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Revista do Instituto de Medicina Tropical de São Paulo

Vera Lúcia Gattás, Patrícia Emília Braga, Marcelo Eiji Koike, Maria Beatriz Bastos Lucchesi, Mayra Martho Moura de Oliveira, Roberta de Oliveira Piorelli, Vivian Queiroz, Alexander Roberto Precioso
Vaccination has been a successful strategy in influenza prevention. However, despite the safety and efficacy of the vaccines, they can cause adverse events following immunization (AEFI). Moreover, due to the vaccination success, most of vaccine-preventable diseases (VPD) have become rare, and public attention has been shifted from VPD to the AEFI associated with vaccination. This manuscript describes the safety of Instituto Butantan (IB) seasonal trivalent influenza vaccine (TIV) from 2013 to 2017. AEFI data were received by the Department of Pharmacovigilance of IB (PV-IB), from January the 1st 2013 to December the 31st 2017, and were recorded in an electronic database (OpenClinica©)...
December 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Rachel Russo, Elisa Teixeira Mendes, Anna Sara Levin, Frederico Dulley, Maura S Oliveira, Maria Aparecida Shikanai-Yasuda, Silvia Figueiredo Costa
We described 235 bloodstream infection (BSI) episodes in 146 hematopoietic stem cell transplantation (HSCT) outpatients and evaluated risk factors for hospitalization and death. Records of outpatients presenting with positive blood cultures over a 5-year period (January 2005 to December 2008) were reviewed. Variables with p< 0.1 in bivariate analysis were used in a regression logistic model. A total of 266 agents were identified, being 175 (66.7%) gram-negative, 80 (30.3%) gram-positive bacteria and 9 (3...
December 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Marcelo Vieira Costa, Taise Natali Landgraf, Priscila C Corrêa, Igor Emiliano Lemos Souza, Fabrício Freitas Fernandes, Ademilson Panunto-Castelo
Although colony-forming unit (CFU) counting is widely used to quantify fungal load in tissue from animal experimentally infected with Paracoccidioides brasiliensis, several technical disadvantages have been described. Here we developed highly accurate quantitative PCR (qPCR) assays to determine the relative P brasiliensis load in lungs from infected mice. SYBR Green- and TaqMan-based assays using primers and probe for the 43-kDa glycoprotein (gp43) gene detected as little as 270 gene copies (about 2 fg of DNA) per reaction...
December 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Thiago Pasqua Narciso, Richardson Costa Carvalho, Luciano Carvalho Campos, Agostinho Gonçalves Viana, Ricardo Toshio Fujiwara, Thales Augusto Barçante, Ingrid Marciano Alvarenga, Joziana Muniz de Paiva Barçante
American visceral leishmaniasis (VL) is a vector-borne disease transmitted by some species of phlebotomine sandflies from the genus Lutzomyia. This neglected tropical zoonosis shows increasing urbanization process, since the end of the 1980s. After the emergence of foci of the disease in urban areas, VL has assumed an important role in public health. Although VL is widely prevalent in several parts of the world, diagnosing the illness is still difficult. We present a case of a 12-year-old girl with a history of recurrent fever, anorexia, cachexia, chronic fatigue, weight loss, left palpebral unilateral edema, persistent cough and pancytopenia...
December 20, 2018: Revista do Instituto de Medicina Tropical de São Paulo
(no author information available yet)
[This corrects the article doi: 10.1590/S1678-9946201860062].
December 10, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Roberto Marques Ribeiro, Marcela de Souza-Basqueira, Léa Campos de Oliveira, Flavia Cristina Salles, Natalia Bueno Pereira, Ester Cerdeira Sabino
Gut microbiota has been the subject of various molecular studies mainly due to its importance and wide-ranging relationships with human hosts. However, the storage of fecal samples prior to DNA extraction is critical when characterizing the composition of intestinal microbiota. Therefore, we aimed to understand the effects of different fecal storage methods to characterize intestinal microbiota using Next Generation Sequencing (NGS) as well as to establish an alternative conservation method of bacterial genetic material in these samples using guanidine...
November 29, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Tassiana Pereira Tomaz, Rosana Gentile, Juberlan Silva Garcia, Bernardo Rodrigues Teixeira, Marta Júlia Faro
Many snail species act as intermediate hosts of helminths that transmit diseases to humans and animals, such as schistosomiasis and angiostrongyliasis. São Gonçalo, a mostly urban municipality in Rio de Janeiro State, Brazil, has undergone fundamental environmental impacts, which favor the establishment of a range of diseases, for which snails act as the intermediate hosts of the etiological agents. In the present study, freshwater and terrestrial snail populations were surveyed in different environments within five city districts, and the presence of helminths was determined in the collected specimens...
