Joseph J Palamar, Nicole D Fitzgerald, Thomas H Carr, Caroline Rutherford, Katherine M Keyes, Linda B Cottler
BACKGROUND: Psilocybin, the principle psychoactive component in "shrooms", is regaining acceptance in therapeutic settings, leading to media coverage of medical benefits associated with use. Possession is also becoming increasingly decriminalized throughout the United States. There is a lack of data on prevalence of shroom use, but trends in law enforcement seizure data can provide one indicator of shroom availability in US communities. We determined whether seizures of shrooms have shifted between 2017 and 2022...
January 29, 2024: Drug and Alcohol Dependence
Shivam Kalhan, Philipp Schwartenbeck, Robert Hester, Marta I Garrido
Adaptive behaviours depend on dynamically updating internal representations of the world based on the ever-changing environmental contingencies. People with a substance use disorder (pSUD) show maladaptive behaviours with high persistence in drug-taking, despite severe negative consequences. We recently proposed a salience misattribution model for addiction (SMMA; Kalhan et al., 2021), arguing that pSUD have aberrations in their updating processes where drug cues are misattributed as strong predictors of positive outcomes, but weaker predictors of negative outcomes...
January 26, 2024: Drug and Alcohol Dependence
Mariel S Bello, Alison R Schulte, Colin R Ring, Junhan Cho, Jessica L Barrington-Trimis, Raina D Pang, Nancy C Jao, Suzanne M Colby, Rachel N Cassidy, Adam M Leventhal
BACKGROUND: Menthol cigarette smoking has remained stable or increased in certain groups, despite an overall decline in cigarette smoking rates in the U.S. Understanding whether e-cigarettes alter patterns of menthol cigarette use is critical to informing efforts for reducing the public health burden of menthol cigarette smoking. This 2019-2020 laboratory pilot study evaluated whether self-administration of mint-, menthol-, or tobacco-flavored e-cigarettes would differentially impact tobacco withdrawal symptoms in e-cigarette-naïve adults who smoke menthol cigarettes daily...
January 25, 2024: Drug and Alcohol Dependence
Kevin A Hallgren, Theresa E Matson, Malia Oliver, Xiaoming Wang, Emily C Williams, Katharine A Bradley
INTRODUCTION: Substance use disorders (SUDs) are underdiagnosed in healthcare settings. The Substance Use Symptom Checklist (SUSC) is a practical, patient-report questionnaire that has been used to assess SUD symptoms based on Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) criteria. This study evaluates the test-retest reliability of SUSCs completed in primary and mental health care settings. METHODS: We identified 1194 patients who completed two SUSCs 1-21 days apart as part of routine care after reporting daily cannabis use and/or any past-year other drug use on behavioral health screens...
January 24, 2024: Drug and Alcohol Dependence
Johannes Petzold, Jean-Baptiste F Pochon, Dara G Ghahremani, Edythe D London
BACKGROUND: Methamphetamine use is surging globally. It has been linked to premature stroke, Parkinsonism, and dementia, suggesting that it may accelerate brain aging. METHODS: We performed a retrospective study to determine if structural indices of brain aging were more prevalent prior to old age (26 - 54 years) in individuals with Methamphetamine Use Disorder (MUD), who were in early abstinence (M ± SD = 22.1 ± 25.6 days) than in healthy control (HC) participants...
January 23, 2024: Drug and Alcohol Dependence
Sterling M McPherson, Crystal L Smith, Luke Hall, André Q Miguel, Theresa Bowden, Abigail Keever, Alex Schmidt, Katie Olson, Nicole Rodin, Michael G McDonell, John M Roll, Jeff LeBrun
BACKGROUND/AIM: Poor medication adherence is one of the main barriers to the long-term efficacy of buprenorphine/naloxone (BUP/NAL). The aims of this pilot investigation were to examine if a Bluetooth-enabled pill cap and mobile application is a feasible, usable tool for increasing BUP/NAL adherence among people with an opioid use disorder. METHODS: This pilot randomized clinical trial (RCT; total n = 41) lasted 12 weeks and was conducted in two office-based BUP/NAL provider locations in Spokane, WA and Coeur d'Alene, ID from January 2020 to September of 2021 with an 11-month gap due to COVID-19...
