journal
https://read.qxmd.com/read/37714795/integrating-palliative-care-into-the-evolving-landscape-of-oncology
#41
JOURNAL ARTICLE
Harry J Han, Carol R Pilgrim, Mary K Buss
Patients with cancer have many palliative care needs. Robust evidence supports the early integration of palliative care into the care of patients with advanced cancer. International organizations, such as the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO), have recommended early, longitudinal integration of palliative care into oncology care throughout the cancer trajectory. In this review, we pose a series of clinical questions related to the current state of early palliative care integration into oncology...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37704491/impact-of-non-brca-genes-in-the-indication-of-risk-reducing-surgery-in-hereditary-breast-and-ovarian-cancer-syndrome-hboc
#42
JOURNAL ARTICLE
Laura Fernández Madrigal, Maria Yeray Rodríguez Garcés, Francisco Javier Jiménez Ruiz
Hereditary breast and ovarian cancer syndrome (HBOC) is associated with other genes beyond BRCA. The performance of prophylactic bilateral mastectomy (PBM) and risk-reducing salpingo-oophorectomy (RRSO) are primary prevention measures that can be recommended depending on the type of pathogenic/likely pathogenic (P/LP) variant detected or family history. Descriptive, retrospective, and observational audit. Between the years 2015 to May 2023, a total of 288 families were studied by a multigene panel using NGS...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37838548/practical-considerations-for-prognostic-communication-in-pediatric-cancer
#43
JOURNAL ARTICLE
Brittany Cowfer, Tammy I Kang, Matthew T McEvoy
High-quality communication is essential for the optimal care of children with cancer and their families. There are opportunities for pediatric oncologists to engage in clear and compassionate prognostic communication across the disease trajectory including at the time of diagnosis, disease recurrence or progression, and end of life. Contrary to previously held beliefs, prognostic disclosure supports parental hope and meets the needs and expectations of families who prefer honest conversations about prognosis...
September 5, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37684197/the-prognostic-value-of-figo-staging-defined-by-combining-mri-and-18-f-fdg-pet-ct-in-patients-with-locally-advanced-cervical-cancer
#44
JOURNAL ARTICLE
Stefano Raffa, Francesco Lanfranchi, Camilla Satragno, Flavio Giannelli, Michela Marcenaro, Angela Coco, Sofia Elizabeth Cena, Luca Sofia, Cecilia Marini, Serafina Mammoliti, Alessia Levaggi, Alberto Stefano Tagliafico, Gianmario Sambuceti, Salvina Barra, Silvia Morbelli, Liliana Belgioia, Matteo Bauckneht
The last version of the FIGO classification recommended imaging tools to complete the clinical assessment of patients with cervical cancer. However, the preferable imaging approach is still unclear. We aimed to explore the prognostic power of Magnetic Resonance Imaging (MRI), contrast-enhanced Computed Tomography (ceCT), and [18 F]-Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET)/CT in patients staged for locally advanced cervical cancer (LACC, FIGO stages IB3-IVA). Thirty-six LACC patients (mean age 55...
September 5, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37467541/gynecologic-and-breast-cancers-what-s-new-in-chemoresistance-and-chemosensitivity-tests
#45
REVIEW
Júlia Caroline Marcolin, Martina Lichtenfels, Camila Alves da Silva, Caroline Brunetto de Farias
Gynecological and breast cancers affect women's health worldwide. Although chemotherapy is one of the principal treatments for cancer, it also has limitations owing to toxicity and tumor resistance to the drugs used. Thus, individualized treatment based on personal tumor characteristics is essential for improving therapeutic outcomes and patient survival. Chemoresistance and chemosensitivity tests can be useful for predicting tumor response and guiding chemotherapy choices. This methodology has already been applied to breast, ovarian, cervical, and endometrial cancers, identifying successfully which drugs cause resistance and sensitivity responses for each individual person, influencing their progression-free survival and overall response...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37418998/advances-in-high-risk-localized-prostate-cancer-staging-and-management
#46
REVIEW
Yeison Reina, Catalina Villaquirán, Herney Andrés García-Perdomo
Nearly 15% of individuals with localized prostate cancer are identified as high risk for recurrence and progression of the disease, which is why the correct staging is vital for the definition of correct treatment-also developing novel therapeutic strategies to find a balance between getting better outcomes without sacrificing the quality of life (QoL). In this narrative review, we introduced the current standards of staging and primary treatment of high-risk localized prostate cancer (PCa), based on international guidelines and arguments in the debate, under the light of the most recent literature...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37364455/repurposing-metformin-in-hematologic-tumor-state-of-art
#47
REVIEW
Min Hu, Yan Chen, Tao Ma, Li Jing
