journal
Journals Archives of Pathology & Labora...

Archives of Pathology & Laboratory Medicine

https://read.qxmd.com/read/38749502/genetic-landscape-and-its-prognostic-impact-in-children-with-langerhans-cell-histiocytosis
#1
JOURNAL ARTICLE
Chan-Juan Wang, Lei Cui, Shuang-Shuang Li, Hong-Hao Ma, Dong Wang, Hong-Yun Lian, Yun-Ze Zhao, Li-Ping Zhang, Wei-Jing Li, Qing Zhang, Xiao-Xi Zhao, Ying Yang, Xiao-Tong Huang, Wei Liu, Yi-Zhuo Wang, Wan-Shui Wu, Tian-You Wang, Rui Zhang, Zhi-Gang Li
CONTEXT.—: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm that predominantly affects young children. OBJECTIVE.—: To investigate genetic alterations and their correlation with clinical characteristics and prognosis in pediatric LCH. DESIGN.—: We performed targeted sequencing to detect mutations in LCH lesions from pediatric patients. RESULTS.—: A total of 30 genomic alterations in 5 genes of the MAPK pathway were identified in 187 of 223 patients (83...
May 16, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38749501/zmiz1-abl1-fusion-an-uncommon-molecular-event-with-clinical-implications-in-pediatric-cancer
#2
JOURNAL ARTICLE
Kevin T A Booth, Rachael R Schulte, Laurin Smith, Hongyu Gao, Ryan A Stohler, Yunlong Liu, Shalini C Reshmi, Gail H Vance
CONTEXT.—: Pediatric B-cell acute lymphoblastic leukemia is genetically and phenotypically heterogeneous, with a genetic landscape including chromosomal translocations that disrupt ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1). OBJECTIVE.—: To characterize an uncommon chromosomal translocation in acute leukemia. DESIGN.—: Genetic testing, including karyotype and fluorescence in situ hybridization (FISH) analysis, was used to determine the underlying genetic aberration driving the disorder and to guide disease classification and risk stratification...
May 16, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38740387/laboratory-considerations-for-releasing-next-generation-sequencing-data-to-patients
#3
JOURNAL ARTICLE
Ann Moyer, Eric Loo, Evan Cadoff, Eric Konnick, Helena Duncan, Jaimie Halley, Katherine Hermina, Patricia Vasalos, Joel T Moncur, Sophia Yohe
CONTEXT.—: Title 45, section 164.524 of the Code of Federal Regulations states that health care systems must provide patient health records upon that patient's request. For complex testing, such as next-generation sequencing (NGS), this raises questions related to what data should be released and the laboratory considerations regarding the release of this data. OBJECTIVE.—: To describe the laboratory implications of releasing different NGS data files and the limitations for the clinical use of different NGS data files...
May 14, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38736213/intraoperative-frozen-section-evaluation-of-pancreatic-specimens-and-related-liver-lesions
#4
JOURNAL ARTICLE
Jennifer Vazzano, Wei Chen, Wendy L Frankel
CONTEXT.—: Frozen sections are essential in the surgical management of patients, especially those with pancreatic masses, because frozen sections can provide answers intraoperatively and aid in treatment decisions. Pancreas frozen sections are challenging because of the small tissue size, processing artifacts, neoadjuvant treatment effects, and concurrent pancreatitis-like obstructive changes. The authors present a review of intraoperative evaluation of pancreatic specimens. OBJECTIVES...
May 13, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38724033/development-of-a-scoring-rubric-assessing-medical-students-explanations-of-pathology-reports
#5
JOURNAL ARTICLE
Felisha M Davis, Jonathan Bowling, Ashish T Khanchandani, Michael C Larkins, Dmitry Tumin, Sunil Badami, Ahmed K Alomari, Shoujun Chen, Moiz Vora, Yaolin Zhou
CONTEXT.—: With increasing availability of immediate patient access to pathology reports, it is imperative that all physicians be equipped to discuss pathology reports with their patients. No validated measures exist to assess how pathology report findings are communicated during patient encounters. OBJECTIVE.—: To pilot a scoring rubric evaluating medical students' communication of pathology reports to standardized patients. DESIGN...
