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Journals Indian Journal of Pathology & ...

Indian Journal of Pathology & Microbiology

https://read.qxmd.com/read/38769818/jejunal-strongyloidiasis-mimicking-crohn-s-colitis-a-diagnostic-dilemma
#1
JOURNAL ARTICLE
Surbhi Goyal, Sandip Barman, Puja Sakhuja, Sanjeev Sachdeva, Poonam Narang, Hirdaya H Nag
We report an unusual case of jejunal strongyloidiasis presenting as chronic malabsorption and intractable small bowel diarrhea in an immunocompetent adolescent boy who posed a diagnostic challenge for pathologists, radiologists, and gastroenterologists. Histopathology revealed chronic active colitis and was consistent with the clinicoradiological diagnosis of Crohn's colitis but nonresponse to immunomodulators warranted full-thickness jejunal biopsy through laparotomy which showed numerous larvae and eggs of Strongyloides...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727689/tumor-necrosis-serves-as-an-important-pathological-characteristic-of-stage-i-ii-colon-cancer
#2
JOURNAL ARTICLE
Shuhui Dong, Jin Xu, Mingshan Li, Guangyi Xiong, Ruilin Wang
BACKGROUND: The long-term prognosis of colon cancer patients remains little changed with relatively high mortality and morbidity. Since the most widely used prognostic parameter TNM staging system is less satisfactory in predicting prognosis in early-stage cancers, numerous clinicopathological factors, including tumor necrosis, have been proposed for prognosis stratification, but substantial evidences are still lacking for early-stage colon cancer. MATERIALS AND METHODS: In the retrospective study, a total of eligible 173 stage I-II colon cancer patients, who received tumor radical resection and lymphadenectomy in the local hospital between January 1, 2010, and December 31, 2018, were enrolled for analyzing the prognostic role of tumor necrosis...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727673/mama-path-expressing-experience-of-pathologists-with-a-subtle-difference
#3
JOURNAL ARTICLE
Archana Shetty
No abstract text is available yet for this article.
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727512/il-6-and-msh3-in-colorectal-carcinoma-expression-relationship-and-prognostic-significance-in-171-colorectal-carcinoma-cases
#4
JOURNAL ARTICLE
Elif Kolay Bayram, Betul Ogut, Mehmet Arda Inan, Ayse Dursun
AIMS: Colorectal cancer (CRC), the most common type of gastrointestinal cancer, mostly develops as a result of environmental factors. Inflammation is a relatively uncommon but crucial contributor to its etiology, and inflammation is also thought to pose a risk in patients without a clinical diagnosis of inflammatory bowel disease. In cell lines, the proinflammatory cytokine interleukin-6 (IL-6) causes a cytosolic shift in the mismatch repair protein MSH3, accompanied by functional loss...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727423/challenges-in-the-diagnosis-and-management-of-autoimmune-hemolytic-anemia-a-case-based-approach-experience-from-a-tertiary-care-hospital-in-the-haryana-region
#5
JOURNAL ARTICLE
Geetika Sharma, Shilpi More, Saroj Rajput, Nimisha Sharma, Sonu Choudhary, Tathagata Chatterjee
BACKGROUND: Autoimmune hemolytic anemia (AIHA) is a rare immune disorder which occurs when antibodies are directed against self red blood cells (RBCs) leading to hemolysis. AIHA is widely classified as warm autoimmune hemolytic anemia, cold agglutinin syndrome, mixed AIHA, paroxysmal cold hemoglobinuria and rarely drug induced AIHA. The pathogenesis of AIHA is complex interplay between genetic predisposition, immune dysregulation and enviornmental triggers. A direct antiglobulin test can be used to assess the immunological origin of the hemolysis in order to diagnose AIHA after identifying laboratory and clinical symptoms of hemolysis...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727422/investigation-of-hyaluronan-synthase-2-and-cd44-immune-reactivity-as-a-biomarker-to-predict-progesterone-resistant-endometrial-hyperplasia-without-atypia-a-retrospective-case-control-study
#6
