journal
Journals Zhonghua Yi Xue za Zhi [Chines...

Zhonghua Yi Xue za Zhi [Chinese medical journal]

https://read.qxmd.com/read/38487820/-expert-consensus-on-multidisciplinary-diagnosis-and-treatment-of-brain-arteriovenous-malformation
#1
JOURNAL ARTICLE
(no author information available yet)
Brain arteriovenous malformation (BAVM) is a cerebral vasculature disorder caused by gene mutation. Current available treatment measures include surgical resection, interventional embolization and stereotactic radiosurgery. The three therapeutic methods have their own advantages for different vascular structures.However, due to the complex vascular architecture of the lesion and its close anatomical relationship with brain tissue, any single treatment can not safely and effectively treat all BAVM cases. Therefore, in order to better regulate and guide the clinical diagnosis and treatment of BAVM patients in China, the National Medical School for Neurological Diseases, the Professional Committee of Neurointervention of the Chinese Medical Doctor Association and the radio-neurosurgery Expert Committee of the World Chinese Neurosurgeons Association jointly discussed and formulated this expert consensus...
March 14, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38487819/-standardization-of-next-generation-sequencing-for-detecting-mutations-associated-with-targeted-therapy-and-immunotherapy-based-on-dynamic-pattern-ofexpandabledetectionrange
#2
JOURNAL ARTICLE
R Zhang, D Wang, J M Li
Next-generation sequencing (NGS) has laid the foundation for precision oncology care. NGS technologynot only represents an innovation in the methodology but also brings about a revolution in the concept of detecting gene alterations for targeted therapy and immunotherapy of cancers. As basic biomedical research and drug development progress, the landscape of biomarkers associated with gene alterations continues to evolve. Thus, the standardization of NGS-based gene alterations detection should take into account the characteristics of NGS methods and the gene alteration biomarkers...
March 14, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38378296/-chinese-guidelines-on-the-diagnosis-of-dystrophinopathy
#3
JOURNAL ARTICLE
(no author information available yet)
Dystrophinopathy refers to a group of X-linked recessive myopathies that primarily affect skeletal and/or cardiac muscle caused by pathogenic variants in the dystrophin-encoding DMD gene, including Duchenne muscular dystrophy, Becker muscular dystrophy, and X-linked dilated cardiomyopathy. The broad and complex spectrum of pathogenic DMD variants complicates the diagnosis and clinical classification in some patients. The precise genetic diagnosis is of great significance for the clinical diagnosis and treatment, multidisciplinary management, genetic counseling, prenatal diagnosis, and selection of gene therapy in dystrophinopathy...
February 7, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38264825/-observation-of-the-consistency-between-intellectualized-and-manual-based-cognitive-assessment-tools-in-the-outpatient-clinic
#4
JOURNAL ARTICLE
Y Xing, Q Qin, Z B Wang, D Y Wang, S Y Li, Y W Sun, H M Jin, G S Wu, L J Cai, X Y Wang, Y Tang
Objective: The intellectualized versions of the Montreal Cognitive Assessment Scale (MoCA) and the Mini-mental State Examination (MMSE) (i-MoCA/i-MMSE) were developed. The validity of this system was evaluated in a clinical sample through comparing with the manual-based assessments. Methods: A total of 88 patients (aged 66.82±11.37years, 30 males and 58 females) were enrolled in the outpatient clinic of Xuanwu Hospital of Capital Medical University with complaints of cognitive decline, from February 2023 to October 2023...
January 24, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38155093/-frontiers-in-biomedical-research
#5
JOURNAL ARTICLE
X T Cao
With continuous breakthroughs in basic research and technological innovation in the field of biomedicine, we have a much deeper understanding of the nature of life and disease pathogenesis. New medical technologies, medicines and medical instruments are emerging, which greatly promote diagnosis, treatment, prevention and healthy lifestyle. Focusing on international engagement together with the development needs of individual businesses is a major task for China's biomedical community in order to achieve high-quality outcomes...
