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Anna Scanu, Chiara Giraudo, Francesca Galuppini, Vanni Lazzarin, Gianmaria Pennelli, Stefano Sivolella, Edoardo Stellini, Francesca Oliviero, Paola Galozzi, Massimo Rugge, Roberto Stramare, Roberto Luisetto, Leonardo Punzi
This study evaluated the arthritogenic effect of lipopolysaccharide (LPS) in a mouse model of periodontal disease. Periodontitis was induced in wild-type CD1 mice by nine LPS injections (10 or 50 ng) into the maxillary mucosa. Untreated mice or injected with LPS at the tail were used as controls. Two weeks after final inoculation, mice were sacrificed to collect blood, maxilla, and paw samples. Development and progression of periodontitis and arthritis were monitored using clinical assessment, micro-computed tomography (micro-CT), ultrasound (US), and histological analysis...
February 19, 2019: Inflammation
Thiago Duarte, Fernanda Barbisan, Beatriz Sadigurski Nunes da Cunha, Verônica Farina Azzolin, Bárbara Osmarin Turra, Marta Maria Medeiros Frescura Duarte, Ivo Emilio da Cruz Jung, Euler Esteves Ribeiro, Pedro Antônio do Prado-Lima, Ivana Beatrice Mânica da Cruz
After publication of our article it came to our attention that it contains a number of errors with regard to the citations. The details are provided below.
February 15, 2019: Inflammation
Ayman M Mahmoud, Walaa G Hozayen, Iman H Hasan, Eman Shaban, May Bin-Jumah
Umbelliferone (UMB) is a natural coumarin that has diverse biological activities. However, its potential to protect against liver fibrosis has not been reported yet. This study aimed to investigate the protective effect of UMB against carbon tetrachloride (CCl4 )-induced liver fibrosis in rats. Rats received CCl4 and UMB for 8 weeks and samples were collected for analyses. CCl4 induced a significant increase in serum levels of liver function markers and pro-inflammatory cytokines. Treatment with UMB significantly ameliorated liver function markers and pro-inflammatory cytokines and prevented CCl4 -induced histological alterations...
February 11, 2019: Inflammation
Vijay Kumar
The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below: In the published article, the subheading "Immunometabolic Reprogramming Among MDSCs During Sepsis" should read as "Immunometabolic Reprogramming Among Endothelial Cells or ECs During Sepsis".
February 9, 2019: Inflammation
Noha F Hassan, Somaia A Nada, Azza Hassan, Mona R El-Ansary, Muhammad Y Al-Shorbagy, Rania M Abdelsalam
The most epidemic liver disorder non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis and inflammation with hepatocellular damage. Recently, it is predictable to be the extensive cause for liver transplantation. The absence of an approved therapeutic agent for NASH is the reason for investigating saroglitazar (SAR) which showed promising effects as a dual PPAR-α/γ agonist in recent studies on NASH. Here, we aimed to investigate the effect of SAR on NASH induced in rats by the administration of high-fat emulsion (HFE) and small doses of lipopolysaccharides (LPS) for 5 weeks...
February 9, 2019: Inflammation
Chao Cao, Yan Zhang, Yanfen Chai, Lijun Wang, Chengfen Yin, Songtao Shou, Heng Jin
Myocardial cell injury or cardiomyopathy is associated with excessive inflammatory response and apoptosis of cardiac myocytes during sepsis. MicroRNA-23b (miR-23b) is a multifunctional miRNA that is considered to regulate immunosuppression in sepsis. The aim of this study was to examine the effect of miR-23b on cardiomyopathy induced by sepsis and to explore the potential mechanism involved. Sprague-Dawley rats were subjected to cecal ligation and puncture (CLP), and the level of miR-23b at different time points was measured by quantitative real-time polymerase chain reaction (qPCR)...