Metformin is an ancient drug for the treatment of type 2 diabetes, and many studies now suggested that metformin can be used as an adjuvant drug in the treatment of many types of tumors. The mechanism of action of metformin for tumor treatment mainly involves: 1. activation of AMPK signaling pathway 2. inhibition of DNA damage repair in tumor cells 3. downregulation of IGF-1 expression 4. inhibition of chemoresistance and enhancement of chemotherapy sensitivity in tumor cells 5. enhancement of antitumor immunity 6...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37285606/beyond-egfr-inhibitors-in-advanced-colorectal-cancer-targeting-braf-and-her2
#48
REVIEW
Vinh Dao, Gregory Heestand
The addition of antiepidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab or panitumumab, to conventional chemotherapy has improved clinical outcomes for rat sarcoma virus (RAS) wild-type advanced colorectal cancer patients, however, durable responses and 5-year overall survival rates remain limited. BRAF V600E somatic mutation and human epidermal growth factor receptor (HER2) amplification/overexpression have been separately implicated in primary resistance to anti-EGFR therapeutic strategies via aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway, resulting in poorer outcomes...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37330401/preface
#49
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37330400/imaging-of-colon-and-rectal-cancer
#50
JOURNAL ARTICLE
Sonia Lee, Venkateswar R Surabhi, Zahra Kassam, Kevin J Chang, Harmeet Kaur
Colon and rectal cancer imaging has traditionally been performed to assess for distant disease (typically lung and liver metastases) and to assess the resectability of the primary tumor. With technological and scientific advances in imaging and the evolution of treatment options, the role of imaging has expanded. Radiologists are now expected to provide a precise description of primary tumor invasion extent, including adjacent organ invasion, involvement of the surgical resection plane, extramural vascular invasion, lymphadenopathy, and response to neoadjuvant treatment, and to monitor for recurrence after clinical complete response...
June 8, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37321909/update-on-the-role-of-imaging-in-staging-of-common-pediatric-abdominal-tumors
#51
JOURNAL ARTICLE
Sujit Kumar Jha, Colin Brown, Lisa Kang, Eric S Diaz, Kriti Gwal, Elysia Alvarez, Erin G Brown, Rebecca Stein-Wexler
Neuroblastoma, Wilms tumor, and hepatoblastoma are the most common pediatric abdominal malignancies. Management of these diseases is a multidisciplinary process that continues to evolve based on the results of international collaborative trials and advances in understanding of tumor biology. Each of these tumors has unique characteristics and behavior which are reflected in their respective staging systems. It is important for clinicians involved in the care of children with abdominal malignancies to be familiar with current staging guidelines and imaging recommendations...
June 7, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37316336/imaging-of-breast-cancer-beyond-the-basics
#52
JOURNAL ARTICLE
Michelle Zhang, Benoit Mesurolle, Melanie Theriault, Sarkis Meterissian, Elizabeth A Morris
Imaging of breast cancer is the backbone of breast cancer screening, diagnosis, preoperative/treatment assessment and follow-up. The main modalities are mammography, ultrasound and magnetic resonance imaging, each with its own advantages and disadvantages. New emerging technologies have also enabled each modality to improve on their weaknesses. Imaging-guided biopsies have allowed for accurate diagnosis of breast cancer, with low complication rates. The purpose of this article is to review the common modalities for breast cancer imaging in current practice with emphasis on the strengths and potential weaknesses, discuss the selection of the best imaging modality for the specific clinical question or patient population, and explore new technologies / future directions of breast cancer imaging...
June 7, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37349190/imaging-cancer-in-neuroradiology
#53
JOURNAL ARTICLE
Osama Raslan, Arzu Ozturk, Kader Karli Oguz, Fatma Sen, Orwa Aboud, Vladimir Ivanovic, Reza Assadsangabi, Lotfi Hacein-Bey
Neuroimaging plays a pivotal role in the diagnosis, management, and prognostication of brain tumors. Recently, the World Health Organization published the fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS5), which places greater emphasis on tumor genetics and molecular markers to complement the existing histological and immunohistochemical approaches. Recent advances in computational power allowed modern neuro-oncological imaging to move from a strictly morphology-based discipline to advanced neuroimaging techniques with quantifiable tissue characteristics such as tumor cellularity, microstructural organization, hemodynamic, functional, and metabolic features, providing more precise tumor diagnosis and management...
June 4, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37321910/imaging-of-hepatobiliary-cancer
#54
JOURNAL ARTICLE
Benjamin W Carney, Michael C Larson, Michael T Corwin, Ramit Lamba
The liver and biliary tree are common sites of primary and secondary malignancies. MRI followed by CT is the mainstay for the imaging characterization of these malignancies with the dynamically acquired contrast enhanced phases being the most important for diagnosis. The liver imaging reporting and data system classification provides a useful framework for reporting lesions in patents with underlying cirrhosis or who are at high risk for developing hepatocellular carcinoma. Detection of metastases is improved with the use of liver specific MRI contrast agents and diffusion weighted sequences...
