journal
https://read.qxmd.com/read/38763226/static-and-temporal-dynamic-in-functional-connectivity-of-large-scale-brain-networks-during-acute-stress-regulate-stress-resilience-differently-the-promotion-role-of-trait-resilience
#1
JOURNAL ARTICLE
Yizhuo Li, Yadong Liu, Xiaolin Zhao, Yipeng Ren, Weiyu Hu, Zijian Yang, Juan Yang
Stress resilience has been largely regarded as a process in which individuals actively cope with and recover from stress. Over the past decade, the emergence of large-scale brain networks has provided a new perspective for the study of the neural mechanisms of stress. However, the role of inter-network functional-connectivity (FC) and its temporal fluctuations in stress resilience is still unclear. To bridge this knowledge gap, seventy-seven participants (age, 17-22 years, 37 women) were recruited for a ScanSTRESS brain imaging study...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38763225/neurorestorative-approaches-for-ischemic-stroke
#2
REVIEW
Paulina Michór, Lydia Renardson, Shen Li, Johannes Boltze
Despite recent advances in acute stroke management, most patients experiencing a stroke will suffer from residual brain damage and functional impairment. Addressing those residual deficits would require neurorestoration, i.e., rebuilding brain tissue to repair the structural brain damage caused by stroke. However, there are major pathobiological, anatomical and technological hurdles making neurorestorative approaches remarkably challenging, and true neurorestoration after larger ischemic lesions could not yet be achieved...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38763224/role-of-the-bcl11a-b-homologue-chronophage-cph-in-locomotor-behaviour-of-drosophila-melanogaster
#3
JOURNAL ARTICLE
Smrithi Murthy, Upendra Nongthomba
Functioning of the nervous system requires proper formation and specification of neurons as well as accurate connectivity and signalling between them. Locomotor behaviour depends upon these events that occur during neural development, and any aberration in them could result in motor disorders. Transcription factors are believed to be master regulators that control these processes, but very few linked to behaviour have been identified so far. The Drosophila homologue of BCL11A (CTIP1) and BCL11B (CTIP2), Chronophage (Cph), was recently shown to be involved in temporal patterning of neural stem cells but its role in post-mitotic neurons is not known...
May 17, 2024: Neuroscience
https://read.qxmd.com/read/38762084/referent-control-of-side-to-side-body-weight-transfer-during-standing-and-stepping-in-adults
#4
JOURNAL ARTICLE
Katharine A Scarlat, Carl A Tchoumi, Anatol G Feldman, Mindy F Levin
Research suggests that locomotion may be primarily caused by shifting stable body balance from one location in the environment to another with subsequent rhythmical muscle activation by the central pattern generator (CPG), constituting a multi-level control system. All levels interact with environmental forces affected by proprioceptive and vestibular reflexes as well as vision. A similar multi-level control schema is likely used to shift body balance laterally when the body weight is rhythmically transferred from side-to-side...
May 16, 2024: Neuroscience
https://read.qxmd.com/read/38762083/brain-expression-levels-of-commonly-measured-blood-biomarkers-of-neurological-damage-differ-with-respect-to-sex-race-and-age
#5
JOURNAL ARTICLE
Grant C O'Connell, Christine G Smothers, Jing Wang, Suebsarn Ruksakulpiwat, Bethany L Armentrout
It is increasingly evident that blood biomarkers have potential to improve the diagnosis and management of both acute and chronic neurological disorders. The most well-studied candidates, and arguably those with the broadest utility, are proteins that are highly enriched in neural tissues and released into circulation upon cellular damage. It is currently unknown how the brain expression levels of these proteins is influenced by demographic factors such as sex, race, and age. Given that source tissue abundance is likely a key determinant of the levels observed in the blood during neurological pathology, understanding such influences is important in terms of identifying potential clinical scenarios that could produce diagnostic bias...
May 16, 2024: Neuroscience
https://read.qxmd.com/read/38759912/exercise-training-alleviates-symptoms-and-cognitive-decline-in-a-reserpine-induced-fibromyalgia-model-by-activating-hippocampal-pgc-1%C3%AE-fndc5-bdnf-pathway
#6
JOURNAL ARTICLE
Muaz Belviranlı, Nilsel Okudan, Tuğba Sezer
The purpose of this study was to assess, from a behavioral, biochemical, and molecular standpoint, how exercise training affected fibromyalgia (FM) symptoms in a reserpine-induced FM model and to look into the potential involvement of the hippocampal PGC-1α/FNDC5/BDNF pathway in this process. Reserpine (1 mg kg-1 ) was subcutaneously injected once daily for three consecutive days and then the rats were exercised for 21 days. Mechanical allodynia was evaluated 1, 11, and 21 days after the last injection...
