Daniil Grinchii, Matar Levin-Greenwald, Noa Lezmy, Tamar Gordon, Ruslan Paliokha, Talah Khoury, Matej Racicky, Leonie Herburg, Claudia Grothe, Eliyahu Dremencov, Segev Barak
Fibroblast growth factor 2 (FGF2) is involved in the development and maintenance of the brain dopamine system. We previously showed that alcohol exposure alters the expression of FGF2 and its receptor, FGF receptor 1 (FGFR1) in mesolimbic and nigrostriatal brain regions, and that FGF2 is a positive regulator of alcohol drinking. Here, we determined the effects of FGF2 and of FGFR1 inhibition on alcohol consumption, seeking and relapse, using a rat operant self-administration paradigm. In addition, we characterized the effects of FGF2-FGFR1 activation and inhibition on mesolimbic and nigrostriatal dopamine neuron activation using in vivo electrophysiology...
May 13, 2023: Drug and Alcohol Dependence