February 8, 2019: Inflammation
Jiexiong Yao, Jihua Zhang, Wenlin Tai, Shuhao Deng, Ting Li, Wenjuan Wu, Lin Pu, Du Fan, Wen Lei, Tao Zhang, Zhaoxing Dong
Paraquat (PQ) intoxication seriously endangers human beings' health, however, the underlying mechanisms are still unclear. Here we found that PQ inhibits human bronchial 16HBE cell proliferation and promotes cell apoptosis, necrosis as well as ROS generation in a dose dependent manner. Of note, low-dose PQ (50 μM) induces cell autophagy, increases Nrf2 as well as p65 levels and has little impacts on Keap1, while high-dose PQ (500 μM) inhibits autophagy, upregulates Keap1 as well as downregulates p65 and Nrf2...
February 8, 2019: Inflammation
Haiming Jin, Qingqing Wang, Jianwei Wu, Xuyao Han, Tianchen Qian, Zengjie Zhang, Jianle Wang, Xiangxiang Pan, Aimin Wu, Xiangyang Wang
Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is a natural bioactive compound with anti-inflammatory effects in different diseases, including inhibition of the inflammatory response in chondrocytes, whose morphology and avascular supply are similar to those of NP cells. Therefore, we hypothesized that baicalein may have a therapeutic effect on IDD by suppressing the inflammatory response...
February 7, 2019: Inflammation
Bongjun Sur, Seungmin Kang, Mijin Kim, Seikwan Oh
This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 and both ears were treated with 5% TMA on day 5 and with 2% TMA from day 6 to day 14. JC3 (1, 5, 10 mg/kg, i.p.) was treated once daily from day 9 to day 14 before TMA treatment. Histological analysis was performed and auricular lymph node weights, ear thicknesses, skin water contents, scratching behaviors, and serum immunoglobulin (IgE) and IFN-γ, and interleukin-4 (IL-4) levels in serum and ear tissues were determined...
February 7, 2019: Inflammation
Zhanqin Zhang, Yi Lei, Chaoying Yan, Xiaopeng Mei, Tao Jiang, Zhi Ma, Qiang Wang
Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes...
February 6, 2019: Inflammation
Chenfei Zheng, Ji Zhang, Xinxin Chen, Jianna Zhang, Xiaokai Ding, Xiaohan You, Lin Fan, Chaosheng Chen, Ying Zhou
Chronic inflammation is a major contributor to obesity-related renal damage. Recent studies have demonstrated that microRNA (miR)-155 is closely associated with hyperglycemia-induced nephropathy, but whether renal miR-155 participates in the inflammatory response and development of obesity-related nephropathy is unknown. In present study, we investigated the pathophysiological role of renal miR-155 in palmitic acid (PA)-treated endothelial cell and high-fat-diet (HFD)-fed mouse models by specific miR-155 sponge...
February 4, 2019: Inflammation
Zhijuan Xie, Jia Yin
Birch pollen allergy is a common cause of spring pollinosis in China. However, there is little research on birch pollen allergen in China and only the major allergen (Bet v 1) has been fully characterized. Chinese birch pollen-induced airway inflammation models in BALB/c mice were developed and administered subcutaneous immunotherapy (SCIT). BALB/c mice were sensitized subcutaneously on days 1, 8, and 15 with 25 μg/μL birch pollen extract. On days 24-26, the mice were challenged with 0.1% birch pollen aerosol...
February 4, 2019: Inflammation
Yijie Cheng, Yanfang Cao, Awais Ullah Ihsan, Farhan Ullah Khan, Xue Li, Dianyou Xie, Xingxing Cui, Wenlu Wang, Ziwei Liu, Cunyu Li, Khalil Ali Ahmad, Kiganda Raymond Sembatya, Reyaj Mikrani, Xiaohui Zhou
The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. Fifty male C57BL/6 mice were randomly divided into five groups of ten mice each. All groups except naïve were subcutaneously injected with 0.2 ml of T2 plus complete Freund adjuvant (CFA) on day 0 and 14 to generate valid CP/CPPS model...
