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Journal of Endodontics

Obadah Austah, Matthias Widbiller, Phillip L Tomson, Anibal Diogenes
INTRODUCTION: Neurotrophic factors play a significant role in the innervation of the pulp-dentin complex during and after organogenesis. There have been numerous bioactive molecules identified in the dentin extracellular matrix; however, the expression of neurotrophic factors in the dentin matrix and their biological activity are largely unknown. The purpose of this study was to characterize the relative expression of neurotrophic factors in human dentin matrix proteins (DMPs) and their effect on neurite outgrowth of trigeminal (TG) neurons...
February 13, 2019: Journal of Endodontics
Athina Maria Mavridou, Petra Hilkens, Ivo Lambrichts, Esther Hauben, Martine Wevers, Lars Bergmans, Paul Lambrechts
Despite the fact that external cervical resorption (ECR) is a well-known and rather frequently met condition, the driving force of this phenomenon still remains unclear. Recently, hypoxia has been linked to ECR. Thus, the aim of this work was to investigate the existence of hypoxia in ECR and hypothesize on its role at the time of extraction. This work is a case study of a tooth with ECR. ECR diagnosis was based on clinical and radiographic examination with cone-beam computed tomographic imaging. The extracted tooth was further analyzed by using nanofocus computed tomographic imaging and immunohistology...
February 13, 2019: Journal of Endodontics
Ji Wook Jeong, Zegar Zegar, Richard Y Liu, Scott R Makins
Knowledge of the prevalent root canal anatomy and potential variations is necessary before the initiation of endodontic treatment. The purpose of this study was to aid in the detection and treatment of the Vertucci type V canal configuration when present in the distal root of the mandibular molars. This case series presents 3 radiographic indications of a type V configuration in the distal roots of the mandibular molars as revealed on conventional periapical radiographs: a "ghost" apex, a fast break canal, and eccentric canal tracing...
February 12, 2019: Journal of Endodontics
Daniel Crossen, Thiago Morelli, Don A Tyndall, Peter Z Tawil
INTRODUCTION: Currently, the success of periapical microsurgery is determined by the restoration of the lamina dura and the elimination of symptoms. However, inadequate site preservation may prevent later implant placement. Although not possible before, the advent of cone-beam computed tomographic imaging and computer-aided registration allows for indirect and accurate 3-dimensional analysis of the surgical site over time. This study analyzed the volumetric healing pattern of the buccal plate after periapical microsurgery, with a specific focus on the buccolingual thickness of bone and the regression of the surface contour of the cortical plate...
February 12, 2019: Journal of Endodontics
Shanon Patel, Risha Patel, Federico Foschi, Franceso Mannocci
INTRODUCTION: The purpose of this study was firstly to compare the impact of radiographs, cone-beam computed tomographic (CBCT) imaging, and 3D Endo software (Dentsply Sirona, Ballaigues, Switzerland) on the assessment of root canal anatomy and radiographic quality of endodontic treatment and secondly to assess stress levels in the same cohort of residents performing endodontic treatment. METHODS: Sixty patients requiring primary molar endodontic treatment were allocated randomly into 3 groups: group 1 (n = 20), conventional radiographs (periapical radiography [PR]) only; group 2 (n = 20), PR and CBCT imaging; and group 3 (n = 20), PR, CBCT imaging, and 3D Endo software...
February 12, 2019: Journal of Endodontics
Venkateshbabu Nagendrababu, Shaju Jacob Pulikkotil, Peerawat Jinatongthai, Sajesh K Veettil, Nattawat Teerawattanapong, James L Gutmann
INTRODUCTION: This review aimed to find the most effective oral premedication in reducing pain in adults after nonsurgical root canal therapy (NSRCT) using network meta-analysis. METHODS: The review protocol was registered in the PROSPERO database (CRD42017071899). A literature search was performed in the MEDLINE and EBSCOhost databases until June 2017 with no language restriction. Randomized controlled trials evaluating the efficacy of oral premedications, whether given alone or in combination, compared with other agents, placebo, or no treatment in adult patients before NSRCT for postoperative pain were included...
