Li Luo, Saiying Wang, Wenna Liu, Zimei Zhang, Minggao Zhao, An Liu
Narirutin (Nar) is a flavonoid that is abundantly present in citrus fruits and has attracted considerable attention because of its diverse pharmacological activities and low toxicity. Here, we evaluated the preventive effects of Nar in middle cerebral artery occlusion/reperfusion (MCAO/R)-injured mice and oxygen-glucose deprivation/reperfusion (OGD/R)-injured bEnd.3 cells. Pretreatment with Nar (150 mg/kg) for 7 days effectively reduced infarct volume, improved neurological deficits, and significantly inhibited neuronal death in the hippocampus and cortex in MCAO/R-injured mice...
December 4, 2023: Neurochemical Research
Miguel Ángel Velázquez-Flores, Gustavo Sánchez-Chávez, Sara L Morales-Lázaro, Ruth Ruiz Esparza-Garrido, Alejandro Canizales-Ontiveros, Rocío Salceda
In the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain; however, the glycine receptor involvement in diabetic neuropathy has not been reported. We determined the expression of the glycine receptor subunits (α1-α3 and β) in streptozotocin-induced diabetic Long-Evans rats by qPCR and Western blot. The total mRNA and protein expression (whole spinal cord homogenate) of the α1, α3, and β subunits did not change during diabetes; however, the α2 subunit mRNA, but not the protein, was overexpressed 45 days after diabetes induction...
November 29, 2023: Neurochemical Research
Qingyang Zhan, Fanyi Kong, Shuai Shao, Bo Zhang, Shuming Huang
Depression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its underlying mechanism remains unclear. Recent investigations have revealed that several pathophysiological changes associated with Alzheimer's disease can lead to mood disorders. These alterations include irregularities in monoamine neurotransmitters, disruptions in glutamatergic synaptic transmission, neuro-inflammation, dysfunction within the hypothalamic-pituitary-adrenocortical (HPA) axis, diminished levels of brain-derived neurotrophic factor (BDNF), and hippocampal atrophy...
November 28, 2023: Neurochemical Research
Zhongni Li, Feng Zhang, Li Huang, Jiehong Deng, Yutong Pan, Ting Xu, Jingyi Liu, Na Gao, Rongrong Duan, Chunyan Shao, Chan Wu, Minrong Wang, Liqun Lu
White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter development in neonatal rats with WMD...
November 28, 2023: Neurochemical Research
Zohreh Ghotbeddin, Mohsen Peysokhan, Anahita Memar Dezfouli, Mohammad Asadi Iraee
Cisplatin, a chemotherapy drug containing platinum, is considered a neurotoxic agent. On the other hand, crocin, the primary component of saffron, possesses neuroprotective and antioxidant properties. In this study, 28 healthy adult male Wistar rats weighing 200-250 g were used (6-7 weeks old). Rats were divided into a control group (Ctr), a crocin group (Cro), a cisplatin group (Cis), and a crocin with cisplatin group (Cro + Cis). Rotarod, open field, and shuttle box tests were performed to assess balance, explorative behavior, and avoidance memory...
November 27, 2023: Neurochemical Research
Tongtong Zhang, Lina Feng, Jie Cui, Weiwei Tong, Han Zhao, Tingchao Wu, Pu Zhang, Xianjun Wang, Yingjun Gao, Jing Su, Xiaoyan Fu
Hexavalent chromium (Cr (VI)), one of the most detrimental pollutants, has been ubiquitously present in the environment and causes serious toxicity to humans, such as hepatotoxicity, nephrotoxicity, pulmonary toxicity, and cardiotoxicity. However, Cr (VI)-induced neurotoxicity in primary neuron level has not been well explored yet. Herein, potassium dichromate (K2 Cr2 O7 ) was employed to examine the neurotoxicity of Cr (VI) in rat primary hippocampal neurons. MTT test was used to examine the neural viability...
November 27, 2023: Neurochemical Research
Raed AlRuwaili, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naif H Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batiha
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and α-Synuclein (α-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway...
