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Journal of Analytical Toxicology

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https://read.qxmd.com/read/31384953/false-positive-amphetamines-and-3-4-methylenedioxymethamphetamine-immunoassays-in-the-presence-of-metoprolol-two-cases-reported-in-clinical-toxicology
#1
Marion Leclercq, Marion Soichot, Brigitte Delhotal-Landes, Emmanuel Bourgogne, Hervé Gourlain, Bruno Mégarbane, Laurence Labat
Amphetamines, frequently used recreational drugs with high risk of toxicity, are commonly included in urine drug screens. This screening is based on enzyme immunoassay, which is a quick and easy-to-perform technique, but may lack specificity resulting from cross-reactivity with other compounds, causing false positive results. We present two cases of presumed false positive MULTIGENT® amphetamine/methamphetamine and MULTIGENT® ecstasy (Abbott®) immunoassays with the beta-blocker metoprolol. Both metoprolol-poisoned patients presented positive urine screening despite no history of drug abuse...
August 2, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31355881/novel-high-throughput-quantitation-of-potent-herg-blocker-dofetilide-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry-application-in-a-phase-1-ecg-biomarker-validation-study
#2
Murali K Matta, Suresh Narayanasamy, Jose Vicente, Robbert Zusterzeel, Vikram Patel, David G Strauss
The authors developed a novel, sensitive high-throughput ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of dofetilide in human plasma. To compensate for the matrix effect, a deuterated internal standard was used. The method employed a very low sample volume (50 μL) of plasma for sample processing by using simple protein precipitation extraction in a 96-well plate. The extracted samples were chromatographed on an Acquity BEH C18 column (2.1 × 100 mm, 1.7 μm) and eluted in a gradient manner at a flow rate of 0...
July 29, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31355869/estimating-uncertainty-in-wisconsin-s-evidential-breath-alcohol-measurements
#3
Diane Brockley-Drinkman, Heather M Barkholtz
Breath alcohol measurement accuracy and precision quantification is a critical component of impaired driving prosecution and is required for laboratory accreditation. The Chemical Testing Section of Wisconsin's Department of Transportation conducted a bottom-up study to quantify uncertainty of breath alcohol measurements conducted on Intoximeter's EC/IR II instrument. After an exercise in combined uncertainty source identification, individual input values were either reported from National Institute of Standards and Technology traceable reference materials or quantified using instrument data from 2014 to 2018...
July 29, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31355413/use-of-uplc-hrms-ms-for-in-vitro-and-in-vivo-metabolite-identification-of-three-methylphenidate-derived-new-psychoactive-substances
#4
Sascha K Manier, Sophia Niedermeier, Jan Schäper, Markus R Meyer
The distribution of so-called new psychoactive substances (NPS) as substitute for common drug of abuse was steadily increasing in the last years, but knowledge about their toxicodynamic and toxicokinetic properties is lacking. However, a comprehensive knowledge of their toxicokinetics, particularly their metabolism, is crucial for developing reliable screening procedures and to verify their intake, e.g., in case of intoxications. The aim of this study was therefore to tentatively identify the metabolites of the methylphenidate-derived NPS isopropylphenidate (isopropyl 2-phenyl-2-(2-piperidyl) acetate, IPH), 4-fluoromethylphenidate (methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl) acetate, 4-FMPH) and 3,4-dichloromethylphenidate (methyl 2-(3,4-dichlorophenyl)-2-(piperidin-2-yl) acetate, 3,4-CTMP) using different in vivo and in vitro techniques and ultra-high performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS/MS)...
