journal
https://read.qxmd.com/read/38808555/tmprss13-promotes-the-cell-entry-of-swine-acute-diarrhea-syndrome-coronavirus
#41
JOURNAL ARTICLE
Yutong Han, Yanlong Ma, Ziqiao Wang, Fei Feng, Ling Zhou, Hui Feng, Jingyun Ma, Rong Ye, Rong Zhang
Swine acute diarrhea syndrome coronavirus (SADS-CoV) has caused severe intestinal diseases in pigs. It originates from bat coronaviruses HKU2 and has a potential risk of cross-species transmission, raising concerns about its zoonotic potential. Viral entry-related host factors are critical determinants of susceptibility to cells, tissues, or species, and remain to be elucidated for SADS-CoV. Type II transmembrane serine proteases (TTSPs) family is involved in many coronavirus infections and has trypsin-like catalytic activity...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38808542/muc5ac-a-potential-biomarker-of-severity-in-pediatric-patients-infected-with-influenza
#42
JOURNAL ARTICLE
Eduardo L López, Fausto Martín Ferolla, Santiago N Meza, Normando Mascardi, Pablo Neira, Agustina Chiormi, Mariana Reyero, Alejandra Retta, María M Contrini, Patricio L Acosta
Numerous factors can increase the risk of severe influenza; however, a majority of severe cases occur in previously healthy children. Identification of high-risk children is important for targeted preventive interventions and prompt treatment. The aim of this study was to evaluate MUC5AC as a biomarker for influenza disease severity in children. For this, a prospective cohort study was conducted in 2019. Children hospitalized with acute respiratory infection (ARI) with confirmed positive influenza infection were enrolled...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38804187/a-prospective-humoral-immune-monitoring-study-of-kidney-transplant-recipients-receiving-three-doses-of-sars-cov-2-mrna-vaccine
#43
JOURNAL ARTICLE
Cinzia Borgogna, Daniela Ferrante, Greta Rosso, Gabriele Guglielmetti, Irene Lo Cigno, Stefano Raviola, Valeria Caneparo, Marco Quaglia, Vincenzo Cantaluppi, Marisa Gariglio
Kidney transplant recipients (KTRs), like other solid organ transplant recipients display a suboptimal response to mRNA vaccines, with only about half achieving seroconversion after two doses. However, the effectiveness of a booster dose, particularly in generating neutralizing antibodies (NAbs), remains poorly understood, as most studies have mainly focused on non-neutralizing antibodies. Here, we have longitudinally assessed the humoral response to the SARS-CoV-2 mRNA vaccine in 40 KTRs over a year, examining changes in both anti-spike IgG and NAbs following a booster dose administered about 5 months post-second dose...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38804180/varicella-zoster-virus-induced-autophagy-in-human-neuronal-and-hematopoietic-cells-exerts-antiviral-activity
#44
JOURNAL ARTICLE
Johanna L Heinz, Daniëla M Hinke, Muyesier Maimaitili, Jiayi Wang, Ira K D Sabli, Michelle Thomsen, Ensieh Farahani, Fanghui Ren, Lili Hu, Thomas Zillinger, Anna Grahn, Joanna von Hofsten, Georges M G M Verjans, Søren R Paludan, Abel Viejo-Borbolla, Vanessa Sancho-Shimizu, Trine H Mogensen
Autophagy is a degradational pathway with pivotal roles in cellular homeostasis and survival, including protection of neurons in the central nervous system (CNS). The significance of autophagy as antiviral defense mechanism is recognized and some viruses hijack and modulate this process to their advantage in certain cell types. Here, we present data demonstrating that the human neurotropic herpesvirus varicella zoster virus (VZV) induces autophagy in human SH-SY5Y neuronal cells, in which the pathway exerts antiviral activity...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38804179/persistence-of-sars-cov-2-infection-and-viral-intra-and-inter-host-evolution-in-covid-19-hospitalized-patients
#45
JOURNAL ARTICLE
Grazia Pavia, Angela Quirino, Nadia Marascio, Claudia Veneziano, Federico Longhini, Andrea Bruni, Eugenio Garofalo, Marta Pantanella, Michele Manno, Simona Gigliotti, Aida Giancotti, Giorgio Settimo Barreca, Francesco Branda, Carlo Torti, Salvatore Rotundo, Rosaria Lionello, Valentina La Gamba, Lavinia Berardelli, Sara Palma Gullì, Enrico Maria Trecarichi, Alessandro Russo, Camillo Palmieri, Carmela De Marco, Giuseppe Viglietto, Marco Casu, Daria Sanna, Massimo Ciccozzi, Fabio Scarpa, Giovanni Matera
