Simona Lattanzi, Eugen Trinka, Emilio Russo, Cinzia Del Giovane, Sara Matricardi, Stefano Meletti, Pasquale Striano, Payam Tabaee Damavandi, Mauro Silvestrini, Francesco Brigo
BACKGROUND: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifelong seizures. The management of seizures in DS has changed in recent years with the approval of new antiseizure medications (ASMs). OBJECTIVE: The aim of this study was to estimate the comparative efficacy and tolerability of the ASMs for the treatment of seizures associated with DS using a network meta-analysis (NMA). METHODS: Studies were identified by conducting a systematic search (week 4, January 2023) of the MEDLINE (accessed by PubMed), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and US National Institutes of Health Clinical Trials Registry ( https://www...
September 11, 2023: Drugs