journal
https://read.qxmd.com/read/37787913/viral-inhibitory-potential-of-hyoscyamine-in-japanese-encephalitis-virus-infected-embryonated-chicken-eggs-involving-multiple-signaling-pathways
#1
JOURNAL ARTICLE
Arghyadeep Bhattacharjee, Rahul Naga, Manish Saha, Srabani Karmakar, Abhishek Pal, Souvik Roy
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. The emergence of new genotypes of the virus and a high rate of mutation make it necessary to develop alternative treatment strategies against this deadly pathogen. Although the antiviral properties of Atropa belladonna and some of its active components, such as atropine and scopolamine, have been studied, the effect of another important component, hyoscyamine, against JEV infection has not yet been investigated. In this study, we investigated the antiviral effect of hyoscyamine against JEV and its immunomodulatory activity in embryonated chicken eggs...
October 3, 2023: Archives of Virology
https://read.qxmd.com/read/37775596/rational-approach-to-vaccination-against-highly-pathogenic-avian-influenza-in-nigeria-a-scientific-perspective-and-global-best-practice
#2
REVIEW
Clement Meseko, Negedu Onogu Ameji, Binod Kumar, Marie Culhane
Since 2006, highly pathogenic avian influenza (HPAI) subtypes H5Nx have adversely affected poultry production in Nigeria. Successive waves of infections in the last two decades have raised concerns about the ability to contain infections by biosecurity alone, and evidence of recurrent outbreaks suggests a need for adoption of additional control measures such as vaccination. Although vaccination can be used to control virus spread and reduce the morbidity and mortality caused by HPAI, no country using vaccination alone as a control measure against HPAI has been able to eliminate or prevent re-infection...
September 29, 2023: Archives of Virology
https://read.qxmd.com/read/37773423/epidemiology-genetic-diversity-and-evolutionary-dynamics-of-tembusu-virus
#3
JOURNAL ARTICLE
Peng Zhou, Bin Ma, Yuan Gao, Yumin Xu, Zhuofei Li, Hui Jin, Rui Luo
Tembusu virus (TMUV) is an emerging pathogenic flavivirus associated with acute egg-drop and fatal encephalitis in domestic waterfowl. Since its initial identification in mosquitoes in 1955, TMUV has been confirmed to infect ducks, pigeons, sparrows, geese, and chickens, posing a significant threat to the poultry industry. Here, we sequenced two DTMUV strains isolated in 2019 and systematically investigated the possible origin, genetic relationships, evolutionary dynamics, and transmission patterns of TMUV based on complete virus genome sequences in the public database...
September 29, 2023: Archives of Virology
https://read.qxmd.com/read/37773422/genomic-characterization-of-the-novel-bacteriophage-ime183-infecting-klebsiella-pneumoniae-of-capsular-type-k2
#4
JOURNAL ARTICLE
Jiayi Xu, Fengjuan Tian, Qiang Feng, Fei Li, Yigang Tong
Klebsiella pneumoniae causes a wide range of serious and life-threatening infections. Klebsiella phage IME183, isolated from hospital sewage, exhibited lytic activity against K. pneumoniae of capsular type K2. Transmission electron microscopy revealed that phage IME183 has a head with a diameter of 50 nm and a short tail. Its genome is 41,384 bp in length with a GC content of 52.92%. It is predicted to contain 50 open reading frames (ORFs). The results of evolutionary analysis suggest that phage IME183 should be considered a member of a new species in the genus Przondovirus...
September 29, 2023: Archives of Virology
https://read.qxmd.com/read/37773227/research-progress-on-pathogenic-and-therapeutic-mechanisms-of-enterovirus-a71
#5
REVIEW
Jianmei Lai, Zhishan Li, Lixin Pan, Yunxia Huang, Zifei Zhou, Chunhong Ma, Jiachun Guo, Lingqing Xu
In recent years, enterovirus A71 (EV-A71) infection has become a major global public health problem, especially for infants and young children. The results of epidemiological research show that EV-A71 infection can cause acute hand, foot, and mouth disease (HFMD) and complications of the nervous system in severe cases, including aseptic pediatric meningoencephalitis, acute flaccid paralysis, and even death. Many studies have demonstrated that EV-A71 infection may trigger a variety of intercellular and intracellular signaling pathways, which are interconnected to form a network that leads to the innate immune response, immune escape, inflammation, and apoptosis in the host...
