journal
https://read.qxmd.com/read/37865539/frailty-and-preoperative-palliative-care-in-surgical-oncology
#21
JOURNAL ARTICLE
Zoe Tao, Elizabeth Hays, Gabrielle Meyers, Timothy Siegel
In this paper, we discuss surgical palliative care for patients with cancer through the lens of frailty and the preoperative context. Historically, palliative care principles such as complex symptom management, high-risk decision-making and communication have played an important role in preoperative discussions of oncologic surgery for both palliative and curative intent. There is increasing motivation among surgeons to integrate palliative care into the perioperative period in order to more effectively and comprehensively address potential adverse functional and quality of life outcomes...
October 16, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37866988/bridging-the-gap-palliative-care-integration-into-survivorship-care
#22
JOURNAL ARTICLE
Brianna Morgan, Vishal Kapadia, Lesa Crawford, Samina Martin, Joseph McCollom
As the number of cancer survivors grows, there is an increasing need for comprehensive care to address the unique physical, psychological, and social needs of this population. Palliative care (PC) integration within survivorship care offers a promising model of care, however, there is no comprehensive review of literature to guide clinical practice. This manuscript presents a scoping review of the research literature on models of care that integrate PC with survivorship care, as well as a detailed description of an exemplar clinical model...
October 15, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37863783/creating-a-culture-for-change-lessons-from-behavioral-economics-and-complexity-science-to-increase-serious-illness-conversations-for-patients-with-cancer
#23
JOURNAL ARTICLE
Ramy Sedhom, Jasmine Tomita-Barber, Christopher R Manz, Ravi B Parikh, Arjun Gupta, Qasim Hussaini, David Dougherty
Patient-centered cancer care requires communication between patients and clinicians about patients' goals, values, and preferences. Serious illness communication improves patient and caregiver outcomes, the value and quality of cancer care, and the well-being of clinicians. Despite these benefits, there are competing factors including time, capacity, bandwidth, and resistance. Health systems and oncology practices have opportunities to invest in pathways that assist patients and clinicians to engage in serious illness conversations...
October 15, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37852848/risk-factors-for-omental-metastasis-and-the-effect-of-omentectomy-on-survival-in-type-2-endometrial-cancer-patients
#24
JOURNAL ARTICLE
Varol Gülseren, İlker Çakır, Esra Canan Kelten, Aykut Özcan, Muzaffer Sancı, Ertuğrul Şen, Zübeyde Emiralioğlu Çakır, İsa Aykut Özdemir, Kemal Güngördük
To investigate the risk factors for occult omental metastasis and the effect of omentectomy on the survival of type 2 endometrial cancer (EC) patients. This study enrolled patients who were diagnosed with high-risk (grade 3, serous, clear cell, undifferentiated, carcinosarcoma, or mixed type) EC between 2000 and 2021 and underwent surgery in our center. Data from 482 patients were analyzed retrospectively. Omentectomy was performed in 405 (84.0%) patients. Omental metastases were detected in 61 (12.7%) patients...
October 13, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37806918/innovations-and-opportunities-for-the-integration-of-palliative-care-in-cancer-care
#25
EDITORIAL
Kristina B Newport, Jason A Webb
No abstract text is available yet for this article.
October 2023: Current Problems in Cancer
https://read.qxmd.com/read/37743212/peripheral-arterial-disease-is-associated-with-higher-rates-of-hospital-encounters-and-mortality-in-cancer-patients-a-retrospective-study-conducted-at-a-tertiary-cancer-center
#26
JOURNAL ARTICLE
Yolanda Bryce, Meier Hsu, Charlie White, Adrian Gonzalez-Aguirre, Adie Friedman, Jonathan Latzman, Chaya S Moskowitz
Cancer and peripheral arterial disease (PAD) have overlapping risk factors and common genetic predispositions. The concomitant effects of PAD and cancer on patients have not been well studied. The objective of this retrospective study is to evaluate outcomes of cancer patients with PAD. A query was made into Memorial Sloan Kettering Cancer Center's database to assess outcome of patients with and without the diagnosis of PAD (using ICD 9 and 10 codes). Inclusion criteria were patients diagnosed with lung, colon, prostate, bladder, or breast cancer between January 1, 2013 and December 12, 2018...