May 15, 2024: Neuroscience
https://read.qxmd.com/read/38754722/myd88-inhibition-attenuates-cerebral-ischemia-reperfusion-injury-by-regulating-the-inflammatory-response-and-reducing-blood-brain-barrier-damage
#7
JOURNAL ARTICLE
Fangchao Jiang, Chen Xu, Xuehui Fan, Shuai Yang, Wei Fan, Meng Li, Jihe Song, Wan Wei, Hongping Chen, Di Zhong, Guozhong Li
Myeloid differentiation primary response gene 88 (MyD88), a downstream molecule directly linked to Toll-like receptor (TLRs) and IL1 receptor, has been implicated in ischemia-reperfusion injury across various organs. However, its role in cerebral ischemia-reperfusion injury (CIRI) remains unclear. Five transient middle cerebral artery occlusion (tMCAO) microarray datasets were obtained from the Gene Expression Omnibus (GEO) database. We screened these datasets for differentially expressed genes (DEGs) using the GSE35338 and GSE58720 datasets and performed weighted gene co-expression network analysis (WGCNA) using the GSE30655, GSE28731, and GSE32529 datasets to identify the core module related to tMCAO...
May 14, 2024: Neuroscience
https://read.qxmd.com/read/38754721/exploring-therapeutic-potential-of-phytoconstituents-as-a-gut-microbiota-modulator-in-the-management-of-neurological-and-psychological-disorders
#8
REVIEW
Prarit Chandel, Komal Thapa, Neha Kanojia, Lata Rani, Pulkit Rohilla
The functioning of the brain and its impact on behavior, emotions, and cognition can be affected by both neurological and psychiatric disorders that impose a significant burden on global health. Phytochemicals are helpful in the treatment of several neurological and psychological disorders, including anxiety, depression, Huntington's disease (HD), Parkinson's disease (PD), Alzheimer's disease (AD), and autism spectrum disorder (ASD), because they have symptomatic benefits with few adverse reactions. Changes in gut microbiota have been associated with many neurological and psychiatric conditions...
May 14, 2024: Neuroscience
https://read.qxmd.com/read/38750924/nigrostriatal-inflammation-is-associated-with-nonmotor-symptoms-in-an-experimental-model-of-prodromal-parkinson-s-disease
#9
JOURNAL ARTICLE
Bruna da Silva Oliveira, Eliana Cristina de Brito Toscano, Larissa Katharina Sabino Abreua, Heliana de Barros Fernandes, Renan Florindo Amorim, Rodrigo Novaes Ferreira, Caroline Amaral Machado, Brener Cunha Carvalho, Maria Carolina Machado da Silva, Antônio Carlos Pinheiro de Oliveira, Milene Alvarenga Rachid, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Elizabeth Ribeiro da Silva, Aline Silva de Miranda
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's disease (PD). Inflammatory response has been associated with symptoms and subtypes of PD. However, it is unclear whether immune changes are involved in the initial pathogenesis of PD, leading to the non-motor symptoms (NMS) observed in its prodromal stage. The current study aimed to characterize the behavioral and cognitive changes in a toxin-induced model of prodromal PD-like syndrome. We also sought to investigate the role of neuroinflammation in prodromal PD-related NMS...
May 13, 2024: Neuroscience
https://read.qxmd.com/read/38735429/facilitation-of-early-and-middle-latency-sep-after-tdcs-of-m1-no-evidence-of-primary-somatosensory-homeostatic-plasticity
#10
JOURNAL ARTICLE
Daniela M Zolezzi, Dennis B Larsen, Anna M Zamorano, Thomas Graven-Nielsen
Homeostatic plasticity is a mechanism that stabilizes cortical excitability within a physiological range. Most homeostatic plasticity protocols have primed and tested the homeostatic response of the primary motor cortex (M1). This study investigated if a homeostatic response could be recorded from the primary sensory cortex (S1) after inducing homeostatic plasticity in M1. In 31 healthy participants, homeostatic plasticity was induced over M1 with a priming and testing block of transcranial direct current stimulation (tDCS) in two different sessions (anodal and cathodal)...
