Spille Dorothee, G Sørensen, L R Olsen, J F Bastlund, F Sotty, D Belling, M H Olsen, T I Mathiesen, K Møller, F Larsen, P Birkeland
Microdialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human IgG, serum albumin, and hemoglobin was performed using two different catheters and perfusion fluids...
March 13, 2024: Neurochemical Research