journal
Journals Investigative Ophthalmology & ...

Investigative Ophthalmology & Visual Science

https://read.qxmd.com/read/38874964/sex-specific-differences-in-the-relationship-between-prematurity-and-ocular-geometry
#1
JOURNAL ARTICLE
Achim Fieß, Alica Hartmann, Eva Mildenberger, Michael S Urschitz, Panagiotis Laspas, Anna Schultheis, Bernhard Stoffelns, Norbert Pfeiffer, Sandra Gißler, Alexander K Schuster
PURPOSE: To explore differences in the relationship between gestational age (GA) and birth weight (BW) percentile and ocular geometry between males and females. METHODS: The Gutenberg Prematurity Eye Study involved a prospective ophthalmic examination of adults, aged 18 to 52 years, who were born preterm or at term, in Germany. The associations between GA and BW percentile on the main outcome measures were evaluated by uni- and multivariable linear regression analyses...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38874963/cardiovascular-autonomic-function-and-progression-of-age-related-macular-degeneration-in-the-irish-longitudinal-study-of-ageing-tilda
#2
JOURNAL ARTICLE
Emma Connolly, Silvin P Knight, Eoin Duggan, Siobhan Scarlett, Louise Newman, Mark Cahill, Rose Anne Kenny, Sarah L Doyle, Roman Romero-Ortuno
PURPOSE: To examine if changes in hemodynamic measures during an orthostatic challenge were associated with progression of age-related macular degeneration (AMD) over a 4-year period in The Irish Longitudinal Study on Ageing. METHODS: Participants with AMD who underwent an active stand (AS) test at wave 1 (2009/2010) and retinal photographs at both wave 1 and wave 3 (2014/2015) were included (N = 159: 121 with no AMD progression and 38 with progression). Beat-to-beat hemodynamic data were non-invasively collected using a Finometer MIDI device during the AS at wave 1, recording systolic blood pressure (sBP), diastolic blood pressure (dBP), mean arterial pressure (MAP), and heart rate...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38869368/identification-of-keratoconus-related-phenotypes-in-three-ppip5k2-mouse-models
#3
JOURNAL ARTICLE
Theresa Akoto, Rachel Hadvina, Skyler Jones, Jingwen Cai, Hongfang Yu, Hayden McCord, Charles X J Jin, Amy J Estes, Lin Gan, Anthony Kuo, Sylvia B Smith, Yutao Liu
PURPOSE: It is necessary to establish a mouse model of keratoconus (KC) for research and therapy. We aimed to determine corneal phenotypes in 3 Ppip5k2 mouse models. METHODS: Central corneal thickness (CCT) was determined using spectral domain optical coherence tomography (SD-OCT) in Ppip5k2+/K^ (n = 41 eyes), Ppip5k2K^/K^ (n = 17 eyes) and 2 knock-in mice, Ppip5k2S419A/+ (n = 54 eyes) and Ppip5k2S419A/S419A (n = 18 eyes), and Ppip5k2D843S/+ (n = 42 eyes) and Ppip5k2D843S/D843S (n = 44 eyes) at 3 and 6 months...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38864813/use-of-sodium-glucose-co-transporter-2-inhibitors-in-patients-with-type-2-diabetes-and-the-incidence-of-retinal-vein-occlusion-in-taiwan
#4
JOURNAL ARTICLE
Hou-Ren Tsai, Yu-Jie Lin, Jih-I Yeh, Shu-Man Lin, Peter Pin-Sung Liu, Yung-Ching Chang, Yuan-Chieh Lee, Ching-Hui Loh, Huei-Kai Huang
PURPOSE: The purpose of this study was to evaluate the risk of newly diagnosed retinal vein occlusion (RVO) in patients with type 2 diabetes (T2D) using sodium-glucose cotransporter-2 inhibitors (SGLT-2i) compared to dipeptidyl peptidase-4 inhibitors (DPP-4i). METHODS: Claims data from the National Health Insurance Research Database of Taiwan were used in this nationwide retrospective cohort study. A target trial emulation framework was applied. Patients with T2D with no prior diagnosis of RVO who had newly commenced treatment with SGLT-2i or DPP-4i between May 1, 2016, and December 31, 2020, were included...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38864812/a-novel-murine-model-for-lupus-like-ocular-chronic-graft-versus-host-disease
#5
JOURNAL ARTICLE
Yan Sun, Yue Zhang, Jiani Shen, Fan Shi, Ye Li, Congyao Wang, Xia Dong, Tingting Chen, Fenfen Yu, Yi Zhou, Pengxia Wan
PURPOSE: Lupus-like chronic graft-versus-host disease (cGVHD) has been previously described, but the ocular findings have not been elucidated. Recipient mice in a lupus-like cGVHD model manifested notable and persistent ocular surface phenotypes. Herein, we further explored immunopathogenic mechanisms underlying these ocular phenotypes. METHODS: A previously described lupus-like cGVHD model was established by intraperitoneal injection of splenocytes from bm12 mice into C57BL/6J mice...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38864811/a-clinician-s-guide-to-sharing-data-for-ai-in-ophthalmology
