Allison Cushman-Vokoun, Ryan J Schmidt, Matthew Charles Hiemenz, Mark Fung, Bing Melody Zhang, Georganne Bradshaw, Manish Gandhi, JinJuan Yao, Sophia Yohe, Amy Beckman, Wayne W Grody, Petros Giannikopoulos
CONTEXT—: Gene editing-based therapies are currently in development in the areas of oncology, inherited disease, and infectious disease. These potentially life-altering therapies are derived from decades of research in both academic and industry settings that developed technologies rooted in principles and products of nature. However, with such technologic developments come many important considerations, including adverse risks, high cost, and ethical questions. OBJECTIVE—: To educate pathologists about gene editing technologies, inform them of potential indications and risks, outline regulatory and practical issues that could affect hospital-based practice and laboratory testing, and advocate that pathologists need to be present at discussions among industry and regulators pertaining to gene editing-based therapies...
August 22, 2023: Archives of Pathology & Laboratory Medicine