journal
https://read.qxmd.com/read/38992489/unveiling-the-role-of-tagln2-in-glioblastoma-from-proneural-mesenchymal-transition-to-temozolomide-resistance
#1
JOURNAL ARTICLE
Yang Li, Xinyu Wang, Tianye Xu, Fan Xu, Tongzheng Chen, Zhengji Li, Yiwei Wang, Hao Chen, Jianguang Ming, Jinquan Cai, Chuanlu Jiang, Xiangqi Meng
Glioblastoma (GBM) presents a daunting challenge due to its resistance to temozolomide (TMZ), a hurdle exacerbated by the proneural-to-mesenchymal transition (PMT) from a proneural (PN) to a mesenchymal (MES) phenotype. TAGLN2 is prominently expressed in GBM, particularly in the MES subtype compared to low-grade glioma (LGG) and the PN subtype. Our research reveals TAGLN2's involvement in PMT and TMZ resistance through a series of in vitro and in vivo experiments. TAGLN2 knockdown can restrain proliferation and invasion, trigger DNA damage and apoptosis, and heighten TMZ sensitivity in GBM cells...
July 9, 2024: Cancer Letters
https://read.qxmd.com/read/38992488/gender-differences-in-gliomas-from-epidemiological-trends-to-changes-at-the-hormonal-and-molecular-levels
#2
REVIEW
Jiale Yin, Gai Liu, Yue Zhang, Yu Zhou, Yuchun Pan, Qiaoshan Zhang, Rutong Yu, Shangfeng Gao
Gender plays a crucial role in the occurrence and development of cancer, as well as in the metabolism of nutrients and energy. Men and women display significant differences in the incidence, prognosis, and treatment response across various types of cancer, including certain sex-specific tumors. It has been observed that male glioma patients have a higher incidence and worse prognosis than female patients, but there is currently a limited systematic evaluation of sex differences in gliomas. The purpose of this study is to provide an overview of the association between fluctuations in sex hormone levels and changes in their receptor expression with the incidence, progression, treatment, and prognosis of gliomas...
July 9, 2024: Cancer Letters
https://read.qxmd.com/read/38992487/drug-induced-senescence-by-aurora-kinase-inhibitors-attenuates-innate-immune-response-of-macrophages-on-gastric-cancer-organoids
#3
JOURNAL ARTICLE
Ruixin Yang, Wingyan Kwan, Yutong Du, Ranlin Yan, Lu Zang, Chen Li, Zhenggang Zhu, Io Hong Cheong, Zisis Kozlakidis, Yingyan Yu
Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with aggressiveness and poor prognosis. It is of great significance to find sensitive drugs for DGC. In the current study, a total of 20 patient-derived organoids (PDOs) were analyzed for screening the therapeutic efficacy of small molecule kinases inhibitors on gastric cancers, especially the therapeutic difference between intestinal-type gastric cancer (IGCs) and DGCs. The IGCs are sensitive to multiple kinases inhibitors, while DGCs are resistant to most of these kinases inhibitors...
July 9, 2024: Cancer Letters
https://read.qxmd.com/read/38986735/targeting-of-human-cancer-stem-cells-predicts-efficacy-and-toxicity-of-fda-approved-oncology-drugs
#4
JOURNAL ARTICLE
Kinga Vojnits, Zhuohang Feng, Paige Johnson, Sibylle Pfammatter, Pierre Thibault, Mick Bhatia
Cancer remains the leading cause of death worldwide with approved oncology drugs continuing to have heterogenous patient responses and accompanied adverse effects (AEs) that limits effectiveness. Here, we examined >100 FDA-approved oncology drugs in the context of stemness using a surrogate model of transformed human pluripotent cancer stem cells (CSCs) vs. healthy stem cells (hSCs) capable of distinguishing abnormal self-renewal and differentiation. Although a proportion of these drugs had no effects (inactive), a larger portion affected CSCs (active), and a unique subset preferentially affected CSCs over hSCs (selective)...