#6
REVIEW
Nayoon Gim, Yue Wu, Marian Blazes, Cecilia S Lee, Ruikang K Wang, Aaron Y Lee
Data is the cornerstone of using AI models, because their performance directly depends on the diversity, quantity, and quality of the data used for training. Using AI presents unique potential, particularly in medical applications that involve rich data such as ophthalmology, encompassing a variety of imaging methods, medical records, and eye-tracking data. However, sharing medical data comes with challenges because of regulatory issues and privacy concerns. This review explores traditional and nontraditional data sharing methods in medicine, focusing on previous works in ophthalmology...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38861275/igf2bp2-maintains-retinal-pigment-epithelium-homeostasis-by-stabilizing-pax6-and-otx2
#7
JOURNAL ARTICLE
Siqi Wu, Fuxi Li, Kunlun Mo, Huaxing Huang, Yankun Yu, Ying Huang, Jiafeng Liu, Mingsen Li, Jieying Tan, Zesong Lin, Zhuo Han, Li Wang, Hong Ouyang
PURPOSE: N6-methyladenosine (m6A) methylation is a chemical modification that occurs on RNA molecules, where the hydrogen atom of adenine (A) nucleotides is replaced by a methyl group, forming N6-methyladenosine. This modification is a dynamic and reversible process that plays a crucial role in regulating various biological processes, including RNA stability, transport, translation, and degradation. Currently, there is a lack of research on the role of m6A modifications in maintaining the characteristics of RPE cells...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38861274/aqueous-vegf-a-levels-as-a-liquid-biopsy-biomarker-of-retinoblastoma-vitreous-seed-response-to-therapy
#8
JOURNAL ARTICLE
Anthony B Daniels, Kamakshi L Sishtla, Carley M Bogan, Janene M Pierce, Sheau-Chiann Chen, Liya Xu, Jesse L Berry, Timothy W Corson
PURPOSE: Regression of retinoblastoma vitreous seeds (VS) during intravitreal chemotherapy can be delayed, resulting in supernumerary injections. Similarly, VS relapse may not be clinically evident at first. A predictive biomarker of tumor regression and relapse could help guide real-time clinical decision making. Retinoblastoma is an oxygen-sensitive tumor; paradoxically, VS survive in the hypoxic vitreous. We hypothesized that VS elaborate pro-angiogenic cytokines. The purpose was to determine if pro-angiogenic cytokine signatures from aqueous humor could serve as a biomarker of VS response to treatment...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38856990/mesenchymal-stem-cell-derived-exosomes-as-drug-carriers-for-delivering-mirna-29b-to-ameliorate-inflammation-in-corneal-injury-via-activating-autophagy
#9
JOURNAL ARTICLE
Jinghua Liu, Juan Gao, Ping Lu, Yuchuan Wang, Shulei Xing, Yarong Yan, Ruifang Han, Peng Hao, Xuan Li
PURPOSE: Corneal injury (CI) resulting in corneal opacity remains a clinical challenge. Exosomes (Exos) derived from bone marrow mesenchymal stem cells (BMSCs) have been proven effective in repairing various tissue injuries and are also considered excellent drug carriers due to their biological properties. Recently, microRNA-29b (miR-29b) was found to play an important role in the autophagy regulation which correlates with cell inflammation and fibrosis. However, the effects of miR-29b and autophagy on CI remain unclear...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38848078/involvement-of-cgas-sting-signaling-in-the-pathogenesis-of-candida-albicans-keratitis-insights-from-genetic-and-pharmacological-approaches
#10
JOURNAL ARTICLE
Shanmei Lyu, Ting Zhang, Peng Peng, Dingwen Cao, Li Ma, Yang Yu, Yanling Dong, Xiaolin Qi, Chao Wei
PURPOSE: Fungal keratitis (FK) is an invasive corneal infection associated with significant risk to vision. Although the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway has been recognized for its role in defending against viral infections, its involvement in FK still remains largely unclear. This study sought to elucidate the contribution of the cGAS/STING signaling pathway to the pathogenesis of FK. METHODS: The expression of cGAS/STING signaling components was assessed in a murine model of Candida albicans keratitis through RNA sequencing, western blot analysis, immunofluorescence staining, and real-time PCR...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38848077/mitochondria-transplantation-promotes-corneal-epithelial-wound-healing
