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Journals Revista do Instituto de Medici...

Revista do Instituto de Medicina Tropical de São Paulo

https://read.qxmd.com/read/37377325/septic-shock-hyperferritinemic-syndrome-and-multiple-organ-dysfunction-without-respiratory-failure-in-a-patient-with-disseminated-histoplasmosis-and-advanced-hiv-disease
#21
(no author information available yet)
[This corrects the article doi: 10.1590/S1678-9946202365028].
June 23, 2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055380/detection-of-bartonella-bovis-dna-in-blood-samples-from-a-veterinarian-in-mexico
#22
Jannete Gamboa-Prieto, Anabel Cruz-Romero, José A Jiménez-Hernández, José Rodrigo Ramos-Vázquez, Gerardo G Ballados-González, Dora Romero-Salas, Violeta T Pardío-Sedas, Sandra C Esparza-Gonzalez, Ingeborg Becker, Sokani Sánchez-Montes
The genus Bartonella encompasses 38 validated species of Gram-negative, facultative intracellular bacteria that colonize the endothelial cells and erythrocytes of a wide spectrum of mammals. To date, 12 Bartonella species have been recorded infecting humans, causing diseases of long historical characterization, such as cat scratch fever and trench fever, and emerging bartonellosis that mainly affect animal health professionals. For this reason, this study aimed to report a documented case of Bartonella bovis infecting a veterinarian from Mexico by the amplification, sequencing and phylogenetic reconstruction of the citrate synthase (gltA) and the RNA polymerase beta-subunit (rpoB) genes, and to report the natural course of this infection...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055379/multidrug-resistant-tuberculous-orchiepididymitis-a-brief-case-report
#23
César Augusto Tomaz de Souza, Jussemara Souza da Silva, Ademir Silva Correia, Denise Silva Rodrigues
Tuberculosis (TB) is one of the leading causes of death by infectious diseases worldwide. Multidrug-resistant tuberculosis is a growing problem, especially in countries with high TB prevalence. Although the lungs are the organs most frequently affected by this disease, Mycobacterium tuberculosis can harm any organ, including the urogenital tract, causing extrapulmonary tuberculosis, which leads to a challenging diagnosis and consequent treatment delays. In this article, we present a case of orchiepididymitis caused by multidrug-resistant TB (MDR-TB) with a significantly delayed diagnosis, the proposed treatment according to the resistance profile, and the clinical outcomes...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055378/cutaneous-naganishia-albida-cryptococcus-albidus-infection-a-case-report-and-literature-review
#24
Vítor Falcão de Oliveira, Alexandre Pereira Funari, Mariane Taborda, Adriana Satie Gonçalves Kono Magri, Anna Sara Levin, Marcello Mihailenko Chaves Magri
Naganishia albida (Cryptococcus albidus) is considered saprophytic fungi, and is rarely reported as a human pathogen. Cutaneous infections caused by non-neoformans cryptococcus are rare. We describe a case of an immunocompetent older male with cutaneous cryptococcosis caused by Naganishia albida following skin trauma, and conduct a literature review in PubMed, Lilacs, and Embase. Only six previous similar reports were found. The seven cases (including ours) were widely distributed geographically (Brazil, the US, the UK, Hungary, South Korea, and Iran), all males, and their ages varied, ranging from 14 to 86 years...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055377/real-world-effectiveness-and-safety-of-direct-acting-antivirals-for-the-treatment-of-hepatitis-c-virus-in-kidney-and-liver-transplant-recipients-experience-of-a-large-transplant-center-in-brazil
#25
JOURNAL ARTICLE
Larissa Sgaria Pacheco, Pedro Enrico Ventura, Roger Kist, Valter Duro Garcia, Gisele Meinerz, Cristiane Valle Tovo, Guido Pio Cracco Cantisani, Maria Lucia Zanotelli, Marcos Mucenic, Elizete Keitel
Direct-acting antivirals are the gold-standard treatment for chronic HCV infections, but few studies have investigated their use on kidney and liver transplant recipients. We conducted a real-world study to evaluate the rates of sustained virological response with direct-acting antivirals in kidney and liver transplant recipients. Moreover, it also aimed to evaluate direct-acting antivirals (DAAs) interference with immunosuppressant levels and to describe the frequency of adverse events. As part of this retrospective observational cohort, we included adult patients that had undergone a kidney transplant (KT) or liver transplant (LT) at our center, had a chronic HCV infection, and were treated with DAAs from June 2016 to December 2021...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055376/immune-system-gene-polymorphisms-associated-with-severe-dengue-in-latin-america-a-systematic-review