May 10, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38724031/localized-urinary-bladder-amyloidosis-as-urothelial-cancer-mimicker
#6
JOURNAL ARTICLE
Aayushma Regmi, Maitri Mehta, Ahmer V Farooq, Thomas M Turk, Eva M Wojcik, Maria M Picken
CONTEXT.—: Localized amyloidosis of the bladder is rare and often mimics bladder malignancy. It is typically associated with the extracellular deposition of monoclonal light chains, either κ or λ. The cause is unknown, but it is thought to be due to chronic inflammation/cystitis. OBJECTIVE.—: To highlight the importance of localized urinary bladder amyloidosis as a rare mimicker of urothelial malignancy and elucidate its clinical, histopathologic, and cytopathologic manifestations...
May 10, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38670546/notable-histologic-findings-in-a-normal-cohort
#7
JOURNAL ARTICLE
Philip A Branton, Leslie Sobin, Mary Barcus, Kelly B Engel, Sarah R Greytak, Ping Guan, Jim Vaught, Helen M Moore
CONTEXT.—: The National Institutes of Health (NIH) Genotype-Tissue Expression (GTEx) project was designed to evaluate how genetic variation and epigenetic effects influence gene expression in normal tissue. OBJECTIVE.—: To ensure that the grossly normal-appearing tissues collected were free from disease, each specimen underwent histologic evaluation. DESIGN.—: In total, nearly 30 000 tissue aliquots collected from almost 1000 postmortem donors underwent histologic review by project pathologists, and detailed observations of any abnormalities or lesions present were recorded...
April 27, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38649152/screening-and-diagnosis-of-rare-thalassemia-variants
#8
JOURNAL ARTICLE
Haishen Tang, Yi Xiong, Jiaqi Tang, Xiaohong Wang, Ya Wang, Liping Huang, Runli Wang, Degang Wang
CONTEXT.—: Rare thalassemia subtypes are often undiagnosed because conventional testing methods can only identify 23 common types of α- and β-thalassemia. OBJECTIVE.—: To assess a comprehensive approach for the screening and diagnosis of rare thalassemia. DESIGN.—: The study cohort included 72 individuals with suspected rare thalassemia variants. Screening was conducted by next-generation sequencing (NGS) combined with third-generation sequencing (TGS) and chromosomal microarray analysis (CMA)/copy number variation sequencing...
April 23, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38649149/democratizing-artificial-intelligence-in-anatomic-pathology
#9
JOURNAL ARTICLE
Thomas J Flotte, Stephanie A Derauf, Rachel K Byrd, Trynda N Kroneman, Debra A Bell, Lucas Stetzik, Seung-Yi Lee, Alireza Samiei, Steven N Hart, Joaquin J Garcia, Gillian Beamer, Thomas Westerling-Bui
CONTEXT.—: Artificial intelligence is a transforming technology for anatomic pathology. Involvement within the workforce will foster support for algorithm development and implementation. OBJECTIVE.—: To develop a supportive ecosystem that enables pathologists with variable expertise in artificial intelligence to create algorithms in a development environment with seamless transition to a production environment. RESULTS.—: The development team considered internal development and vended solutions...
April 23, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38649148/clinicopathological-correlates-of-pit1-and-sf1-multilineage-pituitary-neuroendocrine-tumors-and-the-diagnostic-utility-of-nkx2-2-immunohistochemistry-in-pituitary-pathology
#10
JOURNAL ARTICLE
Fatih Mert Doğukan, Hüseyin Karatay, Sabahattin Yüzkan, Şebnem Burhan, Buruç Erkan, Banu Yılmaz-Özgüven
CONTEXT.—: PIT1 and SF1-multilineage pituitary neuroendocrine tumors (PitNETs) have been defined since the classification of adenohypophysial tumors based on the PIT1, SF1, and TPIT transcription factors. OBJECTIVE.—: To describe the clinicopathologic features of PIT1 and SF1-multilineage PitNETs and to contribute to the pituitary pathology practice by questioning the expression of NKX2.2 in PitNETs. DESIGN.—: We reviewed 345 PitNETs and described the clinicopathologic features of 8 PIT1 and SF1-multilineage tumors...
