journal
https://read.qxmd.com/read/32758904/n-acetycysteine-a-potential-therapeutic-agent-in-covid-19-infection
#21
LETTER
N Jaiswal, M Bhatnagar, H Shah
COVID-19 is an overwhelming pandemic which has shattered the whole world. Lung injury being the main clinical manifestation, it is likely to cause COPD (chronic obstructive pulmonary disease) and ARDS (acute respiratory distress syndrome). The possible cause behind this might be redox imbalance due to viral infection. Elevation in Glutathione (GSH) levels by administration of its promolecule might be effective. N-acetylcysteine is one such drug with potency to scavenge Reactive Oxygen Species, least side effects, and an effective precursor of glutathione...
July 24, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759011/the-distribution-of-chondromas-why-the-hand
#22
Nigora Z Nazarova, Gulrukh Sh Umarova, Michael Vaiman, Michael Abba, Maya Foonberg, Kadri Mametov, Michael Shterenshis
Chondroma is a benign hyaline cartilage tumor and is a relatively common skeletal neoplasm. Uneven distribution of this tumor among the various bones and regions of the skeleton is known but no explanation of this phenomenon followed. The current research aimed to document the exact chondroma distribution in the body. We hypothesized that the cases of all subtypes of chondroma have to be investigated in complex and that obtaining combined data from a large cohort of cases may explain the logic of chondroma distribution and may answer the question of why the hand is the main target of the tumor...
July 23, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759010/re-jacques-beco-and-jack-mouchel-perineural-dextrose-injections-in-the-treatment-of-lower-urinary-tract-symptoms-and-dyspareunia-induced-by-obturator-neuralgia-is-it-the-pudendal-nerve-effect
#23
LETTER
Fouad Aoun, Georges Mjaess, Fabienne Absil, Renaud Bollens
No abstract text is available yet for this article.
July 23, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759009/building-block-osteotomy-a-new-back-muscle-preserving-laminoplasty-for-lumbar-spinal-stenosis
#24
Chuanchao Du, Kaixi Liu, Fei Jia, Yu Liu, Tianli Mao, Bao Hai, Xiaoyu Pan, Xiaoguang Liu
In order to preserve paravertebral muscles and posterior ligaments complex (PLC), this paper proposes a new lumbar laminoplasty surgery for lumbar spinal stenosis (LSS). According to the anatomy of back muscles insertions, building block osteotomy (BBO) which aimed to achieve precise osteotomy and reconstruction based on modular design theory was firstly put forward, and supposed to be achieved by an ultrasound bone scalpel (UBS). In details, lumbar spinous processes are longitudinally split, then supraspinous and interspinous ligaments are sharply cut off longitudinally...
July 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759006/low-incidence-and-mortality-from-sars-cov-2-in-southern-europe-proposal-of-a-hypothesis-for-arthropod-borne-herd-immunity
#25
Martin Balzan
SARS-CoV-2 incidence and mortality in Europe have shown wide variation. Northern Italy in particular the Lombardy region, north-eastern French regions, Switzerland and Belgium were amongst the hardest hit, while the central and southern Italian regions, all the Balkan countries from Slovenia to Greece and the Islands of Malta and Cyprus had much fewer cases and deaths per capita, and deaths per number of cases. Differences in public health measures, and health care delivery, in the author's opinion, can only partly explain the difference...
July 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/32758902/treating-ent-symptoms-and-diseases-induced-by-extraesophageal-acidity-using-plant-extracted-melanin
#26
LETTER
Adila Salih ElObeid, Adil Haseeb
No abstract text is available yet for this article.
July 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721814/the-war-against-the-sars-cov2-infection-is-it-better-to-fight-or-mitigate-it
#27
LETTER
Fabrizio Dal Moro, Igor Vendramin, Ugolino Livi
In trying to understand the biochemical mechanism involved in the recent pandemic COVID-19, there is currently growing interest in angiotensin-converting enzyme II (ACE2). Nevertheless, the attempts to counteract COVID-19 interference with this enzymatic cascade are frustrating, and the results have thus far been inconclusive. Let's start again by considering the involved factors in an alternative way: we could postulate that COVID-19 could be more aggressive/fatal due to a high level of "basal" inflammation with low Nitric Oxide (NO) levels in hypertensive, diabetic and obese patients...