#26
JOURNAL ARTICLE
Jorge Emilio Salazar Flórez, Ángela María Segura Cardona, Berta Nelly Restrepo Jaramillo, Margarita Arboleda Naranjo, Luz Stella Giraldo Cardona, Ángela Patricia Echeverri Rendón
One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/38055375/can-covid-19-impact-the-natural-history-of-paracoccidioidomycosis-insights-from-an-atypical-chronic-form-of-the-mycosis
#27
JOURNAL ARTICLE
César Augusto Tomaz de Souza, Cesar Cilento Ponce, Gisele Burlamaqui Klautau, Nathan Costa Marques, Wladimir Queiroz, Rosely Antunes Patzina, Gil Benard, José Angelo Lauletta Lindoso
Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by Paracoccidioides spp. It can occur as an acute/subacute form (A/SAF), a chronic form (CF) and rarely as a mixed form combining the features of the two aforementioned forms in an immunocompromised patient. Here, we report a 56-year-old male patient with CF-PCM who presented with atypical manifestations, including the development of an initial esophageal ulcer, followed by central nervous system (CNS) lesions and cervical and abdominal lymphatic involvement concomitant with severe SARS-CoV-2 infection...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37878973/influence-of-sex-on-the-exposure-to-isoniazid-in-patients-with-pulmonary-tuberculosis
#28
JOURNAL ARTICLE
Juan Gonzalo Bardalez Rivera, Carlos Augusto Abreu Albério, José Luiz Fernandes Vieira
Isoniazid is a key component of tuberculosis treatment. Adequate exposure is a determinant for therapeutic success; however, considerable inter- and intraindividual variations in drug plasma levels can lead to unfavorable outcomes. While some predictors of isoniazid levels are well-known, others, such as sex, yield controversial results, requiring further investigation to optimize exposure. This study investigates whether the sex of patients influences the dose administered and the concentrations of isoniazid in plasma...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37878972/genetic-variability-of-leishmania-leishmania-infantum-causing-human-visceral-leishmaniasis-in-the-southeastern-brazil
#29
JOURNAL ARTICLE
Vinicius Alves Lima, Renata Elen Costa Silva, Luiz Henrique Moraes Caetano Camargo, Roberto Mitsuyoshi Hiramoto, Elcio de Souza Leal, Lucia Maria Almeida Braz, José Angelo Lauletta Lindoso
Leishmania infantum is a protozoan that causes visceral leishmaniasis (VL) in the Americas and some regions of Europe. The disease is mainly characterized by hepatosplenomegaly and fever, and can be fatal. Factors related to the host and parasite can contribute to the transmission of Leishmania and the clinical outcome. The intraspecific genetic variability of L. infantum strains may be one of these factors. In this study, we evaluated the genetic variability of L. infantum obtained from bone marrow smear slides from patients in the Sao Paulo State, Brazil...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37878971/a-fatal-case-of-disseminated-pulmonary-and-renal-mucormycosis-caused-by-rhizopus-microspores
#30
Liuyang Hu, Xingchun Chen
Rhinocerebral and pulmonary mucormycosis are the main manifestations of mucormycosis; however, disseminated pulmonary associated with renal mucormycosis is rarely reported. In this paper, we report a rare fatal case of disseminated pulmonary and renal mucormycosis caused by Rhizopus microsporus in a 50-year-old man with poorly controlled hypertension, type 2 diabetes, and prolonged use of corticosteroids for the treatment of his reiterative gouty arthritis. In this patient, the use of corticosteroids and poorly controlled diabetes were considered underlying risk factor for his disseminated mucormycosis, along with acute renal dysfunction, suggesting the need for clinical suspicion of disseminated pulmonary and renal mucormycosis in hospitalized patients with poorly controlled diabetes and immunocompromised host...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37878970/associations-of-sars-cov-2-cycle-threshold-values-with-age-gender-sample-collection-setting-and-pandemic-period
#31
JOURNAL ARTICLE
Fernando Franco-Miraglia, Beatriz Martins-Freitas, André Mario Doi, Rubia Anita Ferraz Santana, João Renato Rebello Pinho, Vivian I Avelino-Silva