July 26, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31322674/monitoring-urinary-testosterone-and-epitestosterone-levels-and-their-ratio-in-korean-chemical-castration-subjects-using-liquid-chromatography-tandem-mass-spectrometry
#5
Juhyun Sim, Byungsuk Cho, Meejung Park, Jongsook Rhee, Sangwhan In, Sanggil Choe
In Europe, chemical castration has been adopted as a treatment for paraphilia since the 1930s. Among the various chemical castration agents, luteinizing hormone-releasing hormone (LHRH) agonists are now used widely because of their effectiveness and safety. In South Korea, a legislation of chemical castration to control the sexual impulses of sexual offenders was enforced in July 2011. Most of these subjects are treated with leuprorelin acetate, an LHRH agonist, for chemical castration. Despite this, there are few studies that address the long-term influence of LHRH agonists on testosterone (T) and epitestosterone (E) levels in chemical castration subjects...
July 19, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31287544/proposed-bont-a-and-b-peptide-substrates-cannot-detect-multiple-subtypes-in-the-endopep-ms-assay
#6
Suzanne R Kalb, Jakub Baudys, Kaitlyn Kiernan, Dongxia Wang, François Becher, John R Barr
Botulinum neurotoxins (BoNTs) are a family of protein toxins consisting of seven known serotypes (BoNT/A-BoNT/G) and multiple subtypes within the serotypes, and all of which cause the disease botulism-a disease of great public health concern. Accurate detection of BoNTs in human clinical samples is therefore an important public health goal. To achieve this goal, our laboratory developed a mass spectrometry-based assay detecting the presence of BoNT via its enzymatic activity on a peptide substrate. Recently, publications reported the use of new peptide substrates to detect BoNT/A and /B with improved results over other peptide substrates...
July 9, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31274144/identification-and-quantification-of-5-fluoro-adb-and-the-5-fluoro-adb-ester-hydrolysis-metabolite-in-postmortem-blood-samples-by-lc-ms-ms
#7
Joshua Z Seither, Lisa J Reidy, Diane M Boland
5-Fluoro ADB, also known as 5-fluoro MDMB-PINACA, is a potent synthetic cannabinoid that is an agonist to the human cannabinoid CB1 and CB2 receptors. Adverse physiological and psychological effects that have resulted in hospitalization and/or death have been associated with 5-Fluoro ADB use. In addition, analytical confirmation of 5-Fluoro ADB use has been reported in both forensic human performance toxicology and postmortem cases. An analytical method for the identification and quantification of 5-fluoro ADB and the 5-fluoro ADB ester hydrolysis metabolite in human blood samples by liquid chromatography-tandem mass spectrometry was created and validated...
July 4, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31263897/oral-fluid-drug-testing-analytical-approaches-issues-and-interpretation-of-results
#8
Nathalie A Desrosiers, Marilyn A Huestis
With advances in analytical technology and new research informing result interpretation, oral fluid (OF) testing has gained acceptance over the past decades as an alternative biological matrix for detecting drugs in forensic and clinical settings. OF testing offers simple, rapid, non-invasive, observed specimen collection. This article offers a review of the scientific literature covering analytical methods and interpretation published over the past two decades for amphetamines, cannabis, cocaine, opioids, and benzodiazepines...
June 28, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31241748/corrigendum-to-highresnps-com-an-online-crowd-sourced-hr-ms-database-for-suspect-and-non-targeted-screening-of-new-psychoactive-substances
#9
Marie Mardal, Mette Findal Andreasen, Christian Brinch Mollerup, Peter Stockham, Rasmus Telving, Nikolaos S Thomaidis, Konstantina S Diamanti, Kristian Linnet, Petur Weihe Dalsgaard
No abstract text is available yet for this article.
June 26, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31263904/testing-for-betel-nut-alkaloids-in-hair-of-papuans-abusers-using-uplc-ms-ms-and-uplc-q-tof-ms
#10
Laurie Gheddar, François-Xavier Ricaut, Alice Ameline, Nicolas Brucato, Roxanne Tsang, Matthew Leavesley, Jean-Sébastien Raul, Pascal Kintz
Betel nut is the fruit of Areca palm, growing in Papua New Guinea. Mixed with limestone and stick mustard, arecoline and guvacoline, which are present in betel nut, are hydrolyzed into arecaidine and guvacine, respectively. As part of the study on dietary habits of Papuans residents, our laboratory was asked to analyze the four alkaloids in hair to document long-term exposure. Hair samples were collected from 19 adult subjects (males = 11; females = 8), by some of the authors, and were sent to the laboratory for analysis...