December 22, 2023: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462366/-pathogenetic-analysis-of-transfusion-related-acute-lung-injury-caused-by-human-leukocytes-antigen-antibody-against-human-leukocyte-antigen
#6
JOURNAL ARTICLE
J Deng, X Z Xu, X Ye, Y K Chen, H Q Ding, J Liu, W J Xia, D W Chen, Y R Xu
From September 2019 to October 2020, pathogenetic analysis of three patients clinically diagnosed as transfusion-related acute lung injury (TRALI) caused by human leukocyte antibodies was conducted by Guangzhou Blood Centre, including 2 males and 1 female, aged 56, 50 and 20 years old, respectively. Solid phase agglutination, anti-human globulin test and flow cytometry method were used to detect the presence of antibodies against patients. Sequencing-based human leukocyte antigen (HLA-SBT) typing technique was used to detect the human leukocyte antigen (HLA) genotypes of patients...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462365/-effect-of-plasminogen-activator-urokinase-receptor-gene-on-the-activation-and-apoptosis-of-neutrophil
#7
JOURNAL ARTICLE
J Chen, R X Zhang, M Xie, Q J Ding, J Li
Objective: To investigate the effect of plasminogen activator urokinase receptor (PLAUR) gene on neutrophil activation and apoptosis in neutrophil-like cell model. Methods: Human acute myeloid leukemia cell line HL60 was cultured in vitro and induced to differentiate into neutrophil-like cells by all-trans retinoic acid (ATRA). Lentiviral vectors interfering with human PLAUR gene was constructed and transfected into neutrophil-like cells (siRNA group). The phosphate buffer saline (PBS) group (untransfected neutrophil-like cells) and normal blank control group (NC group) (neutrophil-like cells transfected with blank plasmid) were used as controls ( n =3)...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462364/-comparative-study-of-percutaneous-transfacet-screw-and-pedicle-screw-in-oblique-lumbar-interbody-fusion-for-the-treatment-of-single-level-lumbar-spinal-stenosis
#8
JOURNAL ARTICLE
Z Lang, Q Yuan, D He, Y Q Sun
Objective: To conduct a comparative study of radiological and clinical outcomes between percutaneous transfacet screw (TFS) and pedicle screw (BPS) in oblique lateral lumbar interbody fusion (OLIF) for single-level lumbar spinal stenosis. Methods: A retrospective cohort study. Patients who underwent OLIF with TFS or BPS for the treatment of single-level lumbar spinal stenosis at Beijing Jishuitan Hospital from January 2019 to June 2022 were retrospectively analyzed. Radiological parameters and clinical indicators were compared between the two groups...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462363/-analysis-of-transfusion-effect-of-different-platelet-matching-schemes-in-patients-with-platelet-transfusion-refractoriness
#9
JOURNAL ARTICLE
Y J Liang, H Wang, P Z Zhao, F Wang, Q Li, Y Xu, Y X Wu, D M Zhang, X H He
Objective: To analyze the transfusion effect of different platelet matching schemes in patients with platelet transfusion refractoriness (PTR). Methods: A total of 94 patients with PTR received by Taiyuan Blood Center from January to December 2021 were retrospectively analyzed, including 26 males and 68 females, aged 53(34,66) years. Platelet antibody screening was performed by enzyme-linked immunosorbent assay (ELISA). For patients with positive human leukocyte antigen (HLA) class Ⅰ antibodies, Luminex platform liquid chip assay was used to identify the specificity of antibodies, and platelets with missing allelic expression antigen corresponding to their specific antibodies were found in the platelet donor gene database established in our laboratory...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462362/-establishing-and-verifying-the-threshold-value-of-hla-mixed-antigen-reagent-screening-test-results
#10
JOURNAL ARTICLE
L Y Chen, X J Bao, X N Yuan, L Y Yu, J He
Objective: To establish the threshold value of human leukocyte antigen (HLA) mixed antigen reagent screening test results, and to verify it by HLA single antigen reagent confirmation test results. Methods: The results of 2 255 serum samples tested for HLA antibodies by HLA mixed antigen reagent in the department of HLA Laboratory, the First Affiliated Hospital of Soochow University from October 2017 to December 2021 were retrospectively analyzed. Among them, 1 139 samples were also tested by single antigen HLA Class-Ⅰ reagent and 1 116 samples were also tested by single antigen HLA Class-Ⅱ reagent...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462361/-risk-prediction-and-function-evaluation-by-t-cell-epitope-model-and-expression-model-of-hla-dpb1-mismatching-in-unrelated-donor-hematopoietic-stem-cell-transplantations
#11
JOURNAL ARTICLE
J Qi, T J Wang, M N Wang, L X Shang, L Chen, X F Wang, Y H Li, H Xu, C F Ma