May 10, 2024: Neuroscience
https://read.qxmd.com/read/38734304/acute-combined-cerebrolysin-and-nicotinamide-administration-promote-cognitive-recovery-through-neuronal-changes-in-the-hippocampus-of-rats-with-permanent-middle-cerebral-artery-occlusion
#11
JOURNAL ARTICLE
Nestor I Martínez-Torres, Jhonathan Cárdenas-Bedoya, Blanca Miriam Torres-Mendoza
Stroke is one of the leading causes of disability worldwide, where the Hippocampus (HPC) is affected. HPC organizes memory, which is a cognitive domain compromised after a stroke, where cerebrolysin (CBL) and Nicotinamide (NAM) have been recognized as potentially therapeutic. In this study, we aimed to evaluate the efficacy of a combined administration of CBL and NAM in a rat stroke model. Male Sprague-Dawley rats (n = 36) were divided into four groups: saline (pMCAO - Saline), CBL (pMCAO + CBL), NAM (pMCAO + NAM), and experimental (pMCAO + CBL-NAM) (n = 9 per group)...
May 9, 2024: Neuroscience
https://read.qxmd.com/read/38734303/the-effects-of-ketogenic-diet-on-brain-gene-expressions-in-type-2-diabetes-background
#12
JOURNAL ARTICLE
Qianxu Ren, Junling Fu, Xiaoye Duan, Lina Sun, Zhijing Mu, Wenping Liang, Yu Li, Zhe Wang, Shuangling Xiu
Type 2 diabetes mellitus (T2DM) is a major risk factor of a number of neurodegenerative diseases (NDDs). Ketogenic diet (KD) has significant beneficial effects on glycemic control and may act effectively against NDDs, but the mechanism remains unclear. In this study, we aimed to investigate the potential effects of KD on gene expressions in the brains of T2DM model mice. Male db/db mice at the age of 9 weeks were fed with KD or normal diet to the age of 6 months, and the whole brains were subjected to mRNA-seq analysis for differentially expressed genes...
May 9, 2024: Neuroscience
https://read.qxmd.com/read/38734302/increased-tmem166-level-in-patients-with-postoperative-stroke-after-carotid-endarterectomy
#13
JOURNAL ARTICLE
Yifei Chen, Danyang Wang, Jie Yin, Paul R Krafft, Xin Luo, Dandan Hao, Chengwen Li, Ye Liu, Li Li, Yongbo Zhang, Chen Zhu
Postoperative stroke is a challenging and potentially devastating complication after elective carotid endarterectomy (CEA). We previously demonstrated that transmembrane protein 166 (TMEM166) levels were directly related to neuronal damage after cerebral ischemia-reperfusion injury in rats. In this subsequent clinical study, we aimed to evaluate the prognostic value of TMEM166 in patients suffering from post-CEA strokes. Thirty-five patients undergoing uncomplicated elective CEA and 8 patients who suffered ischemic strokes after CEA were recruited...
May 9, 2024: Neuroscience
https://read.qxmd.com/read/38734301/dcpib-attenuates-ischemia-reperfusion-injury-by-regulating-microglial-m1-m2-polarization-and-oxidative-stress
#14
JOURNAL ARTICLE
Guihua Cao, Jianbin Guo, Kaikai Yang, Rong Xu, Xin Jia, Xiaoming Wang
The inflammatory response plays an indispensable role in ischemia-reperfusion injury, the most significant of which is the inflammatory response caused by microglial polarization. Anti-inflammatory therapy is also an important remedial measure after failed vascular reconstruction. Maintaining the internal homeostasis of the brain is a crucial measure for suppressing the inflammatory response. The mechanism underlying the relationship between DCPIB, a selective blocker of volume-regulated anion channels (VRAC), and inflammation induced by cerebral ischemia-reperfusion injury is currently unclear...
May 9, 2024: Neuroscience
https://read.qxmd.com/read/38729599/prophylactic-effects-of-n-acethylcysteine-on-inflammation-induced-depression-like-behaviors-in-mice
#15
JOURNAL ARTICLE
Zhenhuan Wang, Qi Hu, Chao Tian, Ruipeng Wang, Qingyan Jiao, Feng Chen, Tongrui Wu, Jialiang Wang, Yuxuan Zhu, Aili Liu, Wei Zhang, Jie Li, Hui Shen
Depression, affecting individuals worldwide, is a prevalent mental disease, with an increasing incidence. Numerous studies have been conducted on depression, yet its pathogenesis remains elusive. Recent advancements in research indicate that disturbances in synaptic transmission, synaptic plasticity, and reduced neurotrophic factor expression significantly contribute to depression's pathogenesis. In our study, we utilized adult male C57BL/6J mice. Lipopolysaccharide (LPS) can induce both chronic and acute depression-like symptoms in mice, a widely used model for studying depression associated with inflammation...
