journal
https://read.qxmd.com/read/38821241/spreading-depolarization-induces-a-transient-potentiation-of-excitatory-synaptic-transmission
#21
JOURNAL ARTICLE
Jordan E Weisend, Andrew P Carlson, C William Shuttleworth
Spreading depolarization (SD) is a slowly propagating wave of prolonged activation followed by a period of synaptic suppression. Some prior reports have shown potentiation of synaptic transmission after recovery from synaptic suppression and noted similarities with the phenomenon of long-term potentiation (LTP). Since SD is increasingly recognized as participating in diverse neurological disorders, it is of interest to determine whether SD indeed leads to a generalized and sustained long-term strengthening of synaptic connections...
May 29, 2024: Neuroscience
https://read.qxmd.com/read/38810691/gm1-ameliorates-neuronal-injury-in-rats-after-cerebral-ischemia-and-reperfusion-potential-contribution-of-effects-on-sptbn1-mediated-signaling
#22
JOURNAL ARTICLE
Yun-Wei Shi, Chun-Cheng Xu, Chun-Yan Sun, Jia-Xing Liu, Shu-Yong Zhao, Dong Liu, Xing-Juan Fan, Cai-Ping Wang
Monosialoganglioside GM1 (GM1) has long been used as a therapeutic agent for neurological diseases in the clinical treatment of ischemic stroke. However, the mechanism underlying the neuroprotective function of GM1 is still obscure until now. In this study, we investigated the effects of GM1 in ischemia and reperfusion (I/R) brain injury models. Middle cerebral artery occlusion and reperfusion (MCAO/R) rats were treated with GM1 (60 mg·kg-1 ·d-1 , tail vein injection) for 2 weeks. The results showed that GM1 substantially attenuated the MCAO/R-induced neurological dysfunction and inhibited the inflammatory responses and cell apoptosis in ischemic parietal cortex...
May 27, 2024: Neuroscience
https://read.qxmd.com/read/38810690/mechanisms-of-neuronal-reactivation-in-memory-consolidation-a-perspective-from-pathological-conditions
#23
REVIEW
Lei-Ying Xiang, Xiao-Yi Chen, Li-Ming Lu, Ming-Hui Kong, Qi Ji, Yu Xiong, Mei-Ming Xie, Xin-Ling Jian, Zhi-Ru Zhu
Memory consolidation refers to a process by which labile newly formed memory traces are progressively strengthened into long term memories and become more resistant to interference. Recent work has revealed that spontaneous hippocampal activity during rest, commonly referred to as "offline" activity, plays a critical role in the process of memory consolidation. Hippocampal reactivation occurs during sharp-wave ripples (SWRs), which are events associated with highly synchronous neural firing in the hippocampus and modulation of neural activity in distributed brain regions...
May 27, 2024: Neuroscience
https://read.qxmd.com/read/38806069/quercetin-loaded-human-umbilical-cord-mesenchymal-stem-cell-derived-sevs-for-spinal-cord-injury-recovery
#24
JOURNAL ARTICLE
Changwei Yang, Tao Xu, Yang Lu, Jianhang Liu, Cheng Chen, Heng Wang, Xiaoqing Chen
Following spinal cord injury, the inflammatory environment at the injury site causes local microglia and astrocytes to activate, which worsens the nerve damage in the affected area. Quercetin, an anti-inflammatory agent, has been limited in spinal cord injury due to its poor water solubility and easy degradation. Stem cell-derived extracellular vesicles can go through the blood-brain barrier and are an ideal drug delivery system. In this study, umbilical cord mesenchymal stem cell-derived extracellular vesicles were used to load quercetin to prevent its degradation and allow it to accumulate at the site of spinal cord injury...
May 26, 2024: Neuroscience
https://read.qxmd.com/read/38788830/immortalization-and-characterization-of-gfap-expressing-glial-cells-from-the-adult-mouse-hypothalamus-cortex-and-brain-stem
#25
JOURNAL ARTICLE
Neruja Loganathan, Calvin V Lieu, Denise D Belsham
The generation of astrocyte cell lines from the hypothalamus is key to study glial involvement in hypothalamic physiology, including energy homeostasis. As such, we immortalized astrocytes from the hypothalamus of an adult male CD-1 mouse using SV40 T-antigen to generate the mHypoA-Ast1 cell line. A comparative approach was taken with two other murine GFAP-expressing cell lines that were also generated in this study: a mixed glial cell line from the cortex (mCortA-G1) and an oligodendrocyte cell line from the brainstem (mBstA-Olig1), as well as an established microglial cell line (IMG)...