January 22, 2024: Drug and Alcohol Dependence
Megan E Cooke, Sarah J Knoll, Joanna M Streck, Kevin Potter, Erin Lamberth, Natali Rychik, Jodi M Gilman, A Eden Evins, Randi M Schuster
BACKGROUND: It is important to identify interventions that reduce harm in youth not motivated to change their cannabis use. This study evaluated how short-duration contingency management (CM) impacts cannabis use attitudes and behavior after abstinence incentives are discontinued among non-treatment seeking youth. METHODS: Participants (N=220) were randomized to 4 weeks of abstinence-based CM (CB-Abst; n=126) or monitoring (CB-Mon; n=94). Participants completed self-report and provided biochemical measures of cannabis exposure at baseline, end-of-intervention, and 4-week follow-up...
January 20, 2024: Drug and Alcohol Dependence
Julia Myerson, Mario Montelongo, Katrina Rufino, Michelle Patriquin, Ramiro Salas, Hyuntaek Oh
BACKGROUND: Substance misuse is a major public health issue and research has established attenuated reward responses to drug cues in those who misuse substances. Yet, little is known about whether the expectation of natural reinforcers engages distinct brain regions in substance misuse. METHODS: Using functional magnetic resonance imaging (fMRI), we delivered juice at expected and unexpected times to examine reward processing dysfunctions. We focused on the responses within the left dorsal striatum (DS) in individuals with high-risk substance use (HRU, n = 65), low-risk substance use (psychiatric controls, PC, n = 65), and healthy controls (HC, n = 65)...
January 20, 2024: Drug and Alcohol Dependence
Miguel I Paz-Ramos, Valeria Violante-Soria, Thom Browne, Silvia L Cruz
BACKGROUND: People who use psychostimulant substances can be exposed to unknown adulterants, such as the synthetic opioid fentanyl (FEN) and the anthelmintic cholinergic agent levamisole (LEV). This work explores the rewarding and locomotor effects of methamphetamine (METH) in combination with FEN or LEV. METHODS: We used adult male Wistar rats in the conditioned-place preference (CPP) paradigm (conditioning, extinction, and reinstatement phases) and in the open field test to study effective doses of METH, FEN, or LEV, or ineffective doses of METH+FEN or METH+LEV in combination...
January 20, 2024: Drug and Alcohol Dependence
Samuel F Acuff, Jennifer D Ellis, Jill A Rabinowitz, Martin Hochheimer, J Gregory Hobelmann, Andrew S Huhn, Justin C Strickland
BACKGROUND: Translational research demonstrates that drug use is inversely associated with availability and engagement with meaningful non-drug reinforcers. Evaluation of non-drug reinforcement in treatment-receiving clinical populations is limited, likely owing to the time intensive nature of existing measures. This study explores the association of non-drug reinforcers with treatment outcomes using a novel, brief measure of past month non-drug reinforcement quantifying three elements: relative frequency, access, and enjoyability...
January 18, 2024: Drug and Alcohol Dependence
Asma'u Abba Hassan, Abba M Ibrahim, Abhijit Nadkarni
INTRODUCTION: Substance use (SU) and substance use disorders (SUDs) are associated with adverse health and socio-economic consequences. Due to the shortage of specialist healthcare providers, people with SUDs in low- and middle-income countries (LMICs) have limited access to adequate treatment. Task-sharing with non-specialist health workers (NSHWs) has the potential to improve treatment accessibility for these individuals. This review synthesizes the evidence on the effectiveness of task-sharing interventions for SU and SUDs outcomes in LMICs...
January 17, 2024: Drug and Alcohol Dependence
Guanyi Lu, Ting Fang, Xinyue Li, XiaoJie Zhang, Hong Li, Ning Wu, Feng Liu, Wei Hao, Qi-Nong Ye, Long Cheng, Jin Li, Fei Li
BACKGROUND: Methamphetamine (MA) use increases the risk of age-related diseases. However, it remains uncertain whether MA use exhibits accelerated biological aging, as indicated by telomere length (TL), a proposed marker of aging. Here we conducted studies in both humans and rats to investigate the association between MA use and TL. METHODS: We recruited 125 male MA users and 66 healthy controls, aged 30-40 years. MA users were diagnosed using DSM-5 criteria and categorized into two groups: non-severe (n = 78) and severe (n = 47) MA use disorder (MUD)...
January 17, 2024: Drug and Alcohol Dependence
Rebecca J Evans-Polce, Jennifer L Maggs, Stephanie T Lanza, Megan E Patrick
INTRODUCTION: Drinking intensity among young adults is associated with greater negative alcohol-related consequences, but often studied using categorical drinking thresholds. This study examined how alcohol-related consequences varied as a continuous function of number of drinks consumed, without imposing thresholds, to identify drink ranges for which risk is greatest. METHODS: Analyses included daily surveys from the Young Adult Daily Life study (2019-22) in which individuals reported drinking 1 or more alcoholic drinks (n=5219 days; 832 individuals)...