November 25, 2023: Neurochemical Research
Huan Gao, Xiaoqian Liu, Lulu Xie, Bo Tan, Ruibin Su
Hallucinogenic 5-HT2A receptor (5-HT2A R) agonists-induced head-twitch response (HTR) is regulated by Gs signaling pathway. Formation of heterodimers between 5-HT2A R and metabotropic glutamate mGlu2 receptor (mGluR2) is essential for the hallucinogenic 5-HT2A R agonist-induced HTR. In order to investigate the effects of mGluR2 agonists and inverse agonists on hallucinogenic 5-HT2A R agonists DOM-induced HTR, C57BL/6 mice were pretreated with mGluR2 agonists (LY379268, LY354740, LY404039) or the inverse agonist LY341495, and the HTR was manually counted after administering DOM immediately...
November 21, 2023: Neurochemical Research
Muhammed Mehdi Üremiş, Nuray Üremiş, Mehmet Gül, Semir Gül, Yılmaz Çiğremiş, Merve Durhan, Yusuf Türköz
Acrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in fried and baked carbohydrate-rich foods. ACR is regarded as a typical axonal neurotoxin that induces neuropathy. The brain is protected from oxidative damage by vitamin E, which is regarded as the most powerful fat-soluble antioxidant vitamin. This study aimed to reveal the toxic effect of ACR on the development of myelin in the brain at the molecular level and to examine whether Vitamin E has a neuroprotective effect on the harmful effect of ACR...
November 21, 2023: Neurochemical Research
Yuhan Wang, Wenchao Cheng, Xiuying Chen, Chang Cheng, Lan Zhang, Wen Huang
Neuroinflammation is assumed as the critical pathophysiologic mechanism of white matter lesions (WMLs), and infiltrated peripheral monocyte-derived macrophages are implicated in the development of neuroinflammation. This study sought to explore the blood molecules that promote the migration of peripheral monocytes to the sites of WMLs. The serum protein expression profiles of patients and Sprague-Dawley rat models with WMLs were detected by data-independent acquisition (DIA) proteomics technique. Compared with corresponding control groups, we acquired 62 and 41 differentially expressed proteins (DEPs) in the serum of patients and model rats with WMLs respectively...
November 17, 2023: Neurochemical Research
Rafie Belali, Seyyed Ali Mard, Seyed Esmaeil Khoshnam, Kowsar Bavarsad, Alireza Sarkaki, Yaghoob Farbood
Sleep deprivation increases stress, anxiety, and depression by altering the endocannabinoid system's function. In the present study, we aimed to investigate the anti-anxiety and anti-depressant effects of the endocannabinoid anandamide (AEA) in the chronic sleep deprivation (SD) model in rats. Adult male Wistar rats (200-250 g) were randomly divided into three groups: control + vehicle (Control), chronic sleep deprivation + vehicle (SD), and chronic sleep deprivation + 20 mg/kg AEA (SD + A)...
November 15, 2023: Neurochemical Research
Cheng Zhao, Zhuo Chen, Xu Lu, Wenfeng Hu, Rongrong Yang, Qun Lu, Bingran Chen, Chao Huang
In recent years, the decline of microglia in the hippocampus has been shown to play a role in the development of depression, and its reversal shows marked antidepressant-like effects. β-glucan is a polysaccharide from Saccharomyces cerevisiae and has numerous beneficial effects on the nervous system, including improving axon regeneration and cognition. Considering its immuno-stimulatory activities in cultured microglia and brain tissues, we hypothesize that β-glucan may be a potential candidate to correct the functional deficiency of microglia and thereby alleviate depression-like behaviors in chronically stressed animals...
November 14, 2023: Neurochemical Research
Yanmei Chen, Xiaotao Zhou, Boling Chu, Qunqun Xie, Zhenkun Liu, Di Luo, Jichuan Zhang
Autophagy is a conserved lysosomal degradation process that has recently been found to be associated with stress-related psychological diseases. However, previous studies have yielded inconsistent results regarding the effects of various stress patterns on autophagy in different brain regions. This discrepancy may arise from differences in autophagy flux across nuclei, the type of stress experienced, and the timing of autophagy assessment after stress exposure. In this study, we assessed autophagy flux in the rat hippocampus (HPC), medial prefrontal cortex (mPFC), and basal lateral amygdala (BLA) by quantifying protein levels of p-ULK1, LC3-I, LC3-II, and p62 via Western blot analysis at 15 min, 30 min, and 60 min following various stress paradigms: restraint stress, foot shock, single corticosterone injection, and chronic corticosterone treatment...
