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Medical Hypotheses

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https://read.qxmd.com/read/31262442/phosphodiesterase-5-inhibitors-and-adrenal-incidentalomas
#1
LETTER
Ioannis Ilias, Lina Zabuliene
No abstract text is available yet for this article.
June 24, 2019: Medical Hypotheses
https://read.qxmd.com/read/31088704/corrigendum-to-sarcopenia-as-a-potential-cause-of-chronic-hyponatremia-in-the-elderly-med-hypotheses-127-2019-46-48
#2
Victoria Bertoni, Chiara Nicoletti, Braian M Beker, Carlos G Musso
No abstract text is available yet for this article.
May 11, 2019: Medical Hypotheses
https://read.qxmd.com/read/31203918/crispr-cas-9-system-for-the-treatment-of-dilated-cardiomyopathy-a-hypothesis-related-to-function-of-a-map-kinase
#3
Jéssica Olivaes, Martín Hernán Bonamino, Melissa Medeiros Markoski
Dilated cardiomyopathy (DCM) is a disease with high incidence and mortality rates. Its therapies have one primary goal, which is to minimize symptoms and it has only one effective approach to healing, the heart transplantation. As it is widely associated with genetic causes, the use of gene therapies, such as the CRISPR/Cas9 system, is a promising alternative to treat DCM. For this purpose, it is necessary to analyze possible target genes for this approach and what would be the implications of their use. Here, we hypothesized that cardiac troponin I type 3 interacting kinase (TNI3K), involved with superoxide production in DCM patients, besides other factors, could be a good target for the use of gene editing...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203917/why-is-running-a-marathon-like-giving-birth-the-possible-role-of-oxytocin-in-the-underestimation-of-the-memory-of-pain-induced-by-labor-and-intense-exercise
#4
Dominika Farley, Łukasz Piszczek, Przemysław Bąbel
Pain can be overestimated, underestimated or reported accurately at recall. The way pain is remembered seems to depend on certain factors, including the type of pain or, in other words, its cause, the context, and the meaning it has for the person suffering from it. For instance, episodes of chronic pain, as well as pain related to surgery, are often overestimated at recall. Interestingly, research shows that pain induced by parturition or marathon running is often underestimated at recall despite the fact that both are not only physically grueling but also emotionally intense experiences...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203916/new-idea-for-hair-transplantation-to-preserve-more-donor-hair-follicles
#5
LETTER
Hsi-An Chen, Jiun-Yit Pan, Chi-Hsiang Chiang, An-Hua Jhang, Wen-Tsao Ho
Higher risk of rapid progression in alopecia or male pattern baldness was observed in men who had family history. This could result from accumulation of DHT in hair follicles. Hair follicles on frontal region are more vulnerable to DHT. With development of minimal invasive hair transplantation surgery, hair follicles transplantation could be performed from frontal or occipital region to frontal region. However, limited hair follicles remained a problem. With development of technology of vitrification, we suggested extracting hair follicles from frontal region without affecting the appearance and preserving them with vitrification when the patient was young...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203915/recent-trend-of-increasing-myopia-can-be-traced-to-infancy
#6
Koji Matsuda, Keunsik Park
In recent years, a trend has been noted for increasing numbers of myopia cases found globally, which could potentially be indicative of a bigger problem. However, the cause of this trend remains unknown and in addition, we have yet to be able to establish a reliable method for preventing the onset of myopia. Furthermore, previous myopia studies have not paid adequate attention to hyperopia. That is to say, it has been suggested that the development of refraction in infancy and the onset of myopia are distinct from emmetropization...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203914/beta-blockers-in-non-surgical-patients-with-type-a-aortic-dissection
#7
Shay Brikman, Guy Dori
Type A aortic dissection (TAAD) is a catastrophic condition with 24-48% mortality during the first day, if patients are not surgically treated. Due to old age and associated co-morbidities surgeons may be reluctant to operate and patients are administered medical therapy for the end of reducing systolic blood pressure and heart rate. Beta-blockers (BB) are the "medications of choice". Based on physical and physiological considerations, it was hypothesized that BB may actually exacerbate TAAD.
