journal

Medical Hypotheses

journal
https://read.qxmd.com/read/32460210/-therapeutic-facemasks
#1
LETTER
Deepak Gupta
There must be pathophysiological reason why "cold" viruses like SARS-CoV-2 show proclivity to nasal cavity, oral cavity, pharyngeal cavity and upper airways which have lower temperature than core body temperature. Henceforth, facemasks' "therapeutic" role against SARS-CoV-2 must be explored because personal "therapeutic" environments may get created under facemasks due to rebreathing of ~95°F "hot" and ~80% "humid" exhalations which may constantly mitigate SARS-CoV-2 inside nasal cavity, oral cavity, pharyngeal cavity and upper airways...
May 19, 2020: Medical Hypotheses
https://read.qxmd.com/read/32460208/sodium-chromo-glycate-and-palmitoylethanolamide-a-possible-strategy-to-treat-mast-cell-induced-lung-inflammation-in-covid-19
#2
LETTER
Antonio Gigante, Alberto Aquili, Luca Farinelli, Alessandro Caraffa, Gianpaolo Ronconi, Carla Enrica Gallenga, Giulia Tetè, Spyros K Kritas, Pio Conti
A novel human coronavirus SARS-CoV-2 (also referred to as CoV-19) that emerged in late 2019 causes Covid-19 disease a respiratory tract infection which provokes about 4 million deaths per year. Unfortunately, to date, there is no specific antiviral treatment for COVID-19. Mast cells (MCs) are immune cells implicated in the pathogenesis of viral infections, where they mediate inflammation. Microbes, including virus, activate MCs through TLR releasing chemical pro-inflammatory compounds and cytokines. Although, in biomedical literature there are only few reports on MCs activation by SARS-CoV-2 infection...
May 19, 2020: Medical Hypotheses
https://read.qxmd.com/read/32447099/covid-19-quarantine-and-atopic-dermatitis
#3
LETTER
Cataldo Patruno, Steven Paul Nisticò, Gabriella Fabbrocini, Maddalena Napolitano
No abstract text is available yet for this article.
May 19, 2020: Medical Hypotheses
https://read.qxmd.com/read/32460211/covid-19-disease-will-cause-a-global-catastrophe-in-terms-of-mental-health-a-hypothesis
#4
LETTER
Delia Izaguirre-Torres, Raúl Siche
No abstract text is available yet for this article.
May 18, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425308/covid-19-disease-will-cause-a-global-catastrophe-in-terms-of-mental-health-a-hypothesis
#5
Delia Izaguirre-Torres, Raúl Siche
No abstract text is available yet for this article.
May 18, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425307/mesenchymal-stem-cells-bridge-catalyst-between-innte-and-adaptive-immunity-in-covid-19
#6
Vishal Rao Us, Shalini Thakur, Jyothsna Rao, Gururaj Arakeri, Peter A Brennan, Sachin Jadhav, Mufti Suhail Sayeed, Gururaj Rao
Majority of patients infected with the COVID 19 virus display a mild to moderate course of disease and spontaneously recover at 14 - 20 days,. However, about 15 % of patients progress to severe stages and 2.5% of these patients succumb to this illness. Most patients with severe disease belong to the elderly age group (< 65 years of age) and have multiple associated co-morbidities. The immune responses induced by the COVID 19 virus, during the incubation and non-severe stages, requires the early initiation of a specific adaptive immune response to eliminate the virus and prevent the progress to severe stages...
May 18, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425305/is-the-anti-filarial-drug-diethylcarbamazine-useful-to-treat-covid-19
#7
Anuruddha Abeygunasekera, Saroj Jayasinghe
SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further...
May 18, 2020: Medical Hypotheses
https://read.qxmd.com/read/32460209/the-effect-of-potential-therapeutic-agents-on-qt-interval-in-patients-with-covid-19-infection-the-importance-of-close-monitoring-and-correction-of-electrolytes
#8
LETTER
Parham Habibzadeh, Mohsen Moghadami, Kamran Bagheri Lankarani
No abstract text is available yet for this article.
May 16, 2020: Medical Hypotheses
https://read.qxmd.com/read/32454344/bioactive-compounds-with-possible-inhibitory-activity-of-angiotensin-converting-enzyme-ii-a-gate-to-manage-and-prevent-covid-19
#9
LETTER
Farid Dabaghian, Mahnaz Khanavi, Mohammad M Zarshenas
No abstract text is available yet for this article.
May 16, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425309/the-effect-of-potential-therapeutic-agents-on-qt-interval-in-patients-with-covid-19-infection-the-importance-of-close-monitoring-and-correction-of-electrolytes
#10
Parham Habibzadeh, Mohsen Moghadami, Kamran Bagheri Lankarani
No abstract text is available yet for this article.
May 16, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425306/protective-potential-of-expectorants-against-covid-19
#11
Zohreh Esam
No abstract text is available yet for this article.