JOURNAL ARTICLE
Emine Boybay, Remzi Atilgan, Şehmus Pala, Tuncay Kuloğlu, Gökhan Artaş
BACKGROUND/AIMS: In our study, the effect of hyaluronan synthase 2 (HAS2) and CD44 immunoreactivity as a predictive biomarker in the prediction of progesterone-resistant endometrial hyperplasia (EH) cases without atypia was investigated. SETTINGS AND DESIGN: In this retrospective study, HAS2 and CD44 immunoreactivity in the endometrial tissues of 60 patients diagnosed with EH and treated with progesterone and 20 patients diagnosed with proliferative endometrium (PE) were evaluated...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727421/minocycline-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-masquerading-as-acute-leukemia
#7
JOURNAL ARTICLE
Devika Gupta, Kanwaljeet Singh, Ankit Dhaka, Prasanta Sengupta
Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic drug reaction characterized by fever, rash, and lymphadenopathy associated with atypical lymphocytosis and eosinophilia. Visceral organ involvement is also seen and hence it often mimics hematolymphoid malignancies. A 19-year-old girl presented with generalized pruritic rash, fever, lymphadenopathy, and lymphocytosis. Subsequently, she developed respiratory distress with a fall in SpO2. Flow cytometry, bone marrow studies, and infectious workup were normal...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727419/myasthenia-gravis-with-castleman-disease-a-case-report-with-review-of-literature
#8
JOURNAL ARTICLE
Sujit Nandy, Debashis Bhattacharya, Somenath Kundu, Uttara Chatterjee
Myasthenia gravis is an autoimmune disorder caused by the formation of autoantibodies directed against the synapses of neuromuscular junction. It is most commonly associated with other non-thymomatous lesions. Castleman disease is one of them, which is a benign lymphoproliferative disorder of uncertain origin. Only eight cases of myasthenia gravis associated with Castleman disease have been described so far. Here, we take the opportunity to describe a case of myasthenia gravis with Castleman disease simulating thymoma clinically and radiologically along with review of literature of this rare association...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727418/gossypiboma-mimicking-a-low-grade-sarcoma-and-presenting-twenty-years-after-a-renal-transplantation
#9
JOURNAL ARTICLE
Gwendolyn Fernandes, Gloria Khumanthem, Manali Patil
No abstract text is available yet for this article.
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727417/a-rare-case-of-multisystemic-langerhans-cell-histiocytosis-in-an-adult-affecting-the-thyroid-gland-skeletal-system-and-pituitary-gland-a-case-report
#10
JOURNAL ARTICLE
Dhara Patel, Preeti Doshi, Milind Kesarkhane, Narayan S Mani
Langerhans cell histiocytosis (LCH) is a rare disorder affecting usually children and rarely adults. The most common site affected is bone. The involvement of the thyroid gland in LCH is extremely rare and it is usually observed in an adult as a multisystemic disease. Adult males presented with anterior neck swelling, and fine needle aspiration cytology (FNAC) diagnosed it as suspicious for malignancy. On frozen sectioning, differential diagnosis was given as non-Hodgkin lymphoma and poorly differentiated malignancy...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727414/leiomyosarcoma-of-the-esophagus-arising-from-lamina-muscularis-mucosae-in-a-combination-with-microinvasive-squamous-cell-carcinoma-a-case-report
#11
JOURNAL ARTICLE
Desislava M Bozhkova, Anastas P Chapkanov, Maria S Koleva
Leiomyosarcoma of the esophagus is a very rare disease, accounting for less than 0.5% of malignant esophageal tumors. Esophageal leiomyosarcoma combined with squamous cell carcinoma is even rarer than solitary leiomyosarcoma. To our knowledge, there are less than ten cases of simultaneously diagnosed leiomyosarcoma and squamous cell carcinoma of the esophagus. A 66-year-old male was admitted to our hospital suffering from epigastric pain, asthenia, weight loss, and difficulties when feeding with solid food which had been present for 2 weeks...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727413/bilateral-adrenal-cortical-rests-an-interesting-innocuous-intruder-in-the-fallopian-tubes