July 8, 2024: Cancer Letters
https://read.qxmd.com/read/38986734/pi3k-protac-overcomes-the-lapatinib-resistance-in-pik3ca-mutant-her2-positive-breast-cancer
#5
JOURNAL ARTICLE
Hongyan Zhang, Longlong Zhang, Yuna He, Dewei Jiang, Jian Sun, Qianmei Luo, Huichun Liang, Tiantian Wang, Fubing Li, Yu Tang, Zimo Yang, Wenjing Liu, Yu Rao, Ceshi Chen
Although anti-HER2 therapy has made significant strides in reducing metastasis and relapse in HER2-positive breast cancer, resistance to agents like trastuzumab, pertuzumab, and lapatinib frequently develops in patients undergoing treatment. Previous studies suggest that the hyperactivation of the PI3K-AKT signaling pathway by PIK3CA/PTEN gene mutations is implicated in HER2 resistance. In this study, we introduce a novel PI3K-p110α PROteolysis TArgeting Chimera (PROTAC) that effectively inhibits the proliferation of breast cancer cells by degrading PI3K-p110α...
July 8, 2024: Cancer Letters
https://read.qxmd.com/read/38986733/pp2a-b55%C3%AE-inhibits-epithelial-mesenchymal-transition-via-regulation-of-slug-expression-in-non-small-cell-lung-cancer
#6
JOURNAL ARTICLE
Deepika Singh, Zhaojun Qiu, Spehar M Jonathan, Pengyan Fa, Hannah Thomas, B Prasad Chandra, Shurui Cai, Jing J Wang, Chunhong Yan, Xiaoli Zhang, Monica Venere, Zaibo Li, Steven T Sizemore, Qi-En Wang, Junran Zhang
PP2A B55α, encoded by PPP2R2A, acts as a regulatory subunit of the serine/threonine phosphatase PP2A. Despite a frequent loss of heterozygosity of PPP2R2A in cases of non-small cell lung cancer (NSCLC), research on PP2A B55α's functions remains limited and controversial. To investigate the biological roles of PP2A B55α, we conducted bulk RNA-sequencing to assess the impact of PPP2R2A knockdown using two shRNAs in a NSCLC cell line. Gene set enrichment analysis (GSEA) of the RNA-sequencing data revealed significant enrichment of the epithelial-mesenchymal transition (EMT) pathway, with SNAI2 (the gene encoding Slug) emerging as one of the top candidates...
July 8, 2024: Cancer Letters
https://read.qxmd.com/read/38972347/intratumoral-injection-of-mrna-encoding-survivin-in-combination-with-stat3-inhibitor-stattic-enhances-antitumor-effects
#7
JOURNAL ARTICLE
Min Li, Ying Xie, Jincheng Zhang, Xue Zhou, Lei Gao, Mengmeng He, Xianmei Liu, Xinyi Miao, Yu Liu, Rong Cao, Yi Jia, Zhu Zeng, Lina Liu
Intratumoral delivery of mRNA encoding immunostimulatory molecules can initiate a robust, global antitumor response with little side effects by enhancing local antigen presentation in the tumor and the tumor draining lymph node. Neoantigen-based mRNA nanovaccine can inhibit melanoma growth in mice by intratumoral injection. Myeloid-derived suppressor cells (MDSCs) suppress antitumor immune responses by secreting immunosuppressive agents, such as reactive oxygen species (ROS). Suppression of STAT3 activity by stattic may reduce MDSC-mediated immunosuppression in the TME and promote the antitumor immune responses...
July 5, 2024: Cancer Letters
https://read.qxmd.com/read/38971695/corrigendum-to-scrna-seq-and-imaging-mass-cytometry-analyses-unveil-inkt-cells-mediated-anti-tumor-immunity-in-pancreatic-cancer-liver-metastasis-cancer-lett-2023-may-1-561-216149
#8
Qijun Yi, Jie Wang, Tingting Liu, Yi Yao, Ian Loveless, Kalpana Subedi, Jugmohit Toor, Indra Adrianto, Hua Xiao, Bin Chen, Howard C Crawford, Deyu Fang, Li Zhou, Qing-Sheng Mi
No abstract text is available yet for this article.