February 5, 2019: Journal of Endodontics
Mona H El-Zekrid, Salah H Mahmoud, Fawzy A Ali, Mohamed E Helal, Mohammed E Grawish
INTRODUCTION: Partial pulpotomy is a vital treatment for carious and traumatic exposure, especially in young permanent teeth. Cell-based therapy for partially pulpotomized teeth can be considered a promising approach for dentin-pulp complex regeneration. This study evaluated the healing capacity of autologous bone marrow-derived stem cells (BMSCs) on partially pulpotomized teeth in a dog model. METHODS: Twelve mongrel dogs were selected, and a total number of 192 posterior mandibular and maxillary teeth were involved in the study (16 teeth per dog)...
February 2, 2019: Journal of Endodontics
Maria Messing, Letícia Chaves de Souza, Franco Cavalla, Krishna Kumar Kookal, Gabriella Rizzo, Muhammad Walji, Renato Silva, Ariadne Letra
INTRODUCTION: Apical periodontitis (AP) and cardiovascular diseases (CVDs) are chronic conditions triggered by an inflammatory process and sharing similar pathogeneses and molecular players. Previous studies have suggested that AP may perpetuate a systemic inflammation state and, in turn, contribute to CVD. In this study, we investigated the potential association between endodontic pathology and CVD using epidemiological and genetic approaches. METHODS: Epidemiologic analysis was performed by querying the medical and dental records of >2 million patients...
January 17, 2019: Journal of Endodontics
Nadja Nikolic, Aleksandar Jakovljevic, Jelena Carkic, Katarina Beljic-Ivanovic, Maja Miletic, Ivan Soldatovic, Miroslav Andric, Vladimir Ivanovic, Jelena Milasin
INTRODUCTION: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin [IL]-1β, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratios and determine their potential correlation. METHODS: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy...
December 20, 2018: Journal of Endodontics
Seyed Aliakbar Vahdati, Mahmoud Torabinejad, Robert Handysides, Jamie Lozada
INTRODUCTION: Currently, no study has compared the outcome of nonsurgical root canal treatment (NSRCT) and single-tooth implants (STIs) provided to the same patient. The purpose of this study was to determine if the survival outcome of the 2 treatment modalities is different. METHODS: The medical/dental records of 3671 patients with at least 1 STI and 1 NSRCT were reviewed. One hundred seventy patients with at least a 5-year follow-up were included. The survival outcome of NSRCT and STI and related factors were evaluated...
February 2019: Journal of Endodontics
Kathryn Watts, Stephen Balzer, Melissa Drum, John Nusstein, Al Reader, Sara Fowler, Mike Beck
INTRODUCTION: Previously, ketorolac was available for primary use only via intravenous and intramuscular routes. Its availability in intranasal form offers an alternative route of administration that patients can self-administer. The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis...
February 2019: Journal of Endodontics
David Peñarrocha-Oltra, Isabel Menéndez-Nieto, Juan Cervera-Ballester, Laura Maestre-Ferrín, Miguel Peñarrocha-Diago, María Peñarrocha-Diago
INTRODUCTION: The aim of this study was to evaluate the efficacy of 2 hemostatic agents in periapical surgery and its relationship with patient- and tooth-dependent variables. METHODS: A prospective study was designed with 2 randomized parallel groups established according to the hemostatic agent used: aluminum chloride or electrocauterization. The surgeon and 2 independent blinded observers examined the initial and final bleeding and recorded it as 0 (no hemorrhage control), 1 (slight but apparent intermittent bleeding), or 2 (complete hemorrhage control)...
February 2019: Journal of Endodontics
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February 2019: Journal of Endodontics
Lucas Moreira Maia, Vinicius de Carvalho Machado, Nelson Renato França Alves da Silva, Manoel Brito Júnior, Rodrigo Richard da Silveira, Gil Moreira Júnior, Antônio Paulino Ribeiro Sobrinho
The localization of partial or completed root canal obliteration is a challenging task in endodontic practice. Recently, guided endodontics has become an alternative solution for those cases. Although this technique has already been used clinically in managing anterior teeth, in this report, we describe 3 complex clinical scenarios of calcified root canals of 1 molar and 2 premolars using guided endodontics. The clinical cases reported here show that technological evolutions should make guided endodontic procedures more widespread because their execution is relatively fast and safe even in the case of the upper molar...