#12
JOURNAL ARTICLE
Nidha Gaffoor, Archana Shetty, V Vidhya, P V Nikhil, Vijaya Mysorekar
Ectopic adrenal rests refer to the presence of adrenal tissue outside its normal anatomical location and are usually discovered incidentally on microscopic examination. Literature suggests its occurrence in diverse extrarenal sites, like the genitourinary system and pelvis. Our case describes the rare occurrence of ectopic adrenal rests in the walls of bilateral fallopian tubes of a 43-year-old female patient who presented with a complaint of heavy menstrual bleeding. A total hysterectomy with bilateral salpingo-oophorectomy was performed...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727411/breast-lymphomas-clinical-and-pathological-insights-from-a-tertiary-cancer-care-center-in-india
#13
JOURNAL ARTICLE
Neha Singh, Sadaf Hayat, Sujeet Kumar, Zachariah Chowdhury, Ipsita Dhal, Shashikant Cu Patne, Kavya Kadali, Bal Krishna Mishra, Akhil Kapoor, Anuj Gupta, Anil Singh, Bipinesh Sansar
BACKGROUND: Breast lymphomas are a rare group of malignancies that are further subdivided into primary and secondary. AIMS: To study the pathological and clinical course of breast lymphomas. MATERIALS AND METHODS: This is a retrospective analysis of patients treated at our institute over a period of 4.5 years from September 2018 to February 2023. The details of all the patients diagnosed with breast lymphoma were reviewed and analysed for the histomorphological, immunohistochemical, clinical, and treatment details...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727410/histopathological-analysis-of-skin-adnexal-tumors-an-experience-at-a-tertiary-center
#14
JOURNAL ARTICLE
Gokhan Sahin, Seda Koc Sahin
BACKGROUND: Skin appendage tumors (SATs) are benign and malignant neoplasms. Although there are many studies on their clinical features and epidemiology in the literature, most of these studies have a small number of patients and are not classified according to the WHO 2018 classification. OBJECTIVES: This study aimed to reveal the clinical and histopathological features of the SATs and compare the pre-diagnosis. MATERIALS AND METHODS: Cases diagnosed with SATs in the last 7 years in the Pathology Department were re-evaluated according to the WHO 2018 classification...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38727409/potential-role-of-ctnna3-and-frmpd4-in-vascular-tumorous-thrombosis-of-colon-adenocarcinoma
#15
JOURNAL ARTICLE
Bin Liu, Yu Xiang, Weihua Guo
BACKGROUND: Vascular tumorous thrombosis is a crucial pathological feature of malignant tumors that is closely associated with lymph node metastasis and is considered a form of tumor micrometastasis. Two downregulated genes, catenin alpha 3 (CTNNA3) and FERM and PDZ domain-containing 4 (FRMPD4), were selected by analyzing the differential expression of vascular tumorous thrombus in colon adenocarcinoma and paracancerous tissues. Further investigation revealed their potential role in the development of vascular tumorous thrombosis in colon adenocarcinomas...
May 10, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38718221/determination-of-target-genes-for-classified-molecular-subtypes-of-triple-negative-breast-cancer-form-microarray-gene-expression-profiling-an-integrative-in-silico-approach
#16
JOURNAL ARTICLE
Manisha Ray, Suranjana Banik, Mukund N Sable
BACKGROUND: Highly heterogeneous triple-negative breast cancer (TNBC) has tough clinical features, which were gradually solving and improving in diagnosis by the molecular subtyping of TNBC. AIM: Presently, this study was focused on analyzing the genetic makeup of TNBC subtypes. SETTINGS AND DESIGN: This study explored the MicroArray expression profiling of differentially expressed genes in molecular subtypes BL1, BL2, IM, luminal androgen receptor, M, and mesenchymal stem-like of TNBC by analyzing the Gene Expression Omnibus dataset GSE167213...