September 29, 2023: Archives of Virology
https://read.qxmd.com/read/37770803/evolutionary-characterization-and-pathogenicity-of-getah-virus-from-pigs-in-guangdong-province-of-china
#6
JOURNAL ARTICLE
Jinghua Pan, Haoquan Zhang, Xiuqiao Chen, Mengyi Zeng, Hui Han, Yajing Guo, Jiaming Li, Shicheng Luo, Guangzhi Yan, Shengnan Chen, Meilian Mo, Mingjie Liu, Liangzong Huang
Getah virus (GETV) is an emerging zoonotic virus that can infect humans and many mammals through mosquitoes. In this study, a novel pathogenic GETV strain, GDQY2022, was isolated from a pig farm in Guangdong Province, China. Sequence comparisons and phylogenetic analysis showed that GDQY2022 belongs to group III (GIII) and was most closely related to strain HeN202009-2, with 99.78% nucleotide sequence identity. Histopathological examination revealed significant pathological changes, such as widened alveolar septum in the lungs with mild congestion and hemorrhage...
September 28, 2023: Archives of Virology
https://read.qxmd.com/read/37770801/characterization-of-the-complete-genome-of-oat-sterile-dwarf-virus-a-fijivirus-occurring-in-the-temperate-climate-zone-of-europe
#7
JOURNAL ARTICLE
Tatjana Oja, Pille Sooväli, Merike Sõmera
Oat sterile dwarf virus (OSDV) is a fijivirus whose genome segments 7 to 10 were sequenced earlier. In the current study, the complete genome was sequenced. To confirm the genome ends, rapid amplification and sequencing of cDNA ends were performed. The complete OSDV genome consists of 10 double-stranded RNA (dsRNA) segments with a total size of 28,686 bp. The sense strand sequence of all segments has the terminal consensus sequence motif 5'-AACGA(5-7)… U(6-8)(A/U)GUC-3', in which the length of the stretches of A and U varies, being slightly shorter for segments 1-4 and longer for segments 5-10...
September 28, 2023: Archives of Virology
https://read.qxmd.com/read/37755543/prevalence-and-genomic-analysis-of-t203-like-g9-g9-vi-rotaviruses-circulating-in-children-with-gastroenteritis-in-beijing-china
#8
JOURNAL ARTICLE
Hui-Jin Dong, Li-Ying Liu, Li-Ping Jia, Lin-Qing Zhao, Feng-Hua Jin, Lin Zhou, Yuan Qian
Our previous surveillance revealed that t203-like G9 (tentatively designated subtype G9-VI) rotaviruses re-emerged in 2010 in Beijing and rapidly prevailed over the G9-III subtype (the most common G9 subtype globally) and previously predominant G genotypes over the following two years. G9-VI belongs to the VP7 evolutionary lineage VI, which includes unusual and sporadic human rotaviruses from China (t203) and Japan. To obtain insight into the epidemiology, evolution, and transmission advantages of G9-VI rotavirus, we performed follow-up surveillance (2014-2017) and whole-genome analysis of 12 representative G9 strains...
September 27, 2023: Archives of Virology
https://read.qxmd.com/read/37737963/the-3-end-of-the-coding-region-of-senecavirus-a-contains-a-highly-conserved-sequence-that-potentially-forms-a-stem-loop-structure-required-for-virus-rescue
#9
JOURNAL ARTICLE
Xiaoli Wang, Hailan Meng, Xiaoxiao Duan, Yuxuan Sang, Youming Zhang, Yan Li, Fuxiao Liu
Senecavirus A (SVA) can cause a vesicular disease in swine. It is a positive-strand RNA virus belonging to the genus Senecavirus in the family Picornaviridae. Positive-strand RNA viruses possess positive-sense, single-stranded genomes whose untranslated regions (UTRs) have been reported to contain cis-acting RNA elements. In the present study, a total of 100 SVA isolates were comparatively analyzed at the genome level. A highly conserved fragment (HCF) was found to be located in the 3D sequence and to be close to the 3' UTR...
September 22, 2023: Archives of Virology
https://read.qxmd.com/read/37730885/correction-to-developments-in-the-classification-and-nomenclature-of-arthropod-infecting-large-dna-viruses-that-contain-pif-genes
#10
Monique M van Oers, Elisabeth A Herniou, Johannes A Jehle, Peter J Krell, Adly M M Abd-Alla, Bergmann M Ribeiro, David A Theilmann, Zhihong Hu, Robert L Harrison
No abstract text is available yet for this article.