February 2019: Journal of Endodontics
Elisa Diniz de Lima, Ana Priscila Lira de Farias Freitas, Fernanda Clotilde Mariz Suassuna, Saulo L Sousa Melo, Patricia Meira Bento, Daniela Pita de Melo
INTRODUCTION: This study quantitatively evaluated the type and amount of image artifacts generated by different intracanal materials in birooted teeth scanned at different exposure parameters. METHODS: The sample consisted of 15 birooted premolars. Seven different intracanal material combinations were used in each tooth one at a time: (1) roots without intracanal materials, (2) roots with gutta-percha, (3) a buccal root with gutta-percha and a lingual root with a fiberglass post, (4) a buccal root with gutta-percha and a lingual root with a metal core fiberglass post, (5) buccal and lingual roots with fiberglass posts, (6) buccal and lingual roots with metal core fiberglass posts, and (7) buccal and lingual roots with NiCr metal posts...
February 2019: Journal of Endodontics
Ahmet Keles, Emel Uzunoglu Ozyurek, Mehmet Ozgur Uyanik, Emre Nagas
INTRODUCTION: The aim of this study was to evaluate the effect of different temperatures of sodium hypochlorite (NaOCl) on the cyclic fatigue resistance of the heat-treated file systems. METHODS: The cyclic fatigue resistance of Reciproc 25 (VDW Dental, Munich, Germany), Reciproc Blue R25 (VDW), WaveOne Primary (Dentsply Maillefer, Ballaigues, Switzerland), WaveOne Gold Primary (Dentsply Maillefer), and One Shape (25.06; Micro Mega, Besançon, France) was tested in the following conditions: control (no immersion), immersion in distilled water (DW) at 37°C ± 1°C, immersion in DW at 60°C ± 1°C, immersion in NaOCl at 37°C ± 1°C, and immersion in NaOCl at 60°C ± 1°C...
February 2019: Journal of Endodontics
Joo-Yeong Lee, Sang Won Kwak, Jung-Hong Ha, Ibrahim H Abu-Tahun, Hyeon-Cheol Kim
INTRODUCTION: The aim of this study was to compare the cyclic fatigue, torsional resistance, and bending stiffness of single-file glide path preparation nickel-titanium instruments. METHODS: ProGlider (#16/progressive taper; Dentsply Sirona, Ballaigues, Switzerland), One G (#14/.03; Micro-Mega, Besancon, France), and EdgeGlidePath (#16/progressive taper; Edge Endo, Albuquerque, NM) were tested. For the bending stiffness test, the instrument was bent to a 45° angle along the main axis while 3 mm of the tip was secured...
February 2019: Journal of Endodontics
Gustavo De-Deus, Milla Lessa Cardoso, Felipe Gonçalves Belladonna, Daniele Moreira Cavalcante, Marco Simões-Carvalho, Erick Miranda Souza, Ricardo Tadeu Lopes, Emmanuel João Nogueira Leal Silva
INTRODUCTION: This study assessed the frequency in which Reciproc Blue R25 instruments (VDW, Munich, Germany) reached the full working length (WL) of mandibular molar canals without a glide path. The influence of the type of electric motor (ie, conventional corded or cordless) on the instrument's performance was also assessed. METHODS: One hundred mandibular molars with slight to moderate root canals were selected and randomly assigned into 1 of 2 experimental groups according to the type of electric motor used: conventional corded (VDW Silver, VDW) or cordless motors (VDW...
February 2019: Journal of Endodontics
Weishi Yan, Carolina Montoya, Marit Øilo, Alex Ossa, Avina Paranjpe, Hai Zhang, Dwayne D Arola
INTRODUCTION: Although the strength and toughness of dentin decrease with age, no study has explored if restorative treatments are a contributing factor. METHODS: Multiple extracted teeth were obtained from randomly selected donors and categorized according to donor age and prior root canal treatment. The microstructure and chemical composition of radicular dentin were evaluated using scanning electron microscopy and Raman spectroscopy, respectively, and the strength was evaluated in 4-point flexure to failure...
February 2019: Journal of Endodontics
Hajime Sasaki, Hisako Furusho, Daniel B Rider, Justine M Dobeck, Winston Patrick Kuo, Akira Fujimura, Subbiah Yoganathan, Kimito Hirai, Shuang Xu, Kei Sasaki, Philip Stashenko
INTRODUCTION: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but resolving osteomyelitislike inflammation. In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1...
February 2019: Journal of Endodontics
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