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Current Problems in Cancer

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https://read.qxmd.com/read/30952367/effect-of-clinicopathologic-features-on-survival-of-patients-with-thymic-carcinomas-and-thymic-neuroendocrine-tumors-a-population-based-analysis
#1
Qian Song, Lan-Lin Zhang, Yuan Qi, Kai-Lin Xing, Xiang-Hua Wu
BACKGROUND: Thymic carcinomas (TCs) and thymic neuroendocrine tumors (TNETs) are aggressive cancers with poor survival outcome and limited investigation. This study is to investigate clinicopathologic features on TC and TNET patients' prognosis of a large cohort. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database were used to identify a total of 362 TC and TNET patients with documented clinicopathologic features we investigated. The characteristics and overall survival of the TC and TNET patients were studied...
March 29, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30954277/alterations-in-xrcc1-gene-profile-in-pathogenesis-of-oral-cavity-cancer-a-population-based-study-from-kamrup-urban-district-of-assam-india
#2
Raktim Borkotoky, Biswajit Malakar, Anjan Kr Saikia, Shambhu N Mukherjee, Sujoy Bose
XRCC1 gene is an integral component of the base excision repair pathway regulating DNA repair, the genetic alterations in which has been documented to be associated with cancers of multiple etiologies. The present study aimed to evaluate the key polymorphisms in XRCC1 gene for its association with pathogenesis of oral cavity cancer (OCC) in Kamrup Urban District of Assam, India. Tissue biopsies (N = 152) clinicopathologically characterized OCCs were collected along with whole blood samples (N = 190) from healthy controls with all clinical and habitual details...
March 28, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30929752/microsatellite-instability-profiling-in-egyptian-bladder-cancer-patients-a-pilot-study
#3
Abdel-Rahman N Zekri, Hussein M Khaled, Mai B Mohammed, Fatma M Diab, Mona S Abdellateif, Somaya El Deeb, Abeer M Badr, Marwa Mohanad, Sanaa O Abdallah, Abeer A Bahnassy
Microsatellite alterations have been implicated in the pathogenesis of many cancers; however, they are still not well addressed in the bladder cancer (BC) of Egyptian population. We assessed microsatellite instability (MSI) profile and loss of heterozygosity (LOH) using 13 microsatellite markers in tumor tissue samples and urine sediments obtained from 30 Egyptian patients with BC. The concordance between MSI in tumor tissue and urine samples was determined, and correlated to relevant clinicopathologic features...
March 26, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30904169/aberrant-hypermethylation-of-ogdhl-gene-promoter-in-sporadic-colorectal-cancer
#4
Mohammad Khalaj-Kondori, Mina Hosseinnejad, Asghar Hosseinzadeh, Shahin Behroz Sharif, Shahriar Hashemzadeh
BACKGROUND: Aberrant methylation patterns of certain genes including tumor suppressors, a major epigenetic event, contribute mainly to tumorigenesis. Promoter CpG island methylation in Oxoglutarate dehydrogenase like (OGDHL) gene has been reported to reduce gene expression and hence apoptosis induction. This gene has been shown to be involved in colorectal cancer progression. In the present study, we investigated methylation status of OGDHL gene promoter in patients with colorectal cancer and evaluated its potential as a diagnostic biomarker...
March 16, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30910226/controlling-nutritional-status-score-a-new-prognostic-indicator-for-patients-with-oligometastatic-prostate-cancer
#5
Wentao Zhang, Yuan Wu, Ziwei Zhang, Yadong Guo, Ruiliang Wang, Longsheng Wang, Shiyu Mao, Junfeng Zhang, Xudong Yao
The Controlling Nutritional Status (CONUT) score is associated with prognosis in a variety of cancers, but the association with prognosis in oligometastatic prostate cancer has not been reported. And the effect of the CONUT score on the prognosis of prostate cancer was not compared with the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR). A total of 94 patients who underwent surgery for oligometastatic prostate cancer from January 2015 to December 2017 were retrospectively analyzed...