February 4, 2019: Inflammation
Mariana Rodrigues Davanso, Carolina Caliari-Oliveira, Carlos Eduardo Barra Couri, Dimas Tadeu Covas, Angela Merice de Oliveira Leal, Júlio César Voltarelli, Kelen Cristina Ribeiro Malmegrim, Juliana Navarro Ueda Yaochite
Sitagliptin is a dipeptidyl peptidase-4 inhibitor (iDPP-4), which has been used for type 2 diabetes treatment. Recently, iDPP-4 has been described as a promising treatment of type 1 diabetes (T1D) but is still necessary to evaluate immune effects of sitagliptin. C57BL/6 mice were induced by multiple low doses of streptozotocin. Diabetes incidence, insulin, glucagon, glucagon-like peptide-1 (GLP-1) serum levels, and inflammatory cytokine levels were quantified in pancreas homogenate after 30 and 90 days of treatment...
February 1, 2019: Inflammation
Ting Zhou, Yan Sun, Yanli Wang, Xiaobing Chen, Luo Zhuo, Lin Bu, Suo Xu, Jiayan Han, Xiaomin Li, Jiaxin Shi
Umbilical cord blood mesenchymal stem cells (UCB-MSCs) have been shown to be a source of stem cells for use in cellular therapies and have immunomodulatory effects on several immune cells in an inflammatory environment. However, whether UCB-MSCs have immunomodulatory effects against lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in macrophages and whether it is involved in phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway remain unclear. After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages...
February 1, 2019: Inflammation
Mike Yoshio Hamasaki, Patricia Severino, Renato David Puga, Marcia Kiyomi Koike, Camila Hernandes, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Marcel Cerqueira César Machado, Eduardo Moraes Reis, Fabiano Pinheiro da Silva
Among the clinical manifestations observed in septic patients, sepsis-associated encephalopathy (SAE) is probably the most obscure and poorly explored. It is well established, however, that SAE is more prevalent in aged individuals and related to a worse outcome. In this context, we decided to investigate the acute effects of sepsis, induced by cecal ligation and puncture (CLP), on the cerebral transcriptional profile of young and old rats. The idea was to highlight important signaling pathways possibly implicated in the early stages of SAE...
January 31, 2019: Inflammation
Zhixing He, Lijun Du, Yuehai Ke, Chengping Wen, Yun Zhang
Protein phosphatase 2A (PP2A) is one main serine/threonine phosphatase in eukaryotes, and its activation changes have been linked to modulation of numerous pathological processes, such as cancer, inflammation, fibrosis, and neurodegenerative diseases. Acute respiratory distress syndrome (ARDS), the major cause of respiratory failure, remains with limited therapies available up to now. Alveolar macrophages (AMs) are essential to innate immunity and host defense, participating in the pathogenesis of ARDS. As a result, AMs are considered as a potential therapeutic target for ARDS...
January 25, 2019: Inflammation
Qi-Ying Shen, Ling Wu, Chuan-Sheng Wei, Yan-Nan Zhou, Hui-Mei Wu
Asthma is characterized by chronic airway inflammation, which is the underlying cause of airway remodeling featured by goblet cell hyperplasia, subepithelial fibrosis, and proliferation of smooth muscle. Sevoflurane has been used to treat life-threatening asthma and our previous study shows that sevoflurane inhibits acute lung inflammation in ovalbumin (OVA)-induced allergic mice. However, the effect of sevoflurane on airway remodeling in the context of chronic airway inflammation and the underlying mechanism are still unknown...
January 24, 2019: Inflammation
David Bennett, Martina Salvini, Annalisa Fui, Giuseppe Cillis, Paolo Cameli, Maria Antonietta Mazzei, Antonella Fossi, Rosa Metella Refini, Paola Rottoli
Idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) are the most frequent idiopathic interstitial pneumonias. The aim of this study was to evaluate concentrations of calgranulin B and Krebs von den Lungen 6 (KL-6) in bronchoalveolar lavage (BAL) fluid of patients with IPF and idiopathic NSIP (i-NSIP) with fibrotic pattern. Thirty patients with IPF (68.73 ± 8.63 years), 30 with i-NSIP (68.33 ± 7.45 years), and healthy controls were included in the study. Calgranulin B and KL-6 both proved to be significantly higher in BAL of IPF and i-NSIP patients than in healthy controls (p < 0...
January 24, 2019: Inflammation
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