journal
https://read.qxmd.com/read/38013121/gdp-dissociation-inhibitor-1-gdi1-attenuates-%C3%AE-amyloid-induced-neurotoxicity-in-alzheimer-s-diseases
#1
JOURNAL ARTICLE
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
OBJECTIVE: β-Amyloid (Aβ) induced neurotoxicity is an implicated mechanism in Alzheimer's disease (AD). This study focused on the role of GDP dissociation inhibitor 1 (GDI1) in Aβ-induced neurotoxicity. METHODS: Data from the GEO database for AD-related datasets GSE140829, GSE63061, GSE36980, and GSE60360 were downloaded and identified common differentially expressed genes (coDEGs). The mRNA levels of GDI1 in the serum of AD patients were analyzed by RT-qPCR...
November 25, 2023: Neuroscience Letters
https://read.qxmd.com/read/38013120/neurodegeneration-after-repeated-noise-trauma-in-the-mouse-lower-auditory-pathway
#2
JOURNAL ARTICLE
Moritz Gröschel, Tanyo Manchev, Felix Fröhlich, Sebastian Jansen, Arne Ernst, Dietmar Basta
High intensity noise exposure leads to a permanent shift in auditory thresholds (PTS), affecting both peripheral (cochlear) tissue and the central auditory system. Studies have shown that a noise-induced hearing loss results in significant cell loss in several auditory structures. Degeneration can be demonstrated within hours after noise exposure, particularly in the lower auditory pathway, and continues to progress over days and weeks following the trauma. However, there is limited knowledge about the effects of recurring acoustic trauma...
November 25, 2023: Neuroscience Letters
https://read.qxmd.com/read/38008350/alamandine-injection-in-the-periaqueductal-gray-and-rostral-ventromedial-medulla-attenuates-allodynia-induced-by-sciatic-nerve-ligation-in-rats
#3
JOURNAL ARTICLE
Zahra Gholami, Ava Soltani Hekmat, Ali Abasi, Kazem Javanmardi
Alamandine, a peptide known to interact with Mas-related G protein-coupled receptor subtype D (MrgD), has been implicated in moderating inflammatory signals. MrgD receptors are abundantly found in pain transmission pathways, but the role of alamandine/MrgD in pain modulation has not been thoroughly explored. This study aimed to investigate the effects of alamandine (10, 40, and 100 pmol) in a rat model of allodynia induced by sciatic nerve ligation, with a specific focus on examining the involvement of MrgD receptors, NMDAR1, and serotonin transporter (SERT) in the ventrolateral periaqueductal gray (vlPAG) and rostral ventromedial medulla (RVM)...
November 24, 2023: Neuroscience Letters
https://read.qxmd.com/read/38007086/effects-of-short-term-second-language-learning-on-the-development-of-individual-semantic-networks-in-written-and-spoken-language
#4
JOURNAL ARTICLE
Jie Dong, Wenjia Zhang, Aqian Li, Yujun Lee, Hao Cai, Wenjing Jiang, Hao Yan
Previous studies have primarily focused on the relationship between native language (L1) and second language (L2) in the brain, specifically in one language modality, such as written or spoken language. However, there is limited research on how L2 proficiency impacts both modalities. This study aimed to investigate the functional networks involved in reading and speech comprehension for both L1 and L2, and observe changes in these networks as L2 proficiency improves. The dataset used in this study was obtained from a previous research conducted by Gurunandan et al...
November 23, 2023: Neuroscience Letters
https://read.qxmd.com/read/38007085/exploring-the-effects-of-different-bci-based-attention-training-games-on-the-brain-a-functional-near-infrared-spectroscopy-study
#5
JOURNAL ARTICLE
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
BCI games have been widely employed as non-invasive therapeutic interventions for conditions, but their efficacy remains a subject of debate. This study explores the efficacy of two prevalent forms of Brain-Computer Interface (BCI)-based attention training games: video games (VG) and physical games (PG). The effectiveness of these games has been examined through the lens of neuroscience, using functional Near-Infrared Spectroscopy (fNIRS) to monitor cortical activation. After the fNIRS test, subjects completed an Intrinsic Motivation Inventory (IMI) questionnaire...
