journal
https://read.qxmd.com/read/38760992/bcr-abl-testing-in-the-evaluation-of-neutrophilia
#1
LETTER
Caleb J Smith, Gordon J Ruan, Lindsey Ann Kluck, Mackenzie Maberry, Ronald S Go
No abstract text is available yet for this article.
May 17, 2024: American Journal of Hematology
https://read.qxmd.com/read/38757754/infections-in-patients-with-chronic-lymphocytic-leukemia-treated-with-time-limited-targeted-drug-combinations
#2
LETTER
Petra Langerbeins, Adam Giza, Sandra Robrecht, Paula Cramer, Julia von Tresckow, Othman Al-Sawaf, Anna Maria Fink, Moritz Fürstenau, Arnon Kater, Ellen van der Spek, Carsten Utoft Niemann, Caspar da Cunha-Bang, Eugen Tausch, Christof Schneider, Stephan Stilgenbauer, Kirsten Fischer, Michael Hallek, Barbara Eichhorst
No abstract text is available yet for this article.
May 17, 2024: American Journal of Hematology
https://read.qxmd.com/read/38757717/paving-the-path-for-ongoing-clinical-research-and-education-in-post-retirement-age
#3
JOURNAL ARTICLE
Tiziano Barbui
No abstract text is available yet for this article.
May 17, 2024: American Journal of Hematology
https://read.qxmd.com/read/38752378/new-partners-for-luspatercept-in-%C3%AE-thalassemia
#4
JOURNAL ARTICLE
Francesca Vinchi
No abstract text is available yet for this article.
May 16, 2024: American Journal of Hematology
https://read.qxmd.com/read/38752375/association-of-mpl-k39n-and-r102p-heterozygous-germline-mutations-lead-to-hereditary-thrombocytosis
#5
LETTER
Emeline Voirin, Anne Bouvier, Isabelle Plo, Léa Durix, Annaëlle Beucher, Stephane Giraudier, Valérie Ugo, Jean-François Brasme, Damien Luque Paz
No abstract text is available yet for this article.
May 16, 2024: American Journal of Hematology
https://read.qxmd.com/read/38752374/improving-healthspan-among-people-with-sickle-cell-disease-leveraging-precision-health-in-an-era-of-treatments-with-curative-intent
#6
EDITORIAL
Elaine A Yu, Helena U Zacharias, Shannon Kelly, Elliott Vichinsky
No abstract text is available yet for this article.
May 16, 2024: American Journal of Hematology
https://read.qxmd.com/read/38752361/aspirin-use-in-essential-thrombocythemia-once-daily-or-twice-daily-or-not-at-all
#7
EDITORIAL
Ayalew Tefferi, Tiziano Barbui
Asprin dosing strategy in low risk (young and JAK2 mutated without history of thrombosis) or very low risk (young JAK2 wild-type without history of thrombosis) essential thrombocythemia.
May 16, 2024: American Journal of Hematology
https://read.qxmd.com/read/38751104/combination-therapy-with-hypomethylating-agents-and-venetoclax-versus-intensive-induction-chemotherapy-in-idh1-or-idh2-mutant-newly-diagnosed-acute-myeloid-leukemia-a-multicenter-cohort-study
#8
LETTER
Jan Philipp Bewersdorf, Shai Shimony, Rory M Shallis, Yiwen Liu, Guillaume Berton, Eva J Schaefer, Amer M Zeidan, Aaron Goldberg, Eytan Stein, Guido Marcucci, Rebecca P Bystrom, R Coleman Lindsley, Evan C Chen, Jorge Ramos, Anthony Stein, Vinod Pullarkat, Ibrahim Aldoss, Daniel J DeAngelo, Donna S Neuberg, Richard M Stone, Sylvain Garciaz, Brian Ball, Maximilian Stahl
No abstract text is available yet for this article.
May 15, 2024: American Journal of Hematology
https://read.qxmd.com/read/38747646/pregnancy-in-acquired-bone-marrow-failure-syndromes-antenatal-management-and-maternal-and-fetal-outcomes
#9
LETTER
Marta Bortolotti, Roochi Trikha, Sarah Salter, Joanna Large, Evangelia Vlachodimitropoulou, Shreyans Gandhi, Wilma Barcellini, Jemma Johns, Bruno Fattizzo, Austin Kulasekararaj
No abstract text is available yet for this article.
