journal
https://read.qxmd.com/read/38864944/the-role-of-ferroptosis-in-amyotrophic-lateral-sclerosis-treatment
#1
REVIEW
Le Yi Wang, Lei Zhang, Xin Yue Bai, Rong Rong Qiang, Ning Zhang, Qian Qian Hu, Jun Zhi Cheng, Yan Ling Yang, Yang Xiang
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a challenging treatment landscape, due to its complex pathogenesis and limited availability of clinical drugs. Ferroptosis, an iron-dependent form of programmed cell death (PCD), stands distinct from apoptosis, necrosis, autophagy, and other cell death mechanisms. Recent studies have increasingly highlighted the role of iron deposition, reactive oxygen species (ROS) accumulation, oxidative stress, as well as systemic Xc- and glutamate accumulation in the antioxidant system in the pathogenesis of amyotrophic lateral sclerosis...
June 12, 2024: Neurochemical Research
https://read.qxmd.com/read/38864943/neuroprotective-action-of-selected-natural-drugs-against-neurological-diseases-and-mental-disorders-potential-use-against-radiation-damage
#2
REVIEW
Akhlada, Nazia Siddiqui, Anurag, Alimuddin Saifi, Anuradha Kesharwani, Vipan Kumar Parihar, Alok Sharma
Exposure to radiation, ionizing and non-ionizing radiation, is a significant concern in modern society. The brain is the organ that is most sensitive to radiation exposure. This review describes how exposure to radiation can affect neurotransmitters in different brain regions, affecting brain function. This review covers neurodegenerative diseases such as Alzheimer's, Parkinson's, and neuroinflammation due to changes in neurons in the central nervous system, and the effects thereon of medicinal plants such as Allium cepa, Allium sativum, Centella asiatica, Coriandrum sativum, and Crocus sativus plants, used for centuries in traditional medicine...
June 12, 2024: Neurochemical Research
https://read.qxmd.com/read/38862727/both-enantiomers-of-2-hydroxyglutarate-modulate-the-metabolism-of-cultured-human-neuroblastoma-cells
#3
JOURNAL ARTICLE
Eduard Gondáš, Eva Baranovičová, Peter Bystrický, Jakub Šofranko, Andrea Evinová, Matúš Dohál, Zuzana Hatoková, Radovan Murín
Elevated levels of D-2-hydroxyglutarate (D-2HG) and L-2-hydroxyglutarate (L-2HG) in the brain are associated with various pathological conditions, potentially contributing to neurological symptoms and neurodegeneration. Previous studies on animal models have revealed their capability to interfere with several cellular processes, including mitochondrial metabolism. Both enantiomers competitively inhibit the enzymatic activity of 2-oxoglutarate-dependent dioxygenases. These enzymes also execute several signaling cascades and regulate the level of covalent modifications on nucleic acids or proteins, e...
June 12, 2024: Neurochemical Research
https://read.qxmd.com/read/38862726/idebenone-antagonizes-p53-mediated-neuronal-oxidative-stress-injury-by-regulating-cd38-sirt3-protein-level
#4
JOURNAL ARTICLE
Hao Xu, Ying Guo, Xiao-Jun Liu, Ying Liu, Shi Yin, Qi-Ying Bao, Ru Peng, Wei-Bo Tian, Ying-Yan Xia, Ling Gao, Jia-Mei Liu
Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD38) and Silent message regulator 3 (SIRT3) protein expression and possibly impacting SIRT3's ability to deacetylate Tumor protein p53 (P53). This study explores the relationship between CD38, SIRT3, and P53 in H2 O2 -injured HT22 cells treated with Idebenone. Apoptosis was detected using flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining after determining appropriate H2 O2 and Idebenone concentrations...
June 12, 2024: Neurochemical Research
https://read.qxmd.com/read/38856890/epigenetic-orchestration-of-neurodegenerative-disorders-a-possible-target-for-curcumin-as-a-therapeutic
#5
REVIEW
Shweta Tripathi, Bhawana
Epigenetic modulations play a major role in gene expression and thus are responsible for various physiological changes including age-associated neurological disorders. Neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's disease (HD), although symptomatically different, may share common underlying mechanisms. Most neurodegenerative diseases are associated with increased oxidative stress, aggregation of certain proteins, mitochondrial dysfunction, inactivation/dysregulation of protein degradation machinery, DNA damage and cell excitotoxicity...