May 8, 2024: Neuroscience
https://read.qxmd.com/read/38723837/approach-avoidance-behavior-to-novel-objects-is-correlated-with-the-serotonergic-and-dopaminergic-systems-in-the-brown-rat-rattus-norvegicus
#16
JOURNAL ARTICLE
Yasushi Kiyokawa, Masato Ootaki, Yoshikazu Kambe, Kazuyuki D Tanaka, Goro Kimura, Tsutomu Tanikawa, Yukari Takeuchi
The brown rat (Rattus norvegicus) is known to show three types of behavioral responses to novel objects. Whereas some rats are indifferent to novel objects, neophobic and neophilic rats show avoidance and approach behavior, respectively. Here, we compared the dopaminergic, serotonergic, and noradrenergic systems immunohistochemically among these rats. Trapped wild rats and laboratory rats were first individually exposed to the novel objects in their home cage. Wild rats were divided into neophobic and indifferent rats depending on their behavioral responses...
May 7, 2024: Neuroscience
https://read.qxmd.com/read/38718917/ascorbic-acid-supplementation-improves-adolescent-stress-induced-cognitive-impairment-through-restoration-of-behavioral-biochemical-and-electrophysiological-alterations-in-male-rats
#17
JOURNAL ARTICLE
Sima Gul Ghasemi, Alireza Khoshrou, Samaneh Kakhki, Atefeh Shirinzadeh Feizabadi, Maha Masoudi, Faezeh Bagherifar, Farimah Beheshti
The present research study aimed to investigate the role of Ascorbic acid (AA) on synaptic plasticity, learning, and memory impairment induced by unpredicted chronic mild stress (CUMS) in adolescent male rats. Adolescent male rats were divided into:1) vehicle, 2) CUMS, 3-5) CUMS plus various doses of AA by oral gavage (CUMS-10/100/400 mg/kg), and 6) AA400 mg/kg by oral gavage. In Morris Water Maze, the time latency decreased, while the time spent in the target quadrant increased in CUMS group treated with AA at the dose of 400 mg/kg...
May 6, 2024: Neuroscience
https://read.qxmd.com/read/38718916/lipid-droplets-and-neurodegeneration
#18
REVIEW
Keya Mallick, Shuchismita Paul, Sayani Banerjee, Sugato Banerjee
Energy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation where acetyl-CoA and shorter fatty acid chains are produced along with a significant amount of energy molecule. Further, the complete breakdown of fatty acids occurs when they enter the mitochondrial oxidative phosphorylation...
May 6, 2024: Neuroscience
https://read.qxmd.com/read/38705350/virtual-reality-action-observation-and-motor-imagery-to-enhance-neuroplastic-capacity-in-the-human-motor-cortex-a-pilot-double-blind-randomized-cross-over-trial
#19
JOURNAL ARTICLE
Niamh Connelly, Ellana Welsby, Belinda Lange, Brenton Hordacre
Neuroplasticity is important for learning, development and recovery from injury. Therapies that can upregulate neuroplasticity are therefore of interest across a range of fields. We developed a novel virtual reality action observation and motor imagery (VR-AOMI) intervention and evaluated whether it could enhance the efficacy of mechanisms of neuroplasticity in the human motor cortex of healthy adults. A secondary question was to explore predictors of the change in neuroplasticity following VR-AOMI. A pre-registered, pilot randomized controlled cross-over trial was performed...
May 3, 2024: Neuroscience
https://read.qxmd.com/read/38705349/intranasal-administration-of-umbilical-cord-mesenchymal-stem-cell-exosomes-alleviates-parkinson-s-disease
#20
JOURNAL ARTICLE
Weixiao Huang, Tao Zhang, Xiaodi Li, Leilei Gong, Yu Zhang, Chengcheng Luan, Qi Shan, Xiaosong Gu, Lili Zhao
Parkinson's disease (PD) is a common and complex neurodegenerative disease. This disease is typically characterized by the formation of Lewy bodies in multiple brain regions and dopaminergic neuronal loss in the substantia nigra pars compacta, resulting in non-motor symptoms (e.g., olfactory deficits) and motor dysfunction in the late stages. There is yet no effective cure for Parkinson's disease. Considering the neuroprotective effects of exosomes, we investigated whether intranasal administration of umbilical cord mesenchymal stem cell exosomes could improve behavioral functions in PD mice...
May 3, 2024: Neuroscience
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