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Fumihiro Nishimaki, Shin-Ichi Yamada, Makiko Kawamoto, Akinari Sakurai, Kiyonori Hayashi, Hiroshi Kurita
BACKGROUND: The impact of host systemic conditions/diseases on the prosperity of oral Candida colonies remains unclear. The aim of the present study was to investigate whether a relationship exists between the quantity of oral Candida and the systemic condition/diseases of the host. PATIENTS AND METHODS: The cross-sectional relationship between Candida mannan concentrations and health check-up results was analyzed in consideration of local conditions that influence the prevalence of oral Candida...
March 1, 2019: Mycopathologia
Hong Luo, Kai-Su Pan, Xiao-Lu Luo, Dong-Yan Zheng, Alex Andrianopoulos, Le-Min Wen, Yan-Qing Zheng, Jing Guo, Chun-Yang Huang, Xiu-Ying Li, Rong Hu, Yu-Jiao Li, Tian-Min Li, Justin Joseph, Cun-Wei Cao, Gang Liang
Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52...
February 25, 2019: Mycopathologia
Vasin Vasikasin, Worapong Nasomsong, Chutika Srisuttiyakorn, Wat Mitthamsiri, Nittha Oer-Areemitr, Dhitiwat Changpradub
Disseminated phaeohyphomycosis is an extremely rare clinical syndrome, especially in a host without apparent immunological defect. Here, we report a case of disseminated phaeohyphomycosis in a 22-year-old previously healthy man who showed nonmassive hemoptysis from diffuse lung nodules and cavities, together with a hard palate ulcer and generalized subcutaneous nodules. Histopathology, cultures and subsequent molecular assay from two different sites confirmed Curvularia tuberculata infection. The patient was successfully treated with amphotericin B and itraconazole...
February 11, 2019: Mycopathologia
Ziauddin Khan, Suhail Ahmad, Wadha Alfouzan, Leena Joseph, Soumya Varghese
Fusarium petroliphilum is a recently described species within the Fusarium solani species complex. Some strains of Fusarium species are capable of forming yeast-like structures in tissue as well as in culture through a process known as "adventitious sporulation." Here, we describe the formation of these yeast-like reproductive structures in infected nail tissue obtained from a case of onychomycosis. These structures were also observed in culture grown on RPMI 1640 agar supplemented with 2% glucose...
February 8, 2019: Mycopathologia
Kei Araki, Yusuke Yoshida, Hiroki Kohno, Eiji Sugiyama
An 82-year-old woman presented to our hospital with a deep skin ulcer in her right lower limb. Although the skin biopsy showed necrosis and neutrophil infiltration, we could not initially detect any pathogen. Chest radiography showed multiple nodules despite the lack of respiratory symptoms or fever, and the serum latex agglutination test for cryptococcus showed an elevated titer (1:512). Considering these findings, we performed additional stains of periodic acid-Schiff reaction and Grocott to the skin-biopsy specimen and detected multiple yeast-like fungi...
February 1, 2019: Mycopathologia
Cicero Pinheiro Inácio, Paulo Sérgio Ramos de Araújo, Fabio André Brayner, Luiz Carlos Alves, Dyana Leal Veras, Rejane Pereira Neves
Systemic infections due to Candida tropicalis are conditions which can frequently lead to death. The aim of this report is to describe the features of C. tropicalis biofilm in a patient with catheter-associated fungemia.
February 1, 2019: Mycopathologia
Jessica L Chitty, David J Edwards, Avril A B Robertson, Mark S Butler, John A Duley, Matthew A Cooper, James A Fraser
The fertilizing properties of bird manure, or guano, have played an important role in plant cultivation for thousands of years. Research into its chemical composition by Unger in 1846 identified a novel compound, now known as guanine, a purine base that is essential for DNA and RNA biosynthesis and cell signalling. Nitrogen-rich guano can also harbour human pathogens, one significant example being the fungal pathogen Cryptococcus neoformans. Historically associated with pigeon droppings, C. neoformans is able to infect immunocompromised individuals with the aid of a number of adaptive virulence traits...
