Yong Yang, Zihan Han, Zhaoya Gao, Jiajia Chen, Can Song, Jingxuan Xu, Hanyang Wang, An Huang, Jingyi Shi, Jin Gu
BACKGROUND: Type 2 diabetes mellitus (T2DM) is an independent risk factor for colorectal cancer (CRC), and the patients with CRC and T2DM have worse survival. The human gut microbiota (GM) is linked to the development of CRC and T2DM, respectively. However, the GM characteristics in patients with CRC and T2DM remain unclear. METHODS: We performed fecal metagenomic and targeted metabolomics studies on 36 samples from CRC patients with T2DM (DCRC group, n = 12), CRC patients without diabetes (CRC group, n = 12), and healthy controls (Health group, n = 12)...
March 24, 2023: Chinese Medical Journal