June 10, 2024: Neurochemical Research
https://read.qxmd.com/read/38856889/role-of-brain-derived-neurotrophic-factor-and-related-therapeutic-strategies-in-central-post-stroke-pain
#6
REVIEW
Gayathri Rajamanickam, Andy Thiam Huat Lee, Ping Liao
Brain-derived neurotrophic factor (BDNF) is vital for synaptic plasticity, cell persistence, and neuronal development in peripheral and central nervous systems (CNS). Numerous intracellular signalling pathways involving BDNF are well recognized to affect neurogenesis, synaptic function, cell viability, and cognitive function, which in turn affects pathological and physiological aspects of neurons. Stroke has a significant psycho-socioeconomic impact globally. Central post-stroke pain (CPSP), also known as a type of chronic neuropathic pain, is caused by injury to the CNS following a stroke, specifically damage to the somatosensory system...
June 10, 2024: Neurochemical Research
https://read.qxmd.com/read/38856888/types-of-short-duration-electrical-stimulation-induced-efficiency-in-the-axonal-regeneration-and-recovery-comparative-in-vivo-study-in-rat-model-of-repaired-sciatic-nerve-and-its-tibial-branch-after-transection-injury
#7
JOURNAL ARTICLE
Sareh Naseri, Hosein Samaram, Nadia Naghavi, Morteza Behnam Rassouli, Maryam Mousavinezhad
The restoration of adequate function and sensation in nerves following an injury is often insufficient. Electrical stimulation (ES) applied during nerve repair can promote axon regeneration, which may enhance the likelihood of successful functional recovery. However, increasing operation time and complexity are associated with limited clinical use of ES. This study aims to better assess whether short-duration ES types (voltage mode vs. current mode) are able to produce enhanced regenerative activity following peripheral nerve repair in rat models...
June 10, 2024: Neurochemical Research
https://read.qxmd.com/read/38850437/the-role-and-mechanism-of-ambra1-mediated-mitophagy-in-tdcpp-exposed-mouse-hippocampal-neurons
#8
JOURNAL ARTICLE
Xiaowei Zhang, Chuzhi Lin, Hengfang Hu, Wei Zhao, Guanlin Li, Yun Xia, Nengzhou Chen
Tri(1,3-dichloro-2-propyl)phosphate (TDCPP) is one of the most widely used organophosphorus flame retardants in consumer products. TDCPP has been confirmed to be neurotoxic, but its mechanism has not been clarified and may be related to mitophagy. AMBRA1 can promote neurological autophagy, but whether AMBRA1 is involved in the mechanism of TDCPP-induced neurotoxicity has not been elucidated. In this study, the optimal neuronal damage model was established by exposing mice hippocampal neurons to TDCPP. Furthermore, on the basis of this model, siRNA was used to knock down AMBRA1...
June 8, 2024: Neurochemical Research
https://read.qxmd.com/read/38847910/lrrk2-kinase-inhibitor-pf-06447475-protects-drosophila-melanogaster-against-paraquat-induced-locomotor-impairment-life-span-reduction-and-oxidative-stress
#9
JOURNAL ARTICLE
Diana A Quintero-Espinosa, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Parkinson's disease (PD) is a complex multifactorial progressive neurodegenerative disease characterized by locomotor alteration due to the specific deterioration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). Mounting evidence shows that human LRRK2 (hLRRK2) kinase activity is involved in oxidative stress (OS)-induced neurodegeneration, suggesting LRRK2 inhibition as a potential therapeutic target. We report that the hLRRK2 inhibitor PF-06447475 (PF-475) prolonged lifespan, increased locomotor activity, maintained DAergic neuronal integrity, and reduced lipid peroxidation (LPO) in female Drosophila melanogaster flies chronically exposed to paraquat (PQ), a redox cycling compound, compared to flies treated with vehicle only...
June 7, 2024: Neurochemical Research
https://read.qxmd.com/read/38847909/anandamide-modulates-thermal-avoidance-in-caenorhabditis-elegans-through-vanilloid-and-cannabinoid-receptor-interplay
#10
JOURNAL ARTICLE
Marzieh Abdollahi, Jesus D Castaño, Jennifer Ben Salem, Francis Beaudry
Understanding the endocannabinoid system in C. elegans may offer insights into basic biological processes and potential therapeutic targets for managing pain and inflammation in human. It is well established that anandamide modulates pain perception by binding to cannabinoid and vanilloid receptors, regulating neurotransmitter release and neuronal activity. One objective of this study was to demonstrate the suitability of C. elegans as a model organism for assessing the antinociceptive properties of bioactive compounds and learning about the role of endocannabinoid system in C...