November 13, 2023: Neurochemical Research
Hui-Li Li, Rui-Juan Guo, Zhang-Ran Ai, Song Han, Yun Guan, Jun-Fa Li, Yun Wang
Previous studies suggested that postsynaptic neuroligin-2 may shift from inhibitory toward excitatory function under pathological pain conditions. We hypothesize that nerve injury may increase the expression of spinal MAM-domain GPI-anchored molecule 1 (MDGA1), which can bind to neuroligin-2 and thereby, alter its interactions with postsynaptic scaffolding proteins and increase spinal excitatory synaptic transmission, leading to neuropathic pain. Western blot, immunofluorescence staining, and co-immunoprecipitation studies were conducted to examine the critical role of MDGA1 in the lumbar spinal cord dorsal horn in rats after spinal nerve ligation (SNL)...
November 13, 2023: Neurochemical Research
Mansoureh Tavan, Parichehr Hanachi, María de la Luz Cádiz-Gurrea, Antonio Segura Carretero, Mohammad Hossein Mirjalili
Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in recent years, driven by their various biological activities and therapeutic efficacy in human health...
November 8, 2023: Neurochemical Research
Susu Lin, Ziwei Chen, Zhaoruncheng Wu, Fei Fei, Zijin Xu, Yingpeng Tong, Wenyu Sun, Ping Wang
The current first-line antidepressants have the drawback of slow onset, which greatly affects the treatment of depression. Crocetin, one of the main active ingredients in saffron (Crocus sativus L.), has been demonstrated to have antidepressant activities, but whether it has a rapid antidepressant effect remains unclear. This study aimed to investigate the onset, duration, and mechanisms of the rapid antidepressant activity of crocetin (20, 40 and 80 mg/kg, intraperitoneal injection) in male mice subjected to chronic restraint stress (CRS)...
November 7, 2023: Neurochemical Research
Jiahua Yang, Chenchen Du, Yinghui Li, Rong Liu, Cuiting Jing, Junxia Xie, Jun Wang
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of iron in the substantia nigra. While iron accumulation and inflammation are implicated in PD pathogenesis, their impact on oligodendrocytes, the brain's myelin-forming cells, remains elusive. This study investigated the influence of interleukin-1β (IL-1β), an elevated proinflammatory cytokine in PD, on iron-related proteins in MO3.13 oligodendrocytes. We found that IL-1β treatment in undifferentiated MO3...
November 2, 2023: Neurochemical Research
Jie Gao, Wei Liu, Jiaqi Liu, Niping Hao, Jing Pei, Lifeng Zhang
Aluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer's disease (AD). We uesd a subchronic aluminum chloride exposure model in offspring rats by continuously treating them with AlCl3 solution from the date of birth until day 90 in this research. Then evaluated the neurobehavioral changes in rats, observed the ultrastructural changes of hippocampal synapses and neurons, and examined the level of hippocampal acetylated histone H3 (H3ac), the activity and protein expression of hippocampal HAT1 and G9a, and the protein expression level of H3K9 dimethylation (H3K9me2)...
October 28, 2023: Neurochemical Research
Andrei N Tsentsevitsky, Venera F Khuzakhmetova, Ellya A Bukharaeva, Alexey M Petrov
α2-Adrenoreceptors (ARs) are main Gi -protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely used sedative. We hypothesize that α2-ARs are also potent regulators of neuromuscular transmission via G protein-gated inwardly rectifying potassium (GIRK) channels. Using extracellular microelectrode recording of postsynaptic potentials, we found DEX-induced inhibition of spontaneous and evoked neurotransmitter release as well as desynchronization of evoked exocytotic events in the mouse diaphragm neuromuscular junction...
October 28, 2023: Neurochemical Research
Ru Liu, Lei Sun, Xiaorui Shi, Ci Li, Xi Guo, Yingting Wang, Xiu Wang, Kai Zhang, Yongjun Wang, Qun Wang, Jianping Wu
Recent studies have indicated that functional abnormalities in the KNa 1.2 channel are linked to epileptic encephalopathies. However, the role of KNa 1.2 channel in traumatic brain injury (TBI) remains limited. We collected brain tissue from the TBI mice and patients with post-traumatic epilepsy (PTE) to determine changes in KNa 1.2 channel following TBI. We also investigated whether the MAPK pathway, which was activated by the released cytokines after injury, regulated KNa 1.2 channel in in vitro. Finally, to elucidate the physiological significance of KNa 1...
October 25, 2023: Neurochemical Research
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