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Sexually Transmitted Diseases

Rebecca J Baer, Christina D Chambers, Kelli K Ryckman, Scott P Oltman, Larry Rand, Laura L Jelliffe-Pawlowski
BACKGROUND: Few studies have examined the relationship between sexually transmitted infections (STIs) and preterm birth (<37 weeks gestation) by subtype (<32 weeks, 32 - 36 weeks, spontaneous, provider-initiated). Here, we evaluate the odds of preterm (by subtype) and early term (37 and 38 weeks gestation) birth in women with an STI compared to a propensity score matched reference population. METHODS: The sample was selected from California births in 2007-2012...
February 11, 2019: Sexually Transmitted Diseases
Mahlape P Mahlangu, Etienne E Müller, Johanna Me Venter, Dumisile V Maseko, Ranmini S Kularatne
BACKGROUND: Mycoplasma genitalium is associated with genital discharge syndrome, but limited prevalence data is available in South Africa. The prevalence rates of M. genitalium infection and HIV co-infection were determined in urogenital specimens collected from male and female patients presenting with genital discharge syndrome to a primary health care centre in Johannesburg, South Africa from 2007 through 2014. METHODS: Genital specimens from 4731 patients were tested by a validated in-house multiplex real-time PCR assay for the detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and M...
February 11, 2019: Sexually Transmitted Diseases
Susan Tuddenham, Khalil G Ghanem
No abstract text is available yet for this article.
February 9, 2019: Sexually Transmitted Diseases
Aniruddha Hazra, Timothy W Menza, Kenneth Levine, Chris Grasso, Kenneth H Mayer
For patients assigned male at birth seen at a Boston clinic over a decade, we found disproportionate syphilis cases in young patients, Black and Hispanic/Latinx patients, gay/bisexual patients, cisgender men, and those with new or chronic HIV infection; syphilitic reinfections have significantly increased. ABSTRACT BACKGROUND: United States syphilis rates have increased to levels last seen in the 1990s. We examined syphilis epidemiology of patients attending a Boston community health center specializing in sexual and gender minority health...
February 9, 2019: Sexually Transmitted Diseases
Nicole Liddon, Lisa Carver, Leah Robin, Chris Harper, Colleen Murray, Melissa Habel, Catherine Lesesne
BACKGROUND: In an attempt to increase high school students' STD testing ratesrates, the Centers for Disease Control and Prevention's Division of Adolescent and School Health partnered with ICF and Chicago Public Schools (CPS) to adapt and implement the "GYT: Get Yourself Tested" health marketing campaign for a high school. METHODS: Clinic record data and student retrospective self-report surveys (n=193) tested for differences between the GYT intervention school and a comparison school on a number of outcomes including HIV and STD testing...
February 6, 2019: Sexually Transmitted Diseases
Diana M Sheehan, Merhawi T Gebrezgi, Mariana Sanchez, Tan Li, Kristopher P Fennie, Mary Jo Trepka
OBJECTIVE: To examine the longitudinal relationship between social disorganization (SD) and genital Chlamydia trachomatis infection. METHODS: US county-level data for 2010-2015 were used. Reliability and principal component analysis revealed two SD factors: socioeconomic deprivation and demographic instability. Growth curve models examined the degree to which SD factors affected chlamydia rates (number of new reported cases per 100,000 population) at baseline and over time adjusting for population percentage aged 15-24 years, male to female ratio for population aged 15-24 years, and rural percentage...
January 30, 2019: Sexually Transmitted Diseases
Linda Grillová, David Šmajs
No abstract text is available yet for this article.
January 30, 2019: Sexually Transmitted Diseases
Ivan Kasamba, Stephen Nash, Janet Seeley, Helen A Weiss
BACKGROUND: High attrition and irregular testing for HIV in cohort studies for high-risk populations can bias incidence estimates. We compare incidence trends for high-risk women attending a dedicated HIV prevention and treatment clinic, using common methods for assigning when seroconversion occurs and whether seroconversion occurs among those with attrition. METHODS: Between April 2008-May 2009 women were enrolled into cohort-1 and from January 2013 into cohort-2, then scheduled for follow-up once every three months...