May 22, 2024: Neuroscience
https://read.qxmd.com/read/38788829/loss-of-postnatal-arx-transcriptional-activity-in-parvalbumin-interneurons-reveals-non-cell-autonomous-disturbances-in-ca1-pyramidal-cells
#26
JOURNAL ARTICLE
Donald J Joseph, Markus Von Deimling, Rashmi Risbud, Almedia J McCoy, Eric D Marsh
Maintenance of proper electrophysiological and connectivity profiles in the adult brain may be a perturbation point in neurodevelopmental disorders (NDDs). How these profiles are maintained within mature circuits is unclear. We recently demonstrated that postnatal ablation of the Aristaless (Arx) homeobox gene in parvalbumin interneurons (PVIs) alone led to dysregulation of their transcriptome and alterations in their functional as well as network properties in the hippocampal cornu Ammoni first region (CA1)...
May 22, 2024: Neuroscience
https://read.qxmd.com/read/38788828/reduced-gene-expression-of-kcc2-accelerates-axonal-regeneration-and-reduces-motor-dysfunctions-after-tibial-nerve-severance-and-suturing
#27
JOURNAL ARTICLE
Hironobu Ando, Chigusa Shimizu-Okabe, Nobuhiko Okura, Tsukasa Yafuso, Yoshinori Kosaka, Shiori Kobayashi, Akihito Okabe, Chitoshi Takayama
Gamma-aminobutyric acid and glycine (GABA/Gly) are predominantly inhibitory neurotransmitters in the mature central nervous system; however, they mediate membrane potential depolarization during development. These differences in actions depend on intracellular Cl- concentrations ([Cl- ]i ), which are primarily regulated by potassium chloride cotransporter 2 (KCC2). After nerve injury, KCC2 expression markedly decreases and GABA/Gly mediate depolarization. Following nerve regeneration, KCC2 expression recovers and GABA/Gly become inhibitory, suggesting that KCC2 reduction and GABA/Gly excitation may be crucial for axonal regeneration...
May 22, 2024: Neuroscience
https://read.qxmd.com/read/38782114/glycoprotein-non-metastatic-melanoma-protein-b-gpnmb-protects-against-neuroinflammation-and-neuronal-loss-in-pilocarpine-induced-epilepsy-via-the-regulation-of-microglial-polarization
#28
JOURNAL ARTICLE
Xuejing Hou, Shanshan Xiao, Xiaohong Xu, Mingze Qin, Xuebing Cheng, Xiangping Xu
Epilepsy is a progressive neurodegenerative disease highlighted by recurrent seizures, neuroinflammation, and the loss of neurons. Microglial dysfunction is commonly found in epileptic foci and contributes to neuroinflammation in the initiation and progression of epilepsy. Glycoprotein non-metastatic melanoma protein B (GPNMB), a transmembrane glycoprotein, has been involved in the microglial activation and neuroinflammation response. The present study investigated the functional significance of GPNMB in epilepsy...
May 21, 2024: Neuroscience
https://read.qxmd.com/read/38777136/impact-of-prenatal-lps-and-early-life-constant-light-exposure-on-circadian-gene-expression-profiles-in-various-rat-tissues
#29
JOURNAL ARTICLE
Veronika Spišská, Aneta Kubištová, Jiří Novotný, Zdeňka Bendová
Exposure to lipopolysaccharide (LPS) during prenatal development leads to various changes in neurobiological and behavioural patterns. Similarly, continuous exposure to constant light (LL) during the critical developmental period of the circadian system affects gene expression in various tissues in adulthood. Given the reciprocal nature of the interaction between the circadian and the immune systems, our study primarily investigated the individual effects of both interventions and, more importantly, their combined effect...
May 20, 2024: Neuroscience
https://read.qxmd.com/read/38777135/the-role-of-intestinal-microbiota-and-probiotics-supplementation-in-multiple-sclerosis-management
#30
REVIEW
Nima Hasaniani, Seyed Mostafa Rahimi, Marziyeh Akbari, Fahimeh Sadati, Abazar Pournajaf, Sahar Rostami-Mansoor
Multiple sclerosis (MS) is a neurological autoimmune disorder predominantly afflicting young adults. The etiology of MS is intricate, involving a variety of environmental and genetic factors. Current research increasingly focuses on the substantial contribution of gut microbiota in MS pathogenesis. The commensal microbiota resident within the intestinal milieu assumes a central role within the intricate network recognized as the gut-brain axis (GBA), wielding beneficial impact in neurological and psychological facets...
