Marilyn M Bui, Michael W Riben, Kimberly H Allison, Elizabeth Chlipala, Carol Colasacco, Andrea G Kahn, Christina Lacchetti, Anant Madabhushi, Liron Pantanowitz, Mohamed E Salama, Rachel L Stewart, Nicole E Thomas, John E Tomaszewski, M Elizabeth Hammond
CONTEXT.—: Advancements in genomic, computing, and imaging technology have spurred new opportunities to use quantitative image analysis (QIA) for diagnostic testing. OBJECTIVE.—: To develop evidence-based recommendations to improve accuracy, precision, and reproducibility in the interpretation of human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) for breast cancer where QIA is used. DESIGN.—: The College of American Pathologists (CAP) convened a panel of pathologists, histotechnologists, and computer scientists with expertise in image analysis, immunohistochemistry, quality management, and breast pathology to develop recommendations for QIA of HER2 IHC in breast cancer...
January 15, 2019: Archives of Pathology & Laboratory Medicine