May 15, 2024: American Journal of Hematology
https://read.qxmd.com/read/38747543/three-dimensional-telomere-profiling-predicts-risk-of-progression-in-smoldering-multiple-myeloma
#10
JOURNAL ARTICLE
Shaji Kumar, S Vincent Rajkumar, Dragan Jevremovic, Robert A Kyle, Yulia Shifrin, Michelle Nguyen, Zahabiya Husain, Asieh Alikhah, Anita Jafari, Sabine Mai, Kenneth Anderson, Sherif Louis
Smoldering multiple myeloma (SMM) is a precursor stage that precedes multiple myeloma (MM). SMM is heterogenous with nearly 40% of patients progressing to MM in the first 5 years. The high rate of progression of SMM patients highlights the need for early intervention, which underscores the importance of identifying SMM patients with the highest risk of progression. Several risk stratification models showed utility in identifying high-risk SMM patients; however, these systems showed limited sensitivity...
May 15, 2024: American Journal of Hematology
https://read.qxmd.com/read/38742955/impact-of-busulfan-versus-treosulfan-dose-intensity-in-myelofibrosis-undergoing-hematopoietic-cell-transplantation
#11
JOURNAL ARTICLE
Nico Gagelmann, Claudia Schuh, Sarah Flossdorf, Desiree Kunadt, Matthias Stelljes, Igor W Blau, Arne Brecht, Wolfgang Bethge, Thomas Schroeder, Gerald Wulf, Elisa Sala, Gesine Bug, Katharina Fleischhauer, Nicolaus Kröger
One key aspect of allogeneic hematopoietic cell transplantation (HCT) is pretransplant conditioning, balancing risk for relapse versus non-relapse mortality. Conditioning regimens with different alkylators at different doses can influence outcome, but data are missing for myelofibrosis, a challenging cohort of patients usually presenting at older age and with comorbidities. We evaluated in a multicenter retrospective study the comparative efficacy and safety of busulfan versus treosulfan in combination with fludarabine for myelofibrosis patients undergoing HCT...
May 14, 2024: American Journal of Hematology
https://read.qxmd.com/read/38742870/intravenous-immunoglobulin-as-a-rescue-therapy-for-severe-adult-autoimmune-hemolytic-anemia-results-from-a-french-multicenter-observational-study
#12
LETTER
M Michel, M Saïr, E Rivière, G Moulis, T Comont, N Costedoat-Chalumeau, C Pouchelon, D Boutboul, A Benyamine, A Bert, P-Y Jeandel, S Hamrouni, N Belfeki, H Lobbes, A Dossier, D Gobert, M Mahevas, B Godeau, Y Gallien, M Ebbo
No abstract text is available yet for this article.
May 14, 2024: American Journal of Hematology
https://read.qxmd.com/read/38733355/cost-effectiveness-of-sutimlimab-in-cold-agglutinin-disease
#13
JOURNAL ARTICLE
Satoko Ito, Daniel Wang, Adriana Purcell, Karthik Chetlapalli, Alfred I Lee, Adam Cuker, George Goshua
Primary cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia caused by cold-reactive antibodies that bind to red blood cells and lead to complement-mediated hemolysis. Patients with primary CAD experience the burden of increased health resource utilization and reduced quality of life. The standard-of-care (SOC) in patients with primary CAD has included cold avoidance, transfusion support, and chemoimmunotherapy. The use of sutimlimab, a humanized monoclonal antibody that selectively inhibits C1-mediated hemolysis, was shown to reduce transfusion-dependence and improve quality of life across two pivotal phase 3 studies, further supported by 2-year extension data...
May 11, 2024: American Journal of Hematology
https://read.qxmd.com/read/38733340/azathioprine-hydroxyurea-preconditioning-prior-to-nonmyeloablative-matched-sibling-donor-hematopoietic-stem-cell-transplantation-in-adults-with-sickle-cell-disease-a-prospective-observational-cohort-study
#14
JOURNAL ARTICLE
Elisabeth Dovern, Mesire Aydin, Mette D Hazenberg, Man Wai Tang, Elisabeth M Suijk, Gerianne M Hoogendoorn, Charlotte F J Van Tuijn, Jean-Louis Kerkhoffs, Caroline E Rutten, Sacha S Zeerleder, Josu de la Fuente, Bart J Biemond, Erfan Nur
Nonmyeloablative, matched sibling donor hematopoietic stem cell transplantation with alemtuzumab/total body irradiation (TBI) conditioning is a curative therapy with low toxicity for adults with sickle cell disease (SCD). However, relatively low donor chimerism levels and graft rejection remain important challenges. We hypothesized that adding azathioprine/hydroxyurea preconditioning will improve donor chimerism levels and reduce graft failure rate. In this prospective cohort study, we enrolled consecutive adult patients with SCD undergoing matched sibling donor transplantation at the Amsterdam UMC...