November 23, 2023: Neuroscience Letters
https://read.qxmd.com/read/38000775/serum-biomarkers-associated-with-aging-and-neurodegeneration-in-common-marmosets-callithrix-jacchus
#6
JOURNAL ARTICLE
Kimberley A Phillips, Matthew Lopez, Evelyn Bartling-John, Reagan Meredith, Anna Buteau, Addaline Alvarez, Corinna N Ross
The common marmoset (Callithrix jacchus), a small South American monkey, is an important nonhuman primate model in the study of aging and age-related neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, and related dementias. Thorough characterization of the wild type marmoset brain agingmodel, including biomarkers of aging and neural degeneration, will further the marmoset's utility in translational research. We measured serum concentration of four key biomarkers of neural degeneration [total tau (T-tau), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)] via single molecule array from 24 marmosets (female n = 13, male n = 11) ranging in age from 1...
November 22, 2023: Neuroscience Letters
https://read.qxmd.com/read/38000774/different-paradigms-of-transcranial-electrical-stimulation-induce-structural-changes-in-the-ca1-region-of-the-hippocampus-in-a-rat-model-of-alzheimer-s-disease
#7
JOURNAL ARTICLE
Amir Hossein Zarifkar, Asadollah Zarifkar, Sepideh Safaei
One of the prominent sign of Alzheimer's disease (AD) is structural changes in the hippocampus. Recently, the new methods used to treat this disease is transcranial electrical stimulation (tES). This study evaluated the effect of four primary standards of tES, including tDCS, tACS, tRNS, and tPCS on beta-amyloid 25-35 (Aβ25-35)-induced structural changes in the CA1 region of hippocampus in male rats. For this purpose, rats weighing 250-275 g were selected, the cannula was embedded reciprocally into the hippocampi...
November 22, 2023: Neuroscience Letters
https://read.qxmd.com/read/37996051/effects-of-transcranial-electrical-stimulation-of-the-right-posterior-parietal-cortex-on-physical-control-responses
#8
JOURNAL ARTICLE
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
The posterior parietal cortex plays an important role in postural stability by adapting to changes in input from the visual, vestibular, and proprioceptive systems. However, little is known regarding whether transcranial electrical stimulation of the posterior parietal cortex affects reactive postural responses. This study aimed to investigate changes in physical control responses to anodal and cathodal transcranial direct current stimulation and transcranial random noise stimulation of the right posterior parietal cortex using a simultaneous inertial measurement unit...
November 21, 2023: Neuroscience Letters
https://read.qxmd.com/read/37996050/the-use-of-textured-foot-orthoses-to-facilitate-cutaneous-afferent-input-during-walking
#9
JOURNAL ARTICLE
Kelly A Robb, Lara A Green, Stephen D Perry
No abstract text is available yet for this article.
November 21, 2023: Neuroscience Letters
https://read.qxmd.com/read/37984485/promising-efficacy-of-low-dose-rituximab-in-muscle-specific-kinase-antibody-positive-myasthenia-gravis
#10
JOURNAL ARTICLE
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
AIMS: The study aims to evaluate the efficacy of low dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). METHODS: This is a single-center, retrospective study. A total of 10 patients with MuSK-MG were admitted to the Department of Neurology, First Hospital, Shanxi Medical University, between April 2021 to April 2023. Of them, 9 patients had been treated with low dose RTX (500 mg every 6 month) and recruited in this study...
November 19, 2023: Neuroscience Letters
https://read.qxmd.com/read/37984486/extracellular-vesicles-derived-from-monomeric-%C3%AE-synuclein-treated-microglia-ameliorate-neuroinflammation-by-delivery-of-mirnas-targeting-prak
#11
JOURNAL ARTICLE
Na Li, Yang Huang, Yufeng Wu, Qilong Wang, Pengyu Ji
Parkinson's disease (PD) is characterized by the formation of Lewy body, which mainly contains misfolded α-synuclein. Microglial activation plays a role in neurodegeneration. The pathologically oligomeric α-synuclein promotes inflammatory microglia, while physiologically monomeric α-synuclein induces anti-inflammatory microglia, the relationship between these two forms in activating microglia and the molecular mechanism is essentially unknown. In this study, using in vivo and in vitro models, we challenged primary or BV2 microglia with exogenous stimuli including α-synuclein...