April 23, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38631690/estrogen-receptor-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-rates-in-invasive-breast-carcinoma-a-study-of-21-institutions
#11
JOURNAL ARTICLE
Daniel D Mais, Alia N Nazarullah, Anthony J Guidi, Suzanne Dintzis, Barbara J Blond, Thomas A Long, Suzanne N Coulter, Richard W Brown
CONTEXT.—: Laboratories performing predictive marker testing for breast carcinoma are encouraged to compare patient results to published benchmarks. OBJECTIVE.—: To collect expression rates for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) in invasive breast carcinoma from multiple laboratories. DESIGN.—: Participants submitted data from up to 50 primary cases during the study period...
April 18, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38631685/the-presence-of-small-size-circulating-tumor-cells-predicts-worse-prognosis-in-non-small-cell-lung-cancer-patients
#12
JOURNAL ARTICLE
Qianqian Sun, Weiqing Li, Donghua Yang, Peter Ping Lin, Lina Zhang, Huiqin Guo
CONTEXT.—: Most patients with non-small cell lung cancers (NSCLC) are diagnosed at advanced stages. The 5-year survival rate of patients with advanced lung cancer is less than 20%, which makes lung cancer the leading cause of cancer-related deaths worldwide. OBJECTIVE.—: To identify indicators that can predict the prognosis of lung cancer patients. DESIGN.—: To determine the correlation between circulating tumor cells (CTCs), circulating tumor-derived endothelial cells (CTECs), and their subtypes and the prognosis of patients with NSCLC, 80 patients with lung cancer were recruited and 48 patients who met the enrollment criteria were selected in this study...
April 18, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38625026/programmed-death-ligand-1-and-tumor-mutation-burden-testing-of-patients-with-lung-cancer-for-selection-of-immune-checkpoint-inhibitor-therapies-guideline-from-the-college-of-american-pathologists-association-for-molecular-pathology-international-association
#13
JOURNAL ARTICLE
Lynette M Sholl, Mark Awad, Upal Basu Roy, Mary Beth Beasley, Richard Walter Cartun, David M Hwang, Gregory Kalemkerian, Fernando Lopez-Rios, Mari Mino-Kenudson, Ajit Paintal, Kearin Reid, Lauren Ritterhouse, Lesley A Souter, Paul E Swanson, Christina B Ventura, Larissa V Furtado
CONTEXT.—: Rapid advancements in the understanding and manipulation of tumor-immune interactions have led to the approval of immune therapies for patients with non-small cell lung cancer. Certain immune checkpoint inhibitor therapies require the use of companion diagnostics, but methodologic variability has led to uncertainty around test selection and implementation in practice. OBJECTIVE.—: To develop evidence-based guideline recommendations for the testing of immunotherapy/immunomodulatory biomarkers, including programmed death ligand-1 (PD-L1) and tumor mutation burden (TMB), in patients with lung cancer...
April 16, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38599590/ten-years-of-pathology-on-twitter-x-landscape-and-evolution-of-pathology-on-twitter-from-2012-to-2023
#14
JOURNAL ARTICLE
Roland Tian, Eric Wang, Priyadharshini Sivasubramaniam, Swikrity U Baskota, Anurag Sharma, Matthew J Cecchini
CONTEXT.—: Social media is a powerful tool in pathology education and professional networking that connects pathologists and pathology trainees from around the world. Twitter (X) appears to be the most popular social media platform pathologists use to share pathology-related content and connect with other pathologists. Although there has been some published research on pathology-related activity on Twitter during short time frames, to date there has not been published research examining pathology-related Twitter activity in totality from its earliest days of activity to recently...
April 11, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38599589/the-interplay-between-human-leukocyte-antigen-antibody-profile-and-covid-19-vaccination-in-waitlisted-renal-transplant-patients
#15
JOURNAL ARTICLE
Yayuan Zhao, Pramath Kakodkar, Henry Pan, Richard Zhu, Khalid Musa, Abubaker Hassan, Ahmed Shoker, Destinie Webster, Twyla Pearce, Pouneh Dokouhaki, Fang Wu, Ahmed Mostafa
CONTEXT.—: Mass COVID-19 vaccination is mandated in vulnerable populations in our renal transplant waitlist cohort. However, the anti-human leukocyte antigen (anti-HLA) profile after COVID-19 vaccination is controversial, and the side effects are yet to be discerned. OBJECTIVE.—: To evaluate the status of HLA antibodies in waitlist renal transplant patients before and 3 weeks after each vaccination and if comorbidities are associated with the HLA antibody profile...