May 11, 2024: American Journal of Hematology
https://read.qxmd.com/read/38727145/clinical-and-biological-characterization-of-involvement-of-nasal-associated-lymphoid-tissues-in-chronic-lymphocytic-leukemia
#15
LETTER
Thimali Ranaweera Arachchige, Catherine Mendiburu, Antoine Martin, Carole Fleury, Elisabetta Dondi, Rémi Letestu, Virginie Eclache, Fanny Baran-Marszak, Florence Cymbalista, Gregory Lazarian
No abstract text is available yet for this article.
May 10, 2024: American Journal of Hematology
https://read.qxmd.com/read/38727135/ponatinib-review-of-historical-development-current-status-and-future-research
#16
REVIEW
Hagop M Kantarjian, Helen T Chifotides, Fadi G Haddad, Nicholas J Short, Sanam Loghavi, Elias Jabbour
Ponatinib is a third-generation BCR::ABL1 tyrosine kinase inhibitor (TKI) with high potency against Philadelphia chromosome (Ph)-positive leukemias, including T315I-mutated disease, which is resistant to first- and second-generation TKIs. Ponatinib was approved for T315I-mutated chronic myeloid leukemia (CML), CML resistant/intolerant to ≥2 prior TKIs, advanced phase CML and Ph-positive acute lymphoblastic leukemia (ALL) where no other TKIs are indicated, and T315I-mutated CML and Ph-positive ALL. The response-based dosing of ponatinib in chronic phase CML (CP-CML) improved treatment tolerance and reduced the risk of toxicities, including cardiovascular risks...
May 10, 2024: American Journal of Hematology
https://read.qxmd.com/read/38712755/correction-to-benefit-of-axicabtagene-ciloleucel-vs-chemoimmunotherapy-in-older-patients-and-or-patients-with-poor-ecog-performance-status-with-relapsed-or-refractory-large-b-cell-lymphoma-after-2-or-more-lines-of-prior-therapy
#17
https://read.qxmd.com/read/38712616/dendritic-cell-vaccines-extend-car-t-cell-persistence-and-improve-the-efficacy-of-cd19-car-t-cell-therapy-in-refractory-or-relapsed-adult-b-all-patients
#18
LETTER
Sanfang Tu, Lijuan Zhou, Rui Huang, Xuan Zhou, Jilong Yang, Yanjie He, Yuxing Hu, Honghao Zhang, Xiaoling Xie, Yuhua Li
No abstract text is available yet for this article.
May 7, 2024: American Journal of Hematology
https://read.qxmd.com/read/38712615/clinically-meaningful-improvements-in-patient-reported-outcomes-in-mitapivat-treated-patients-with-pyruvate-kinase-deficiency
#19
LETTER
Kevin H M Kuo, Rachael F Grace, Eduard J van Beers, Wilma Barcellini, Andreas Glenthøj, Susanne Holzhauer, Vanessa Beynon, Susan Morris, Junlong Li, Erin Zagadailov, Parija Patel, Hanny Al-Samkari
Clinically meaningful benefits in the signs, symptoms, and impacts of #PKDeficiency as assessed by disease-specific patient-reported outcome measures were observed in mitapivat-treated adult patients in two phase 3 clinical trials.
May 7, 2024: American Journal of Hematology
https://read.qxmd.com/read/38708915/unswitched-memory-b-cell-deficiency-in-children-with-sickle-cell-disease-and-response-to-pneumococcal-polysaccharide-vaccine
#20
JOURNAL ARTICLE
Venée N Tubman, Daniel Maysonet, Norma Estrada, Tripti Halder, Lindsey Ramos, Sameera Bhamidipati, Alexandre F Carisey, Charles G Minard, Carl E Allen
Early mortality in sickle cell disease (SCD) is attributed to increased infections due to loss of splenic function. Marginal zone B cells are important for initial opsonization of pathogens and can be absent in spleen histopathology in SCD. The frequency of unswitched memory B cells (UMBC), the circulating correlate of marginal zone B cells, reflects the immunologic function of the spleen. We hypothesized that asplenia in SCD is associated with alterations in the peripheral blood lymphocyte population and explored whether UMBC deficiency was associated with a clinical phenotype...
May 6, 2024: American Journal of Hematology
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