Omar F Pinjari, Gregory H Jones, Courtney M Vecera, Kacy Smith, Anita Barrera, Rodrigo Machado-Vieira
Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review...
May 21, 2023: Frontiers in Neuroendocrinology