Objective: To evaluate the risk prediction and assessment function of HLA-DPB1 T-cell epitope (TCE) model and expression model in human leukocyte antigen (HLA)-matched unrelated hematopoietic stem cell transplantation (MUD-HSCT) with HLA-DPB1 mismatching. Methods: A total of 364 (182 pairs) potential MUD-HSCT donors and recipients confirmed by HLA high-resolution typing in Shaanxi Blood Center from 2016 to 2019 were analyzed retrospectively. Of the 182 recipients, there were 121 males and 61 females with an average age of (26...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462360/-effect-of-sirolimus-combined-with-anti-cd20-monoclonal-antibody-desensitization-on-the-prognosis-of-patients-underwent-haploidentical-stem-cell-transplantation
#12
JOURNAL ARTICLE
N Ma, Z D Wang, Y Q Sun, C H Yan, F R Wang, X D Mo, M Lyu, X Y Zhao, X S Zhao, W Han, H Chen, Y Y Chen, Y Wang, L P Xu, Y F Cheng, X H Zhang, K Y Liu, X J Huang, Y J Chang
Objective: To investigate the effects of sirolimus combined with anti-CD20 monoclonal antibody desensitization on the prognosis of patients with haploidentical stem cell transplantation (haplo-SCT). Methods: Fifteen consecutive patients who received haplo-SCT and pre-transplant donor specific anti-human leukocyte antigen (HLA) antibody (DSA) positive [mean fluorescence intensity (MFI)≥2 000] in the Institute of Hematological Diseases from November 2021 to March 2023 were retrospectively recruited into the desensitized group...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462359/-establishment-and-validation-of-prediction-models-for-human-leukocyte-antigen-haplotypes-and-human-leukocyte-antigen-genotypes
#13
JOURNAL ARTICLE
Y Li, D Du, T T Zhang, Y Han, Y Song, X N Yuan, X J Bao, J He
Objective: To establish prediction models for human leukocyte antigen (HLA) haplotypes and HLA genotypes, and verify the prediction accuracy. Methods: The prediction models were established based on the characteristic of HLA haplotype inheritance and linkage disequilibrium (LD), as well as the invention patents and software copyrights obtained. The models include algorithm and reference databases such as HLA A-C-B-DRB1-DQB1 high-resolution haplotypes database, B-C and DRB1-DQB1 LD database, G group alleles table, and NMDP Code alleles table...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462358/-guidelines-for-clinical-application-of-micronutrients-in-chinese-adult-patients-2024-edition
#14
JOURNAL ARTICLE
(no author information available yet)
Micronutrients, including trace elements and vitamins, are essential nutrients in human metabolism. The majority of patients who need nutritional therapy have different levels of micronutrient deficiency for various reasons, which can lead to disease progression and affect clinical outcomes. In order to further standardize the application of micronutrients in medical nutrition therapy, nearly 100 experts in related fields were organized by the Chinese Society of Parenteral and Enteral Nutrition (CSPEN) to elaborate on the role and dosage of micronutrients based on the existing evidence-based medical evidence in common clinical conditions such as severe illness, surgery, burns, inflammatory bowel disease, short bowel disease, malignant tumors, chronic liver and kidney disease, elderly comorbidity, weight loss and chronic infection...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462357/-challenges-and-solutions-in-current-human-leukocyte-antigen-confirmatory-typing-of-hematopoietic-stem-cell-transplantation
#15
JOURNAL ARTICLE
X J Bao, X N Yuan, J He
The impact of human leukocyte antigen (HLA) on hematopoietic stem cell transplantation (HSCT) necessitates high precision in HLA genotyping. Confirmatory typing for patients and their related or unrelated donors before HSCT is critical. This study seeks to standardize HLA confirmatory typing in laboratories by examining the current state of HLA genotyping in the country, building upon the National Standards and Industrial Standards for HLA, and highlighting the significance of confirmatory typing for patients and potential donors prior to HSCT...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462356/-lncrna-snhg11-promotes-malignant-progression-of-colorectal-cancer-cells-through-the-pi3k-akt-mtor-signaling-pathway
#16
JOURNAL ARTICLE
S N Tao, X C Liu, Y Y Wang, H Yang
Objective: To investigate the effects of lncRNA SNHG11 on proliferation, migration, invasion and apoptosis of colorectal cancer cancer cells and possible mechanisms. Methods: qRT-PCR was performed to detect the expression level of lncRNA SNHG11 in colorectal cancer tissues and its related cell lines. The correlation between SNHG11 expression and clinical prognosis of patients was assessed by bioinformatics techniques. Cultured CRC cell lines were transfected with shCtrl (shCtrl group), shSNHG11#1 (shSNHG11#1 group), shSNHG11#2 (shSNHG11#2 group), Control cDNA (Control cDNA group), and SNHG11 cDNA (SNHG11 cDNA), respectively...