November 18, 2023: Neuroscience Letters
https://read.qxmd.com/read/37984484/7-8-dihydroxyflavone-ameliorates-cognitive-impairment-induced-by-repeated-neonatal-sevoflurane-exposures-in-mice-through-increasing-tau-o-glcnacylation
#12
JOURNAL ARTICLE
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
BACKGROUND: Sevoflurane, one of the most commonly used general anesthetics for pediatric anesthesia, has recently gained significant attention in both preclinical and clinical settings due to its potential neurotoxicity in the developing brain. Tau phosphorylation, induced by sevoflurane, is recognized as one of the major causes of neurotoxicity. 7,8-dihydroxyflavone (DHF), a TrkB receptor agonist, has been reported to exhibit potential neuroprotective effects against tauopathies. In this study, our objective was to investigate whether DHF could provide neuroprotective effects against sevoflurane-induced neurotoxicity and explore the underlying molecular mechanisms...
November 18, 2023: Neuroscience Letters
https://read.qxmd.com/read/37979715/neuroprotective-effect-of-plasmalogens-on-alcl-3-induced-alzheimer-s-disease-zebrafish-via-acting-on-the-regulatory-network-of-ferroptosis-apoptosis-and-synaptic-neurotransmission-release-with-oxidative-stress-as-the-center
#13
JOURNAL ARTICLE
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Plasmalogens (Pls) are considered to play a potential role in the treatment of neurodegenerative diseases. In the present study, an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 was established to investigate whether the marine-derived Pls could alleviate cognitive impairments of AD zebrafish. Behavioral tests were carried out to assess the athletic ability. The transcriptional profiles of zebrafish in the control, AD model and AD_PLS group were compared and analyzed to determine the potential mechanisms of dietary Pls on AD...
November 16, 2023: Neuroscience Letters
https://read.qxmd.com/read/37972685/central-effects-of-the-serotoninergic-gabaergic-and-cholecystokinin-systems-on-neuropeptide-vf-npvf-induced-hypophagia-and-feeding-behavior-in-neonatal-broiler-chicken
#14
JOURNAL ARTICLE
Anahita Vosoughi, Morteza Zendehdel, Shahin Hassanpour
The study was performed to evaluate the role of central serotoninergic, GABAergic, and cholecystokinin systems in neuropeptide VF (NPVF)-induced hypophagia in broiler chickens. In this study, 9 experiments were designed, each with one control and three treatment groups (n = 44 in each experiment). Control chicks of all groups were subjected to normal saline + Evans blue 0.1 % Intracerebroventricular (ICV) injection. In the first experiment, 3 groups of chicks received NPVF (4, 8, and 16 nmol)...
November 14, 2023: Neuroscience Letters
https://read.qxmd.com/read/37972684/distribution-connection-and-function-of-aldh1a1-th-neurons-in-substantia-nigra-pars-reticulata-of-mouse
#15
JOURNAL ARTICLE
Hao Liu, Zhuo Gong, Zhao Li, Tonglin Ye, Anqi Cao, Shuaiying He, Sijia Lin, Jinhai Duan, Xian Lin
The massive cell death of dopaminergic neurons (DANs) in substantia nigra pars compacta (SNC) is associated with motor diseases, such as Parkinson's disease. Moreover, as a subtype of DANs in SNC, ALDH1A1+ neurons show better resistance to PD related neurotoxin. DANs can also be found in the substantia nigra pars reticulata (SNR), however, whether they are ALDH1A1+ neurons are rarely reported, as well as their projection, function, and reaction in the PD pathology. We studied the distribution of ALDH1A1+ neurons and track their projection by injecting pAAV...
November 14, 2023: Neuroscience Letters
https://read.qxmd.com/read/37951301/evaluation-of-the-separate-and-combined-effects-of-anodal-tdcs-over-the-m1-and-f3-regions-on-pain-relief-in-patients-with-type-2-diabetes-suffering-from-neuropathic-pain
#16
JOURNAL ARTICLE
Ahmad Alipour, Roghayeh Mohammadi
BACKGROUND: Neuropathic pain (NP) is a common complication of chronic diabetes that negatively affects the routine functioning and sleep of patients. The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from NP. METHODS: The statistical population of this double-blind randomized clinical trial consisted of all the members of the Bonab Diabetes Association in 2022 aged 45 to 65 years who were diagnosed with NP by a specialist...