#11
JOURNAL ARTICLE
Daniel Raz, Keren Ben-Yaakov, Michal Levi, Marina Bertolin, Stefano Ferrari, Diego Ponzin, Massimo Busin, Hana Leiba, Arie L Marcovich, Avital Eisenberg-Lerner, Ziv Rotfogel
PURPOSE: The integrity of the corneal epithelium is essential in maintaining normal corneal function. Conditions disrupting the corneal epithelial layer range from chemical burns to dry eye disease and may result in impairment of both corneal transparency and sensation. Identifying factors that regulate corneal wound healing is key for the development of new treatment strategies. Here, we investigated a direct role of mitochondria in corneal wound healing via mitochondria transplantation...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38848076/associations-between-visual-functions-and-severity-gradings-corneal-scatter-or-higher-order-aberrations-in-fuchs-endothelial-corneal-dystrophy
#12
JOURNAL ARTICLE
Chifune Kai, Yoshinori Oie, Nozomi Nishida, Suzuka Doi, Chihomi Fujimoto, Sanae Asonuma, Sayo Maeno, Takeshi Soma, Shizuka Koh, Vishal Jhanji, Ryo Kawasaki, Kohji Nishida
PURPOSE: The purpose of this study was to investigate the associations between visual function and severity grading, corneal scatter, or higher-order aberrations (HOAs) in patients with Fuchs endothelial corneal dystrophy (FECD). METHODS: This observational case series study included 49 eyes of 27 patients with FECD and 10 eyes of 10 healthy individuals. We evaluated corrected distance visual acuity (CDVA) using Landolt-C and Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity using the CSV-1000E chart and CSV-1000RN letter chart...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38842831/applicability-of-oculomics-for-individual-risk-prediction-repeatability-and-robustness-of-retinal-fractal-dimension-using-dart-and-automorph
#13
JOURNAL ARTICLE
Justin Engelmann, Diana Moukaddem, Lucas Gago, Niall Strang, Miguel O Bernabeu
PURPOSE: To investigate whether fractal dimension (FD)-based oculomics could be used for individual risk prediction by evaluating repeatability and robustness. METHODS: We used two datasets: "Caledonia," healthy adults imaged multiple times in quick succession for research (26 subjects, 39 eyes, 377 color fundus images), and GRAPE, glaucoma patients with baseline and follow-up visits (106 subjects, 196 eyes, 392 images). Mean follow-up time was 18.3 months in GRAPE; thus it provides a pessimistic lower bound because vasculature could change...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38842830/intereye-microvascular-differences-in-patients-with-same-stage-diabetic-retinopathy-revealed-by-octa
#14
JOURNAL ARTICLE
Heiko Stino, Kim Lien Huber, Laura Kunze, Irene Steiner, Alexandros Bampoulidis, Ursula Schmidt-Erfurth, Andreas Pollreisz
PURPOSE: To evaluate microvascular intereye differences in diabetic patients with same-stage diabetic retinopathy (DR) in both eyes as assessed using optical coherence tomography angiography (OCTA). METHODS: In this cross-sectional study, fovea-centered swept-source 6 × 6 mm OCTA scans were acquired using a 200 kHz OCTA device. Vessel density (VD) and fractal dimension were calculated on binarized, vessel-segmented images in the superficial capillary plexus (SCP) and deep capillary plexus (DCP)...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38842829/the-role-of-ccl-chemokines-in-experimental-staphylococcus-aureus-endophthalmitis
#15
JOURNAL ARTICLE
Aaron C Parrott, Phillip S Coburn, Frederick C Miller, Austin L LaGrow, Md Huzzatul Mursalin, Michelle C Callegan
PURPOSE: To test the hypothesis that (C-C motif) ligand 2 (CCL2) and CCL3 impact retinal function decline and inflammation during Staphylococcus aureus endophthalmitis. METHODS: Experimental endophthalmitis was initiated by intravitreal injection of 5000 colony-forming units of S. aureus into the eyes of C57BL/6J, CCL2-/-, or CCL3-/- mice. At 12 and 24 hours post-infection, retinal function, bacterial load, and myeloperoxidase levels were quantified. RESULTS: During S...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38837168/an-overview-of-optic-pathway-glioma-with-neurofibromatosis-type-1-pathogenesis-risk-factors-and-therapeutic-strategies