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203913/vitiligo-and-hashimoto-s-thyroiditis-autoimmune-diseases-linked-by-clinical-presentation-biochemical-commonality-and-autoimmune-oxidative-stress-mediated-toxicity-pathogenesis
#8
Dongmei Li, Guanzhao Liang, Richard Calderone, Joseph A Bellanti
Vitiligo (VL) is a chronic autoimmune pigmentation disorder characterized by destruction of melanocytes. The condition is associated with several other autoimmune diseases, but autoimmune thyroid diseases, especially Hashimoto's thyroiditis (HT), is the most prevalent organ-specific autoimmune disease with a co-morbidity up to 34%. Among the many hypotheses that have been proposed for the pathogenesis of both diseases, autoimmunity and oxidative stress-mediated toxicity in melanocytes or thyrocytes, respectively, have been the most widely accepted - with autoimmunity being the presumed consequence of oxidative stress-mediated toxicity...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203912/a-new-approach-for-digestive-disease-diagnosis-dynamics-of-gastrointestinal-electrical-activity
#9
Roham Mazloom
Various methods are used for analyzing the status of the human body. In digestive system, myoelectrical activity is recorded from the abdominal surface. Frequency and power of Gastrointestinal (GI) activity is usually assessed using power spectral analysis. However, spectral analysis of GI electrical activity is a nonspecific test, failing to distinguish diseases. Other dimensions of GI electrical waves may help identify diseases more precisely. Studying complex systems is one of the approaches that can be taken for research on body systems...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203911/a-hypothetic-role-of-minocycline-as-a-neuroprotective-agent-against-methylphenidate-induced-neuronal-mitochondrial-dysfunction-and-tau-protein-hyper-phosphorylation-possible-role-of-pi3-akt-gsk3%C3%AE-signaling-pathway
#10
Pegah Salehi, Zhara Yaraei Shahmirzadi, Fatemeh Sadat Mirrezaei, Farima Shirvani Boushehri, Fatemeh Mayahi, Mojtaba Songhori, Maryam Abofazeli, Majid Motaghinejad, Sepideh Safari
The underlining mechanism in neural mitochondrial dysfunction and consequences neurotoxicity, and cognitive behavior after methylphenidate (MPH) prolonged uses is unclear and proposing of therapeutic approaches for treatment of these types of neurotoxicity is one of the main goals of scientist in this manner. MPH-induced mitochondrial dysfunction in neural cells caused induction of oxidative stress, apoptosis, inflammation and cognition impairment, which leads to neurotoxicity, was reported previously but role of key neural cells proteins and involved signaling pathway in this manner remained indeterminate...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203910/fluorine-may-intensify-the-mechanisms-of-polycystic-ovary-syndrome-pcos-development-via-increased-insulin-resistance-and-disturbed-thyroid-stimulating-hormone-tsh-synthesis-even-at-reference-levels
#11
Małgorzata Szczuko, Joanna Splinter, Marta Zapałowska-Chwyć, Maciej Ziętek, Dominika Maciejewska
We were interested whether fluorine, at the concentrations regarded as normal, can play a role in PCOS pathogenesis. The effect was not described in PCOS. Women with PCOS were diagnosed according to Rotterdam's criteria. The average age of 40 examined women with PCOS was 26.3 ± 5.5 years, BMI-29.16 ± 0.8, WHR-0.91 ± 0.08. Main Outcome Measures: ECLIA was used to analyse testosterone, FSH, LH, oestradiol, TSH, prolactin, insulin and SHBG. Fluorine content was analysed by potentiometry using ion selective electrode...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203909/rf9-may-it-be-a-new-therapeutic-option-for-hypogonadotropic-hypogonadism
#12
Zafer Sahin, Haluk Kelestimur
Hypogonadotropic hypogonadism (secondary hypogonadism), congenital or acquired, is a form of hypogonadism that is due to problems with either the hypothalamus or pituitary gland affecting gonadotropin levels. Pulsatile secretion of gonadotropin-releasing hormone (GnRH) by hypothalamus is a primer step to initiate the release of pituitary gonadotropins. Kisspeptin and gonadotropin-inhibitory hormone (GnIH) are accepted as two major players in the activation and inhibition of GnRH regarding the neuroendocrine functioning of the hypothalamic pituitary gonadal axis...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203908/spontaneous-coronary-artery-dissection-and-associated-myocardial-bridging-current-evidence-from-cohort-study-and-case-reports
#13
Farbod Zahedi Tajrishi, Asrar Ahmad, Adeel Jamil, Sadaf Sharfaei, Sogand Goudarzi, Fatemeh Homayounieh, Anmol Pitliya, Farima Kahe, Gerald Chi
Spontaneous coronary artery dissection (SCAD) is a relatively uncommon and under-diagnosed disease characterized by the dissociation of intima and media of coronary artery wall due to an intimal tear or intramural hemorrhage. The exact pathophysiology of SCAD remains elusive and may involve multiple predisposing or precipitating factors including genetic abnormalities, inherited or acquired vasculopathies, hormonal influences, inflammation, intense exercise, emotional stress, and recreational drugs. Accruing reports, including five case reports and one cohort study, have recently addressed the concurrence of SCAD and myocardial bridging (MB), an anatomic variant in which a segment of the epicardial coronary descends and traverses in the myocardium...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203907/photogrammetry-as-an-alternative-for-acquiring-digital-dental-models-a-proof-of-concept