February 1, 2019: Mycopathologia
Rui Kano, Mai Sakai, Masato Hiyama, Kenji Tani
Aspergillus caninus (synonym: Phialosimplex caninus) is an anamorphic fungus species associated with systemic infections in dogs that has been transferred from the genus Phialosimplex to Aspergillus. Here, we report the first case of canine A. caninus infection in Japan. A castrated Japanese Shiba Inu (6 years old; weight, 12.5 kg) was referred to the Yamaguchi University Animal Medical Center, Yamaguchi, Japan, in June 2017 showing vitality loss and depression. Computed tomography revealed iliac and splenic hilum lymphopathies, and histologic examination of an iliac lymph node by biopsy revealed granulomatous lesions with numerous oval to round yeast-like fungal cells...
January 31, 2019: Mycopathologia
Ruifeng Zhang, Yuping Ran, Hao Zhang, Yaling Dai, Xin Ran, Chaoliang Zhang, Wei Qin, Liyan Xi
No abstract text is available yet for this article.
January 30, 2019: Mycopathologia
Dorothy Wong, James Plumb, Hosamiddine Talab, Mouhamad Kurdi, Keshav Pokhrel, Peter Oelkers
Perturbing ergosterol synthesis has been previously shown to reduce the virulence of Candida albicans. We tested the hypothesis that further altering cell membrane composition by limiting phospholipid synthesis or remodeling will have the same effect. To model partial inhibition, C. albicans strains independently harboring heterozygous deletion of four genes that encode for enzymes that mediate phospholipid synthesis or modification were generated. Quantitative PCR determined that heterozygous deletion routinely caused a nearly 50% reduction in the respective gene's transcript abundance...
January 28, 2019: Mycopathologia
Zhaoyang Liu, Jing Tang, Yi Sun, Lujuan Gao
Mucormycosis is an aggressive and high-mortality opportunistic fungal infection, especially in immunocompromised patients. Conventional antifungals or surgery showed a limited effect on this disease. The antimicrobial photodynamic therapy (aPDT) has been proven to be a promising therapeutic choice against multiple pathogenic fungi. We evaluated the effect of aPDT by using methylene blue (MB) combined with a light emitting diode (LED) on the viability of Rhizopus oryzae, as well as the antifungal susceptibility after aPDT treatment in vitro...
January 28, 2019: Mycopathologia
Kamal Kant Sahu, Uday Yanamandra, Nandita Kakkar, Pankaj Malhotra
No abstract text is available yet for this article.
January 25, 2019: Mycopathologia
Mei-Hua Fu, Jia Liu, Guan-Zhao Liang, Cheng-Rang Li, Xiao-Mei Zhu, Le Wang, Hao Chen, Wen-Long Hu, Gui-Xia Lv, Wei-da Liu
We report a case of eczema-like cutaneous mucormycosis caused by Rhizopus arrhizus. A 4-year-old child was presented to our hospital with a history of gradually enlarging papule and plaque in the periumbilical area for nearly 4 years since 2 weeks after his birth, and it has been misdiagnosed as eczema for nearly 3 years. Based on histopathology examination, the fungus culture test and DNA sequencing, it was revealed that R. arrhizus should be the responsible fungus for skin infection. The patient was successfully cured by combination of intravenous drip and percutaneous injection amphotericin B for nearly 3 months, and no recrudescence was seen during a follow-up of 6-month observation...
January 22, 2019: Mycopathologia
Maria Rosa Felix de Souza Gomide Guimarães, Luciano Tavares Angelo Cintra, Rui Rafael Durlacher, Francine Benetti, Gustav Guimarães
No abstract text is available yet for this article.