July 5, 2024: Cancer Letters
https://read.qxmd.com/read/38971491/biphasic-co-detection-of-melanoma-aneuploid-tumor-cells-and-tumor-endothelial-cells-in-guidance-of-specifying-the-field-cancerized-surgical-excision-margin-and-administering-immunotherapy
#9
JOURNAL ARTICLE
Zhengzheng Fu, Lina Zhang, Rongyi Chen, Jipang Zhan, Jing Zhong, Wen Zheng, Jingwen Zou, Peng Wang, Xiaohua Deng, Alexander Y Lin, Daisy Dandan Wang, Peter Ping Lin, Renliang He
An optimum safety excision margin (EM) delineated by precise demarcation of field cancerization along with reliable biomarkers that enable predicting and timely evaluating patients' response to immunotherapy, significantly impact effective management of melanoma. In this study, optimized biphasic "immunofluorescence-staining integrated with fluorescence-in situ-hybridization" (iFISH) was conducted along the diagnosis-metastasis-treatment-cellular MRD axis to longitudinally co-detect a full spectrum of intact CD31- tumor cells (TCs), CD31+ aneuploid tumor endothelial cells (TECs), viable and necrotic CTCs and circulating TECs (CTECs) expressing PD-L1/Ki67/p16/Vimentin in unsliced specimens of the resected primary tumor, EM, dissected sentinel lymph nodes (SLNs) and peripheral blood in an early-stage melanoma patient...
July 4, 2024: Cancer Letters
https://read.qxmd.com/read/38971490/inhibition-of-kif20a-enhances-the-immunotherapeutic-effect-of-hepatocellular-carcinoma-by-enhancing-c-myc-ubiquitination
#10
JOURNAL ARTICLE
Shujia Chen, Lili Zhao, Jie Liu, Ping Han, Wentao Jiang, Yonggang Liu, Jiancun Hou, Fengmei Wang, Jia Li
Immune therapy has significantly improved the prognosis of hepatocellular carcinoma (HCC) patients, yet its efficacy remains limited, underscoring the urgency to identify new therapeutic targets and biomarkers. Here, we investigated the pathological and physiological roles of KIF20A and assess its potential in enhancing HCC treatment efficacy when combined with PD-1 inhibitors. We initially assess KIF20A's oncogenic function using liver-specific KIF20A knockout (Kif20a CKO) mouse models and orthotopic xenografts...
July 4, 2024: Cancer Letters
https://read.qxmd.com/read/38969163/measurable-residual-disease-testing-by-next-generation-sequencing-is-more-accurate-compared-with-multiparameter-flow-cytometry-in-adults-with-b-cell-acute-lymphoblastic-leukemia
#11
JOURNAL ARTICLE
Nan Yan, Zi-Long Wang, Xiao-Juan Wang, Robert Peter Gale, Ya-Lan Zhou, Ming-Yue Zhao, Li-Xin Wu, Ming-Yue Liao, Jie Yang, Chun-Yang Wang, Jian-Hua Zhu, Hao Jiang, Qian Jiang, Yan-Rong Liu, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Tong-Hui Ma, Xiao-Jun Huang, Guo-Rui Ruan
Results of measurable residual disease (MRD)-testing by next-generation sequencing (NGS) correlate with relapse risk in adults with B-cell acute lymphoblastic leukemia (ALL) receiving chemotherapy or an allotransplant from a human leukocyte antigen (HLA)-identical relative or HLA-matched unrelated donor. We studied cumulative incidence of relapse (CIR) and survival prediction accuracy using a NGS-based MRD-assay targeting immunoglobulin genes after 2 courses of consolidation chemotherapy cycles in 93 adults with B-cell ALL most receiving HLA-haplotype-matched related transplants...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969162/loss-of-function-mutation-of-rev1-p-r704q-mediates-cetuximab-primary-resistance-by-activating-autophagy-in-ras-wild-type-metastatic-colorectal-cancer
#12
JOURNAL ARTICLE
Ning Zhu, Yuwei Ding, Mi Mi, Jiawen Yang, Mengyuan Yang, Dan Li, Yan Zhang, Xuefeng Fang, Shanshan Weng, Ying Yuan
Cetuximab in combination with FOLFIRI/FOLFOX is the standard first-line treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, some patients experience rapid tumor progression after treatment with cetuximab (primary resistance). Our previous research identified a gene mutation, REV1 p.R704Q, which may be a key biomarker for primary cetuximab resistance. This study aimed to study the mechanism of cetuximab resistance caused by REV1 p.R704Q mutation and reveal a novel mechanism to induce cetuximab resistance...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969161/gut-microbial-metabolites-in-lung-cancer-development-and-immunotherapy-novel-insights-into-gut-lung-axis
#13
REVIEW
Xinpei Li, Shijie Shang, Meng Wu, Qian Song, Dawei Chen
Metabolic derivatives of numerous microorganisms inhabiting the human gut can participate in regulating physiological activities and immune status of the lungs through the gut-lung axis. The current well-established microbial metabolites include short-chain fatty acids (SCFAs), tryptophan and its derivatives, polyamines (PAs), secondary bile acids (SBAs), etc. As the study continues to deepen, the critical function of microbial metabolites in the occurrence and treatment of lung cancer has gradually been revealed...
