Ole J Kemi, Morten A Hoydal, Per M Haram, Godfrey L Smith, Oyvind Ellingsen, Lauren G Koch, Steven L Britton, Ulrik Wisloff
Cardiorespiratory performance segregates into rat strains of inherited low- and high-capacity runners (LCRs and HCRs); during adulthood, this segregation remains stable, but widens in senescence and is followed by segregated function, health, and mortality. However, this segregation has not been investigated prior to adulthood. We, therefore, assessed cardiorespiratory performance and cardiac cell (cardiomyocyte) structure-function in 1- and 4-month-old LCRs and HCRs. Maximal oxygen uptake was 23% less in LCRs at 1-month compared to HCRs at 1-month, and 72% less at 4 months...
March 23, 2024: Annals of the New York Academy of Sciences