#16
REVIEW
Ying Chen, Jie Yu, Shengfang Ge, Renbing Jia, Xin Song, Yefei Wang, Xianqun Fan
Optic pathway gliomas (OPGs) are most predominant pilocytic astrocytomas, which are typically diagnosed within the first decade of life. The majority of affected children with OPGs also present with neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome. OPGs in individuals with NF1 primarily affect the optic pathway and lead to visual disturbance. However, it is challenging to assess risk in asymptomatic patients without valid biomarkers. On the other hand, for symptomatic patients, there is still no effective treatment to prevent or recover vision loss...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38837167/time-resolved-dynamic-optical-coherence-tomography-for-retinal-blood-flow-analysis
#17
JOURNAL ARTICLE
Philippe Valmaggia, Philippe C Cattin, Robin Sandkühler, Nadja Inglin, Tilman P Otto, Silke Aumann, Michel M Teussink, Richard F Spaide, Hendrik P N Scholl, Peter M Maloca
PURPOSE: Optical coherence tomography (OCT) representations in clinical practice are static and do not allow for a dynamic visualization and quantification of blood flow. This study aims to present a method to analyze retinal blood flow dynamics using time-resolved structural OCT. METHODS: We developed novel imaging protocols to acquire video-rate time-resolved OCT B-scans (1024 × 496 pixels, 10 degrees field of view) at four different sensor integration times (integration time of 44...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38833261/the-factors-affecting-the-stability-of-iop-homeostasis
#18
JOURNAL ARTICLE
Darryl R Overby, C Ross Ethier, Changxu Miao, Ruth A Kelly, Ester Reina-Torres, W Daniel Stamer
PURPOSE: Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that normally contributes to IOP homeostasis. Our goal was to analyze the response of this homeostatic system under constant flow perfusion (as occurs in vivo) vs. constant pressure perfusion (as typical for laboratory perfusions). METHODS: A mathematical model of aqueous humor dynamics, including shear-mediated NO signaling, was formulated and analyzed for stability...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38833260/self-reported-functional-vision-in-ush2a-associated-retinal-degeneration-as-measured-by-the-michigan-retinal-degeneration-questionnaire
#19
JOURNAL ARTICLE
Bela Parekh, Jacque L Duncan, Lassana Samarakoon, Michele Melia, Maria Fernanda Abalem, Chris A Andrews, Isabelle Audo, Allison R Ayala, Chris Bradley, Janet K Cheetham, Gislin Dagnelie, Todd A Durham, Rachel M Huckfeldt, Gabrielle D Lacy, Brett Malbin, Michel Michaelides, David C Musch, Nicholas Peck-Dimit, Katarina Stingl, Christina Y Weng, Alex Z Zmejkoski, K Thiran Jayasundera
PURPOSE: The purpose of this study was to evaluate self-reported functional vision (FV) and the impact of vision loss in patients with USH2A-associated retinal degeneration using a patient-reported outcome (PRO) measure, the Michigan Retinal Degeneration Questionnaire (MRDQ), to correlate MRDQ scores with well-established visual function measurements. DESIGN: An observational cross-sectional study (n = 93) of participants who had Usher Syndrome Type 2 (USH2, n = 55) or autosomal recessive non-syndromic retinitis pigmentosa (ARRP; n = 38) associated with biallelic variants in the USH2A gene...
June 3, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38833259/choroidalyzer-an-open-source-end-to-end-pipeline-for-choroidal-analysis-in-optical-coherence-tomography
#20
JOURNAL ARTICLE
Justin Engelmann, Jamie Burke, Charlene Hamid, Megan Reid-Schachter, Dan Pugh, Neeraj Dhaun, Diana Moukaddem, Lyle Gray, Niall Strang, Paul McGraw, Amos Storkey, Paul J Steptoe, Stuart King, Tom MacGillivray, Miguel O Bernabeu, Ian J C MacCormick
PURPOSE: To develop Choroidalyzer, an open-source, end-to-end pipeline for segmenting the choroid region, vessels, and fovea, and deriving choroidal thickness, area, and vascular index. METHODS: We used 5600 OCT B-scans (233 subjects, six systemic disease cohorts, three device types, two manufacturers). To generate region and vessel ground-truths, we used state-of-the-art automatic methods following manual correction of inaccurate segmentations, with foveal positions manually annotated...
June 3, 2024: Investigative Ophthalmology & Visual Science
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