July 4, 2024: Cancer Letters
https://read.qxmd.com/read/38969160/targeting-lsd1-in-cancer-molecular-elucidation-and-recent-advances
#14
REVIEW
Wenpeng Cai, Chu Xiao, Tao Fan, Ziqin Deng, Di Wang, Yixiao Liu, Chunxiang Li, Jie He
Histones are the main components of chromatin, functioning as an instructive scaffold to maintain chromosome structure and regulate gene expression. The dysregulation of histone modification is associated with various pathological processes, especially cancer initiation and development, and histone methylation plays a critical role. However, the specific mechanisms and potential therapeutic targets of histone methylation in cancer are not elucidated. Lys-specific demethylase 1A (LSD1) was the first identified demethylase that specifically removes methyl groups from histone 3 at lysine 4 or lysine 9, acting as a repressor or activator of gene expression...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969159/neutrophil-extracellular-traps-promote-immune-escape-in-hepatocellular-carcinoma-by-up-regulating-cd73-through-notch2
#15
JOURNAL ARTICLE
Yang Yu, Congyi Zhang, Bowen Dong, Zhihua Zhang, Xiaoqing Li, Shizhuan Huang, Daowei Tang, Xiaowei Jing, Shan Yu, Tongsen Zheng, Dehai Wu, Sheng Tai
Immune escape is the main reason that immunotherapy is ineffective in hepatocellular carcinoma (HCC). Here, this study illustrates a pathway mediated by neutrophil extracellular traps (NETs) that can promote immune escape of HCC. Mechanistically, we demonstrated that NETs up-regulated CD73 expression through activating Notch2 mediated nuclear factor kappa B (NF-κB) pathway, promoting regulatory T cells (Tregs) infiltration to mediate immune escape of HCC. In addition, we found the similar results in mouse HCC models by hydrodynamic plasmid transfection...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969158/periodontitis-is-an-immune-related-adverse-event-associated-with-immune-checkpoint-inhibitors-a-multi-center-cohort-study
#16
JOURNAL ARTICLE
Kevin Sheng-Kai Ma, Cho-Hung Chiang, Steven T Chen, Yen Dinh, Cho-Hsien Chiang, Thomas E Van Dyke, Ryan Sullivan, Ashwin N Ananthakrishnan, Yuan Ping Hsia, Cheng-Ming Peng, Cho-Han Chiang
Immune checkpoint inhibitors (ICIs) cause immune-related adverse events (irAEs) across various organ systems including oral health complications such as dry mouth and stomatitis. In this study, we aimed to determine the risk of periodontitis among patients on immune checkpoint inhibitors (ICIs) and to test the associations between ICI-associated periodontitis and other immune-related adverse events (irAEs). We performed a retrospective cohort study involving adult cancer patients between January 2010 and November 2021...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969157/aptamer-functionalized-hypoxia-potentiating-agent-and-hypoxia-inducible-factor-inhibitor-combined-with-hypoxia-activated-prodrug-for-enhanced-tumor-therapy
#17
JOURNAL ARTICLE
Yuan Ma, Huarui Zhang, Xinyang Shen, Xin Yang, Yan Deng, Yuan Tian, Zefeng Chen, Yufei Pan, Hang Luo, Chuanxin Zhong, Sifan Yu, Aiping Lu, Baoting Zhang, Tao Tang, Ge Zhang
