Mark A Smith, Alexandra N Johansen, Hannah S H Cha, Mackenzie H Morris, Zizhan Yao, Samantha L Biancorosso, Jacob D Camp, Salome H Hailu
RATIONALE: A return to cocaine use following abstinence frequently occurs in a social context, and the presence of other individuals using cocaine may contribute to the likelihood of use. Previous studies have reported that chronic d-amphetamine treatment decreases cocaine self-administration in laboratory animals and reduces a return to cocaine use following abstinence in humans. OBJECTIVE: The purpose of this study was to examine the effects of chronic d-amphetamine treatment on the reacquisition of cocaine use in rats self-administering cocaine in different social contexts...
May 13, 2024: Drug and Alcohol Dependence
Wei Li, Danielle R Davis, Grace Kong, Krysten W Bold, Meghan E Morean, Deepa Camenga, Akshika Sharma, Juhan Lee, Suchitra Krishnan-Sarin
BACKGROUND: E-cigarette flavors that produce cooling sensations may reduce nicotine harshness and enhance appeal among youth. While previous research has shown that use of cooling flavors is associated with more frequent vaping among youth, it is unknown whether the same holds true for e-cigarette dependence. This study examines the relationship between cooling flavor use and e-cigarette dependence among youth accounting for vaping frequency. METHODS: In Fall 2022, a survey was conducted among Connecticut high school students to assess past-month nicotine e-cigarette use, ever use of cooling flavors, cooling flavor types (e...
May 11, 2024: Drug and Alcohol Dependence
Kathryn Wouk, Lauren Caton, Rebekah Bass, Bina Ali, Tammy Cody, Emily P Jones, Olivia Caron, Winnie Luseno, Melinda Ramage
BACKGROUND: Substance use during the perinatal period (i.e., pregnancy through the first year postpartum) can pose significant maternal and infant health risks. However, access to lifesaving medications and standard care remains low for perinatal persons who use substances. This lack of substance use disorder treatment access stems from fragmented services, stigma, and social determinants of health-related barriers that could be addressed using patient navigators. This systematic review describes patient navigation models of care for perinatal people who use substances and associated outcomes...
May 8, 2024: Drug and Alcohol Dependence
Jennifer L Stewart, Kaiping Burrows, April C May, Breanna A McNaughton, Ryan Smith, Rayus Kuplicki, Martin P Paulus, Leandra Figueroa-Hall
BACKGROUND: Inflammatory biomarkers may differentiate clinical disorders, which could lead to more targeted interventions. Analyses within a clinical sample (May et al., 2021) revealed that females with substance use disorders (SUD) exhibited lower C-reactive protein (CRP) and higher interleukin (IL)-8 and -10 concentrations than females without SUD who met criteria for mood/anxiety disorders. We aimed to replicate these findings in a new sample. METHODS: Hypotheses and analyses were preregistered...
May 8, 2024: Drug and Alcohol Dependence
Carrie B Oser, Myles D Moody, Anna C Hansen, Danelle Stevens-Watkins, Michele Staton, Amanda M Bunting
BACKGROUND: The purpose of this study includes: 1) identifying classes of substance-related needs among Black women, and 2) examining the effect of substance-related need classes and culturally-relevant factors on Black women's use of substance use disorder (SUD) treatment and mutual support groups. METHODS: As part of a longitudinal cohort study, Black women were recruited in prison nearing release, on probation, and in the community without involvement in the criminal legal system (CLS, n=565) and followed-up at 18-months...
May 8, 2024: Drug and Alcohol Dependence
Sibylle Mauries, Geoffrey Dufayet, Ariane Lengereau, Michel Lejoyeux, Pierre A Geoffroy, Irène Dupong
INTRODUCTION: Cannabis currently stands as the most prevalent illicit substance used by adolescents in France. Its use is associated with an elevated risk of developing psychiatric disorder, affecting neuro-cognitive development, or leading to psycho-social challenges in the long run. Cognitive-behavioral therapies (CBT) have emerged as a preferred approach for treating cannabis use disorders (CUD) in adults. METHODS: This review is grounded in a systematic search of the PubMed scientific database for randomized controlled trials focusing on CBT treatment for adolescents (12-18 years old) with CUD...
May 4, 2024: Drug and Alcohol Dependence
Maricruz Reséndiz-Flores, María-Isabel Miranda
Sweet foods activate the reward system that is essential in processing natural reinforcers. Maturation changes in this system during adolescence are linked to heightened impulsivity and risk-seeking behavior, including the use of drugs like ethanol. This usually starts with the consumption of sugary mixtures. However, the influence of sugar exposure on ethanol consumption remains inconclusive. The present research examines the effect of long-term sugar exposure on sugary ethanol (S-EtOH) preference and net intake, exploring the implications of sex, age, accessor restriction of sugar, and its effect during the transition into adulthood...