March 12, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462355/-the-application-of-setting-tube-voltage-and-iodine-delivery-rate-in-weight-grouped-for-reducing-the-radiation-and-contrast-medium-dose-in-coronary-ct-angiography
#17
JOURNAL ARTICLE
Y Zhang, J X Wu, Y Wang, H S Yuan
Objective: To evaluate the application value of reducing tube voltage and iodine delivery rate according to body weight in coronary CT angiography (CCTA). Methods: A prospective randomized controlled study. A total of 297 subjects, 172 males and 125 females, aged [ M ( Q 1 , Q 3 )]60.0 (50.0, 68.0) years, who underwent CCTA examination in Peking University Third Hospital due to clinically suspected coronary heart disease from May to December 2022 were included. According to the odd or even visit dates, the subjects were randomly divided into test group ( n =156) and control group ( n =141)...
March 12, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462354/-correlation-between-weight-variability-and-the-risk-of-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus
#18
JOURNAL ARTICLE
Y Q Fang, W W Wang, H H Liu, F L Tang, T J Yau-Jiunn, Q Q Lou
Objective: To evaluate the relationship between different indexes of weight variability and the risk of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Methods: A retrospective cohort study. The clinical data of 2 180 T2DM patients without DKD who underwent case management at Lee's United Clinic in Taiwan, China from 2002 to 2018 were retrospectively analyzed, including 1 103 females and 1 077 males, with an average age of (64.8±12.4) years. Regular follow-up was conducted for patients for at least 2 years, and their metabolic indexes were monitored annually...
March 12, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462353/-postoperative-lymph-node-metastasis-status-and-related-factors-in-patients-with-early-stage-low-risk-endometrial-cancer-assessed-by-the-mayo-criteria
#19
JOURNAL ARTICLE
X W Shi, D F Wang, G N Zhang, J Zhang
Objective: To investigate the postoperative lymph node metastasis status and related factors of patients with early-stage low-risk endometrial cancer evaluated by the Mayo criteria in order to make the preoperative evaluation more accurate. Methods: A total of 172 patients with early-stage low-risk endometrial cancer who underwent surgery in Sichuan Provincial Cancer Hospital from 2009 to 2018 and were evaluated as early low-risk according to the "Mayo criteria" were retrospectively enrolled, and were divided into lymph node metastasis group (7 cases) and non-metastasis group (165 cases) according to the results of postoperative pathological examination...
March 12, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38462352/-the-long-term-efficacy-of-metformin-in-megestrol-acetate-based-fertility-sparing-treatment-for-patients-with-endometrial-atypical-hyperplasia-and-endometrioid-endometrial-cancer
#20
JOURNAL ARTICLE
Y T Dong, J Guan, B Y Yang, Gulinazi Yierfulati, Y Xue, X J Chen
Objective: To assess the long-term efficacy of metformin in megestrol acetate (MA)-based fertility-sparing treatment for patients with endometrial atypical hyperplasia (EAH) and endometrioid endometrial cancer (EEC). Methods: The randomized controlled trail study was conducted from October 2013 to October 2017 in the Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. Patients with EAH or EEC were firstly stratified according to pathology, and randomized to receive MA (160 mg orally, daily) plus metformin (500 mg orally, three times a day) or MA (160 mg orally, daily)...
March 12, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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