January 19, 2019: Sexually Transmitted Diseases
Jeb Jones, Kevin Weiss, Jonathan Mermin, Patricia Dietz, Eli S Rosenberg, Thomas L Gift, Harrell Chesson, Patrick S Sullivan, Cynthia Lyles, Kyle T Bernstein, Samuel M Jenness
BACKGROUND: Sexually transmitted infections (STIs) are associated with an increased risk of HIV acquisition and transmission. We estimated the proportion of HIV incidence among men who have sex with men attributable to infection with the two most common bacterial STIs, Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). METHODS: We used a stochastic, agent-based model of a sexual network of MSM with co-circulating HIV, NG, and CT infections. Relative risk (RR) multipliers, specific to anatomic site of infection, modified the risk of HIV transmission and acquisition based on STI status...
January 19, 2019: Sexually Transmitted Diseases
Edward W Hook, Matthew R Golden, Stephanie N Taylor, Eugenia Henry, Carol Tseng, Jerri Swerdlow, Ashley Nenninger, Sue Cammarata
BACKGROUND: We evaluated single oral dose delafloxacin versus single intramuscular (IM) ceftriaxone in participants with uncomplicated urogenital gonorrhea (primary objective). Secondary objectives included the efficacy, safety, and tolerability of delafloxacin versus ceftriaxone for uncomplicated urogenital, rectal, and/or pharyngeal gonorrhea. METHODS: In this open-label, multicenter study, 460 participants at 25 study centers were randomized (2:1) to receive a single 900mg oral dose of delafloxacin or 250mg IM ceftriaxone...
January 19, 2019: Sexually Transmitted Diseases
T C Laschober, J M Serovich, M J Brown, J A Kimberly, C M Lescano
BACKGROUND: People living with HIV (PLWH) are faced with the often difficult decision of whether, when, and how to disclose their seropositive status. This study draws on the transtheoretical model of change to examine men and women's decision readiness to disclose their HIV-positive status to family members and to assess predictors (decisional balance and decision self-efficacy) of their decision readiness. METHODS: Cross-sectional data were collected from 346 PLWH - 191 males and 155 females...
January 19, 2019: Sexually Transmitted Diseases
David M Bamberger, Georgia Graham, Lesha Dennis, Mary M Gerkovich
BACKGROUND: Current guidelines recommend screening for extragenital gonorrhea (GC) and chlamydia (CT) only among men having sex with men (MSM). Extragenital GC and CT is associated with treatment failure and disease transmission. The prevalence of exragenital GC/CT infections in women and in men having sex with women (MSW) are less well studied. We sought to determine the prevalence of extragenital CG and CT among all persons attending a sexually transmitted diseases clinic who engaged in extragenital sexual activity...
January 19, 2019: Sexually Transmitted Diseases
Darcy White Rao, Jason Carr, Kelly Naismith, Julia E Hood, James P Hughes, Martina Morris, Steven M Goodreau, Eli S Rosenberg, Matthew R Golden
BACKGROUND: Many state and local health departments now promote and support the use of HIV pre-exposure prophylaxis (PrEP), yet monitoring use of the intervention at the population level remains challenging. METHODS: We report the results of an online survey designed to measure PrEP use among men who have sex with men (MSM) in Washington State. Data on the proportion of men with indications for PrEP based on state guidelines and levels of awareness, interest, and use of PrEP are presented for 1,080 cisgender male respondents who completed the survey between January 1 and February 28, 2017...
January 19, 2019: Sexually Transmitted Diseases
Vanessa Mulligan, Yvonne Lynagh, Susan Clarke, Magnus Unemo, Brendan Crowley
This is the first prevalence study of Mycoplasma genitalium and antimicrobial resistance study in Ireland. In urine samples from MSM (n=400) attending an STD clinic in Dublin, the prevalence of M. genitalium was 3% (12/400 specimens; 95% CI, 1.3-4.7%) and the prevalence of macrolide resistance (75%), fluoroquinolone resistance (33.3%) and MDR (33.3%) which was very high.