July 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721807/certainty-in-ascending-sensory-signals-the-unexplored-driver-of-analgesic-placebo-response
#28
P Kuperman, D Talmi, Np Katz, R Treister
Previous frameworks have failed to adequately explain the observed correlation between within-subject variability in pain reporting and analgesic placebo response. These relationships have been observed in both clinical and experimental setups. Within-subject variability of clinical pain scores is traditionally assessed based on daily pain diaries collected during the pre-intervention stage. Experimental variability can be assessed by the Focused Analgesia Selection Test (FAST), which calculates the relationship between noxious stimuli administrated at various intensities and pain reports...
July 22, 2020: Medical Hypotheses
https://read.qxmd.com/read/32763657/possible-mechanisms-responsible-for-acute-coronary-events-in-covid-19
#29
Aakash R Sheth, Udhayvir S Grewal, Harsh P Patel, Samarthkumar Thakkar, Subhash Garikipati, Jashwanth Gaddam, Danish Bawa
The novel coronavirus (SARS-CoV-2) is primarily a respiratory pathogen and its clinical manifestations are dominated by respiratory symptoms, the most severe of which is acute respiratory distress syndrome (ARDS). However, COVID-19 is increasingly recognized to cause an overwhelming inflammatory response and cytokine storm leading to end organ damage. End organ damage to heart is one of the most severe complications of COVID-19 that increases the risk of death. We proposed a two-fold mechanism responsible for causing acute coronary events in patients with COVID-19 infection: Cytokine storm leading to rapid onset formation of new coronary plaques along with destabilization of pre-existing plaques and direct myocardial injury secondary to acute systemic viral infection...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32763656/the-potential-role-of-micro-rna-211-in-the-pathogenesis-of-sleep-related-hypermotor-epilepsy
#30
Sandra Graf Zupcic, Miroslav Zupcic, Viktor Duzel, Tatjana Simurina, Livija Sakic, Igor Grubjesic, Dinko Tonković, Ingrid Sutic Udovic, Vjera Matkovic Ferreri
Sleep-related hypermotor epilepsy (SHE) is a rare epileptic syndrome characterized by epileptic seizures which occur during the non-rapid eye movement (NREM) stage of sleep. It manifests with hypermotor semiology resembling violent limb movements and an asymmetric tonic-dystonic posture. The genes which are responsible for the autosomal dominant form of SHE (ADSHE) and whose function is to code the sub-unit of the neuronal acetylcholine receptor are well known. Considering that ADSHE is a prototype of SHE, it is thought that the dysfunction of the cortico-subcortical cholinergic network, which regulates the cycle of sleep, has a key role in the epileptogenesis of this syndrome...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759008/fenofibrate-increases-the-amount-of-sulfatide-which-seems-beneficial-against-covid-19
#31
LETTER
Karsten Buschard
Fenofibrate, which is a PPAR-alfpha agonist, increases the level of sulfatide. In this letter we hypothesize on the background of various findings that this is beneficial against COVID-19. Fenofibrate has been used for decades against hypercholesterolemia and has no serious side effects. Therefore, a trial giving fenofibrate to patients with corona virus infection is recommended.
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32759007/prostaglandin-d-2-as-a-mediator-of-lymphopenia-and-a-therapeutic-target-in-covid-19-disease
#32
LETTER
Ajay Gupta, Kate Chander Chiang
A characteristic feature of COVID-19 disease is lymphopenia. Lymphopenia occurs early in the clinical course and is a predictor of disease severity and outcomes. The mechanism of lymphopenia in COVID-19 is uncertain. It has been variously attributed to the release of inflammatory cytokines including IL-6 and TNF-α; direct infection of the lymphocytes by the virus; and rapid sequestration of lymphocytes in the tissues. Additionally, we postulate that prostaglandin D2 (PGD2 ) is a key meditator of lymphopenia in COVID-19...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32758903/mevalonate-pathway-selenoproteins-redox-balance-immune-system-covid-19-reasoning-about-connections
#33
Giampaolo Minetti
It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been subjected to in the months/years preceding the infection could be immunocompromising. Statins are among the most widely prescribed cholesterol-lowering drugs. As competitive inhibitors of HMG-CoA-reductase, the key enzyme of the "mevalonate pathway" through which essential compounds, not only cholesterol, are synthesized, statins decrease the levels of cholesterol, and thus LDLs, as an innate defense mechanism, with controversial results in decreasing mortality from cardiovascular disease...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32758901/acute-respiratory-distress-syndrome-from-covid-19-a-perfect-storm-from-free-radicals-proposal-for-a-new-treatment
#34
LETTER
Giulio Scigliano, Giuseppe Augusto Scigliano
No abstract text is available yet for this article.