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) persistence in COVID-19 patients could play a key role in the emergence of variants of concern. The rapid intra-host evolution of SARS-CoV-2 may result in an increased transmissibility, immune and therapeutic escape which could be a direct consequence of COVID-19 epidemic currents. In this context, a longitudinal retrospective study on eight consecutive COVID-19 patients with persistent SARS-CoV-2 infection, from January 2022 to March 2023, was conducted...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38804172/development-of-a-single-domain-antibody-to-target-a-g-quadruplex-located-on-the-hepatitis-b-virus-covalently-closed-circular-dna-genome
#46
JOURNAL ARTICLE
Gerardo B Figueroa, Simmone D'souza, Higor S Pereira, Gunjan Vasudeva, Sara B Figueroa, Zachary E Robinson, Maulik D Badmalia, Vanessa Meier-Stephenson, Jennifer A Corcoran, Guido van Marle, Yi Ni, Stephan Urban, Carla S Coffin, Trushar R Patel
To achieve a virological cure for hepatitis B virus (HBV), innovative strategies are required to target the covalently closed circular DNA (cccDNA) genome. Guanine-quadruplexes (G4s) are a secondary structure that can be adopted by DNA and play a significant role in regulating viral replication, transcription, and translation. Antibody-based probes and small molecules have been developed to study the role of G4s in the context of the human genome, but none have been specifically made to target G4s in viral infection...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38783823/global-and-regional-burden-of-vaccine-associated-facial-paralysis-1967-2023-findings-from-the-who-international-pharmacovigilance-database
#47
JOURNAL ARTICLE
Yi Deun Jeong, Kyeongmin Lee, Sooji Lee, Jaeyu Park, Hyeon Jin Kim, Jinseok Lee, Jiseung Kang, Louis Jacob, Lee Smith, Masoud Rahmati, Guillermo F López Sánchez, Elena Dragioti, Yejun Son, Soeun Kim, Seung Geun Yeo, Hayeon Lee, Dong Keon Yon
The scarce and conflicting data on vaccine-associated facial paralysis limit our understanding of vaccine safety on a global scale. Therefore, this study aims to evaluate the global burden of vaccine-associated facial paralysis and to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health Organization International Pharmacovigilance Database...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38783821/influenza-a-virus-infection-disrupts-the-function-of-syncytiotrophoblast-cells-and-contributes-to-adverse-pregnancy-outcomes
#48
JOURNAL ARTICLE
Jiao Wang, Wenyu Liu, Yichao Zhuang, Jiaxin Yang, Yetian Zhao, Aihui Hong, Jingjing Du, Huihui Kong, Jingfei Wang, Yongping Jiang, Yan Wang
Pregnancy heightens susceptibility to influenza A virus (IAV) infection, thereby increasing the risk of severe pneumonia and maternal mortality. It also raises the chances of adverse outcomes in offspring, such as fetal growth restriction, preterm birth, miscarriage, and stillbirth in offsprings. However, the underlying mechanisms behind these effects remain largely unknown. Syncytiotrophoblast cells, crucial in forming the placental barrier, nutrient exchange and hormone secretion, have not been extensively studied for their responses to IAV...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38783790/high-risk-hpv-oncoproteins-e6-and-e7-and-their-interplay-with-the-innate-immune-response-uncovering-mechanisms-of-immune-evasion-and-therapeutic-prospects
#49
REVIEW
Irene Lo Cigno, Federica Calati, Carlo Girone, Marta Catozzo, Marisa Gariglio
Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses causally associated with 5% of human cancers, comprising both anogenital and upper aerodigestive tract carcinomas. Despite the availability of prophylactic vaccines, HPVs continue to pose a significant global health challenge, primarily due to inadequate vaccine access and coverage. These viruses can establish persistent infections by evading both the intrinsic defenses of infected tissues and the extrinsic defenses provided by professional innate immune cells...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38783788/multifunctional-orf3-protein-of-hepatitis-e-virus
#50
REVIEW
Xiaoxuan Li, Xuwen Sun, Ji Pinpin, Qin Zhao, Yani Sun
Hepatitis E virus (HEV) is an emerging zoonotic pathogen that is transmitted primarily through the fecal-oral route and can cause acute hepatitis in humans. Since HEV was identified as a zoonotic pathogen, different species of HEV strains have been globally identified from various hosts, leading to an expanding range of hosts. The HEV genome consists of a 5' noncoding region, three open reading frames (ORFs), and a 3' noncoding region. The ORF3 protein is the smallest but has many functions in HEV release and pathogenesis...