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer. Hypoxia-activated prodrugs (HAPs) have shown promise as potential therapeutic agents for TNBC. While increasing hypoxia levels may promote the HAP activation, it raises concerns regarding HIF1α-dependent drug resistance. It is desirable to develop a targeted approach that enhances tumor hypoxia for HAP activation without promoting HIF1α-dependent drug resistance in TNBC treatment. Herein, we proposed a multi-responsive carrier-free self-assembled nanomedicine named AQ4N@CA4T1ASO...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38969156/o-glcnac-signaling-implications-for-stress-induced-adaptive-response-pathway-in-the-tumor-microenvironment
#18
REVIEW
Yu Zhao, Renlong Li, Weizhen Wang, Haohao Zhang, Qiujin Zhang, Jialu Jiang, Ying Wang, Yan Li, Feng Guan, Yongzhan Nie
The tumor microenvironment (TME) consists of tumor cells, non-tumor cells, extracellular matrix, and signaling molecules, which can contribute to tumor initiation, progression, and therapy resistance. In response to starvation, hypoxia, and drug treatments, tumor cells undergo a variety of deleterious endogenous stresses, such as hypoxia, DNA damage, and oxidative stress. In this context, to survive the difficult situation, tumor cells evolve multiple conserved adaptive responses, including metabolic reprogramming, DNA damage checkpoints, homologous recombination, up-regulated antioxidant pathways, and activated unfolded protein responses...
July 3, 2024: Cancer Letters
https://read.qxmd.com/read/38964733/m6a-modified-lncrna-fam83h-as1-promotes-colorectal-cancer-progression-through-ptbp1
#19
JOURNAL ARTICLE
Xiao-Jing Luo, Yun-Xin Lu, Yun Wang, Runjie Huang, Jia Liu, Ying Jin, Ze-Kun Liu, Ze-Xian Liu, Qi-Tao Huang, Heng-Ying Pu, Zhao-Lei Zeng, Ruihua Xu, Qi Zhao, Qi-Nian Wu
LncRNA plays a crucial role in cancer progression and targeting, but it has been difficult to identify the critical lncRNAs involved in colorectal cancer (CRC) progression. We identified FAM83H-AS1 as a tumor-promoting associated lncRNA using 21 pairs of stage IV CRC tissues and adjacent normal tissues. In vitro and in vivo experiments revealed that knockdown of FAM83H-AS1 in CRC cells inhibited tumor proliferation and metastasis, and vice versa. m6A modification is critical for FAM83H-AS1 RNA stability through the writer METTL3 and the readers IGF2BP2/IGFBP3...
July 2, 2024: Cancer Letters
https://read.qxmd.com/read/38964732/appendix-removal-affects-the-subsequent-cancer-risk-in-asian-adults-a-territory-wide-population-based-cohort-study
#20
JOURNAL ARTICLE
Chenhao Hu, Cosmos Liutao Guo, Harry Cheuk-Hay Lau, Feiyu Shi, Zhe Zhang, Gang Guo, Gaixia Liu, Yinnan Chen, Louis Ho-Shing Lau, Lei Zhang, Xuejun Sun, Sunny Hei Wong, Lei Zhang, Junjun She, Jun Yu
Human appendix is critical for the maintenance of intestinal homeostasis. Appendicectomy has been the optimal treatment of acute appendicitis, yet the cancer incidence after appendix removal remains unclear. In this territory-wide retrospective cohort study, adult participants who underwent appendicectomy from 2000 to 2018 were retrieved from a population database (n=43,983), while matched reference participants were retrieved as controls (n=85,853). After appendicectomy, the overall cancer risk was significantly increased (subdistribution hazard ratio (SHR)=1...
July 2, 2024: Cancer Letters
journal
journal
26571
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.