March 15, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30898366/axillary-web-syndrome-incidence-pathogenesis-and-management
#6
REVIEW
Konstantinos Dinas, Matthias Kalder, Leonidas Zepiridis, Georgios Mavromatidis, Georgios Pratilas
Axillary web syndrome (AWS) refers to the development of fibrotic bands or "cords" in the axilla of patients who have undergone axillary lymph node dissection for breast cancer. We review the incidence, pathogenesis, risk factors, and management of AWS. AWS is a common complication in patients who undergo axillary lymph node dissection. Even though AWS is self-limited in most cases, it causes significant morbidity. The optimal management of AWS is unclear but physiotherapy appears to be beneficial...
March 15, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30827742/pseudoprogression-on-treatment-with-immune-checkpoint-inhibitors-in-patients-with-gastrointestinal-malignancies-case-series-and-short-literature-review
#7
Vasiliki Michalarea, Elisa Fontana, Alvaro Ingles Garces, Anja Williams, Elizabeth C Smyth, Simona Picchia, Sheela Rao, Ian Chau, David Cunningham, Maria Antonietta Bali
Gastrointestinal cancers are very common cancers with colorectal being the fourth most common type, gastric the sixth, and esophageal the tenth. Although recent advances have been made in management including incorporation of antiangiogenic, anti-EGFR, and anti-HER2 directed therapies, overall their prognosis remains poor. Anti-PD-1 therapy with nivolumab and pembrolizumab are licensed for advanced chemorefractory gastroesophageal cancer and many other checkpoint inhibitor therapies are being assessed alone and in combination in these diseases...
February 21, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30826126/young-age-onset-colorectal-cancer-in-brazil-analysis-of-incidence-clinical-features-and-outcomes-in-a-tertiary-cancer-center
#8
Andrea C B Silva, Maria Fernanda B Vicentini, Elizabeth Z Mendoza, Fernanda K Fujiki, Leonardo G da Fonseca, Maria Ignez F M Braghiroli, Paulo M Hoff
BACKGROUND: Recent studies report increasing incidence of colorectal cancer (CRC) in the young-age population, but data concerning clinical behavior, pathologic findings, and prognosis are controversial for this group. Early recognition of CRC in young patients is a challenge and diagnosis at advanced stage is clearly associated with worse outcomes. MATERIALS AND METHODS: We retrospectively reviewed medical records of 5806 patients diagnosed with CRC between January/2011 and November/2016 and identified 781 patients aged less than 50-years-old...
February 20, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30777344/comparative-effectiveness-study-of-single-high-dose-cisplatin-with-fractionated-doses-cisplatin-in-first-line-therapy-for-treatment-naive-chinese-patients-with-advanced-non-small-cell-lung-cancer
#9
Xiaoyou Li, Xia Zhao, Muhammad Abbas, Li Wang, Chenchen Li, Siwen Liu, Jifeng Feng, Meiqi Shi
BACKGROUND: Cisplatin is one of the most effective chemotherapeutic drugs for patients with advanced non-small-cell lung cancer (NSCLC). Single high-dose cisplatin is a commonly used chemotherapy regimen in the world. At present, fractionated doses cisplatin is used in most hospitals in China. Although many doctors have begun to try a single dose of cisplatin, there are still few studies on the comparison of the 2 regimens. This study describes the efficacy and side effects of cisplatin single-dose administration and fractionated doses regimen in the treatment of advanced NSCLC...
February 13, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30770127/a-tumor-board-report-of-an-83-year-old-woman-with-stage-ib-grade-3-endometrioid-endometrial-adenocarcinoma
#10
LETTER
Stephanie Alimena, Steven Fiascone, Carolyn Krasner, Martin King, Neil Horowitz
An 83-year-old woman presented with postmenopausal bleeding ultimately leading to surgery and a final diagnosis of stage IB grade 3 endometrioid endometrial adenocarcinoma. The tumor board reviewed current literature regarding the efficacy of sentinel lymph node dissection in appropriately allocating stage in high-grade endometrial cancer. The optimal role of adjuvant treatment in this setting is unclear. Current literature surrounding adjuvant radiation and chemotherapy, as well as current practices in molecular diagnostics for endometrial cancer were reviewed...
