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JOURNAL ARTICLE
Stephen M Ansell
DISEASE OVERVIEW: Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 8570 new patients annually and representing ~10% of all lymphomas in the United States. DIAGNOSIS: HL is composed of two distinct disease entities: classical HL and nodular lymphocyte predominant HL (also called nodular lymphocyte predominant B-cell lymphoma). Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich HL are subgroups of classical HL...
September 6, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Frédéric Baron, Myriam Labopin, Jurjen Versluis, Jan Vydra, Peter A von dem Borne, Emma Nicholson, Didier Blaise, Rachel Protheroe, Alexander Kulagin, Claude Eric Bulabois, Montserrat Rovira, Patrice Chevallier, Edouard Forcade, Jenny Byrne, Jaime Sanz, Annalisa Ruggeri, Mohamad Mohty, Fabio Ciceri
The best donor option for acute myeloid leukemia (AML) patients lacking an HLA-matched donor has remained intensively debated. We herein report the results of a large retrospective registry study comparing hematopoietic cell transplantation (HCT) outcomes between double-unit umbilical cord blood transplantation (dCBT, n = 209) versus 9/10 HLA-matched unrelated donor (UD) with posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis (UD 9/10, n = 270) in patients with AML in first complete remission (CR1)...
August 31, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Eli Muchtar, Morie A Gertz, Raphael Mwangi, Hamza Hassan, Angela Dispenzieri, Nelson Leung, Francis K Buadi, David Dingli, Andrew Staron, Vaishali Sanchorawala
Renal AL amyloidosis can be complicated by end-stage renal disease (ESRD) requiring renal replacement therapy (RRT). In this study, we describe the long-term outcomes of renal AL amyloidosis patients undergoing autologous stem cell transplantation (ASCT) and assess the utility of the renal staging system. Retrospective study of renal AL patients (n = 697; Mayo Clinic, Boston University) who underwent ASCT between 2003 and 2020. Renal stage was assigned based on 24-h proteinuria and estimated glomerular filtration rate measurements...
August 29, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Hui Chong Lau, Sinead M Sinnott, Shady Abohashem, Giovanni Civieri, Wesam Aldosoky, Krystel Karam, Maria Khalil, Iqra Qamar, Rachel P Rosovsky, Michael T Osborne, Ahmed Tawakol, Antonia V Seligowski
Depression and anxiety are linked to deep venous thrombosis (DVT) and posttraumatic disorder (PTSD) increases risk of venous thromboembolism in women. However, the mechanisms underlying this relationship remain unknown. We hypothesized that PTSD would associate with increased DVT risk, that neuroimmune mechanisms would mediate the PTSD-DVT link, and that these associations would be stronger in women. This cohort study included N = 106 427 participants from a large biobank. PTSD and DVT were defined using ICD-10 codes...
August 29, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Yuekun Qi, Hujun Li, Kunming Qi, Feng Zhu, Hai Cheng, Wei Chen, Zhiling Yan, Depeng Li, Wei Sang, Xiaoming Fei, Weiying Gu, Yuqing Miao, Hongming Huang, Ying Wang, Tingting Qiu, Jianlin Qiao, Bin Pan, Ming Shi, Gang Wang, Zhenyu Li, Junnian Zheng, Kailin Xu, Jiang Cao
Relapsed/refractory multiple myeloma patients with extramedullary disease (EMD) have unfavorable prognosis and lack effective therapy. Chimeric antigen receptor (CAR) T-cell activities in EMD have yet to be determined; how EMD-specific microenvironment influences the clinical outcomes of CAR T-cell therapy remains of great interest. In this prospective cohort study, patients with histologically confirmed extra-osseous EMD were enrolled and treated with combined anti-BCMA and anti-CD19 CAR T-cell therapy from May 2017 to September 2023...
August 28, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Michael Keith Alister Zimmerman, Lindsay Wilde
No abstract text is available yet for this article.
August 28, 2024: American Journal of Hematology
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LETTER
Wei-Ying Jen, Elias Jabbour, Nicholas J Short, Ghayas C Issa, Fadi G Haddad, Nitin Jain, Naveen Pemmaraju, Naval G Daver, Lucia Masarova, Gautam Borthakur, Kelly Chien, Rebecca Garris, Hagop M Kantarjian
Twenty adults with newly diagnosed (ND) or relapsed/refractory (RR) Ph-positive acute lymphoblastic leukemia (ALL), or chronic myeloid leukemia in lymphoid blast phase (CML-LBP), were treated with mini-hyperCVD, ponatinib, and blinatumomab. Complete molecular response was achieved in 78% of ND patients, while CR/CRi was achieved in 100% of RR and CML-LBP. The 3-year overall survival rate was 76% (95% CI, 47%-90%).