June 7, 2024: Neurochemical Research
https://read.qxmd.com/read/38844706/biomarkers-and-target-specific-small-molecule-drugs-in-alzheimer-s-diagnostic-and-therapeutic-research-from-amyloidosis-to-tauopathy
#11
REVIEW
Li Sheng, Rajiv Bhalla
Alzheimer's disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal deposition of β-amyloid and the accumulation of neurofibrillary tangles have been recognised as the two pathological hallmarks targeted by AD diagnostic imaging as well as therapeutics. With the progression of pathological studies, the two hallmarks and their related pathways have remained the focus of researchers who seek for AD diagnostic and therapeutic strategies in the past decades...
June 6, 2024: Neurochemical Research
https://read.qxmd.com/read/38839706/aerobic-exercise-ameliorates-cognitive-disorder-and-declined-oxidative-stress-via-modulating-the-nrf2-signaling-pathway-in-d-galactose-induced-aging-mouse-model
#12
JOURNAL ARTICLE
Guangjing Xie, Zixuan Xu, Feizhou Li, Meng Kong, Ping Wang, Yuping Shao
The aim of this research was to explore the potential of treadmill exercise in preventing brain aging and neurodegenerative diseases caused by oxidative stress, by studying its effects on D-galactose-induced mice and the mechanisms involved. The results showed that C57BL/6 mice induced with D-gal exhibited cognitive impairment and oxidative stress damage, which was ameliorated by treadmill exercise. The Morris water maze also showed that exercise improved cognitive performance in aging mice and alleviated hippocampal and mitochondrial damage...
June 6, 2024: Neurochemical Research
https://read.qxmd.com/read/38837094/vitamin-d-relieves-epilepsy-symptoms-and-neuroinflammation-in-juvenile-mice-by-activating-the-mtor-signaling-pathway-via-raf1-insights-from-network-pharmacology-and-molecular-docking-studies
#13
JOURNAL ARTICLE
Tiantian Lu, Xiuling Chen, Qin Zhang, Kun Shang, Xiaogui Yang, Wei Xiang
Epilepsy is a common neurological disorder, and the exploration of potential therapeutic drugs for its treatment is still ongoing. Vitamin D has emerged as a promising treatment due to its potential neuroprotective effects and anti-epileptic properties. This study aimed to investigate the effects of vitamin D on epilepsy and neuroinflammation in juvenile mice using network pharmacology and molecular docking, with a focus on the mammalian target of rapamycin (mTOR) signaling pathway. Experimental mouse models of epilepsy were established through intraperitoneal injection of pilocarpine, and in vitro injury models of hippocampal neurons were induced by glutamate (Glu) stimulation...
June 5, 2024: Neurochemical Research
https://read.qxmd.com/read/38837093/glur2-can-drive-neuroinflammation-and-cognitive-impairments-following-peripherally-repeated-lipopolysaccharide-exposures
#14
JOURNAL ARTICLE
Xue He, Xiao-Yi Hu, Xiao-Yu Yin, Xin-Miao Wu, Qing-Ren Liu, Jin-Chun Shen
Neuroinflammation is being increasingly recognized as a vital factor in the development of various neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an outer membrane component of gram-negative bacteria, can trigger innate immune responses, resulting in neuroinflammation and subsequent cognitive deficits. The expression of glutamate receptors (GluRs) on glial cells can induce glial activation. Therefore, we hypothesized that repeated LPS exposure can increase GluR levels, promoting microglial activation and ultimately affecting synaptic plasticity and cognitive function...
June 5, 2024: Neurochemical Research
https://read.qxmd.com/read/38837092/morphine-induced-neuroprotection-in-ischemic-stroke-by-activating-autophagy-via-mtor-independent-activation-of-the-jnk1-2-pathway
#15
JOURNAL ARTICLE
Wenying Chi, Yaru Huang, Peilong Li, Xia Wang, Junfa Li, Fanjun Meng
Morphine (Mor) has exhibited efficacy in safeguarding neurons against ischemic injuries by simulating ischemic/hypoxic preconditioning (I/HPC). Concurrently, autophagy plays a pivotal role in neuronal survival during IPC against ischemic stroke. However, the involvement of autophagy in Mor-induced neuroprotection and the potential mechanisms remain elusive. Our experiments further confirmed the effect of Mor in cellular and animal models of ischemic stroke and explored its potential mechanism. The findings revealed that Mor enhanced cell viability in a dose-dependent manner by augmenting autophagy levels and autophagic flux in neurons subjected to oxygen-glucose deprivation/reoxygenation (OGD/R)...