May 3, 2024: Drug and Alcohol Dependence
Saba Ghodrati, Lawrence M Carey, Charles P France
BACKGROUND: A single administration of the opioid receptor antagonist methocinnamox (MCAM) antagonizes the antinociceptive effects of µ-opioid receptor agonists for 2 weeks or longer. Such a long duration of antagonism could necessitate the use of nonopioid drugs for treating pain in patients receiving MCAM for opioid use disorder (OUD). METHODS: The antinociceptive effects of fentanyl and nonopioid drugs were assessed in 24 male Sprague Dawley rats using a complete Freund's adjuvant (CFA) model of inflammatory pain...
April 29, 2024: Drug and Alcohol Dependence
Angela M Haeny, Melissa R Schick, Claudia McKenley, Aishwarya Chowdhary, Chyrell D Bellamy, Stephanie S O'Malley, Rajita Sinha
BACKGROUND: The objective of this study was to pilot test newly developed personalized imagery procedures to investigate the impact of racial stress on alcohol craving and emotional and physiological response in Black adults with alcohol use disorder (AUD). METHODS: Twenty Black adults (45% women, meanage =37.05, SDage =13.19) with AUD participated in two sessions. In the first, participants described a stressful personal event involving their race and a neutral relaxing situation and these descriptions were used to develop scripts for the subsequent laboratory exposure session...
April 26, 2024: Drug and Alcohol Dependence
Candice D Donaldson, David A Stupplebeen, Elizabeth T Couch, Adrianna I Rojas, Omara Farooq, Xueying Zhang, Stuart A Gansky, Benjamin W Chaffee
INTRODUCTION: Electronic cigarettes (also termed e-cigarette or vapes) often contain nicotine, an addictive psychoactive substance, which can have harmful effects during adolescence. Frequent experiences of discrimination are one risk factor shown to increase susceptibility to tobacco use, especially for individuals that identify as a social minority. Applying Intersectionality Theory, this research examined the relationship between youth experiences of discrimination and vape use at the intersection of race/ethnicity and sexual orientation...
April 26, 2024: Drug and Alcohol Dependence
Megan E Roberts, Jill M Singer, Bo Lu, Dylan D Wagner, Loren E Wold, Rui Qiang, Peter F Craigmile, Alayna P Tackett
BACKGROUND: Emerging data indicate that many adolescents and young adults ("youth") engage in infrequent, or occasional, e-cigarette use. However, little is known about this population as they are often subsumed into the broader "any past-30-day use" category used to define youth "current use." This study aimed to focus on infrequent e-cigarette use by youth, examining its correlates and transitional outcomes. METHODS: Participants were from a prospective cohort study of youth (aged 15-24 at baseline)...
April 26, 2024: Drug and Alcohol Dependence
Lina Lantz, Zheng Chang, Suvi Virtanen
BACKGROUND: Substance use disorders are highly prevalent in people within the criminal justice system. Psychological programs are the most common type of treatment available and have been shown to decrease recidivism, but dropping out of treatment is common. Risk factors associated with treatment dropout remain unclear in this setting, and whether the risk factors differ by treatment form (group-based vs. individual). METHODS: Outcome (treatment dropout) was defined as not finishing the program due to client's own wish, misbehavior, no-shows, or because program leader found client to be unsuitable...
April 26, 2024: Drug and Alcohol Dependence
Ben Tscharke, Michael Livingston, Jake W O'Brien, Richard Bade, Kevin V Thomas, Jochen F Mueller, Wayne Hall, Bradley S Simpson, Emma Jaunay, Cobus Gerber, Jason M White, Phong K Thai
BACKGROUND: Wastewater analysis provides a complementary measure of alcohol use in whole communities. We assessed absolute differences and temporal trends in alcohol consumption by degree of remoteness and socioeconomics indicators in Australia from 2016 to 2023. METHODS: Alcohol consumption estimates from 50 wastewater treatment plants (WWTP) in the Australian National Wastewater Drug Monitoring Program were used. Trends were analysed based on 1) site remoteness: Major Cities, Inner Regional and a combined remoteness category of Outer Regional and Remote, and 2) using two socioeconomic indexes from the Australian Bureau of Statistics (ABS) relating to advantage and disadvantage for Income, education, occupation, and housing...
April 26, 2024: Drug and Alcohol Dependence
William H Eger, Daniela Abramovitz, Angela R Bazzi, Annick Bórquez, Carlos F Vera, Alicia Harvey-Vera, Joseph R Friedman, Steffanie A Strathdee
BACKGROUND: Amidst an increasingly toxic drug supply in North America, people who inject drugs may be transitioning to smoking them. We aimed to assess changes in injecting and smoking opioids and methamphetamine among a cohort of people who inject drugs from San Diego, California. METHODS: Over five six-month periods spanning October 2020-April 2023, we assessed prevalence of injecting and smoking opioids or methamphetamine and whether participants used these drugs more frequently by smoking than injecting...