August 28, 2024: American Journal of Hematology
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LETTER
Mariam A Mostafa, Martin Zand, Jeremy Taylor, Peter Kouides
No abstract text is available yet for this article.
August 23, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Biswadip Hazarika, Barbara J Bain
No abstract text is available yet for this article.
August 23, 2024: American Journal of Hematology
#10
JOURNAL ARTICLE
Austin Kulasekararaj, Francesco Lanza, Alexandros Arvanitakis, Saskia Langemeijer, Satheesh Chonat, Anil Tombak, Vladimir Hanes, Jia Cao, Mieke Jill Miller, Alexander Colbert, Benjamin Shander, Daniel T Mytych, Vincent Chow, Haby Henary
ABP 959 is a biosimilar to the eculizumab reference product (RP), which is approved for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). This multicenter, randomized, double-blind, active-controlled, two-period crossover study randomized eculizumab RP-treated patients with PNH to one of two treatment sequences (ABP 959/eculizumab RP or eculizumab RP/ABP 959) to evaluate the clinical similarity of ABP 959 when compared with eculizumab RP. This study evaluated the efficacy of ABP 959 when compared with eculizumab RP based on control of intravascular hemolysis as measured by lactate dehydrogenase (LDH) and by the time-adjusted area under the effect curve of LDH...
August 22, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Laurent Garderet, Luuk Gras, Linda Koster, Laurien Baaij, Nada Hamad, Anita Dsouza, Noel Estrada-Merly, Parameswaran Hari, Wael Saber, Andrew J Cowan, Minako Iida, Shinichiro Okamoto, Hiroyuki Takamatsu, Shohei Mizuno, Koji Kawamura, Yoshihisa Kodera, Bor-Sheng Ko, Christopher Liam, Kim Wah Ho, A Sim Goh, S Keat Tan, Alaa M Elhaddad, Ali Bazarbachi, Qamar Un Nisa Chaudhry, Rozan Alfar, Mohamed-Amine Bekadja, Malek Benakli, Cristobal Augusto Frutos Ortiz, Eloisa Riva, Sebastian Galeano, Francisca Bass, Hira S Mian, Arleigh McCurdy, Feng Rong Wang, Ly Meng, Daniel Neumann, Mickey Koh, John A Snowden, Stefan Schönland, Donal P McLornan, Patrick John Hayden, Anna Sureda, Hildegard T Greinix, Mahmoud Aljurf, Yoshiko Atsuta, Dietger Niederwieser
Autologous hematopoietic cell transplantation (AHCT) is a commonly used treatment in multiple myeloma (MM). However, real-world global demographic and outcome data are scarce. We collected data on baseline characteristics and outcomes from 61 725 patients with newly diagnosed MM who underwent upfront AHCT between 2013 and 2017 from nine national/international registries. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS), relapse incidence (RI) and non-relapse mortality (NRM)...
August 19, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Cavan Bennett, Anne Pettikiriarachchi, Alistair R D McLean, Rebecca Harding, Marnie E Blewitt, Cyril Seillet, Sant-Rayn Pasricha
Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic iron status. Circadian regulation (endogenous ~24-h periodic oscillation of a biologic function) governs many critical physiologic processes. It is unknown whether serum iron levels are regulated by circadian machinery; likewise, the circadian nature of key players of iron homeostasis is unstudied. Here we show that serum iron, transferrin saturation (TSAT), hepatic transferrin receptor (TFR1) gene (Tfrc) expression, and erythropoietic activity exhibit circadian rhythms...
August 17, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Jay Gunawardana, Soi C Law, Muhammed B Sabdia, Éanna Fennell, Aoife Hennessy, Ciara I Leahy, Paul G Murray, Karolina Bednarska, Sandra Brosda, Judith Trotman, Leanne Berkahn, Andreea Zaharia, Simone Birch, Melinda Burgess, Dipti Talaulikar, Justina N Lee, Emily Jude, Eliza A Hawkes, Sanjiv Jain, Karthik Nath, Cameron Snell, Fiona Swain, Joshua W D Tobin, Colm Keane, Mohamed Shanavas, Emily Blyth, Christian Steidl, Kerry Savage, Pedro Farinha, Merrill Boyle, Barbara Meissner, Michael R Green, Francisco Vega, Maher K Gandhi
In classical Hodgkin lymphoma (cHL), responsiveness to immune-checkpoint blockade (ICB) is associated with specific tumor microenvironment (TME) and peripheral blood features. The role of ICB in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is not established. To gain insights into its potential in NLPHL, we compared TME and peripheral blood signatures between HLs using an integrative multiomic analysis. A discovery/validation approach in 121 NLPHL and 114 cHL patients highlighted >2-fold enrichment in programmed cell death-1 (PD-1) and T-cell Ig and ITIM domain (TIGIT) gene expression for NLPHL versus cHL...