#14
Vitor T Stuani, Rafael Ferreira, Gustavo G P Manfredi, Matheus V Cardoso, Adriana C P Sant'Ana
Photogrammetry is a mathematical technique that generates three-dimensional coordinates of specific points identified from multiple images of the same object obtained at different angles. This technique may be a low-cost alternative for traditional scanning. The objective of this proof of concept was to evaluate the accuracy and precision in obtaining digital models (DM) from a plaster model (PM) using photogrammetry. Five DM were generated from 50 photographs taken surrounding the PM. The photographs were taken by a single operator on five consecutive days using natural light...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203906/the-sequencing-process-generated-by-the-cerebellum-crucially-contributes-to-social-interactions
#15
Frank Van Overwalle, Mario Manto, Maria Leggio, José María Delgado-García
The capacity to understand another person's emotions, intentions, beliefs and personality traits, based on observed or communicated behaviors, is termed social cognition. During the last decade, social neuroscience has made great progress in understanding the neural correlates of social cognition. However, because the cerebellum is traditionally viewed as only involved in motor processing, the contribution of this major part of the brain in social processing has been largely ignored and its specific role in social cognition remains unclear...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203905/are-the-antidepressive-effects-of-massage-therapy-mediated-by-restoration-of-impaired-interoceptive-functioning-a-novel-hypothetical-mechanism
#16
Michael Eggart, Silvia Queri, Bruno Müller-Oerlinghausen
Interoception is an individual person's sense of the physiological condition of his/her entire body. Recent research has shown that depression is associated with impaired interoceptive accuracy. Treatments that can improve disturbed interoception are scarce in clinical practice and could complement established therapies. Accumulating evidence suggests that massage therapy significantly alleviates symptoms of depression. However, the mechanisms underlying these effects have remained unclear. We are going to propose a novel mechanism linking these antidepressive effects to a massage-induced modulation of interoceptive states...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203904/potential-role-of-calcifying-nanoparticles-in-the-etiology-of-multiple-sclerosis
#17
Birsen Can Demirdöğen
Nanobacteria or calcifying nanoparticles are 80-500 nm sized nano-organisms that are physically associated with carbonate apatite mineral formations. They have been indicated in various diseases, including kidney stone formation, Alzheimer's disease, and atherosclerosis. Nanoparticles contain calcium and apatite-binding protein fetuin-A, a calcification inhibitor. However, recent evidence indicates that fetuin-A can form nucleation seeds or nidi that grow in size through ion sedimentation to become larger amorphous nanoparticles in the presence of excess calcium and apatite ions...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203903/kamst-simple-method-for-patients-with-migraine-screening
#18
Antanas Vaitkus, Raminta Macaitytė, Inga Kiudulaitė
Migraine is highly prevalent and disabling disorder, but despite that one of the main problems that remains in the clinical practice is delayed diagnosis and delayed specific treatment that has impact on patients' quality of life and productivity. There should be easy acceptable method to select those patients who might have migraine and who need to be referred to neurologist's consultation. We hypothesize that our created KAMST questionnaire is reliable method to select patients who might have migraine in primary care...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203902/otoconial-loss-or-lack-of-otoconia-an-overlooked-or-ignored-diagnosis-of-balance-deficits
#19
S C A Hegemann, C J Bockisch
HYPOTHESIS: Lack of otoconia or otoconial loss may be the major reason for increasing imbalance with age, posttraumatic dizziness and residual dizziness as well as other so far unexplained imbalance affecting probably millions of people. BACKGROUND: It is written in every textbook that we need sensation of gravity for stable gait and stance, especially on two legs. Lack of otoconia is known to cause lifelong balance problems in animals. Loss of otoconia is happening in aging humans, like shown by increasing incidence of benign paroxysmal positional vertigo (BPPV) and in histological sections...
July 2019: Medical Hypotheses
https://read.qxmd.com/read/31203901/frontolimbic-affective-bias-and-false-narratives-from-brain-disease
#20
Mario F Mendez
Since the nineteenth century, clinicians and investigators have systematically evaluated the origin of delusions and psychotic thinking. One major clue to understanding the neurobiological underpinnings of delusions is the emergence of false narratives from brain disease. In addition to delusions themselves, there are a range of other false narratives not due to deliberate lying and resulting from neurological disorders, including provoked confabulations, fantastic confabulations, false memories, magical thinking, dream delusions, and "fantastic thinking"...
July 2019: Medical Hypotheses
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