April 26, 2024: Drug and Alcohol Dependence
Mats Hallgren, Emil Bojsen Moller, Sven Andreasson, David W Dunstan, Davy Vancampfort, Örjan Ekblom
BACKGROUND: Physical activity (PA) is increasingly used as an adjunct treatment for alcohol use disorder (AUD). Previous studies have relied on self-report measures of PA, which are prone to measurement error. In the context of a randomized controlled trial of PA for AUD, we examined: (1) associations between device-measured and self-reported PA, (2) associations between PA measurements and alcohol use, and (3) the feasibility of obtaining device-measured PA data in this population. METHOD: One-hundred and forty individuals with clinician-diagnosed AUD participated in a 12-week intervention comparing usual care (phone counselling) to yoga-based exercise and aerobic exercise...
April 26, 2024: Drug and Alcohol Dependence
Megan S Schuler, Andrew W Dick, Adam J Gordon, Brendan Saloner, Rose Kerber, Bradley D Stein
BACKGROUND: We examined the number and characteristics of high-volume buprenorphine prescribers and the nature of their buprenorphine prescribing from 2009 to 2018. METHODS: In this observational cohort study, IQVIA Real World retail pharmacy claims data were used to characterize trends in high-volume buprenorphine prescribers (clinicians with a mean of 30 or more active patients in every month that they were an active prescriber) during 2009-2018. Very high-volume prescribing (mean of 100+ patients per month) was also examined...
April 16, 2024: Drug and Alcohol Dependence
Wesley R Tackett, Jyostna Yalakala, Michael D Hambuchen
BACKGROUND: The incidence of combination methamphetamine (METH)-opioid overdose has substantially increased in recent years. While agitation is uncommon after the naloxone (NLX) reversal of opioids, it is a major clinical concern in acute METH intoxication and can be physiologically antagonized by opioid-induced sedation. This study aimed to perform initial preclinical analysis of the safety and efficacy of dexmedetomidine (DEXMED) co-administered with NLX to attenuate METH-induced locomotor activity, as a rat model of agitation, after the reversal of fentanyl (FENT)-induced sedation...
April 16, 2024: Drug and Alcohol Dependence
Shikhar Shrestha, Thomas J Stopka, Jaclyn M W Hughto, Patricia Case, Wilson R Palacios, Brittni Reilly, Traci C Green
BACKGROUND: We introduce the concept of harm reduction capital (HRCap) as the combination of knowledge, resources, and skills related to substance use risk reduction, which we hypothesize to predict MOUD use and opioid overdose. In this study, we explored the interrelationships between ethnicity, HRCap, nonfatal overdose, and MOUD use among PWUD. METHODS: Between 2017 and 2019, people who currently or in the past used opioids and who lived in Massachusetts completed a one-time survey on substance use history, treatment experiences, and use of harm reduction services...
April 15, 2024: Drug and Alcohol Dependence
Liam Browning, Ciara N Cannoy, Tabitha E H Moses, Leslie H Lundahl, David M Ledgerwood, Mark K Greenwald
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent and associated with opioid use disorder (OUD). Yet, little is known about the mechanisms by which ADHD (which is a heterogeneous construct/diagnosis) might alter the trajectory of OUD outcomes in persons who use heroin. AIM: We examined whether ADHD subtypes are related to heroin-use consequences and the extent to which the effects of ADHD on lifetime heroin-use consequences are mediated by two impulsivity factors that may be partly independent of ADHD: foreshortened time perspective and drug-use impulsivity...
April 13, 2024: Drug and Alcohol Dependence
Agustina Aragón-Daud, Sofía Milagros Oberti De Luca, Sofía Schurmann Vignaga, Pilar Prado, Rosario Figueras, Lucia Lizaso, María Luz González-Gadea, Facundo Manes, Marcelo Cetkovich, Carla Pallavicini, Teresa Torralva, Laura Alethia de la Fuente
BACKGROUND: Cocaine consumption is associated with reduced attentional event-related potentials (ERPs), namely P3a and P3b, indicating bottom-up and top-down deficits respectively. At cognitive level, these impairments are larger for faster routes of administration (e.g., smoked cocaine [SC]) than slower routes (e.g., insufflated cocaine [IC]). Here we assess these ERPs considering the route of cocaine administration. We hypothesized that SC dependent (SCD) would exhibit reduced amplitude of the P3a, while both SCD and IC dependent (ICD) would show reduced amplitude of the P3b...
April 10, 2024: Drug and Alcohol Dependence
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