Cycle threshold (Ct) values in COVID-19 reverse-transcription polymerase chain reaction (RT-PCR) tests estimate the viral load in biological samples. Studies have investigated variables associated with SARS-CoV-2 viral load, aiming to identify factors associated with higher transmissibility. Using the results from tests performed between May/2020-July/2022 obtained from the database of a referent hospital in Sao Paulo, Brazil, we investigated associations between Ct values and patient's age, gender, sample collection setting and pandemic period according to the predominant SARS-CoV-2 variant locally...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37820248/prevalence-of-sars-cov-2-infection-among-health-care-workers-in-a-reference-hospital-in-brazil
#32
JOURNAL ARTICLE
Vanessa Neves Almeida, Roberta Figueiredo Cavalin, Juliana Failde Gallo, Cleide Aparecida Guerra, Karen Cristina Rolim Madureira, Meire Bócoli Rossi, Rozania Soeli Dos Santos Sobreira, Ana Paula Santos, Expedito Luna, José Angelo Lauletta Lindoso
Health care workers (HCW) are the frontline workforce for COVID-19 patient care and, consequently, are exposed to SARS-CoV-2 infection due to close contact to infected patients. Here, we evaluate the prevalence of SARS-CoV-2 infection among HCW from an infectious disease hospital, reference center for COVID-19 care in the metropolitan area of Sao Paulo city, Brazil. Among 2,204 HCW, 1,417 (64.29%) were subjected to detection of anti-SARS-CoV-2 antibodies by chemiluminescent immunoassay. Out of the total, 271 (19...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37820247/overview-of-chagas-disease-surveillance-in-an-endemic-region-in-southeastern-brazil
#33
JOURNAL ARTICLE
Aline Ferreira Rafael, Raquel Aparecida Ferreira, Ariela Ferreira Mota, Renata Fiúza Damasceno, Agna Soares da Silva Menezes, Bartolomeu Teixeira Lopes, Gustavo Libério de Paulo, Ester Cerdeira Sabino, Antônio Luiz Pinho Ribeiro, Nayara Dornela Quintino, Thallyta Maria Vieira
Chagas disease (CD) is a neglected disease caused by the protozoan Trypanosoma cruzi. It has high morbidity and mortality rates and mainly affects socially vulnerable populations. This is a cross-sectional study, with retrospective and prospective data collection. Using questionnaires applied to environmental surveillance coordinators, we characterized the status of CD surveillance activities in municipalities endemic for the disease in Northern Minas Gerais State (MG) and Jequitinhonha Valley (Vale do Jequitinhonha)...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37820246/covid-19-related-multisystem-inflammatory-syndrome-in-adult-the-first-death-in-brazil
#34
Maria Lúcia Machado Salomão, Flávia Queiroz, Lina de Moura Mendes, Taiza Maschio de Lima, Murillo de Souza Tuckumantel, Marcia Wakai Catelan, Neymar Elias de Oliveira, Maurício Lacerda Nogueira, Cassia Fernanda Estofolete
The precise pathogenesis of COVID-19-related multisystem inflammatory syndrome remains largely elusive, despite its rarity. The syndrome symptoms often overlap with those of other infections, posing challenges for prompt diagnosis. A male patient, 34 years old, was admitted with suspicion of severe dengue, rapidly progressing to multiple organ dysfunction. Dengue tests resulted negative, and he passed away after four days. This case occurred approximately four weeks after the initial onset of COVID-19 and met all diagnostic criteria as defined by the Centers for Disease Control and Prevention...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37729270/first-report-of-aedes-albopictus-diptera-culicidae-in-the-north-of-colombia
#35
JOURNAL ARTICLE
María Claudia Atencia-Pineda, Alfonso Calderón-Rangel, Richard Hoyos-López, Javier García-Leal, Rafael Bolaños, Paula Pareja-Loaiza, Ronald Maestre-Serrano
Aedes albopictus is considered a potential vector of arboviruses in Colombia. Females and males naturally infected with dengue, Zika and chikungunya viruses have already been found in this country. We document the first record of Ae. albopictus in the Cordoba department, in North of Colombia. The finding was carried out during Ae. aegypti collection activities in the Ayapel, Montelibano, Planeta Rica, Pueblo Nuevo and Puerto Libertador municipalities. The entomological material was collected in water containers such as cement water tanks, tanks, bottles, tires, abandoned toilets, and plastic lids with natural water located in the intradomicile, peridomicile, and extra-domicile spaces of the homes...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37703119/first-report-of-human-infection-with-leptospira-interrogans-serovar-bratislava-in-the-eastern-black-sea-region-of-turkey