November 29, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Paulo Sergio Ramos de Araújo, Valter Romão de Souza Junior, Carlos Eduardo Padilha, Marta Iglis de Oliveira, Luciana Cardoso Arraes, Roberto Vieira, Ana Antunes, Reginaldo Goncalves de Lima Neto, Armando Marsden
Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. The first cases of coccidioidomycosis in Brazil were reported in 1978. Since then, there have been other reports mainly from desert regions of Northeastern Brazil. The present report describes three cases of coccidioidomycosis on male farmers from Serra Talhada county, Pernambuco State, who developed pneumonia and were subsequently diagnosed with pulmonary coccidioidomycosis...
November 14, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Hareton Teixeira Vechi, Eduardo Teodoro Gurgel de Oliveira, Marise Reis de Freitas, Flávia Rossi, Maria Helena Marques Fonseca de Britto, Manoella do Monte Alves
Rhodococcus equi is a facultative aerobic, intracellular, non-motile, non-spore-forming, Gram-positive, weakly acid-fast coccobacillus belonging to the group of nocardioform actinomycetes. R. equi infections are rare opportunistic illnesses in patients with Acquired Immunodeficiency Syndrome (AIDS), associated with a high mortality rate. The most common clinical presentation of R. equi infections is a chronic cavitary pneumonia. Due to its acid-fastness, R. equi can be mistaken for others acid-fast organisms, as Mycobacterium tuberculosis...
November 14, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Cid Carlos Soares de Alcântara, Laís Regina Lacerda Santana, Priscila Dourado Evangelista, André Costa Teixeira, Geraldo Bezerra da Silva Junior, Elizabeth De Francesco Daher
Visceral leishmaniasis (VL) is an endemic parasitic disease frequently found in Northeast Brazil and may cause acute kidney injury (AKI) and glomerulonephritis. After appropriate treatment, renal function recovery may occur. We describe the rare case of a patient with VL, who developed severe AKI requiring dialysis and was subsequently diagnosed with Chagas disease coinfection. After specific treatment for VL, there was partial recovery of the renal function, followed by the onset of Chagas disease cardiomyopathy...
November 14, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Fabiane Mateus Siqueira, Vinicius Lins Ferreira, Helena Hiemisch Lobo Borba, Roberto Pontarolo
Due to the severity of chronic hepatitis C, there are multiple factors that can negatively affect the quality of life of infected patients. The aim of this study was to evaluate changes in the health-related quality of life (HRQoL) in patients under second-generation direct-acting antiviral (DAA) (interferon-free) therapies and to assess treatment effectiveness. This was an observational study conducted in Curitiba (Brazil) using two instruments (a generic and a specific) for measuring the quality of life in patients with chronic hepatitis C, the Short Form-36 (SF-36) and the Chronic Liver Disease Questionnaire (CLDQ) for liver disease evaluation...
November 14, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Felipe Francisco Tuon, Carolina Rocio Santos, Juliette Cieslinski, Regina Maia de Souza, Rui Imamura, Valdir Sabbaga Amato
No abstract text is available yet for this article.
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Yu-Kang Chang, Kou-Huang Chen, Kow-Tong Chen
Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and control. The morbidity rate of EV-A71 infection differs between countries. The pathogen's genetic lineages are undergoing rapid evolutionary changes. An association between the occurrence of EV-A71 infection and the circulation of different genetic strains of EV-A71 virus has been identified around the world...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Fernanda Gil de Souza, Francini Pereira da Silva, Rodrigo Staggemeier, Caroline Rigotto, Fernando Rosado Spilki
Hepatitis A virus (HAV), a member of Picornaviridae family, is the main causative agent of acute viral hepatitis in the world, mainly in developing countries. HAV may be present in contaminated water and food and its presence is often associated to a lesser extent with socioeconomic factors and environmental quality. The main goals in the present study were to standardize a cell culture combined to a polymerase chain reaction protocol for the detection and quantification of viral viability and analyze whether the virus could be found in water samples collected in four urban streams of Sinos River watershed...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Denise Costa Boamorte Cortela, Maria Renata Sales Nogueira, Ana Carla Pereira, Alcione Lescano de Souza Junior, Eliane Ignotti
The inflammatory cytokines involved in the immune response to chronic periodontal disease (CPD) in the context of leprosy reactions (LR) were analyzed in 57 new cases of multibacillary leprosy (MBL). They were stratified by the presence of CPD and LR. Messenger RNA (mRNA) expression of inflammatory mediators was determined by qRT-PCR using skin biopsy and by ELISA using serum samples, maintaining 5% of significance level in ANOVA and correlation analyses. Twenty-three (40.4%) patients presented the first LR, whereas 22 (45...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Leticia Ferrigolo Zanella, Iara Beatriz Andrade de Sousa, Marcelo Dos Santos Barbosa, Odival Faccenda, Simone Simionatto, Silvana Beutinger Marchioro
Leprosy remains a public health problem in Brazil, and the Mato Grosso do Sul State (MS) had the seventh highest rate of detection of new cases in the country in 2015 (26.59 per 100,000 inhabitants) which was classified as very high. This work aimed to determine the epidemiological characteristics of leprosy in MS. Descriptive statistics were performed with data from the Information System on Diseases of Compulsory Declaration (SINAN) between 2001 and 2015, with all patients included in the system serving as the sample...