September 19, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37716878/examining-the-cultural-appropriateness-of-advance-care-planning-tools-for-adolescents-and-young-adults-with-cancer-an-example-of-cross-cultural-adaptation-of-the-voicing-my-choices-tool
#27
JOURNAL ARTICLE
Holly E Evans, Sophie Jessop, Sima Z Bedoya, Maureen E Lyon, Lori Wiener, Ursula M Sansom-Daly
Advance care planning (ACP) is crucial in supporting optimal, patient-centered care for adolescents and young adults (AYAs) with life-limiting illnesses and can reduce unwanted outcomes at end-of-life. While several ACP tools and interventions have been designed for AYAs, most of these were developed in the United States of America (USA). This paper describes a study designed to adapt the AYA ACP tool, Voicing My CHOiCES (VMC), for the Australian population. A 2-stage mixed methods approach was used. Stage 1 involved a multiperspective interview to determine changes for the new Australian VMC...
September 11, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37718232/innovations-for-the-integration-of-palliative-care-for-hematologic-malignancies
#28
JOURNAL ARTICLE
Neha Kayastha, Alison R Kavanaugh, Jason A Webb, Thomas W LeBlanc
Specialist palliative care provides additional support to facilitate living well with a serious illness, like cancer, even while pursuing disease-directed therapy. For patients with hematologic malignancies, integrated specialist palliative care improves symptom burden, mood, and quality of life, with benefits even extending to caregivers. Despite this, patients with hematologic malignancies continue to have significant unmet palliative care needs and typically access palliative care late in their disease trajectories, if at all...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37714796/integrated-dual-training-in-palliative-care-and-oncology
#29
JOURNAL ARTICLE
Kathryn DeCarli, Rachel Rodenbach, Ramy Sedhom, Jamie Von Roenn, Briana Ketterer
Fellowship training in Hospice and Palliative Medicine (HPM) and Hematology/Oncology (Hem/Onc) share common themes and roots in the holistic care of people living with cancer. As of 2021, approximately 630 physicians in the United States were board-certified in both HPM and Hem/Onc. There is increasing demand for an integrated fellowship pathway, and the inaugural integrated fellowship Match took place in 2022. We present the historical context of the overlap in HPM and Hem/Onc fellowship training, limitations of the standard training paradigm, and an overview of the recently developed integrated training pathway accredited by the Accreditation Council for Graduate Medical Education (ACGME)...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37714795/integrating-palliative-care-into-the-evolving-landscape-of-oncology
#30
JOURNAL ARTICLE
Harry J Han, Carol R Pilgrim, Mary K Buss
Patients with cancer have many palliative care needs. Robust evidence supports the early integration of palliative care into the care of patients with advanced cancer. International organizations, such as the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO), have recommended early, longitudinal integration of palliative care into oncology care throughout the cancer trajectory. In this review, we pose a series of clinical questions related to the current state of early palliative care integration into oncology...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37704491/impact-of-non-brca-genes-in-the-indication-of-risk-reducing-surgery-in-hereditary-breast-and-ovarian-cancer-syndrome-hboc
#31
JOURNAL ARTICLE
Laura Fernández Madrigal, Maria Yeray Rodríguez Garcés, Francisco Javier Jiménez Ruiz
Hereditary breast and ovarian cancer syndrome (HBOC) is associated with other genes beyond BRCA. The performance of prophylactic bilateral mastectomy (PBM) and risk-reducing salpingo-oophorectomy (RRSO) are primary prevention measures that can be recommended depending on the type of pathogenic/likely pathogenic (P/LP) variant detected or family history. Descriptive, retrospective, and observational audit. Between the years 2015 to May 2023, a total of 288 families were studied by a multigene panel using NGS...
September 6, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37838548/practical-considerations-for-prognostic-communication-in-pediatric-cancer
#32
JOURNAL ARTICLE
Brittany Cowfer, Tammy I Kang, Matthew T McEvoy
High-quality communication is essential for the optimal care of children with cancer and their families. There are opportunities for pediatric oncologists to engage in clear and compassionate prognostic communication across the disease trajectory including at the time of diagnosis, disease recurrence or progression, and end of life. Contrary to previously held beliefs, prognostic disclosure supports parental hope and meets the needs and expectations of families who prefer honest conversations about prognosis...
September 5, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37684197/the-prognostic-value-of-figo-staging-defined-by-combining-mri-and-18-f-fdg-pet-ct-in-patients-with-locally-advanced-cervical-cancer
#33
JOURNAL ARTICLE
Stefano Raffa, Francesco Lanfranchi, Camilla Satragno, Flavio Giannelli, Michela Marcenaro, Angela Coco, Sofia Elizabeth Cena, Luca Sofia, Cecilia Marini, Serafina Mammoliti, Alessia Levaggi, Alberto Stefano Tagliafico, Gianmario Sambuceti, Salvina Barra, Silvia Morbelli, Liliana Belgioia, Matteo Bauckneht
The last version of the FIGO classification recommended imaging tools to complete the clinical assessment of patients with cervical cancer. However, the preferable imaging approach is still unclear. We aimed to explore the prognostic power of Magnetic Resonance Imaging (MRI), contrast-enhanced Computed Tomography (ceCT), and [18 F]-Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET)/CT in patients staged for locally advanced cervical cancer (LACC, FIGO stages IB3-IVA). Thirty-six LACC patients (mean age 55...