September 20, 2023: Archives of Virology
https://read.qxmd.com/read/37728769/asymptomatic-arbovirus-and-campylobacter-infections-in-german-travelers-to-asia
#11
JOURNAL ARTICLE
Werner Dammermann, Isabel-Elena Haller, Katrin Singethan, Christof D Vinnemeier, Florian Hentschel
The true risk for many travel diseases is unknown because most studies do not detect asymptomatic infections. In this study, we performed ELISA for dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), hepatitis E virus (HEV), and Campylobacter jejuni on samples from 81 healthy Germans before and after they traveled to Asia. ELISA found five seroconversions for C. jejuni, two for DENV, one for ZIKV, and zero for HEV. For CHIKV, three subjects were positive before travel and negative afterwards...
September 20, 2023: Archives of Virology
https://read.qxmd.com/read/37715108/identification-of-a-novel-polyomavirus-in-wild-sonoran-desert-rodents-of-the-family-heteromyidae
#12
JOURNAL ARTICLE
Karla L Vargas, Simona Kraberger, Joy M Custer, Elise N Paietta, Melanie Culver, Adrian Munguia-Vega, Greer A Dolby, Arvind Varsani
Rodents are the largest and most diverse group of mammals. Covering a wide range of structural and functional adaptations, rodents successfully occupy virtually every terrestrial habitat, and they are often found in close association with humans, domestic animals, and wildlife. Although a significant amount of research has focused on rodents' prominence as known reservoirs of zoonotic viruses, there has been less emphasis on the viral ecology of rodents in general. Here, we utilized a viral metagenomics approach to investigate polyomaviruses in wild rodents from the Baja California peninsula, Mexico, using fecal samples...
September 15, 2023: Archives of Virology
https://read.qxmd.com/read/37710056/molnupiravir-an-antiviral-drug-against-covid-19
#13
REVIEW
Bhavarth Dave, Kashvi C Shah, Mehul R Chorawala, Nirav Shah, Pranjal Patel, Suzan Patel, Palak Shah
SARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths worldwide and poses significant challenges. Researchers have recently studied a new antiviral drug called molnupiravir for treating COVID-19. This review examines the causes and immunopathogenesis of COVID-19, as well as the role of molnupiravir in its treatment. Molnupiravir is a prodrug of β-D-N4-hydroxyctytidine (NHC) and has demonstrated activity against various viruses, including MERS-CoV, SARS-CoV, SARS-CoV-2, and influenza virus...
September 15, 2023: Archives of Virology
https://read.qxmd.com/read/37702836/genetic-diversity-of-rotavirus-a-in-argentina-during-2019-2022-detection-of-g6-strains-and-insights-regarding-its-dissemination
#14
JOURNAL ARTICLE
Juan Ignacio Degiuseppe, Antonella Martelli, Christian Barrios Mathieur, Juan Andrés Stupka
One of the challenges associated with introducing a vaccine is monitoring its impact through clinical and molecular surveillance. The aims of this study were to analyze the genetic diversity of rotavirus A in Argentina between 2019 and 2022 and to assess the phylogenetic and phylodynamic features of the unusual G6 strains detected. A significant decline in the Wa-like genogroup strains was observed, and G6 strains were detected for the first time in Argentina, in association with P[8] and P[9]. Spatiotemporal analysis showed that the G6-lineage I strains detected recently in Argentina and Brazil might have emerged from European strains...
September 13, 2023: Archives of Virology
https://read.qxmd.com/read/37691052/characterization-of-a-novel-hypovirus-isolated-from-the-phytopathogenic-fungus-colletotrichum-camelliae
#15
JOURNAL ARTICLE
Pushuang Wang, Du Hai, Qili Li, Xiaowen Xu, Jiatao Xie, Lihua Tang
Some members of genus Colletotrichum are important plant pathogens. Here, we report a novel positive single-stranded RNA virus, Colletotrichum camelliae hypovirus 1 (CcHV1), from strain GXNN11-2 of Colletotrichum camelliae. The complete genome of CcHV1 is 9907 nucleotides (nt) in length and contains a single large open reading frame (ORF) from nt 352 to 9006. This ORF encodes a polyprotein with four conserved domains, namely UDP-glycosyltransferase, RNA-dependent RNA polymerase (RdRp), peptidase, and DEAD-like helicase...
September 10, 2023: Archives of Virology
https://read.qxmd.com/read/37684418/genotyping-tool-for-salmonid-gill-pox-virus-sgpv-obtained-from-farmed-and-wild-atlantic-salmon-salmo-salar
#16
JOURNAL ARTICLE
Are Nylund, Thomas Kloster-Jensen, Faezeh Mohammadi, Erwan Lagadec, Heidrun Plarre
Poxviruses are common viruses found in vertebrate species. In 2006, the first poxvirus associated with salmon, salmonid gill poxvirus (SGPV), was identified during an outbreak of gill disease at a smolt production site in northern Norway and at two marine farms in western Norway. Poxviruses had previously been detected in ayu (Plecoglossus altivelis) and koi carp (Cyprinus carpio). In all three fish species, poxviruses are associated with gill disease. It has not been possible to culture SGPV from Norway, and little is known about its virulence...