June 2024: Journal of Medical Virology
https://read.qxmd.com/read/38773828/unveiling-the-role-of-kshv-infected-human-mesenchymal-stem-cells-in-kaposi-s-sarcoma-initiation
#51
JOURNAL ARTICLE
Ezequiel Lacunza, Anuj Ahuja, Omar A Coso, Martin Abba, Juan Carlos Ramos, Ethel Cesarman, Enrique A Mesri, Julian Naipauer
Kaposi's sarcoma (KS) may derive from Kaposi's sarcoma herpesvirus (KSHV)-infected human mesenchymal stem cells (hMSCs) that migrate to sites characterized by inflammation and angiogenesis, promoting the initiation of KS. By analyzing the RNA sequences of KSHV-infected primary hMSCs, we have identified specific cell subpopulations, mechanisms, and conditions involved in the initial stages of KSHV-induced transformation and reprogramming of hMSCs into KS progenitor cells. Under proangiogenic environmental conditions, KSHV can reprogram hMSCs to exhibit gene expression profiles more similar to KS tumors, activating cell cycle progression, cytokine signaling pathways, endothelial differentiation, and upregulating KSHV oncogenes indicating the involvement of KSHV infection in inducing the mesenchymal-to-endothelial (MEndT) transition of hMSCs...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38773825/exploring-free-amino-acid-profiles-in-crimean-congo-hemorrhagic-fever-patients-implications-for-disease-progression
#52
JOURNAL ARTICLE
Seyit Ali Büyüktuna, Serra İlayda Yerlitaş, Gözde Ertük Zararsız, Kübra Doğan, Demet Kablan, Gökhan Bağcı, Selda Özer, Cihad Baysal, Yasemin Çakır, Ahu Cephe, Necla Koçhan, Gökmen Zararız, Halef Okan Doğan
This study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus infection and alterations in amino acid metabolism. The primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38773815/rotavirus-trends-and-distribution-of-genotypes-before-and-during-covid-19-pandemic-era-bangladesh-2017-2021
#53
JOURNAL ARTICLE
Warda Haque, Muhammad Talha, Sezanur Rahman, Mehedi Hasan, Shaheen Alam, Zahid Hassan, Sayra Moni, Sadia H Khan, Mohammad E Hossain, Abu S G Faruque, S M Tafsir Hasan, Soroar H Khan, Tahmeed Ahmed, Khalequz Zaman, Mustafizur Rahman
Rotavirus gastroenteritis is accountable for an estimated 128 500 deaths among children younger than 5 years worldwide, and the majority occur in low-income countries. Although the clinical trials of rotavirus vaccines in Bangladesh revealed a significant reduction of severe rotavirus disease by around 50%, the vaccines are not yet included in the routine immunization program. The present study was designed to provide data on rotavirus diarrhea with clinical profiles and genotypes before (2017-2019) and during the COVID-19 pandemic period (2020-2021)...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38773810/predictive-role-of-early-treatment-dynamics-of-hbv-rna-and-hbcrag-for-hbeag-seroconversion-in-children-with-chronic-hepatitis-b
#54
JOURNAL ARTICLE
Xin Lai, Wenxian OuYang, Shuangjie Li, Jun Qiu, Hui Zhang, Tao Jiang, Xiaomei Qin, Lian Tang, Yingping Gu, Zhenzhen Yao, Songxu Peng
This study aimed to assess the predictive capacity of emerging serological markers, serum HBV RNA and HBcrAg, for HBeAg seroconversion in children with HBeAg-positive chronic hepatitis B (CHB). Treatment-naïve HBeAg-positive CHB children who admitted to the Liver Disease Center of Hunan Children's Hospital between April 2021 and September 2022 and received treatment with the combined entecavir and interferon-alpha treatment were recruited. Serum HBV RNA and HBcrAg were measured at baseline and Weeks 12, 24, and 48 of treatment...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38773784/discovery-and-mechanistic-study-of-imperatorin-that-inhibits-hbsag-expression-and-cccdna-transcription
#55
JOURNAL ARTICLE
Fang Ren, Shiqiao Zhao, Xin He, Hanghong Lo, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Anguo Wu, Juan Zhang
Chronic hepatitis B virus (HBV) infection remains a significant global health challenge due to its link to severe conditions like HBV-related cirrhosis and hepatocellular carcinoma (HCC). Although current treatments effectively reduce viral levels, they have limited impact on certain HBV elements, namely hepatitis B surface antigen (HBsAg) and covalently closed circular DNA (cccDNA). This highlights the urgent need for innovative pharmaceutical and biological interventions that can disrupt HBsAg production originating from cccDNA...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38767190/ten-different-viral-agents-infecting-and-co-infecting-children-with-acute-gastroenteritis-in-southern-italy-role-of-known-pathogens-and-emerging-viruses-during-and-after-covid-19-pandemic
#56
JOURNAL ARTICLE