May 20, 2024: Neuroscience
https://read.qxmd.com/read/38763226/static-and-temporal-dynamic-in-functional-connectivity-of-large-scale-brain-networks-during-acute-stress-regulate-stress-resilience-differently-the-promotion-role-of-trait-resilience
#31
JOURNAL ARTICLE
Yizhuo Li, Yadong Liu, Xiaolin Zhao, Yipeng Ren, Weiyu Hu, Zijian Yang, Juan Yang
Stress resilience has been largely regarded as a process in which individuals actively cope with and recover from stress. Over the past decade, the emergence of large-scale brain networks has provided a new perspective for the study of the neural mechanisms of stress. However, the role of inter-network functional-connectivity (FC) and its temporal fluctuations in stress resilience is still unclear. To bridge this knowledge gap, seventy-seven participants (age, 17-22 years, 37 women) were recruited for a ScanSTRESS brain imaging study...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38763225/neurorestorative-approaches-for-ischemic-stroke
#32
REVIEW
Paulina Michór, Lydia Renardson, Shen Li, Johannes Boltze
Despite recent advances in acute stroke management, most patients experiencing a stroke will suffer from residual brain damage and functional impairment. Addressing those residual deficits would require neurorestoration, i.e., rebuilding brain tissue to repair the structural brain damage caused by stroke. However, there are major pathobiological, anatomical and technological hurdles making neurorestorative approaches remarkably challenging, and true neurorestoration after larger ischemic lesions could not yet be achieved...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38763224/role-of-the-bcl11a-b-homologue-chronophage-cph-in-locomotor-behaviour-of-drosophila-melanogaster
#33
JOURNAL ARTICLE
Smrithi Murthy, Upendra Nongthomba
Functioning of the nervous system requires proper formation and specification of neurons as well as accurate connectivity and signalling between them. Locomotor behaviour depends upon these events that occur during neural development, and any aberration in them could result in motor disorders. Transcription factors are believed to be master regulators that control these processes, but very few linked to behaviour have been identified so far. The Drosophila homologue of BCL11A (CTIP1) and BCL11B (CTIP2), Chronophage (Cph), was recently shown to be involved in temporal patterning of neural stem cells but its role in post-mitotic neurons is not known...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38762084/referent-control-of-side-to-side-body-weight-transfer-during-standing-and-stepping-in-adults
#34
JOURNAL ARTICLE
Katharine A Scarlat, Carl A Tchoumi, Anatol G Feldman, Mindy F Levin
Research suggests that locomotion may be primarily caused by shifting stable body balance from one location in the environment to another with subsequent rhythmical muscle activation by the central pattern generator (CPG), constituting a multi-level control system. All levels interact with environmental forces affected by proprioceptive and vestibular reflexes as well as vision. A similar multi-level control schema is likely used to shift body balance laterally when the body weight is rhythmically transferred from side-to-side...
May 16, 2024: Neuroscience
https://read.qxmd.com/read/38762083/brain-expression-levels-of-commonly-measured-blood-biomarkers-of-neurological-damage-differ-with-respect-to-sex-race-and-age
#35
JOURNAL ARTICLE
Grant C O'Connell, Christine G Smothers, Jing Wang, Suebsarn Ruksakulpiwat, Bethany L Armentrout
It is increasingly evident that blood biomarkers have potential to improve the diagnosis and management of both acute and chronic neurological disorders. The most well-studied candidates, and arguably those with the broadest utility, are proteins that are highly enriched in neural tissues and released into circulation upon cellular damage. It is currently unknown how the brain expression levels of these proteins is influenced by demographic factors such as sex, race, and age. Given that source tissue abundance is likely a key determinant of the levels observed in the blood during neurological pathology, understanding such influences is important in terms of identifying potential clinical scenarios that could produce diagnostic bias...
May 16, 2024: Neuroscience
https://read.qxmd.com/read/38759912/exercise-training-alleviates-symptoms-and-cognitive-decline-in-a-reserpine-induced-fibromyalgia-model-by-activating-hippocampal-pgc-1%C3%AE-fndc5-bdnf-pathway
#36
JOURNAL ARTICLE
Muaz Belviranlı, Nilsel Okudan, Tuğba Sezer
The purpose of this study was to assess, from a behavioral, biochemical, and molecular standpoint, how exercise training affected fibromyalgia (FM) symptoms in a reserpine-induced FM model and to look into the potential involvement of the hippocampal PGC-1α/FNDC5/BDNF pathway in this process. Reserpine (1 mg kg-1 ) was subcutaneously injected once daily for three consecutive days and then the rats were exercised for 21 days. Mechanical allodynia was evaluated 1, 11, and 21 days after the last injection...