June 19, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31263895/characterization-of-an-amphetamine-interference-from-gabapentin-in-an-lc-hrms-method
#11
Ana Celia Muñoz-Muñoz, Teresa Pekol, Dana Schubring, Robin Hyland, Charlene Johnson, Lawrence Andrade
An amphetamine interference was observed during the development of an liquid chromatography-high-resolution mass spectrometry (LC-HRMS) multi-class confirmation method for the determination of 47 drugs and metabolites in urine. The interference passed all qualitative criteria for amphetamine leading to potential false-positive results. Upon investigation, it was found that the amphetamine interference was correlated with the presence of high levels of gabapentin. Gabapentin is routinely detected in patient urine specimens at levels in excess of 1 mg/mL as it is widely prescribed at high doses and does not undergo significant metabolism...
June 19, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31141151/a-tool-for-automatic-correction-of-endogenous-concentrations-application-to-bhb-analysis-by-lc-ms-ms-and-gc-ms
#12
Brigitte Desharnais, Marie-Jo Lajoie, Julie Laquerre, Stéphanie Savard, Pascal Mireault, Cameron D Skinner
Several substances relevant for forensic toxicology purposes have an endogenous presence in biological matrices: beta-hydroxybutyric acid (BHB), gamma-hydroxybutyric acid (GHB), steroids and human insulin, to name only a few. The presence of significant amounts of these endogenous substances in the biological matrix used to prepare calibration standards and quality control samples (QCs) can compromise validation steps and quantitative analyses. Several approaches to overcome this problem have been suggested, including using an analog matrix or analyte, relying entirely on standard addition analyses for these analytes, or simply ignoring the endogenous contribution provided that it is small enough...
May 29, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31141150/a-novel-liquid-chromatography-tandem-mass-spectrometry-technique-using-multi-period-multi-experiment-of-mrm-epi-mrm3-with-library-matching-for-simultaneous-determination-of-amphetamine-type-stimulants-related-drugs-in-whole-blood-urine-and-dried-blood-stain
#13
Fathiah A Zubaidi, Yeun-Mun Choo, Guan-Huat Tan, Hamimah Abd Hamid, Yap Ken Choy
A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. The ATS-related drugs analyzed in this study include ephedrine, pseudoephedrine, amphetamine, methamphetamine, MDMA (3,4-Methylenedioxymethamphetamine), MDA (3,4-Methylenedioxyamphetamine), MDEA (3,4-Methylenedioxy-N-ethylamphetamine) and phentermine...
May 29, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/30951168/quantitation-of-cannabinoids-in-breath-samples-using-a-novel-derivatization-lc-ms-ms-assay-with-ultra-high-sensitivity
#14
Yiqi Ruben Luo, Cassandra Yun, Kara L Lynch
As the legalization of medical and recreational marijuana use expands, measurement of tetrahydrocannabinol (THC) in human breath has become an area of interest. The presence and concentration of cannabinoids in breath have been shown to correlate with recent marijuana use and may be correlated with impairment. Given the low concentration of THC in human breath, sensitive analytical methods are required to further evaluate its utility and window of detection. This paper describes a novel derivatization method based on an azo coupling reaction that significantly increases the ionization efficiency of cannabinoids for LC-MS/MS analysis...
June 1, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095712/simultaneous-determination-of-cocaine-and-metabolites-in-human-plasma-using-solid-phase-micro-extraction-fiber-tips-c18-and-uplc-ms-ms
#15
Lilian de Lima Feltraco Lizot, Anne Caroline Cezimbra da Silva, Marcos Frank Bastiani, Tales Fernando Maurer, Roberta Zilles Hahn, Magda Susana Perassolo, Marina Venzon Antunes, Rafael Linden
The determination of cocaine (COC) and its metabolites ecgonine methyl ester (EME), benzoylecgonine (BZE), norcocaine (NCOC) and cocaethylene (CE) in human plasma is relevant in clinical and forensic toxicology. An efficient extraction and clean-up of plasma specimens for the simultaneous determination of BZE along with COC and basic metabolites is challenging due to their widely different polarities and ionization characteristics. Recently, biocompatible SPME LC tips C18 became commercially available. We applied SPME LC tips C18 to the simultaneous extraction of COC, BZE, EME, NCOC, and CE by direct immersion of the fiber in plasma diluted with a buffer at pH 8...