August 17, 2024: American Journal of Hematology
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LETTER
Qiudan Shen, Elias J Jabbour, Guilin Tang, Hong Fang, Wei Wang, Nicholas J Short, M James You, L Jeffrey Medeiros, Shimin Hu
No abstract text is available yet for this article.
August 17, 2024: American Journal of Hematology
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LETTER
Jeffrey H Lipton
No abstract text is available yet for this article.
August 14, 2024: American Journal of Hematology
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JOURNAL ARTICLE
Jeremy W Jacobs, Caroline G Stanek, Garrett S Booth, Argiris Symeonidis, Andrew W Shih, Elizabeth S Allen, Eleni Gavriilaki, Brenda J Grossman, Katerina Pavenski, Amy Moorehead, Flora Peyvandi, Pasquale Agosti, Ilaria Mancini, Laura D Stephens, Jay S Raval, Maria Eva Mingot-Castellano, Elizabeth P Crowe, Laetitia Daou, Menaka Pai, Donald M Arnold, Marisa B Marques, Ryan Henrie, Tyler W Smith, Gayatri Sreenivasan, Rance C Siniard, Lisa R Wallace, Chisa Yamada, Miriam Andrea Duque, Yanyun Wu, Thomas J Harrington, Diana M Byrnes, Aikaterini Bitsani, Amanda K Davis, Danielle H Robinson, Quentin Eichbaum, Cristina A Figueroa Villalba, Justin E Juskewitch, Georgia Kaiafa, Eleni Kapsali, Ellen Klapper, Ingrid Perez-Alvarez, Monica S Klein, Nikolaos Kotsiou, Chrysavgi Lalayanni, Evdokia Mandala, Fatima Aldarweesh, Rahaf Alkhateb, Lisandro Fortuny, Zois Mellios, Apostolia Papalexandri, Meredith G Parsons, Annette J Schlueter, Christopher A Tormey, Cameron Wellard, Erica M Wood, Shiyang Jia, Allison P Wheeler, Amy A Powers, Christopher B Webb, Sean G Yates, Raïda Bouzid, Paul Coppo, Evan M Bloch, Brian D Adkins
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed the epidemiology of iTTP and determined whether it displays a seasonal pattern. Patients with both initial and relapsed iTTP (defined as a disintegrin and metalloprotease with thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada, France, Greece, Italy, Spain, and the US were included...
August 13, 2024: American Journal of Hematology
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REVIEW
Philippe Connes, Emeric Stauffer, Robert I Liem, Elie Nader
Sickle cell disease (SCD) is a genetic disorder characterized by complex pathophysiological mechanisms leading to vaso-occlusive crisis, chronic pain, chronic hemolytic anemia, and vascular complications, which require considerations for exercise and physical activity. This review aims to elucidate the safety, potential benefits, and recommendations regarding exercise and training in individuals with SCD. SCD patients are characterized by decreased exercise capacity and tolerance. Acute intense exercise may be accompanied by biological changes (acidosis, increased oxidative stress, and dehydration) that could increase the risk of red blood cell sickling and acute clinical complications...
August 12, 2024: American Journal of Hematology
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EDITORIAL
Christin B DeStefano, Nicholas Burwick, Drew A Helmer
No abstract text is available yet for this article.
August 9, 2024: American Journal of Hematology
#19
LETTER
Layla Van Doren, Carlo Brugnara
No abstract text is available yet for this article.
August 9, 2024: American Journal of Hematology
#20
LETTER
Samer Al Hadidi, Obada Ababneh, Carolina Schinke, Sharmilan Thanendrarajan, Clyde Bailey, Guido Tricot, John Shaughnessy, Fenghuang Zhan, Jeffrey Sawyer, Eric R Siegel, Maurizio Zangari, Bart Barlogie, Frits van Rhee
No abstract text is available yet for this article.
August 7, 2024: American Journal of Hematology
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