September 5, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37467541/gynecologic-and-breast-cancers-what-s-new-in-chemoresistance-and-chemosensitivity-tests
#34
REVIEW
Júlia Caroline Marcolin, Martina Lichtenfels, Camila Alves da Silva, Caroline Brunetto de Farias
Gynecological and breast cancers affect women's health worldwide. Although chemotherapy is one of the principal treatments for cancer, it also has limitations owing to toxicity and tumor resistance to the drugs used. Thus, individualized treatment based on personal tumor characteristics is essential for improving therapeutic outcomes and patient survival. Chemoresistance and chemosensitivity tests can be useful for predicting tumor response and guiding chemotherapy choices. This methodology has already been applied to breast, ovarian, cervical, and endometrial cancers, identifying successfully which drugs cause resistance and sensitivity responses for each individual person, influencing their progression-free survival and overall response...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37418998/advances-in-high-risk-localized-prostate-cancer-staging-and-management
#35
REVIEW
Yeison Reina, Catalina Villaquirán, Herney Andrés García-Perdomo
Nearly 15% of individuals with localized prostate cancer are identified as high risk for recurrence and progression of the disease, which is why the correct staging is vital for the definition of correct treatment-also developing novel therapeutic strategies to find a balance between getting better outcomes without sacrificing the quality of life (QoL). In this narrative review, we introduced the current standards of staging and primary treatment of high-risk localized prostate cancer (PCa), based on international guidelines and arguments in the debate, under the light of the most recent literature...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37364455/repurposing-metformin-in-hematologic-tumor-state-of-art
#36
REVIEW
Min Hu, Yan Chen, Tao Ma, Li Jing
Metformin is an ancient drug for the treatment of type 2 diabetes, and many studies now suggested that metformin can be used as an adjuvant drug in the treatment of many types of tumors. The mechanism of action of metformin for tumor treatment mainly involves: 1. activation of AMPK signaling pathway 2. inhibition of DNA damage repair in tumor cells 3. downregulation of IGF-1 expression 4. inhibition of chemoresistance and enhancement of chemotherapy sensitivity in tumor cells 5. enhancement of antitumor immunity 6...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37285606/beyond-egfr-inhibitors-in-advanced-colorectal-cancer-targeting-braf-and-her2
#37
REVIEW
Vinh Dao, Gregory Heestand
The addition of antiepidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab or panitumumab, to conventional chemotherapy has improved clinical outcomes for rat sarcoma virus (RAS) wild-type advanced colorectal cancer patients, however, durable responses and 5-year overall survival rates remain limited. BRAF V600E somatic mutation and human epidermal growth factor receptor (HER2) amplification/overexpression have been separately implicated in primary resistance to anti-EGFR therapeutic strategies via aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway, resulting in poorer outcomes...
August 2023: Current Problems in Cancer
https://read.qxmd.com/read/37330401/preface
#38
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37330400/imaging-of-colon-and-rectal-cancer
#39
JOURNAL ARTICLE
Sonia Lee, Venkateswar R Surabhi, Zahra Kassam, Kevin J Chang, Harmeet Kaur
Colon and rectal cancer imaging has traditionally been performed to assess for distant disease (typically lung and liver metastases) and to assess the resectability of the primary tumor. With technological and scientific advances in imaging and the evolution of treatment options, the role of imaging has expanded. Radiologists are now expected to provide a precise description of primary tumor invasion extent, including adjacent organ invasion, involvement of the surgical resection plane, extramural vascular invasion, lymphadenopathy, and response to neoadjuvant treatment, and to monitor for recurrence after clinical complete response...
June 8, 2023: Current Problems in Cancer
https://read.qxmd.com/read/37321909/update-on-the-role-of-imaging-in-staging-of-common-pediatric-abdominal-tumors
#40
JOURNAL ARTICLE
Sujit Kumar Jha, Colin Brown, Lisa Kang, Eric S Diaz, Kriti Gwal, Elysia Alvarez, Erin G Brown, Rebecca Stein-Wexler
Neuroblastoma, Wilms tumor, and hepatoblastoma are the most common pediatric abdominal malignancies. Management of these diseases is a multidisciplinary process that continues to evolve based on the results of international collaborative trials and advances in understanding of tumor biology. Each of these tumors has unique characteristics and behavior which are reflected in their respective staging systems. It is important for clinicians involved in the care of children with abdominal malignancies to be familiar with current staging guidelines and imaging recommendations...
June 7, 2023: Current Problems in Cancer
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