May 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095711/pregabalin-and-its-involvement-in-coronial-cases
#16
Amanda Thompson, Sarah Morey, Andrew Griffiths
Pregabalin is an anticonvulsant and analgesic designed to treat neuropathic pain and partial seizure disorders and has been available in Australia as a prescription medication since 2005. Studies have found high rates of polydrug use associated with pregabalin and it is reportedly used recreationally for its euphoric and relaxing effects as well as to self-manage opioid withdrawal symptoms. A robust analytical method for the analysis of pregabalin using protein precipitation and LC/MS/MS was developed, validated and employed in routine case work...
May 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095710/acute-psychiatric-disorders-related-to-fake-cathinone-ephylone
#17
Anais Serre, Olivier Vuillot, Céline Eiden, Julien Gambier, Aude Berger, Olivier Mathieu, Thomas Nefau, Mustapha Sebbane, Hélène Donnadieu-Rigole, Hélène Peyrière
No abstract text is available yet for this article.
May 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095707/comparison-of-the-detection-windows-of-heroin-metabolites-in-human-urine-using-online-spe-and-lc-ms-ms-importance-of-morphine-3-glucuronide
#18
Luying Wang, Chunfang Ni, Hongliang Shen, Zhenhai Sheng, Chen Liang, Rong Wang, Yurong Zhang
Heroin abuse is a serious problem that endangers human health and affects social stability. Though often being used as confirmation of heroin use, 6-monoacetylmorphine (6-MAM) has limitations due to its short detection window. To compare the detection windows of heroin metabolites (morphine (MOR), 6-MAM, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G)) in human urine, an automated online solid phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and fully validated...
May 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095699/determination-of-quinolone-antibiotic-residues-in-human-serum-and-urine-using-high-performance-liquid-chromatography-tandem-mass-spectrometry
#19
Xiaoli Wang, Tao Guo, Yunbo Wei, Guiju Xu, Na Li, Jinhong Feng, Rusong Zhao
Quinolone antibiotic residues may pose potential threat to human health. A rapid and sensitive method was developed for the determination of quinolone residues in human serum and urine. After solid phase extraction (SPE) process, eight quinolone residues were analyzed by high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) using ciprofloxacin-d8 as the internal standard. The relative standard deviation of intra-day and inter-day precision for the eight quinolones were less than 7.52% and the accuracies ranged from 95...
May 16, 2019: Journal of Analytical Toxicology
https://read.qxmd.com/read/31095696/highresnps-com-an-online-crowd-sourced-hr-ms-database-for-suspect-and-non-targeted-screening-of-new-psychoactive-substances
#20
Marie Mardal, Mette Findal Andreasen, Christian Brinch Mollerup, Peter Stockham, Rasmus Telving, Nikolaos S Thomaidis, Konstantina S Diamanti, Kristian Linnet, Petur Weihe Dalsgaard
The number of new psychoactive substances (NPS) is constantly increasing. However, although the number might be large, most NPS have a low prevalence of use, so keeping screening libraries updated with the relevant analytical targets becomes a challenge. One way to ensure sufficient screening coverage is to use shared high resolution-mass spectrometry (HR-MS) databases, such as HighResNPS.com: a free, online, spreadsheet-format, crowd-sourced HR-MS database for NPS screening. The aims of this study were (i) to present the database to the scientific community and (ii) to verify that the HighResNPS database can be utilized in suspect screening workflows for LC-HR-MS instruments and software from four different instrument vendors...
May 16, 2019: Journal of Analytical Toxicology
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