#36
Ersin Kuloglu, Kubilay Issever
Leptospirosis is one of the most common zoonotic bacterial infections worldwide. It is an infection that usually affects people with low socioeconomic status, with morbidity and mortality risk. The clinical course of the disease may range from mild, featuring nonspecific clinical signs and symptoms, to severe, resulting in death. The respective studies conducted in Turkey indicate that leptospirosis seropositivity in animals and humans is higher in coastal and rural areas. Turkey's Eastern Black Sea Region has a humid climate with heavy rainfalls and a large population of mice and other rodents...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37703118/factors-associated-with-mucosal-involvement-in-tegumentary-leishmaniasis-a-nation-based-study-using-surveillance-data-from-brazil
#37
JOURNAL ARTICLE
Clarisse Fonseca Monachesi, Adriano Gomes-Silva, Filipe Anibal Carvalho-Costa
This study aimed to assess the factors associated with mucosal leishmaniasis (ML) within the scope of tegumentary leishmaniasis (TL) cases reported in Brazil. Surveillance data were assessed, and comparisons were made between ML and cutaneous leishmaniasis (CL) cases. Additionally, ML incidence rates for municipalities were depicted through a geographic information system. From 2007 to 2017, 235,489 TL cases were reported, of which 235,232 were classified as follows: 14,204 (6%) were ML cases and 221,028 (94%) were CL cases...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37703117/maternal-a90v-mutation-in-the-pres1-gene-of-sub-genotype-c2-hepatitis-b-virus-is-associated-with-intrauterine-transmission
#38
JOURNAL ARTICLE
Linzhu Yi, Jiaxin Wu, Zhiqing Yang, Yandi Li, Jia Lian, Tian Yao, Shuying Feng, Bo Wang, Yongliang Feng, Suping Wang
PreS/S gene mutations could impact virus secretion, infection and immune evasion. However, the relationship between PreS/S mutations and intrauterine transmission has not yet been clarified. Thus, we aimed to explore the associations between PreS/S gene mutations of HBV isolated from mothers and intrauterine transmission. We analyzed the mutations of PreS/S regions of the HBV genome in mothers with HBV DNA levels ≥ 106 IU/mL whose neonates experienced HBV intrauterine transmission (transmission group, GT) and those whose neonates did not experience intrauterine transmission (control group, GC) analyzed using clone-based sequencing...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37610941/acute-pulmonary-histoplasmosis-a-case-series-from-an-outbreak-in-southeastern-brazil
#39
Danyelle Cristina de Souza, Antonio Augusto Rodrigues-Neto, Graziela Mululo Bianco Monnerat, Mayra Sardou, Patrícia Lima Hottz, Josiana de Oliveira, Billy McBenedict, Remberto Maurício de La Cruz Vargas Vilte, Sandra Costa Fonseca, Ezequias Batista Martins
Histoplasmosis is a systemic mycosis prevalent in the Americas. Humans become infected via the respiratory route by inhaling aerosols from soil contaminated with bird and bat excretions. Acute pulmonary histoplasmosis is usually asymptomatic and is more often a self-limiting illness. We report a series of seven acute pulmonary cases in adults during an outbreak in Nova Friburgo city, Rio de Janeiro State, Brazil, in a group of volunteers who were cleaning an old, abandoned house without using personal protective equipment...
2023: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/37436253/pancreatic-tuberculosis-in-a-liver-transplant-recipient-a-case-report
#40
David Romeiro Victor, Pedro Henrique Teotônio Medeiros Peixoto, Paulo Ricardo Andrade de Medeiros, Haldson Cesar Barbosa Neto, Amanda de Oliveira Ramos Silva, Maria Eugênia Romeiro Victor, Tiago Luiz Lagedo Ferraz
The pancreatic form of tuberculosis (TB) is rare and its diagnosis is challenging, since it manifests itself with non-specific symptoms and non-pathognomonic radiological findings, mimicking a neoplasia of the pancreas. Here, we report the case of a patient who had previously undergone liver transplantation and sought care for abdominal pain, weight loss, anorexia, hematochezia and postprandial fullness. Following an exploratory laparotomy and nucleic acid amplification testing on a pancreatic sample that had been collected, the patient was diagnosed with pancreatic TB...
2023: Revista do Instituto de Medicina Tropical de São Paulo
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