Maria Grazia Amoroso, Alessia Pucciarelli, Francesco Serra, Giovanni Ianiro, Michele Iafusco, Filomena Fiorito, Maria Grazia Polverino, Maria Dimatteo, Marina Monini, Daniela Ferrara, Luigi Martemucci, Ilaria Di Bartolo, Esterina De Carlo, Giovanna Fusco
Acute gastroenteritis (AGE) represents a world public health relevant problem especially in children. Enteric viruses are the pathogens mainly involved in the episodes of AGE, causing about 70.00% of the cases. Apart from well-known rotavirus (RVA), adenovirus (AdV) and norovirus (NoV), there are various emerging viral pathogens potentially associated with AGE episodes. In this study, the presence of ten different enteric viruses was investigated in 152 fecal samples collected from children hospitalized for gastroenteritis...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38767184/elevated-pretreatment-serum-apolipoprotein-e-level-associated-with-poor-prognosis-of-patients-with-covid-19-during-the-omicron-ba-5-and-bf-7-wave
#57
JOURNAL ARTICLE
Shengping Gong, Chao Ma, Ruishuang Ma, Ting Zhu, Xiaoqin Ge, Rongrong Xie, Qingsong Tao, Guifang Ouyang, Cong Shi
The SARS-CoV-2 virus is responsible for the human disease known as COVID-19. This virus is capable of generating a spectrum of infections ranging from moderate to severe. Serum apolipoprotein E (ApoE) inhibits inflammation by preserving immune regulatory function. Nonetheless, the relationship between serum ApoE and clinical prognosis in omicron remains elusive. A cohort of 231 patients was observed for 65 days, with death as the primary outcome. Based on their ApoE levels, the patients were categorized into patients with elevated ApoE levels and those with lower ApoE levels...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38767144/nanomedicine-mediated-recovery-of-antioxidant-glutathione-peroxidase-activity-after-oxidative-stress-cellular-damage-insights-for-neurological-long-covid
#58
JOURNAL ARTICLE
Thelma Akanchise, Borislav Angelov, Angelina Angelova
Nanomedicine for treating post-viral infectious disease syndrome is at an emerging stage. Despite promising results from preclinical studies on conventional antioxidants, their clinical translation as a therapy for treating post-COVID conditions remains challenging. The limitations are due to their low bioavailability, instability, limited transport to the target tissues, and short half-life, requiring frequent and high doses. Activating the immune system during coronavirus (SARS-CoV-2) infection can lead to increased production of reactive oxygen species (ROS), depleted antioxidant reserve, and finally, oxidative stress and neuroinflammation...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38767142/comparison-of-diagnostic-performance-among-abbott-realtime-hcv-genotyping-ii-abbott-hcv-genotype-plus-ruo-and-roche-cobas-hcv-genotyping-assays-for-hepatitis-c-virus-genotyping
#59
COMPARATIVE STUDY
Yu-Ping Chang, Chiuan-Bo Huang, Tung-Hung Su, Chun-Jen Liu, Tai-Chung Tseng, Shang-Chin Huang, Pei-Jer Chen, Jia-Horng Kao, Chen-Hua Liu
Comparison of diagnostic accuracy for commercial hepatitis C virus (HCV) genotyping (Abbott RealTime HCV Genotyping II, Roche Cobas Genotyping) and investigational Abbott HCV Genotype plus RUO assays designed to discriminate genotype (GT)-1a, 1b or 6 in cases of ambiguous GT from the Abbott commercial assay remains limited. 743 HCV-viremic samples were subjected to analysis using Abbott and Roche commercial as well as Abbott HCV Genotype plus RUO assays. Next-generation sequencing (NGS) targeting core region was employed as the reference standard...
May 2024: Journal of Medical Virology
https://read.qxmd.com/read/38757870/risks-of-alopecia-areata-in-long-covid-binational-population-based-cohort-studies-from-south-korea-and-japan
#60
JOURNAL ARTICLE
Seoyeon Kyung, Yejun Son, Minji Kim, Jiseung Kang, Lee Smith, Hayeon Lee, Dong Keon Yon
Previous studies have proposed alopecia areata (AA) as a potential outcome of COVID-19 infection among autoimmune diseases, yet the findings might be inconclusive and difficult to generalize due to limited sample sizes and evidence levels. Thus, we aimed to investigate in detail the long-term risk of AA following SARS-CoV-2 infection based on large, binational, general population-based cohort studies. Our study investigated the long-term AA risk after SARS-CoV-2 infection by analyzing bi-national, claim-based cohorts in South Korea and Japan: a Korean nationwide cohort (K-COV-N cohort; discovery cohort; total n = 10 027 506) and a Japanese claims-based cohort (JMDC cohort; validation cohort; total n = 12 218 680)...
May 2024: Journal of Medical Virology
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