September 8, 2023: Archives of Virology
https://read.qxmd.com/read/37682357/complete-genome-sequence-of-a-novel-fusarivirus-from-the-phytopathogenic-fungus-fusarium-sp
#17
JOURNAL ARTICLE
Fuhong Gao, Rex Frimpong Anane, Zhengling Liu, Shaomei Zi, Shangyun Li, Zefen Yang, Bifan Chu, Xingquan Chen, Zeli Chen, Mingfu Zhao
Fusarium diseases include wilts, blights, rots, and cankers of many horticultural, field, ornamental, and forest crops in both agricultural and natural ecosystems, and they significantly hinder food plant production. Here, we describe a novel mycovirus, tentatively designated as "Fusarium fusarivirus 1" (FuFV1), which was discovered in an isolate of the phytopathogenic fungus Fusarium sp. FuFV1 has a positive-sense single-stranded RNA (+ssRNA) genome of 6,391 nucleotides (nt) containing three open reading frames (ORFs)...
September 8, 2023: Archives of Virology
https://read.qxmd.com/read/37676512/complete-genome-sequence-analysis-of-valeriana-jatamansi-tymovirus-1-a-novel-member-of-the-genus-tymovirus-infecting-valeriana-jatamansi-jones
#18
JOURNAL ARTICLE
Bifan Chu, Rex Frimpong Anane, Shangyun Li, Like Gao, Shaomei Zi, Kai Yan, Kaifei Ji, Zeli Chen, Mingfu Zhao
A new positive-sense, single-stranded RNA virus, tentatively named "Valeriana jatamansi tymovirus 1" (VaJV1, OQ730267), was isolated from Valeriana jatamansi Jones displaying symptoms of vein-clearing in Yunnan Province, China. The complete genome of VaJV1 consists of 6,215 nucleotides and contains three open reading frames (ORFs). The genome structure of VaJV1 is typical of members of the genus Tymovirus. BLASTn analysis and multiple sequence alignments showed that the complete genome and coat protein of VaJV1 shared the most sequence similarity (65...
September 7, 2023: Archives of Virology
https://read.qxmd.com/read/37676508/first-detection-and-complete-genome-sequence-of-a-new-potexvirus-naturally-infecting-adenium-obesum
#19
JOURNAL ARTICLE
Marie-Emilie A Gauthier, Shamila W Abeynayake, Ruvini V Lelwala, Cassie A McMaster, Robin Eichner, Jennifer Morrison, Candace E Elliott, Sonia Fiorito, Adrian Dinsdale, Julie Pattemore, Roberto A Barrero
Here, we report the detection and complete genome sequence of a novel potexvirus, tentatively named "Adenium obesum virus X" (AobVX), isolated from Adenium obesum, that was sent for virus screening at Australian Government post-entry quarantine (PEQ) facilities after being imported into Australia from China. The AobVX genome is 6781 nucleotides in length excluding the poly(A) tail and is predicted to encode conserved potexvirus proteins and sequence motifs across five open reading frames. The RNA-dependent RNA polymerase of this virus shares the highest amino acid sequence similarity with that of nerine potexvirus 1 (58...
September 7, 2023: Archives of Virology
https://read.qxmd.com/read/37676345/coinfection-of-porcine-astrovirus-and-other-porcine-viruses-in-diarrheic-pigs-in-haryana-india
#20
JOURNAL ARTICLE
Vaishali, Renu Gupta, Mohit Kumar, Nitish Bansal, Vivek, Parveen Kumar, Pawan Kumar, Naresh Jindal
In this study, 306 rectal swabs from diarrheal pigs of various ages (0-3 weeks, 3-6 weeks, and >6 weeks) were collected from 54 piggery units in different climatic zones in Haryana state, India. These samples were tested for the presence of porcine astrovirus (PAstV), porcine rotavirus group A (PRV-A), and classical swine fever virus (CSFV) by reverse transcription polymerase chain reaction (RT-PCR), and porcine circovirus 2 (PCV-2) by polymerase chain reaction (PCR). Out of the 306 samples tested, 153 (50%), 108 (35...
September 7, 2023: Archives of Virology
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