June 4, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37316337/imaging-of-lung-cancer
#55
JOURNAL ARTICLE
Mohammad H Madani, Jonathan W Riess, Lisa M Brown, David T Cooke, H Henry Guo
Lung cancer is the leading cause of cancer-related mortality globally. Imaging is essential in the screening, diagnosis, staging, response assessment, and surveillance of patients with lung cancer. Subtypes of lung cancer can have distinguishing imaging appearances. The most frequently used imaging modalities include chest radiography, computed tomography, magnetic resonance imaging, and positron emission tomography. Artificial intelligence algorithms and radiomics are emerging technologies with potential applications in lung cancer imaging...
June 4, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37236055/bone-health-in-breast-cancer
#56
REVIEW
Praful Pandey, Aparna Sharma, Ajay Gogia
Early breast cancer is among the most common cancers worldwide. Recent advances continue to improve outcomes and increase long-term survivorship. However, therapeutic modalities are deleterious for patients' bone health. While antiresorptive therapy may partially negate this, consequent reduction in rates of fragility fractures remains unproven. Selective prescription of bisphosphonates or denosumab may be an amicable middle ground. Recent evidence also suggests a possible role of osteoclast inhibitors as adjuvant therapy, but the evidence is modest at best...
June 2023: Current Problems in Cancer
https://read.qxmd.com/read/36966677/long-term-outcomes-in-patients-with-central-and-ultracentral-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiotherapy-single-institution-experience
#57
JOURNAL ARTICLE
Xue Song, Lijun Zhao, Ning Jiang, Naixin Ding, Dan Zong, Nan Zhang, Dejun Wang, Jing Wen, Xia He, Cheng Kong, Xiangzhi Zhu
OBJECTIVE: Treatment-related toxicity following stereotactic ablative radiotherapy (SABR) in patients with central and ultracentral non-small cell lung cancer (NSCLC) is of potential concern, and the best regimens are still being explored. This study aimed to evaluate the clinical outcomes and toxicities of the patients with ultracentral and central NSCLC treated with SABR at our institution. METHOD: This retrospective study included patients with central and ultracentral NSCLC treated with SABR to prescription doses of 50 Gy in five fractions, 56 Gy in seven fractions, or 60 Gy in ten fractionsat Jiangsu Cancer Hospital between May 2013 and October 2018...
June 2023: Current Problems in Cancer
https://read.qxmd.com/read/36842202/tisotumab-vedotin-in-recurrent-or-metastatic-cervical-cancer
#58
REVIEW
Giorgio Bogani, Robert L Coleman, Ignace Vergote, Francesco Raspagliesi, Domenica Lorusso, Bradley J Monk
Tisotumab vedotin (TV) is an antibody-drug conjugate used for the treatment of adult patients with recurrent or metastatic cervical cancer. TV comprised of a monoclonal antibody against tissue factor and monomethyl auristatin E (MMAE), a potent inhibitor of cell division. The innovaTV-201 and innovaTV-204/GO30xx/ENGOT-cx6 trials showed that TV has clinically meaningful and durable antitumor activity in pretreated patients with recurrent or metastatic cervical cancer. The innovaTV-204 trial showed that TV monotherapy resulted in an objective response rate of 24% (including 7% and 17% complete and partial responses, respectively)...
June 2023: Current Problems in Cancer
https://read.qxmd.com/read/37271639/selinexor-in-patients-with-advanced-and-recurrent-endometrial-cancer
#59
REVIEW
Giorgio Bogani, Bradley J Monk, Robert L Coleman, Ignace Vergote, Ana Oakin, Isabelle Ray-Coquard, Andrea Mariani, Giovanni Scambia, Francesco Raspagliesi, Bruno Bolognese
Selinexor is an oral inhibitor of the nuclear export protein called Exportin 1 (XPO1) with demonstrated antitumor activity in hematological and solid tumors. Selinexor, blocking XPO1, induces nuclear localization of tumor suppressor proteins (including p53, p73, BRCA1, and pRB), leading to the selective induction of apoptosis, and inhibition of DNA damage repair proteins. XPO1 overexpression is common in endometrial cancers. Phase I and II trials reported the antitumor activity of selinexor in patients with endometrial carcinoma...
May 30, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37247442/risk-nomogram-for-assessing-renal-recovery-in-patients-with-newly-diagnosed-multiple-myeloma-related-renal-impairment
#60
JOURNAL ARTICLE
Shaobo Li, Min Zhang, Jin Liu, Shaojun Liu, Chen Zhu, Da Shang, Yi Guan, Qian Wang
To determine risk factors affecting renal recovery in newly diagnosed multiple myeloma (NDMM) patients with renal impairment (RI) and establish a risk nomogram. This multi-center, retrospective cohort study included 187 NDMM patients with RI, 127 of whom were admitted to Huashan Hospital and assigned to the training cohort and 60 were admitted to Changzheng Hospital and assigned to the external validation cohort. The baseline data of the 2 cohorts were compared, and survival and renal recovery rates were analyzed...
May 23, 2023: Current Problems in Cancer
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