Yevgeniy Sazhnyev, Tzu-Ni Sin, Anthony Ma, Ellie Chang, Leon Huynh, Karolina Roszak, Sangwan Park, Kevin Choy, Sina Farsiu, Ala Moshiri, Sara M Thomasy, Glenn Yiu
PURPOSE: Choroidal vascular changes occur with normal aging and age-related macular degeneration (AMD). Here, we evaluate choroidal thickness and vascularity in aged rhesus macaques to better understand the choroid's role in this nonhuman primate model of AMD. METHODS: We analyzed optical coherence tomography (OCT) images of 244 eyes from 122 rhesus macaques (aged 4-32 years) to measure choroidal thickness (CT) and choroidal vascularity index (CVI). Drusen number, size, and volume were measured by semiautomated annotation and segmentation of OCT images...
September 1, 2023: Investigative Ophthalmology & Visual Science