Fatma M Sabry, Marwa A Masoud, Gehan S Georgy
The continuous high intake of caffeinated products may harm CNS. Sodium benzoate (SB), broadly used for food preservation, may also have an impact. The current research studied the influence of caffeine and two doses of SB during adolescence period on behavior and brain alterations. Adolescent rats (90-120 gm) were exposed to vehicle, SB 100 and 400 mg/kg, p.o, caffeine (30 mg/kg, i.p), SB 100 or 400 + caffeine for 28 days. Locomotor performances were assessed by the open field, learning and memory were considered with novel object and y-maze, while anxiety was evaluated by light and dark as well as successive allays tests...
April 27, 2024: Neuroscience Letters
Farhan Zameer, Pratheek Jain, Kounaina Khan, P Pramod Kumar, K V Harish Prashanth, Vidya Niranjan, H Ravish
MicroRNAs (miRNAs) have emerged as critical regulators of post-transcriptional gene expression, impacting various biological processes (development, differentiation, and progression). In medicine, miRNAs are promising diagnostic biomarkers for neurodegenerative diseases, including Parkinson's disease (PD). The current study aims at exploring the role of miRNAs and transcription factors (TFs) in regulating genes-associated with PD. Deploying bioinformatics tools, the study identifies specific miRNAs and TFs involved in PD and their potential connections to the organ-disease junction...
April 25, 2024: Neuroscience Letters
Michela Balconi, Laura Angioletti
This work examined the impact of interoceptive manipulation and the presence of a shared goal on inter-brain entrainment (IBE) during a motor synchronization task. A multimodal functional Near Infrared Spectroscopy - Electroencephalogram (fNIRS-EEG) system-based hyperscanning approach was applied to 13 dyads performing the motor synchrony task during an interoceptive (focus on the breath) and control condition. Additionally, two version of the motor task-one with and one without a clearly defined common goal-were presented to participants to emphasize the task's collaborative purpose...
April 24, 2024: Neuroscience Letters
Daniele Cavaleri, Ilaria Riboldi, Cristina Crocamo, Giuseppe Paglia, Giuseppe Carrà, Francesco Bartoli
The antidepressant effects of ketamine and esketamine are well-documented. Nonetheless, most of the underlying molecular mechanisms have to be uncovered yet. In the last decade, metabolomics has emerged as a useful means to investigate the metabolic phenotype associated with depression as well as changes induced by antidepressant treatments. This mini-review aims at summarizing the main findings from preclinical and clinical studies that used metabolomics to investigate the metabolic effects of subanesthetic, antidepressant doses of ketamine and esketamine and their relationship with clinical response...
April 24, 2024: Neuroscience Letters
Jurong Ding, Zhiling Tang, Qiang Chen, Yihong Liu, Chenyu Feng, Yuan Li, Xin Ding
OBJECTIVE: To explore degree centrality (DC) abnormalities in ischemic stroke patients and determine whether these abnormalities have potential value in understanding the pathological mechanisms of ischemic stroke patients. METHODS: Sixteen ischemic stroke patients and 22 healthy controls (HCs) underwent resting state functional magnetic resonance imaging (rs-fMRI) scanning, and the resulting data were subjected to DC analysis. Then we conducted a correlation analysis between DC values and neuropsychological test scores, including Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE)...
April 24, 2024: Neuroscience Letters
Ju Li, Yaping Cao, Minghao Huang, Zhongcheng Li, Zhe Qin, Jian Lang
Studies have indicated that skilled soccer players possess superior decision-making abilities compared to their less-skilled counterparts. However, the underlying neural mechanism for this phenomenon remains incompletely understood. In our investigation, we explored distinctions in the topology of functional brain networks between skilled and less-skilled soccer players. Employing mediating analysis, we scrutinized the relationships among functional brain network parameters, training duration, and decision-making accuracy...
April 18, 2024: Neuroscience Letters
Qian Sun, Li Zhang, Xiuyan Huang, Min Wang
BACKGROUND: Salidroside (Sal) has been found to protect against multiple impairments caused by diabetes, and we designed this study to investigate the effect of Sal on gestational hypertension (GHP)-induced impairment of offspring learning and memory. METHODS: We established a GHP rat model by intraperitoneal injection of NG-nitro-L-arginine methyl ester (L-NAME), and treated with Sal by daily gavage. We used Morris Water Maze test to evaluate the learning and memory ability of offspring rats...