March 25, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38718214/prevalence-and-clinicopathological-features-of-driver-gene-mutations-profile-in-bcr-abl1-negative-classical-myeloproliferative-neoplasm-a-single-center-study-from-north-india
#17
JOURNAL ARTICLE
Khaliqur Rahman, Seema Biswas, Akhilesh Sharma, Kusum Gupta, Dinesh Chandra, Manish K Singh, Ruchi Gupta, Ashish Mishra, Sanjeev Kumar, Anshul Gupta, Faheema Hasan, Soniya Nityanand, Rajesh Kahsyap
BACKGROUND: Recurrent somatic mutations in the JAK2, CALR, and the MPL genes are noted in BCR: ABL1 negative classic myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). MATERIALS AND METHODS: Mutation profile and clinical features of MPN cases diagnosed at a tertiary care center in North India are being described. JAK2V617F mutation was screened using ARMS PCR, and CALR mutation was screened using allele-specific PCR followed by fragment analysis...
March 25, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38718204/diagnostic-prognostic-and-predictive-importance-of-neutrophil-lymphocyte-ratio-nlr-platelet-lymphocyte-ratio-plr-and-ca125-in-endometrial-hyperplasia-and-carcinoma
#18
JOURNAL ARTICLE
Bharti Kumari, Debaditya Haldar, Guddi R Singh, Sweta Kumari, Sangeeta Pankaj, Rajnikant Prasad
BACKGROUND: Inflammation has an important role in the progression of endometrial carcinoma. AIMS: The aim of this study is to find the association between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial hyperplasia and endometrial carcinoma. The study also focuses on the association of CA125, NLR, and PLR with histopathological parameters in endometrial carcinoma that are of prognostic importance. MATERIALS AND METHODS: This is a prospective cross-sectional study on 57 biopsy-proven cases of endometrial hyperplasia and carcinoma conducted over a period of two years...
March 25, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38718202/primary-bone-solitary-b-cell-lymphoblastic-lymphoma-aberrant-expression-fli-1-and-erg-a-case-report
#19
JOURNAL ARTICLE
Huan Chen, JiaSi Li, Yong Huang
Primary non-Hodgkin bone lymphoma is a rare disease, and within this category, B-cell lymphoblastic lymphoma (B-LBL) is an even rare clinical entity that has only been reported in small case series or individual case reports. B-LBL can mimic Ewing's sarcoma both clinically and histologically, leading to misdiagnosis. We present a case of primary B-LBL of the bone in a 7-year-old girl. The tumor cells are uniform and small with a diffuse and infiltrative growth pattern similar to EWS. Immunohistochemical results are positive for CD99, Fli-1, ERG, TDT, PAX5, and CD79α, but negative for leukocyte common antigen, CD3, CD20, and NKX2...
March 25, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38587095/micronodular-thymoma-with-lymphoid-stroma-as-benign-as-it-sounds
#20
JOURNAL ARTICLE
Kanica Chaudhary, Roshani Gala, Jay Mehta
Micronodular thymoma (MNT) is a rare subtype of thymoma (reported incidence is approximately 1-5%). We report a case received as a core biopsy from the "right lung mass" of a 31-year-old female. CT scan showed an 8.1 cm large well-defined mass lesion in the right middle lobe, causing indentation and mild compression of the right atrium. Microscopically, the biopsy showed a thymic neoplasm comprised of multiple discrete and coalescing nodules of bland epithelioid tumor cells separated by an epithelial cell-free lymphocyte-rich stroma...
March 25, 2024: Indian Journal of Pathology & Microbiology
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