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Journals Transactions of the American C...

Transactions of the American Clinical and Climatological Association

https://read.qxmd.com/read/37701611/impact-of-the-covid-19-pandemic-on-public-hospitals-in-the-united-states
#21
JOURNAL ARTICLE
Will Ross, Matt Reidhead, Robert Jansen, Cynthia Boyd, Elvin Geng
The country's public hospitals, guided by the principles established by the first such hospital in 1736 and codified through the policies of the Surgeon General in 1936, have played an outsized role as safety net institutions for disadvantaged populations. Public hospitals are predominantly located in urban, under-resourced neighborhoods and treat a larger percentage of low-income individuals who are uninsured or enrolled in Medicaid. In assessing the status of public hospitals and urban communities in the twenty-first century, the impact of the COVID-19 pandemic was evaluated at two high-performing public hospitals, Grady Memorial Hospital and Rush University Medical Center, and a network of safety hospitals affiliated with the Missouri Hospital Association...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701610/index
#22
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701609/born-to-wheeze-or-learned-when-we-were-young-maternal-and-environmental-factors-influence-atopic-risk
#23
JOURNAL ARTICLE
Patricia W Finn, David L Perkins
The prevalence of atopic diseases is increasing globally, particularly in children. Heritable genetics can partially explain risk of disease. Evidence also points to acquired genetic material, in the form of the microbiome, as an important factor in disease pathogenesis. The acquisition of the microbiome dynamically changes in response to differences in lifestyle and environmental factors. Also, in utero , maternal and environmental factors influence atopic risk for allergic rhinitis, eczema, asthma, and food allergy...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701608/fgf23-and-altered-mineral-homeostasis-in-kidney-disease-and-following-intravenous-iron
#24
JOURNAL ARTICLE
Myles Wolf
Fibroblast growth factor 23 (FGF23) is an endocrine hormone that stimulates renal phosphate excretion and suppresses circulating concentrations of 1,25-dihydroxyvitamin D (1,25D). These effects of FGF23 are most evident in rare diseases that are characterized by FGF23-mediated hypophosphatemic rickets-osteomalacia. More commonly, elevated FGF23 is a ubiquitous, early consequence of chronic kidney disease (CKD) in which it helps to maintain normal serum phosphate levels but causes secondary hyperparathyroidism by suppressing 1,25D, and directly promotes cardiovascular disease and death...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701607/present-members
#25
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701606/the-gordon-wilson-memorial-lecture
#26
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701605/president-s-address-virology-through-the-lens-of-the-american-clinical-and-climatological-association
#27
JOURNAL ARTICLE
Peter M Howley
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701604/officers-and-council-fall-2023
#28
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701603/the-mary-allen-engle-award
#29
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701602/endometrial-carcinoma-the-interplay-of-genetics-and-hormones
#30
JOURNAL ARTICLE
Lora Hedrick Ellenson
Endometrial carcinoma is the most common malignancy of the genital tract in females in the United States, and it is one of the few human cancers increasing in incidence and mortality. Numerous studies have found an association of endometrial carcinoma with obesity, diabetes, and unopposed estrogen stimulation. Molecular studies, in our lab and others, have shown that endometrial carcinoma has a high frequency of alterations in the Phosphoinositide 3-kinase (PIK3) pathway, and notably, coexisting abnormalities in more than one member of the pathway are common...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701601/banquet-speakers
#31
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701600/suppresion-of-mitochondrial-respiration-is-a-feature-of-cellular-glucose-toxicity
#32
JOURNAL ARTICLE
Kumar Sharma, Guanshi Zhang, Rintaro Saito
Glucose toxicity is central to the myriad complications of diabetes and is now believed to encompass neurodegenerative diseases and cancer as well as microvascular and macrovascular disease. Due to the widespread benefits of SGLT2 inhibitors, which affect glucose uptake in the kidney proximal tubular cell, a focus on cell metabolism in response to glucose has important implications for overall health. We previously found that a -Warburg-type effect underlies diabetic kidney disease and involves metabolic reprogramming...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701599/the-bert-and-peggy-dupont-lecture
#33
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701598/learning-to-pivot-developing-talent-and-a-championship-team
#34
JOURNAL ARTICLE
W Kimryn Rathmell
Developing the future leaders of biomedical science is fundamentally the most important role that we play in academic medicine. Similar to the path to elite championship athletics, the path begins early: engaging young minds to find excitement in science, enlightening medical students on the importance of curiosity, challenging faculty to achieve milestones and mature as leaders. Coaching strategies are critical and are different at each developmental stage. It may seem that it is becoming harder to entice young talent to pursue a career in biomedical research, or that the perpetually leaky pipeline is corroding to the point of hemorrhage...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701597/acca-presidents-past-and-present-and-spouses
#35
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701596/the-theodore-e-woodward-award
#36
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701595/improving-diverse-participation-in-cancer-clinical-trials
#37
JOURNAL ARTICLE
Ruben Mesa, Rebecca T Jones
Despite significant improvement in overall cancer mortality (>30% since 1991), these survival benefits have not been experienced by all groups uniformly especially in those of diverse heritage. Drivers of cancer health inequity are multi-factorial including more adverse social determinants of health, later stage cancer presentation, decreased health care access, decreased health literacy, and cultural barriers to prompt cancer care. Adding to these disparities is the historical inclusion of primarily well-insured Caucasian patients into cancer clinical trials leading to deep gaps in understanding both the efficacy and safety of new therapies in the actual populations for which these medications will be used...
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701594/reaffirming-the-core-values-of-academic-cardiology
#38
JOURNAL ARTICLE
Joaquin E Cigarroa, Richard A Lange
Academic medical centers are rapidly evolving into academic health systems with expanding clinical activity. These changes coupled with financial pressures due to decreased clinical reimbursements and failure of the NHLBI budget to keep pace with inflation are challenging the ability to succeed in all our missions. New governance structures and financial models may be necessary to success in our research and educational missions.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701593/instructions-to-authors-transactions-of-the-american-clinical-and-climatological-association
#39
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2023: Transactions of the American Clinical and Climatological Association
https://read.qxmd.com/read/37701592/closing-the-gap-between-medical-knowledge-and-patient-outcomes-through-new-training-infrastructure
#40
JOURNAL ARTICLE
Melvin Blanchard
The biomedical research infrastructure of our academic medical centers elucidates disease mechanisms and develops diagnostic tests and treatments with scientific rigor, but the mechanism for reliably moving these findings into clinical settings lacks careful design. Hence, there is a wide gap between medical discoveries and the health benefit realized by the U.S. population. Performance improvement (PI) is a discipline that focuses on intentional redesign of core processes in our health system to close these gaps...
2023: Transactions of the American Clinical and Climatological Association
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