January 17, 2024: Drug and Alcohol Dependence
Victoria R Votaw, Karl Mann, Henry R Kranzler, Corey R Roos, Helmut Nakovics, Katie Witkiewitz
No abstract text is available yet for this article.
January 17, 2024: Drug and Alcohol Dependence
E Kroon, Y J Toenders, L N Kuhns, J Cousijn, F Filbey
BACKGROUND: The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cannabis attitudes might affect the brain processes underlying cannabis use. METHODS: Resting state functional connectivity (RSFC) within and between the executive control network (ECN), salience network (SN), and default mode network (DMN) was assessed in 110 near-daily cannabis users with cannabis use disorder (CUD) and 79 controls from The Netherlands and Texas, USA...
January 15, 2024: Drug and Alcohol Dependence
Sugy Choi, Sueun Hong, Ohshue S Gatanaga, Alexander J Yum, Sahnah Lim, Charles J Neighbors, Stella S Yi
BACKGROUND: The increasing relevance of substance use disorder (SUD) within the Asian American, Native Hawaiian, and Pacific Islander (AA&NH/PI) communities, particularly amidst rising anti-Asian hate incidents and the disproportionate health and economic challenges faced by the NH/PI community during the COVID-19 pandemic, underscores the urgency of understanding substance use patterns, treatment disparities, and outcomes. METHODS: Following PRISMA guidelines, 37 out of 231 studies met the search criteria...
January 11, 2024: Drug and Alcohol Dependence
Øystein Bruun Ericson, Desiree Eide, Philipp Lobmaier, Thomas Clausen
BACKGROUND: People who use opioids (PWUO) have an excess mortality from a range of causes. The cumulative effect of behavioral, social, and health risk factors complicates the interpretation of the effects of suitable interventions. This study explores mortality causes among a cohort of PWUO in the take-home naloxone (THN) program. METHODS: This was a prospective cohort study of PWUO who received THN between 2015 and 2023. Participant data was linked with death registry data...
January 11, 2024: Drug and Alcohol Dependence
Pallav Pokhrel, Crissy T Kawamoto, Sharon Lipperman-Kreda, Samia Amin, Paxton Charles, Ana Danko, Thomas Valente, Steve Sussman
BACKGROUND: Young people often make lifestyle choices or engage in behaviors, including tobacco product use, based on the norms of peer crowds they affiliate with. Peer crowds are defined as reputation-based peer groups centered around lifestyle norms (e.g., Hipster, Surfer, Hip Hop). This study examined the effects of peer crowd affiliation on e-cigarette use via increased exposure to e-cigarette advertising and increased social network e-cigarette use. METHOD: Data were collected from 1398 ethnically diverse young adults (Mean age = 22...
January 9, 2024: Drug and Alcohol Dependence
Genevieve F Dash, Ian R Gizer, Wendy S Slutske
BACKGROUND: Only a small proportion of individuals who initiate nonmedical use of prescription opioids (NUPO) transition to heroin, suggesting that more nuanced aspects of NUPO may be better indicators of risk for escalating opioid use trajectories. This study leveraged panel data to identify NUPO typologies based on NUPO characteristics associated with opioid risk trajectories (route of administration, motives) and compared rates of heroin initiation at follow-up across typologies. METHODS: Latent class analyses were run among respondents with no history of heroin use from the Monitoring the Future Panel Study (base year N=10,408) at modal ages 18, 19/20, 21/22, 23/24, and 25/26...
January 9, 2024: Drug and Alcohol Dependence
Oshin Miranda, Peihao Fan, Xiguang Qi, Haohan Wang, M Daniel Brannock, Thomas Kosten, Neal David Ryan, Levent Kirisci, LiRong Wang
BACKGROUND: Identifying co-occurring mental disorders and elevated risk is vital for optimization of healthcare processes. In this study, we will use DeepBiomarker2, an updated version of our deep learning model to predict the adverse events among patients with comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD), a high-risk population. METHODS: We analyzed electronic medical records of 5565 patients from University of Pittsburgh Medical Center to predict adverse events (opioid use disorder, suicide related events, depression, and death) within 3 months at any encounter after the diagnosis of PTSD+AUD by using DeepBiomarker2...
January 9, 2024: Drug and Alcohol Dependence
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