February 7, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30738577/breast-cancer-after-multiple-myeloma-treatment
#11
Ahmet Gulmez
Breast cancer is the most common cancer in women. In addition, it is the second leading cause of death after lung cancer.1 , 2 The prevalence of epidemiological studies in previous studies is 22%-26%. The risk of mortality due to breast cancer is around 18%.3 , 4 Multiple myeloma (MM) is a malignant disease of differentiated plasma cells. It is also the most common hematological neoplasm after lymphoma. Thirty five percent of MM patients are under the age of 65, 28% are between 65 and 74 of age and 37% are over the age of 75...
February 1, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30732924/cognitive-and-emotional-representations-of-pain-in-cancer-patients-at-an-inpatient-unit-and-home-palliative-care
#12
Agata Zdun-Ryżewska, Gabriela Chojnacka-Szawłowska, Krzysztof Basiński, Wojciech Leppert, Mikolaj Majkowicz
PURPOSE: To compare symptomatic treatment at inpatient palliative care unit and at home in terms of: pain intensity; negative impact of pain on functioning in different areas of life; and beliefs about pain (cognitive and emotional aspects according to Leventhal's theory). PATIENTS: The sample consisted of 74 cancer patients qualified for palliative care at an inpatient unit (N = 53) and at home (N = 21). METHODS: Brief Pain Inventory--Short Form (measurement of pain intensity and pain interference with daily activities), Karnofsky Scale (performance status), Illness Perception Questionnaire for cognitive and emotional representations and beliefs about pain, and Hospital Anxiety and Depression Scale...
January 31, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30709557/effectiveness-and-safety-of-combined-neurokinin-1-antagonist-aprepitant-treatment-for-multiple-day-anthracycline-induced-nausea-and-vomiting
#13
Quanfu Li, Yungaowa Wu, Wenjuan Wang, Shuqin Deng, Caihong Jiang, Feng Chen, Jun Zhao, Hui Li, Xiaojun Bai, Jixiang Hou, Lenggaowa Da, Lanzhen Zhao, Jiali Gao, Gaowa Jin
OBJECTIVE: To assess the safety and efficacy of combined neurokinin-1 antagonist aprepitant treatment for multiple-day anthracycline chemotherapy-induced nausea and vomiting. METHODS: One hundred patients with breast cancer from department of Medical Oncology of Ordos Central Hospital from June 2015 to February 2018 were selected and randomize subdivided into 2 groups. All cases received anthracycline (30 mg/m2 /d for pirarubicin or 45 mg/m2 /d for epirubicin) and cyclophosphamide adjuvant chemotherapy, along with either the standard therapy (dexamethasone and tropisetron) or the combined aprepitant therapy (aprepitant plus dexamethasone and tropisetron)...
January 23, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30686567/hepatosteatosis-may-predict-late-recurrence-of-breast-cancer-a-single-center-observational-study
#14
Tulay Kus, Havva Yesil Cinkir, Gokmen Aktas, Huseyin Abali
AIM: The positive energy balance and insulin resistance caused by weight gain, physical inactivity, poor dietary quality are linked to a decreased breast cancer (BC)-specific survival. The aim of the present study was to assess whether or not hepatosteatosis, which reflect underlying insulin resistance, has a predictive value on recurrence in patients with nonmetastatic BC. MATERIAL METHOD: All diagnosed nonmetastatic BC patients between 2005 and 2016 were included in this retrospective analysis...
January 23, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30685067/pericardial-effusion-due-to-pembrolizumab-induced-immunotoxicity-a-case-report-and-literature-review
#15
Suheil Albert Atallah-Yunes, Anis John Kadado, Myat Han Soe
The advent of immune checkpoint inhibitors has revolutionized cancer treatment. These novel agents have provided promising treatment options in patients with different types of cancers. One of these agents is pembrolizumab, which works by blocking the binding of T-lymphocytes to programmed cell death ligand 1 receptors on tumor cells, thus enabling immune activation of T-lymphocytes against tumor cells. Pembrolizumab is commonly used in metastatic nonsmall cell lung cancer and melanoma. However, despite the remarkable efficacy this agent has achieved, multiple immune-related adverse events have been reported including hepatitis, colitis, thyroid dysfunction, and pneumonitis...