April 11, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38586983/guidelines-for-pathologic-diagnosis-of-mesothelioma
#16
JOURNAL ARTICLE
Aliya N Husain, David B Chapel, Richard Attanoos, Mary Beth Beasley, Luka Brcic, Kelly Butnor, Lucian R Chirieac, Andrew Churg, Sanja Dacic, Francoise Galateau-Salle, Kenzo Hiroshima, Yin P Hung, Sonja Klebe, Thomas Krausz, Andras Khoor, Leslie Litzky, Alberto Marchevsky, Kazuki Nabeshima, Andrew G Nicholson, Elizabeth N Pavlisko, Anja C Roden, Victor Roggli, Jennifer L Sauter, Jefree J Schulte, Michael Sheaff, William D Travis, Ming-Sound Tsao, Ann E Walts, Thomas V Colby
CONTEXT.—: Mesothelioma is an uncommon tumor that can be difficult to diagnose. OBJECTIVE.—: To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. DATA SOURCES.—: Pathologists involved in the International Mesothelioma Interest Group and others with expertise in mesothelioma contributed to this update. Reference material includes peer-reviewed publications and textbooks. CONCLUSIONS...
April 8, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38576236/clinically-undiagnosed-diseases-in-autopsies-frequency-and-risk-factors
#17
JOURNAL ARTICLE
Umberto Maccio, Christoph Andreas Meier, Michael Reinehr, Frank Ruschitzka, Reto Schüpbach, Holger Moch, Zsuzsanna Varga
CONTEXT.—: Autopsies can reveal clinically undiagnosed diseases. However, the frequency of first diagnoses at autopsy and their association with clinically known risk factors are not well understood because of lack of systematic analyses addressing this topic. OBJECTIVE.—: To perform a large retrospective cohort analysis on the frequency of clinically undiagnosed postmortem findings and correlate these with patients' risk factors. DESIGN...
April 5, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38576208/is-fragmentation-of-prostate-core-biopsies-inevitable-a-quality-improvement-initiative
#18
JOURNAL ARTICLE
Krithika Shenoy, Richard J Cote, Gayathri Kini, Mary Anthes-Bartlow, Vijayalakshmi Padmanabhan
CONTEXT.—: Core biopsies are standard of care for diagnosis and surveillance of prostate cancer. Fragmentation makes numeric assessment of cancer challenging and increases risk of inaccurate staging with direct implications on management. OBJECTIVE.—: To determine factors responsible for fragmentation at our institution. DESIGN.—: Prostate core biopsies performed at 2 hospital sites during 1 week were prospectively identified...
April 5, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38576184/therapeutic-drug-monitoring-of-6-new-generation-antiseizure-medications-using-a-mass-spectrometry-method-analysis-of-2-year-experience-in-a-large-cohort-of-korean-epilepsy-patients
#19
JOURNAL ARTICLE
Sang-Mi Kim, Won Young Heo, Hyeonju Oh, Eun Yeon Joo, Young-Min Shon, Seung Bong Hong, Soo-Youn Lee, Dae-Won Seo
CONTEXT.—: New-generation antiseizure medications (ASMs) are increasingly prescribed, and therapeutic drug monitoring (TDM) has been proposed to improve clinical outcome. However, clinical TDM data on new-generation ASMs are scarce. OBJECTIVE.—: To develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for therapeutic drug monitoring (TDM) of 6 new-generation ASMs in serum and analyze the clinical TDM data from a large cohort of Korean patients with epilepsy...
April 5, 2024: Archives of Pathology & Laboratory Medicine
https://read.qxmd.com/read/38569599/high-grade-transformation-and-carcinosarcoma
#20
JOURNAL ARTICLE
Anuj Verma, Raja R Seethala, He Wang
CONTEXT.—: High-grade transformation, previously known as dedifferentiation, in salivary gland carcinoma and carcinosarcoma ex pleomorphic adenoma is a rare phenomenon. It is, however, clinically relevant and affects treatment and prognosis. OBJECTIVE.—: To review the existing literature, describe the histologic and immunophenotypic features, and highlight the diagnostic criteria of high-grade transformation in various salivary gland carcinomas and carcinosarcoma; to review its effect on clinical presentation and prognosis; and to review relevant molecular characteristics and recent concepts and advances...
April 4, 2024: Archives of Pathology & Laboratory Medicine
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