January 17, 2019: Mycopathologia
Tatiana Borba Spader, Mauricio Ramírez-Castrillón, Patricia Valente, Sydney Hartz Alves, Luiz Carlos Severo
Rhodotorula species are emerging as opportunistic pathogens, causing catheter-associated fungemia in patients with compromised immunity. R. mucilaginosa is considered the most common species involved in human infections. Correct identification and susceptibility testing of Rhodotorula isolates recovered from the blood stream or central nervous system are essential to determine the best management of this unusual infection. The antifungal susceptibility tests showed that Rhodotorula was susceptible to low concentrations of amphotericin B (AMB) but was less susceptible to voriconazole...
January 10, 2019: Mycopathologia
Fernanda Harumi Maruyama, Daphine Ariadne Jesus de Paula, Isabela de Godoy Menezes, Olívia Cometti Favalessa, Rosane Christine Hahn, Arleana do Bom Parto Ferreira de Almeida, Valéria Régia Franco Sousa, Luciano Nakazato, Valéria Dutra
Cryptococcosis is caused by fungi of the genus Cryptococcus. Owing to its importance, this study aimed to analyze the genetic diversity of C. gattii isolates from animals, humans, and the environment in Mato Grosso State (MT), Brazil, during November 2010-December 2017. All isolates of the C. gattii species complex were subjected to molecular genotyping via Restriction Fragment Length Polymorphism (PCR-RFLP) and Multi-locus Sequence Typing (MLST). PCR-RFLP analysis revealed that 21 isolates presented the genotype VGII, which is considered the most common and virulent genotype globally among...
January 9, 2019: Mycopathologia
Ying Gao, Guanzhao Liang, Qiong Wang, Xiaodong She, Dongmei Shi, Yongnian Shen, Xiaohong Su, Xiang Wang, Wenmei Wang, Dongmei Li, Weida Liu
OBJECTIVE: The immunological mechanisms behind different mucosa against candidiasis are largely unknown. In this study, we investigate the natural protective mechanisms and local cytokine responses of C. albicans-infected oral and vaginal epithelial cells. METHOD: The cell lines (Leuk-1 and VK2/E6E7) were cultured with C. albicans (SC5314, Δals3, and Δssa1) in indicated ratio, respectively. The morphological changes and colony growth of C. albicans were observed to evaluate the fungicidal ability of epithelial cells, and the cellular morphological changes and LDH activity measurements were used to assess cell damage...
January 1, 2019: Mycopathologia
Jean-Philippe Bouchara, Vishnu Chaturvedi
Case reports describe the unusual occurrence and complications of diseases, diagnostic challenges, and notable therapeutic successes. Some journals have discontinued the case reports, while new case report journals have appeared in recent years. During the eightieth anniversary of Mycopathologia, it is fitting to examine the relevance of the case report since the journal continues to traverse the boundaries of basic and clinical sciences. A random sample of recent case reports and other articles were selected from Mycopathologia...
December 20, 2018: Mycopathologia
S V Flórez-Muñoz, J F Alzate, A C Mesa-Arango
BACKGROUND: Sporotrichosis is a subcutaneous mycosis that affects humans and other animals. Infection prevails in tropical and subtropical countries. Until a few years ago, it was considered that two varieties of Sporothrix schenckii caused this mycosis, but by applying molecular taxonomic markers, it has been demonstrated that there are several cryptic species within S. schenckii complex which varies in susceptibility, virulence, and geographic distribution. OBJECTIVE: This study aimed to identify the clinical isolates of Sporothrix spp...
December 15, 2018: Mycopathologia
Zimeng You, Xiaoxiao Yang, Jianbin Yu, Jiangan Zhang, Yuping Ran
Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. First case of chromoblastomycosis due to Fonsecaea nubica in Northern China is reported in a 75-year-old Chinese male. We firstly summarized molecular identification methods of Fonsecaea spp. and all the strains of F. nubica reported in the literature. Sequencing of internal transcribed spacer alone and/or combined with actin (ACT1), partial cell division cycle (CDC42) and partial beta-tubulin (BT2) were most commonly used to identify species, while lactase (Lac), homogentisate (HmgA) and polyketide synthase (PKS1) were also used in some cases...
December 13, 2018: Mycopathologia
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