April 17, 2024: Neuroscience Letters
Tomomi Ishida, Hiroshi Nittono
Omitted stimulus potentials (OSPs) are elicited in response to the omission of expected stimuli and are thought to reflect prediction errors. If prediction errors are signaled in the sensory cortex, OSPs are expected to be generated in the sensory cortex. The present study investigated the involvement of the early visual cortex in the generation of OSPs by testing whether omitted visual stimuli elicit brain responses in a spatially specific manner. Checkerboard pattern stimuli were presented alternately in the upper and lower visual fields, and the stimuli were omitted in 10% of the trials...
April 13, 2024: Neuroscience Letters
Ilaria D'Atri, Emily-Rose Martin, Liming Yang, Elizabeth Sears, Emma Baple, Andrew H Crosby, John K Chilton, Asami Oguro-Ando
The endoplasmic reticulum (ER) plays an indispensable role in cellular processes, including maintenance of calcium homeostasis, and protein folding, synthesized and processing. Disruptions in these processes leading to ER stress and the accumulation of misfolded proteins can instigate the unfolded protein response (UPR), culminating in either restoration of balanced proteostasis or apoptosis. A key player in this intricate balance is CLCC1, an ER-resident chloride channel, whose essential role extends to retinal development, regulation of ER stress, and UPR...
April 13, 2024: Neuroscience Letters
Carla Liria Sánchez-Lafuente, Laura Martinez-Verbo, Jenessa N Johnston, Jennifer Floyd, Manel Esteller, Lisa E Kalynchuk, Juan Ausió, Hector J Caruncho
Women are disproportionately affected by stress-related disorders like depression. In our prior research, we discovered that females exhibit lower basal hypothalamic reelin levels, and these levels are differentially influenced by chronic stress induced through repeated corticosterone (CORT) injections. Although epigenetic mechanisms involving DNA methylation and the formation of repressor complexes by DNA methyl-transferases (DNMTs) and Methyl-CpG binding protein 2 (MeCP2) have been recognized as regulators of reelin expression in vitro, there is limited understanding of the impact of stress on the epigenetic regulation of reelin in vivo and whether sex differences exist in these mechanisms...
April 12, 2024: Neuroscience Letters
Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou
The occurrence and development of Alzheimer's disease (AD) is closely related to neuronal loss, inflammatory response, cholinergic imbalance, and Tau protein hyperphosphorylation. Previous studies have confirmed that Streptozotocin (STZ) can be used to establish a rat model of AD by injecting it into the rat brain via the lateral ventricle. Our previous research showed that Danshentone IIA (Tan IIA) can improve cognitive dysfunction in rats caused by CC chemokine ligand 2, and network pharmacology results show that Tan IIA is very likely to improve AD symptoms through the cyclic adenosine monophosphate response element binding protein (CREB), brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor protein (TrkB) pathway...
April 12, 2024: Neuroscience Letters
Xinyu Gong, Bohua Hu, Senrong Liao, Bingxin Qi, Liang Wang, Qinghua He, Ling-Xiang Xia
BACKGROUND: Aggression outcome expectation is an important cognitive factor of aggression. Discovering the neural mechanism of aggression outcome expectation is conducive to developing aggression research. However, the neural correlates underlying aggression outcome expectation and its effect remain elusive. METHODS: We utilized voxel-based morphometry (VBM) to unravel the neural architecture of aggression outcome expectation measured by the Social Emotional Information Processing Assessment for Adults and its relationship with aggression measured by the Buss Perry Aggression Questionnaire in a sample of 185 university students (114 female; mean age = 19...
April 9, 2024: Neuroscience Letters
Behrang Keshavarz, Meaghan Adams, Grace Gabriel, Lauren E Sergio, Jennifer L Campos
Concussion can lead to various symptoms such as balance problems, memory impairments, dizziness, and/or headaches. It has been previously suggested that during self-motion relevant tasks, individuals with concussion may rely heavily on visual information to compensate for potentially less reliable vestibular inputs and/or problems with multisensory integration. As such, concussed individuals may also be more sensitive to other visually-driven sensations such as visually induced motion sickness (VIMS). To investigate whether concussed individuals are at elevated risk of experiencing VIMS, we exposed participants with concussion (n = 16) and healthy controls (n = 15) to a virtual scene depicting visual self-motion down a grocery store isle at different speeds...