May 15, 2024: Neuroscience
https://read.qxmd.com/read/38754722/myd88-inhibition-attenuates-cerebral-ischemia-reperfusion-injury-by-regulating-the-inflammatory-response-and-reducing-blood-brain-barrier-damage
#37
JOURNAL ARTICLE
Fangchao Jiang, Chen Xu, Xuehui Fan, Shuai Yang, Wei Fan, Meng Li, Jihe Song, Wan Wei, Hongping Chen, Di Zhong, Guozhong Li
Myeloid differentiation primary response gene 88 (MyD88), a downstream molecule directly linked to Toll-like receptor (TLRs) and IL1 receptor, has been implicated in ischemia-reperfusion injury across various organs. However, its role in cerebral ischemia-reperfusion injury (CIRI) remains unclear. Five transient middle cerebral artery occlusion (tMCAO) microarray datasets were obtained from the Gene Expression Omnibus (GEO) database. We screened these datasets for differentially expressed genes (DEGs) using the GSE35338 and GSE58720 datasets and performed weighted gene co-expression network analysis (WGCNA) using the GSE30655, GSE28731, and GSE32529 datasets to identify the core module related to tMCAO...
May 14, 2024: Neuroscience
https://read.qxmd.com/read/38754721/exploring-therapeutic-potential-of-phytoconstituents-as-a-gut-microbiota-modulator-in-the-management-of-neurological-and-psychological-disorders
#38
REVIEW
Prarit Chandel, Komal Thapa, Neha Kanojia, Lata Rani, Pulkit Rohilla
The functioning of the brain and its impact on behavior, emotions, and cognition can be affected by both neurological and psychiatric disorders that impose a significant burden on global health. Phytochemicals are helpful in the treatment of several neurological and psychological disorders, including anxiety, depression, Huntington's disease (HD), Parkinson's disease (PD), Alzheimer's disease (AD), and autism spectrum disorder (ASD), because they have symptomatic benefits with few adverse reactions. Changes in gut microbiota have been associated with many neurological and psychiatric conditions...
May 14, 2024: Neuroscience
https://read.qxmd.com/read/38750924/nigrostriatal-inflammation-is-associated-with-nonmotor-symptoms-in-an-experimental-model-of-prodromal-parkinson-s-disease
#39
JOURNAL ARTICLE
Bruna da Silva Oliveira, Eliana Cristina de Brito Toscano, Larissa Katharina Sabino Abreua, Heliana de Barros Fernandes, Renan Florindo Amorim, Rodrigo Novaes Ferreira, Caroline Amaral Machado, Brener Cunha Carvalho, Maria Carolina Machado da Silva, Antônio Carlos Pinheiro de Oliveira, Milene Alvarenga Rachid, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Elizabeth Ribeiro da Silva, Aline Silva de Miranda
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's disease (PD). Inflammatory response has been associated with symptoms and subtypes of PD. However, it is unclear whether immune changes are involved in the initial pathogenesis of PD, leading to the non-motor symptoms (NMS) observed in its prodromal stage. The current study aimed to characterize the behavioral and cognitive changes in a toxin-induced model of prodromal PD-like syndrome. We also sought to investigate the role of neuroinflammation in prodromal PD-related NMS...
May 13, 2024: Neuroscience
https://read.qxmd.com/read/38735429/facilitation-of-early-and-middle-latency-sep-after-tdcs-of-m1-no-evidence-of-primary-somatosensory-homeostatic-plasticity
#40
JOURNAL ARTICLE
Daniela M Zolezzi, Dennis B Larsen, Anna M Zamorano, Thomas Graven-Nielsen
Homeostatic plasticity is a mechanism that stabilizes cortical excitability within a physiological range. Most homeostatic plasticity protocols have primed and tested the homeostatic response of the primary motor cortex (M1). This study investigated if a homeostatic response could be recorded from the primary sensory cortex (S1) after inducing homeostatic plasticity in M1. In 31 healthy participants, homeostatic plasticity was induced over M1 with a priming and testing block of transcranial direct current stimulation (tDCS) in two different sessions (anodal and cathodal)...
May 10, 2024: Neuroscience
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