) initiative in the United States. We analyzed HIV testing data to evaluate the prevalence of and factors associated with rapid linkage to HIV medical care. METHODS: We used HIV testing data reported by CDC-funded 60 state and local health departments and 29 community-based organizations during 2019-2020...

BACKGROUND: Transgender and nonbinary (TNB) people are diverse in their sexual orientation and partnerships. We describe the epidemiology of HIV/STI prevalence and prevention utilization among the partners of TNB people in Washington State. METHODS: We pooled data from five 2017-2021 cross-sectional HIV surveillance data sources to generate a large sample of TNB people and cisgender people who had a TNB partner in the past year. We describe characteristics of recent partners of trans women, trans men, and nonbinary people and use Poisson regression to assess if having a TNB partner was associated with self-reported HIV/STIs prevalence, testing, and PrEP use...

BACKGROUND: Manually performed nontreponemal assays, such as rapid plasma reagin (RPR), are labor intensive and time consuming. Recently, commercial automated RPR assays gained attention. The aim of this study was to compare the qualitative and quantitative performance of the AIX1000TM (RPR-A) (Gold Standard Diagnostics) to a manual RPR test (RPR-M) (Becton Dickinson Macrovue) within a high prevalence setting. METHODS: A retrospective panel of 223 samples was selected for comparison between RPR-A and RPR-M, including 24 samples from patients with known syphilis stages and 57 samples from 11 patients in follow-up...

BACKGROUND: Availability of laboratory confirmation of sexually transmitted infections (STIs) is increasing in low- and middle-income countries, but costs continue to limit their access. Chlamydia trachomatis (CT) is an STI of significant clinical importance, particularly among women. This study aimed to develop a risk score to identify women with a higher likelihood of CT infection, who could then be prioritized for laboratory testing, in a population of Kenyan women planning pregnancies...

BACKGROUND: The detection and reporting of disseminated gonococcal infection (DGI) has been increasing across the United States (US). METHODS: We conducted a retrospective chart review of DGI case-patients diagnosed between 2010 and 2019 at a large tertiary care hospital in North Carolina. RESULTS: We identified 12 DGI case-patients (7 males and 5 females, aged 20 to 44 years old) of whom 5 had Neisseria gonorrheae isolated from a sterile site (confirmed), 2 had N...

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Observational studies demonstrated 30-40% effectiveness of OMV meningococcal serogroup-B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.

BACKGROUND: Extragenital testing (rectal and oropharyngeal) of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) increases the detection of CT/NG infections, compared to genital testing alone. The Centers for Disease Control and Prevention (CDC) recommends annual extragenital CT/NG screening for men who have sex with men, and additional screenings for women and transgender or gender-diverse individuals if certain sexual behaviors and exposures are reported. METHODS: Prospective computer-assisted telephonic interviews (CATI) were conducted with 873 clinics between June 2022 and September 2022...