April 8, 2024: Neuroscience Letters
Waleed Ibrahim, Jeonghyun An, Yanghong Yang, Kelly P Cosgrove, David Matuskey
INTRODUCTION: The neuroimmune system performs a wide range of functions in the brain and the central nervous system. The microglial translocator protein (TSPO) has an established role as a cell marker in identification of the neuroimmune system. Previously, human studies have shown TSPO differences in neuropsychiatric disorders. Seasonal variability has also been demonstrated in multiple systems of healthy individuals. Therefore, in this study, we attempt to understand whether seasonal changes affect brain TSPO levels using [11 C]PBR28 positron emission tomography (PET) imaging...
April 5, 2024: Neuroscience Letters
Yongjin Zhang, Fangping Wu
BACKGROUND: To explore the diagnostic role and potential mechanism of serum lncRNA UCA1 in Alzheimer's disease (AD). METHODS: UCA1 concentration was determined using quantitative PCR. The receiver operating characteristic curve was plotted to assess the diagnostic value. Cell viability and apoptotic capacity were assessed by Cell counting kit-8 (CCK-8) and flow cytometry. Water maze experiments were used to test cognitive function in mice. The target genes of UCA1 were identified with a dual luciferase reporter...
April 5, 2024: Neuroscience Letters
B G Sunila, T Dhanushkumar, K R Dasegowda, Karthick Vasudevan, Majji Rambabu
BACKGROUND: Ataxia Telangiectasia (AT) is a genetic disorder characterized by compromised DNA repair, cerebellar degeneration, and immune dysfunction. Understanding the molecular mechanisms driving AT pathology is crucial for developing targeted therapies. METHODS: In this study, we conducted a comprehensive analysis to elucidate the molecular mechanisms underlying AT pathology. Using publicly available RNA-seq datasets comparing control and AT samples, we employed in silico transcriptomics to identify potential genes and pathways...
April 4, 2024: Neuroscience Letters
Carlo Cristini, Laura Colautti, Annamaria Della Vedova, Alessandro Antonietti
In the paper the possible links between creative thinking and humor are sketched and their role in promoting well-being in the elderly is taken into account. The specific features of creative thinking in older people and its developmental trend in aging are outlined. The changes in humor which occur during aging are considered as well. The connections between creative thinking and humor are analysed, by highlighting the cognitive mechanisms which are shared and the alleged common neural underpinnings. The functions which creativity and humor can play to promote well-being in late adulthood are discussed...
April 2, 2024: Neuroscience Letters
T V Kozyreva, I V Orlov, A R Boyarskaya, I P Voronova
The role of the hypothalamic cold-sensitive ion channels - transient receptor potential melastatin 8 (TRPM8) and transient receptor potential ankyrin 1 (TRPA1) in homeostatic systems of thermoregulation and water-salt balance - is not clear. The interaction of homeostatic systems of thermoregulation and water-salt balance without additional temperature load did not receive due attention, too. On the models of water-balance disturbance, we tried to elucidate some aspect of these problems. Body temperature (Tbody ), O2 consumption, CO2 excretion, electrical muscle activity (EMA), temperature of tail skin (Ttail ), plasma osmolality, as well as gene expression of hypothalamic TRPM8 and TRPA1 have been registered in rats of 3 groups: control; water-deprived (3 days under dry-eating); and hyperhydrated (6 days without dry food, drinking liquid 4 % sucrose)...
April 2, 2024: Neuroscience Letters
Vincent J Coppola, Holden R Scribner, Caillie Barnett, Kaylyn A S Flanigan, Victoria R Riesgo, Verner P Bingman
While studies have identified age-related cognitive impairment in pigeons (Columba livia), no study has detected the brain atrophy which typically accompanies cognitive impairment in older mammals. Instead, Coppola and Bingman (Aging is associated with larger brain mass and volume in homing pigeons (Columba livia), Neurosci. Letters 698 (2019) 39-43) reported increased whole brain mass and telencephalon volume in older, compared to younger, homing pigeons. One reason for this unexpected finding might be that the older pigeons studied were not old enough to display age-related brain atrophy...
March 29, 2024: Neuroscience Letters
Yunxuan Huang, Xiaoyu Zhang, Wei Li
The primary somatosensory cortex (S1) is responsible for processing information related to tactile stimulation, motor learning and control. Despite its significance, the connection between S1 and the primary motor cortex (M1), as well as its role in motor learning, remains a topic of ongoing exploration. In the present study, we silenced S1 by the GABA receptor agonist muscimol to study the potential roles of S1 in motor learning and task execution. Our results show that the inhibition of S1 leads to an immediate impairment in performance during the training session and also a substantial reduction in performance improvement during post-test session on the subsequent day...
March 28, 2024: Neuroscience Letters
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