November 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Amanda Gabryelle Nunes Cardoso Mello, Michelle Valéria Dias Ferreira Vieira, Luann Wendel Pereira de Sena, Thiago Portal da Paixão, Ana Carla Godinho Pinto, Daniella Paternostro de Araújo Grisólia, Margareth Tavares Silva, José Luiz Fernandes Vieira
In the last two years, a substantial increase in the number of malaria vivax cases has occurred in the Brazilian Amazon basin. The adequate exposure of hypnozoites to primaquine is a matter of interest as these dormant forms are responsible for the maintenance or even the increase of malaria burden in endemic areas. The aim of this study was to estimate the levels of primaquine and carboxyprimaquine in whole blood samples of patients with P. vivax treated with chloroquine and an abbreviated regimen of primaquine (0...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Guilherme Almeida Rosa da Silva, Heloisa Loureiro de Sá Neves Motta, Erik Friedrich Alex de Souza, Pedro Afonso Nogueira Moises Cardoso, José Henrique Pilotto, Walter Araujo Eyer-Silva, Luiz Cláudio Pereira Ribeiro, Mônica Soares Dos Santos, Marcelo Costa Velho Mendes de Azevedo, Jorge Francisco da Cunha Pinto, Rogerio Neves Motta, Fernando Raphael de Almeida Ferry
A prevalence of 3.47% of asymptomatic Chlamydia trachomatis urethritis has been previously reported among males living with HIV infection in Brazil. This study aims to assess the recurrence of C. trachomatis urethritis three years later in the same cohort of patients and analyze associated risk factors. A total of 115 male patients diagnosed with HIV infection, with no symptoms of urethritis and observed since May of 2015 in followup visits were enrolled. They had urine samplers tested by PCR for C. trachomatis and N...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Vivian Iida Avelino-Silva, Conrado Alvarenga, Carolina Abreu, Tania Regina Tozetto-Mendoza, Cynthia Liliane Motta do Canto, Erika Regina Manuli, Maria Cassia Mendes-Correa, Ester Cerdeira Sabino, Walter Manso Figueiredo, Aluísio Cotrim Segurado, Philippe Mayaud
BACKGROUND: Zika virus (ZIKV) sexual transmission and prolonged viral shedding in semen have been previously reported, suggesting a strong viral affinity for genital tissues. A transient impact of ZIKV on male fertility was shown in animal and human studies. METHODS: Adult male patients with confirmed ZIKV infection diagnosed in the city of Araraquara, Brazil during the epidemic season of 2016 were invited one year after the acute infection to respond to a questionnaire of genital symptoms and to provide a semen sample for molecular ZIKV testing and spermogram analysis, as well as a serum sample for hormonal testing...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Jocieli Malacarne, Ida Viktoria Kolte, Lais Picinini Freitas, Jesem Douglas Yamall Orellana, Maximiliano Loiola Ponte de Souza, Reinaldo Souza-Santos, Paulo Cesar Basta
The Mato Grosso do Sul State (MS) has the second-largest indigenous population and the highest incidence rates of TB among indigenous people in Brazil. However, little is known about the risk factors associated with active TB in indigenous people in the region, especially regarding socioeconomic factors. The aim of this study is to assess the effect of the Family Allowance Program (BFP) and of other predictors of active TB in a high-risk indigenous population in Brazil. We conducted a case-control study with incident TB cases matched by age and by village of residence (1:2 proportion) between March 2011 and December 2012...
October 25, 2018: Revista do Instituto de Medicina Tropical de São Paulo
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