June 5, 2024: Neurochemical Research
https://read.qxmd.com/read/38837091/a-perspective-on-the-characterization-of-early-neural-progenitor-cell-derived-extracellular-vesicles-for-targeted-delivery-to-neuroblastoma-cells
#16
JOURNAL ARTICLE
Oğuz Kaan Kırbaş, Batuhan Turhan Bozkurt, Melis Rahime Yıldırım, Pakize Neslihan Taşlı, Hüseyin Abdik, Fikrettin Şahin, Ezgi Avşar Abdik
As an element of the cellular signaling systems, extracellular vesicles (EVs) exhibit many desirable traits for usage as targeted delivery vehicles. When administered, EVs cause little to no toxic or immune response, stay in circulation for longer periods compared to synthetic carriers, preferentially accumulate in tissues that are the same or similar to their cell-of-origin and can pass through the blood-brain barrier. Combined, these traits make neural EVs a particularly promising tool for delivering drugs to the brain...
June 5, 2024: Neurochemical Research
https://read.qxmd.com/read/38834846/raddeanin-a-protects-the-brb-through-inhibiting-inflammation-and-apoptosis-in-the-retina-of-alzheimer-s-disease
#17
JOURNAL ARTICLE
Xiao-Fang Wang, Xiao-Hong Xiang, Jing Wei, Peng-Bo Zhang, Qin Xu, Meng-Han Liu, Li-Qun Qu, Xing-Xia Wang, Lu Yu, An-Guo Wu, Da-Lian Qing, Jian-Ming Wu, Betty Yuen-Kwan Law, Chong-Lin Yu, Yong-Tang
Neuroinflammation and endothelial cell apoptosis are prominent features of blood-brain barrier (BBB) disruption, which have been described in Alzheimer's disease (AD) and can predict cognitive decline. Recent reports revealed vascular β-amyloid (Aβ) deposits, Muller cell degeneration and microglial dysfunction in the retina of AD patients. However, there has been no in-depth research on the roles of inflammation, retinal endothelial cell apoptosis, and blood-retinal barrier (BRB) damage in AD retinopathy...
June 4, 2024: Neurochemical Research
https://read.qxmd.com/read/38834845/neuroprotective-and-neurite-outgrowth-stimulating-effects-of-new-low-basicity-5-ht-7-receptor-agonists-in-vitro-study-in-human-neuroblastoma-sh-sy5y-cells
#18
JOURNAL ARTICLE
Klaudia Jakubowska, Adam S Hogendorf, Sławomir Gołda, Danuta Jantas
There is some evidence that the serotonin receptor subtype 7 (5-HT7 ) could be new therapeutic target for neuroprotection. The aim of this study was to compare the neuroprotective and neurite outgrowth potential of new 5-HT7 receptor agonists (AH-494, AGH-238, AGH-194) with 5-CT (5-carboxyamidotryptamine) in human neuroblastoma SH-SY5Y cells. The results revealed that 5-HT7 mRNA expression was significantly higher in retinoic acid (RA)-differentiated cells when compared to undifferentiated ones and it was higher in cell cultured in neuroblastoma experimental medium (DMEM) compared to those placed in neuronal (NB) medium...
June 4, 2024: Neurochemical Research
https://read.qxmd.com/read/38834844/dl-3-n-butylphthalide-ameliorates-post-stroke-emotional-disorders-by-suppressing-neuroinflammation-and-panoptosis
#19
JOURNAL ARTICLE
Yanhui Cui, Zhaolan Hu, Laifa Wang, Bi Zhu, Ling Deng, Hui Zhang, Xueqin Wang
Post-stroke emotional disorders such as post-stroke anxiety and post-stroke depression are typical symptoms in patients with stroke. They are closely associated with poor prognosis and low quality of life. The State Food and Drug Administration of China has approved DL-3-n-butylphthalide (NBP) as a treatment for ischemic stroke (IS). Clinical research has shown that NBP alleviates anxiety and depressive symptoms in patients with IS. Therefore, this study explored the role and molecular mechanisms of NBP in cases of post-stroke emotional disorders using network pharmacology and experimental validation...
June 4, 2024: Neurochemical Research
https://read.qxmd.com/read/38834843/ferritinophagy-and-ferroptosis-in-cerebral-ischemia-reperfusion-injury
#20
REVIEW
Xiaoyue Liu, Canming Xie, Yao Wang, Jing Xiang, Litong Chen, Jia Yuan, Chutao Chen, Haomei Tian
Cerebral ischemia-reperfusion injury (CIRI) is the second leading cause of death worldwide, posing a huge risk to human life and health. Therefore, investigating the pathogenesis underlying CIRI and developing effective treatments are essential. Ferroptosis is an iron-dependent mode of cell death, which is caused by disorders in iron metabolism and lipid peroxidation. Previous studies demonstrated that ferroptosis is also a form of autophagic cell death, and nuclear receptor coactivator 4(NCOA4) mediated ferritinophagy was found to regulate ferroptosis by interfering with iron metabolism...
June 4, 2024: Neurochemical Research
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