May 16, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425303/bioactive-compounds-with-possible-inhibitory-activity-of-angiotensin-converting-enzyme-ii-a-gate-to-manage-and-prevent-covid-19
#12
Farid Dabaghian, Mahnaz Khanavi, Mohammad M Zarshenas
No abstract text is available yet for this article.
May 16, 2020: Medical Hypotheses
https://read.qxmd.com/read/32460207/reflection-on-lower-rates-of-covid-19-in-children-does-childhood-immunizations-offer-unexpected-protection
#13
Jinglu Lyu, Tianyu Miao, Jiajia Dong, Ranran Cao, Yan Li, Qianming Chen
The incidence of COVID-19 in children and teenagers is only about 2% in China. Children had mild symptoms and hardly infected other children or adults. It is worth considering that children are the most vulnerable to respiratory pathogens, but fatal SARS-like virus had not caused severe cases among them. According to the pathological studies of COVID-19 and SARS, a sharp decrease in T lymphocytes leads to the breakdown of the immune system. The cellular immune system of children differs from that of adults may be the keystone of atypical clinical manifestations or even covert infection...
May 15, 2020: Medical Hypotheses
https://read.qxmd.com/read/32442677/topical-delivery-of-tacrolimus-using-liposome-containing-gel-an-emerging-and-synergistic-approach-in-management-of-psoriasis
#14
Shammy Jindal, Rajendra Awasthi, Dhananjay Singhare, Giriraj T Kulkarni
Psoriasis is a chronic relapsing inflammatory and hyperproliferative skin disease affecting quality of life. It affects an estimated 8 million Americans and more than 125 million people worldwide. The estimated cost to treat psoriasis in USA is over 13 billion US dollars per year. Treatment of psoriasis may include topical steroid-sparing agent, topical corticosteroids, phototherapy or biologics. Tacrolimus has 10-fold greater immunosuppressive activity than the ciclosporin A which has been recommended for effective treatment of psoriasis...
May 15, 2020: Medical Hypotheses
https://read.qxmd.com/read/32425304/reflection-on-lower-rates-of-covid-19-in-children-does-childhood-immunizations-offer-unexpected-protection
#15
Jinglu Lyu, Tianyu Miao, Jiajia Dong, Ranran Cao, Yan Li, Qianming Chen
The incidence of COVID-19 in children and teenagers is only about 2% in China. Children had mild symptoms and hardly infected other children or adults. It is worth considering that children are the most vulnerable to respiratory pathogens, but fatal SARS-like virus had not caused severe cases among them. According to the pathological studies of COVID-19 and SARS, a sharp decrease in T lymphocytes leads to the breakdown of the immune system. The cellular immune system of children differs from that of adults may be the keystone of atypical clinical manifestations or even covert infection...
May 15, 2020: Medical Hypotheses
https://read.qxmd.com/read/32460206/mentalexo-approach-for-diagnosis-of-psychiatric-disorders
#16
Ahmet Topuzoğlu, Can Ilgın
INTRODUCTION: Psychiatric disorders cause a high burden of disease and disability for the society. Liquid biopsies provide potent opportunities for screening programs, diagnosis, prognostic stratification and treatment monitorization. Previously, the liquid biopsy studies were mainly focused on the several malignancies without proper screen methods, but this approach has also a strong potential for decreasing disease burden in CNS pathologies. The main restriction for the diagnosis of CNS diseases is the lack of the methods to receive biochemical/functional information form a tightly enveloped compartment...
May 12, 2020: Medical Hypotheses
https://read.qxmd.com/read/32447232/covid-19-beta-thalassemia-subjects-immunised
#17
Edouard Lansiaux, Philippe Pierre Pébaÿ, Jean-Laurent Picard, Joachim Son-Forget
The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link...
May 12, 2020: Medical Hypotheses
https://read.qxmd.com/read/32442679/automatic-phase-reversal-detection-in-routine-eeg
#18
Sema Yıldırım, Hasan Erdinç Koçer, Ahmet Hakan Ekmekçi
Electroencephalograph (EEG), a valuable tool in the clinical evaluation, is readily available, safe and provides information about brain function. EEG interpretation is important for the diagnosis of neurological disorders. The long-term EEG data may be required to document and study neurosciences that include many epileptic activities and phase reversal (PR) etc. However, analyze of the long-term EEG done by an expert neurologist is much time consuming and quite difficult. Therefore, an automatic PR determination method for analyzing of long-term EEG is described in this study...
May 12, 2020: Medical Hypotheses
https://read.qxmd.com/read/32428811/exercise-as-medicine-for-covid-19-an-ace-in-the-hole
#19
LETTER
Kevin S Heffernan, Sae Young Jae
No abstract text is available yet for this article.
May 12, 2020: Medical Hypotheses
https://read.qxmd.com/read/32428810/do-pets-protect-their-owners-in-the-covid-19-era
#20
LETTER
Jan Jurgiel, Krzysztof J Filipiak, Łukasz Szarpak, Miłosz Jaguszewski, Jacek Smerka, Tomasz Dzieciątkowski
No abstract text is available yet for this article.
May 12, 2020: Medical Hypotheses
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