January 19, 2019: Sexually Transmitted Diseases
Jamie Perin, Jacky M Jennings, Renata Arrington-Sanders, Kathleen R Page, Penny S Loosier, Patricia J Dittus, Arik V Marcell
BACKGROUND: To address sexual and reproductive health (SRH) needs of young minority urban males, we developed and evaluated Project Connect Baltimore (Connect), which was adapted from a program with demonstrated effectiveness among young females. The objectives were to determine 1) the feasibility of Connect as adapted for young minority men, 2) whether the program increased SRH knowledge and resource sharing of youth-serving professionals (YSPs) working with young men, and 3) whether the program improved awareness and use of resources for young minority men in Baltimore City, an urban environment with high rates of STDs...
January 15, 2019: Sexually Transmitted Diseases
Kristal J Aaron, Barbara Van Der Pol, Stephen J Jordan, Jane R Schwebke, Edward W Hook
BACKGROUND: Symptom awareness, behavioral factors, and other barriers associated with timely STI healthcare provision in men is not well-studied. METHODS: Men attending an STI clinic answered a questionnaire regarding their symptoms, sexual behavior, and socio-demographic and behavioral characteristics. Characteristics of symptomatic men were compared between those who did and did not delay seeking healthcare services. Delayed care-seeking was defined as clinic attendance >7 days after symptoms while early care-seeking was defined as clinic attendance ≤7 days...
January 10, 2019: Sexually Transmitted Diseases
Katharine J McCarthy, Erica L Gollub, Lauren Ralph, Janneke van de Wijgert, Heidi E Jones
BACKGROUND: Evidence suggests that some forms of hormonal contraception (HC) increase women's risk of non-HIV sexually transmitted infections (STIs), yet evidence has not been reviewed since 2008. We conducted an updated systematic review to incorporate studies published between January 2009 and June 2017 to examine the relationship between HCs and incident and/or recurrent STIs. METHODS: We searched PubMed and EMBASE to identify prospective studies comparing risk of Chlamydia trachomatis, Neisseria gonorrhoeae, human papillomavirus (HPV), herpes simplex virus type 2 (HSV-2), Treponema pallidum, or Trichomonas vaginalis, between women using HC vs...
January 8, 2019: Sexually Transmitted Diseases
Yetunde F Fakile, Myra Brinson, Victoria Mobley, Ina U Park, Anne M Gaynor
BACKGROUND: In this study, we evaluate the performance of the Syphilis Health Check™ (SHC) in clinical and laboratory settings using fingerstick whole-blood and serum. METHODS: Fingerstick whole-blood and serum specimens from adult patients (n=562) without prior syphilis history presenting at two county health department STD clinics in North Carolina were tested. Fingerstick specimens were tested with the SHC in clinic, and serum specimens were tested at the North Carolina State Laboratory of Public Health with: 1) qualitative rapid plasma reagin (RPR), 2) treponemal EIA and 3) SHC...
January 8, 2019: Sexually Transmitted Diseases
Kathryn Peebles, Jennifer Velloza, Jennifer E Balkus, R Scott McClelland, Ruanne V Barnabas
BACKGROUND: Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age and is associated with important adverse health outcomes. Estimates of the burden of BV and associated costs are needed to inform research priorities. METHODS: We conducted a systematic review and meta-analysis of global BV prevalence among reproductive-aged women in the general population. We searched PubMed and Embase, and used random effects models to estimate BV prevalence by global regions...
January 7, 2019: Sexually Transmitted Diseases
Sofya Maslyanskaya, Elizabeth M Alderman, Avni M Bhalakia, Michael L Rinke
Hospitalizations offer chlamydia and gonorrhea screening opportunities for youth who may not seek preventive care. Tracking of screening test results still pending after hospital discharge is an important component of clinical care. This process can be improved by protocol use and enhanced by effective, automated electronic health record tools.
January 7, 2019: Sexually Transmitted Diseases
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