January 18, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30685068/the-prognostic-effects-of-hyponatremia-and-hyperchloremia-on-postoperative-nsclc-patients
#16
Wei Li, Xiaowei Chen, Liguang Wang, Yu Wang, Cuicui Huang, Guanghui Wang, Jiajun Du
Electrolytic disorders are common in lung cancer patients. But the association between serum electrolytes levels and survival in patients undergoing lung cancer resections for non-small-cell lung cancer (NSCLC) has been poorly investigated. A retrospective study was conducted on consecutive postoperative NSCLC patients. Pearson's test was used to determine the association between serum sodium and chlorine levels and clinical characteristics, and cox regression and Kaplan-Meier model were applied to analyze risk factors on overall survival...
January 17, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30683325/vitamin-d-deficiency-in-cancer-patients-and-predictors-for-screening-d-onc-study
#17
Ali Alkan, Elif Berna Köksoy
INTRODUCTION: Vitamin D is a prohormone that is vital for calcium/phosphate balance, bone structure, and physiological functioning. Vitamin D deficiency (VDD) is an important clinical problem worldwide. However, there are no standardized protocols for screening of patients with a diagnosis of cancer. The purpose of this study is to define the prevalence of VDD in cancer patients and establish the predictors of VDD to address a specific group of patient for screening. MATERIAL/METHODS: The study was designed as a retrospective case-control study...
January 17, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30683324/hepatoid-adenocarcinoma-of-the-renal-pelvis-in-a-59-year-old-male-with-nephrolithiasis-case-report-and-review-of-the-literature
#18
Jun Huang, Ruilong Zhu, Ronghai Wu, Ronggang Li, Nan Yao, Shuo Deng
BACKGROUND: Hepatoid adenocarcinoma arising from urological system is extremely rare, and the pathogenesis and therapeutic regimen have been poorly understood. CASE REPORT: we report a unique case of ɑ-fetaprotein (AFP)-producing neoplasm of renal pelvis associated with nephrolithiasis. A 59-year-old male patient was diagnosed with right renal tumor and nephrolithiasis with no evidence of lesions in his digestive or reproductive system. He was successfully treated with right laparoscopic radical nephroureterectomy and lymph node dissection...
January 17, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30678988/yes-associated-protein-expression-in-paired-primary-and-local-recurrent-breast-cancer-and-its-clinical-significance
#19
Nianhua Ding, Ting Huang, Jiaqi Yuan, Jie Mao, Yumei Duan, Weihua Liao, Zhi Xiao
Yes-associated protein (YAP) protein acts as tumorigenic factor in many solid tumors, but the situation in breast cancer is under debate. Here, we would analyze its status in breast cancer. YAP expression in the 110 primary breast cancer and their paired local recurrent tumors was investigated. Clinicopathologic data for age, histologic grading, hormone status, lymph nodes and HER2 status were also gathered and analyzed. 46.4% (51/110) primary breast cancer tissues were positive for total YAP expression which was significantly higher than that in the recurrent tissues (10...
January 17, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30670303/diagnostic-accuracy-of-ca125-and-he4-in-ovarian-carcinoma-patients-and-the-effect-of-confounders-on-their-serum-levels
#20
Alshymaa A Ahmed, Ahmed M Abdou
OBJECTIVES: To evaluate the diagnostic accuracy of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in the prediction of malignant ovarian masses then to analyze the effect of personal criteria and medical diseases on this accuracy. STUDY DESIGN: This prospective study was performed in Zagazig University Hospital. The eligibility criteria for inclusion were; consecutive women, at any age ≥18 years, with established diagnosis of ovarian mass based on symptoms, signs, and imaging techniques...
January 16, 2019: Current Problems in Cancer
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