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721813/-the-double-edged-sword-an-hypothesis-for-covid-19-induced-salivary-biomarkers
#35
John Adeoye, Peter Thomson
Utilising biomarkers for COVID-19 diagnosis, prediction of treatment response and overall prognostication have been investigated recently. However, these ventures have only considered the use of blood-based molecular markers. Saliva is another biofluid that warrants being applied in similar fashion with major advantages that centres on its non-invasive and repeatable collection as well as cost-efficiency. To this end, this article presents a hypothesis for the sources of biomarkers useful clinically for COVID-19 disease outcome estimation and identify the likely implications of their detection in saliva...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721812/holistic-approach-to-psoriasis-patient-what-about-epicardial-fat-tissue
#36
LETTER
Eleonora Cinelli, Gabriella Fabbrocini, Matteo Megna
No abstract text is available yet for this article.
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721811/the-early-diagnosis-of-fibromyalgia-in-irritable-bowel-syndrome-patients
#37
Muhammed Zubeyr Üçüncü, Bestegül Çoruh Akyol, Dilek Toprak
Irritable bowel syndrome (IBS) is a common disorder worldwide, but the diagnosis is often overlooked. This study aimed to evaluate the sociodemographic characteristics of IBS patients and the relationship between IBS and fibromyalgia. 202 patients with gastrointestinal system complaints who were admitted to Sisli Hamidiye Etfal Trainnig and Research Hospital, Family Medicine Clinic were included in the study. P < 0.05 was considered statistically significant. Fibromyalgia was associated with IBS in 26...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721810/determining-the-probability-of-juvenile-delinquency-by-using-support-vector-machines-and-designing-a-clinical-decision-support-system
#38
Ilknur Ucuz, Ayla Uzun Ciçek, Ali Ari, Ozlem Ozel Ozcan, Seda Aybüke Sari
It is a known fact that individuals who engaged in delinquent behavior in childhood are more probable to carry on similar behavior in adulthood. If the factors that lead children to involve in delinquency are defined, the risk of dragging children into crime can be detected before they are involved in crime and delinquency can be prevented with appropriate preventive rehabilitation programs, in the early period. However, given that delinquent behavior occurs under the influence of multiple conditions and factors rather than a single risk factor; the need for diagnostic tools to evaluate multiple factors together is obvious...
July 21, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721809/kawasaki-like-disease-in-children-with-covid-19-a-hypothesis
#39
LETTER
Hamideh Amirfakhryan
With rapid spread of severe acute respiratory syndrome- corona virus-2 (SARS-COV-2) globally, some new aspects of the disease have been reported. Recently, it has been reported the incidence of Kawasaki-like disease among children with COVID-19. Since, children had been known to be less severely affected by the virus in part due to the higher concentration of Angiotensin converting enzyme (ACE)-2 receptor, this presentation has emerged concerns regarding the infection of children with SARS-COV2. ACE2 has anti-inflammatory, anti-fibrotic and anti-proliferative characteristics through converting angiotensin (Ag)-II to Ang (1-7)...
July 18, 2020: Medical Hypotheses
https://read.qxmd.com/read/32721808/prior-infection-with-intestinal-coronaviruses-moderates-symptom-severity-and-mortality-in-patients-with-covid-19-a-hypothesis-and-preliminary-evidence
#40
Ravi Philip Rajkumar
The pandemic of acute respiratory illness caused by the novel betacoronavirus SARS-CoV-2, officially designated COVID-19, has attained the proportions of a global health crisis. Though all nations of the world have been affected by this disease, there have been marked cross-national variations in prevalence, severity and mortality rates. Various explanations, based on demographic, social and climatic factors, have been suggested to account for this variability, but these remain unverified to date. Based on recent research findings suggesting that human enterocytes may serve as a point of entry for SARS-CoV-2, leading to intestinal viral replication, this paper puts forward the hypothesis that prior intestinal infection with coronaviruses, either symptomatic or asymptomatic, may moderate this process and minimize the severity of SARS-CoV-2 infection...
July 18, 2020: Medical Hypotheses
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