November 9, 2023: Neuroscience Letters
https://read.qxmd.com/read/37951300/pupillary-dilations-in-a-target-distractor-visual-task-paradigm-and-attention-deficit-hyperactivity-disorder-adhd
#17
JOURNAL ARTICLE
Claudio M Privitera, Sean Noah, Thom Carney, Stanley A Klein, Agatha Lenartowicz, Stephen P Hinshaw, James T McCracken, Joel T Nigg, Sarah L Karalunas, Mercedes Oliva, Samantha S Betts, Gregory V Simpson
ADHD is a neurocognitive disorder characterized by attention difficulties, hyperactivity, and impulsivity, often persisting into adulthood with substantial personal and societal consequences. Despite the importance of neurophysiological assessment and treatment monitoring tests, their availability outside of research settings remains limited. Cognitive neuroscience investigations have identified distinct components associated with ADHD, including deficits in sustained attention, inefficient enhancement of attended Targets, and altered suppression of ignored Distractors...
November 9, 2023: Neuroscience Letters
https://read.qxmd.com/read/37949292/mild-traumatic-brain-injury-induces-pericyte-detachment-independent-of-stroke-vulnerability
#18
JOURNAL ARTICLE
Bailey Whitehead, Deborah Corbin, Ali Albowaidey, Ning Zhang, Kate Karelina, Zachary M Weil
Mild traumatic brain injury (mTBI) is an independent risk factor for ischemic stroke and can result in poorer outcomes- an effect presumed to involve the cerebral vasculature. Here we tested the hypothesis that mTBI-induced pericyte detachment from the cerebrovascular endothelium is responsible for worsened stroke outcomes. We performed a mild closed-head injury and/or treated C57/bl6 mice with imatinib mesylate, a tyrosine kinase inhibitor that induces pericyte detachment. The time course of pericyte detachment was assessed 7, 14, and 28 days post injury (DPI)...
November 8, 2023: Neuroscience Letters
https://read.qxmd.com/read/37949291/downregulation-of-nrp1-transcription-promotes-blood-brain-barrier-disruption-following-experimental-cerebral-ischemia-reperfusion
#19
JOURNAL ARTICLE
Xiang Xu, Gang Chen, Hai Zhou, Yangyang Liu, Haojie Ding, Zongqi Wang, Haitao Shen, Xiang Li, Haiying Li
Disruption of the blood-brain barrier (BBB) following cerebral ischemia-reperfusion injury (CIRI) is a major factor in the pathophysiology of stroke. Endothelial cell-cell communication is essential for maintaining BBB integrity. By analyzing GSE227651 data, we found that a decrease in endothelial cell-cell communication mediated by Sema3/Nrp1 may be due to the downregulation of Nrp1 transcription, which could contribute to BBB breakdown after CIRI. We confirmed this hypothesis by using western blot analysis to show a reduction in Nrp1 protein levels in penumbra endothelial cells after CIRI in mice...
November 8, 2023: Neuroscience Letters
https://read.qxmd.com/read/37926292/behavioral-deficits-after-mild-traumatic-brain-injury-by-fluid-percussion-in-rats
#20
JOURNAL ARTICLE
Fernando da Silva Fiorin, Caroline Cunha do Espírito Santo, Raphael Santos do Nascimento, Angela Patricia França, Luiz Fernando Freire Royes
Mild traumatic brain injury (TBI) can lead to various disorders, encompassing cognitive and psychiatric complications. While pre-clinical studies have long investigated behavioral alterations, the fluid percussion injury (FPI) model still lacks a comprehensive behavioral battery that includes psychiatric-like disorders. To address this gap, we conducted multiple behavioral tasks over two months in adult male Wistar rats, focusing on mild FPI. Statistical analyses revealed that both naive and sham animals exhibited an increase in sweet liquid consumption over time...
November 4, 2023: Neuroscience Letters
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