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Journals British Journal of Clinical Ph...

British Journal of Clinical Pharmacology

https://read.qxmd.com/read/38646796/no-observed-bidirectional-effect-between-tenofovir-diphosphate-concentrations-and-gender-affirming-hormone-concentrations-among-transgender-persons-switching-from-tenofovir-disoproxil-fumarate-emtricitabine-to-tenofovir-alafenamide-emtricitabine-for-hiv-pre
#1
JOURNAL ARTICLE
Nimish Patel, Sheldon Morris, Leah Burke, Karen Chow, Deedee Pacheco, Peter Anderson, Frank Stancyzk, Jill Blumenthal
AIMS: Many transgender and gender diverse (TGD) individuals have expressed concerns about the potential for oral pre-exposure prophylaxis to affect hormonal concentrations achieved from taking gender-affirming hormone therapy (GAHT). The purpose of this study was to understand the bidirectional effects between hormone and intraerythrocytic tenofovir diphosphate concentrations when switching from tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) to tenofovir alafenamide/emtricitabine (TAF/FTC) in TGD users/nonusers of GAHT...
April 22, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38632083/evaluation-of-critical-parameters-in-the-hollow-fibre-system-for-tuberculosis-a-case-study-of-moxifloxacin
#2
JOURNAL ARTICLE
Diana A Aguilar-Ayala, Fernando Sanz-García, Marie Sylvianne Rabodoarivelo, Budi O Susanto, Rebeca Bailo, Maxime R Eveque-Mourroux, Nicolas Willand, Ulrika S H Simonsson, Santiago Ramón-García, Ainhoa Lucía
No abstract text is available yet for this article.
April 17, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38627941/administration-mode-matters-for-5-fluorouracil-therapy-physiologically-based-pharmacokinetic-evidence-for-avoidance-of-myelotoxicity-by-continuous-infusion-but-not-intravenous-bolus
#3
JOURNAL ARTICLE
Chih-Jia Chao, Iain Gardner, Chun-Jung Lin, Kun-Huei Yeh, Wan-Chen Lu, Khaled Abduljalil, Yunn-Fang Ho
AIMS: Pre-emptive prediction to avoid myelosuppression and harmful sequelae is difficult given the complex interplay among patients, drugs and treatment protocols. This study aimed to model plasma and bone marrow concentrations and the likelihood of myelotoxicity following administration of 5-fluorouracil (5-FU) by diverse intravenous (IV) bolus or continuous infusion (cIF) regimens. METHODS: Using physicochemical, in vitro and clinical data obtained from the literature consisting of various regimens and patient cohorts, a 5-FU physiologically based pharmacokinetic (PBPK) model was developed...
April 16, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38627909/from-taboo-to-treatment-the-emergence-of-psychedelics-in-the-management-of-pain-and-opioid-use-disorder
#4
REVIEW
Jeremy Weleff, Julio C Nunes, Gabriel P A Costa, Mehmet Sofuoglu, R Ross MacLean, Joao P De Aquino
The rise of psychedelics in contemporary medicine has sparked interest in their potential therapeutic applications. While traditionally associated with countercultural movements and recreational use, recent research has shed light on the potential benefits of psychedelics in various mental health conditions. In this review, we explore the possible role of psychedelics in the management of chronic pain and opioid use disorder (OUD), 2 critical areas in need of innovative treatment options. Pain control remains a significant clinical challenge, particularly for individuals with OUD and those who receive long-term opioid therapy who develop marked tolerance to opioid-induced analgesia...
April 16, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38627211/thirst-and-drugs-a-study-in-the-world-health-organization-s-pharmacovigilance-database
#5
JOURNAL ARTICLE
Jean-Louis Montastruc
Thirst is a complex physiological compensatory mechanism but could also be associated with drugs. This association was poorly investigated previously. Using the WHO global pharmacovigilance database, Vigibase®, disproportionality analyses potential associations between exposure to drugs and thirst reports were performed. All reports of thirst in adults between 01/01/2000 and 31/12/2023 were included. Results are expressed as reporting odds ratio (ROR). Analysis of the 3186 reports of thirst (978 'serious') allowed, first, to confirm the association between thirst and exposure to vasopressin antagonists (tolvaptan), lithium, gliflozins (dapagliflozin, empagliflozin), pregabalin and antimuscarinic drugs (glycopyronium, oxybutynin, tiotropium)...
April 16, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38616514/physiologically-based-pharmacokinetic-modelling-guided-dose-evaluations-of-nirmatrelvir-ritonavir-in-renal-impairment-for-the-management-of-covid-19
#6
JOURNAL ARTICLE
Tat Ming Ng, Ziteng Wang, Eric Chun Yong Chan
We aimed to address factors contributing to the pharmacokinetic changes of nirmatrelvir/ritonavir in renal impaired (RI) patients and recommend dosing adjustment via a physiologically-based pharmacokinetic (PBPK) modelling approach. A PBPK model of nirmatrelvir/ritonavir was developed via Simcyp® Simulator. Sensitivity analysis of the influence of hepatic CYP3A4 intrinsic clearance and abundance, as well as hepatic non-CYP3A4 metabolism (other human liver microsomes [HLM] CLint ) was performed to evaluate the effects of RI on oral clearance of nirmatrelvir...
April 14, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38616172/public-preferences-for-pharmacogenetic-testing-in-the-nhs-embedding-a-discrete-choice-experiment-within-service-design-to-better-meet-user-needs
#7
JOURNAL ARTICLE
John H McDermott, Videha Sharma, William G Newman, Paul Wilson, Katherine Payne, Stuart Wright
AIMS: Genetic testing can be used to improve the safety and effectiveness of commonly prescribed medicines-a concept known as pharmacogenetics. This study aimed to quantify members of the UK public's preferences for a pharmacogenetic service to be delivered in primary care in the National Health Service. METHODS: Members of the UK population were surveyed via an online panel company. Respondents completed 1 of 2 survey versions, asking respondents to select their preferred pharmacogenetic testing service in the context of a presentation of low mood or pain...
April 14, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38604986/validating-use-of-diagnostic-codes-in-canadian-administrative-data-for-identification-of-adverse-drug-events
#8
JOURNAL ARTICLE
Maeve E Wickham, Kimberlyn M McGrail, Michael R Law, Amber Cragg, Corinne M Hohl
AIMS: While diagnostic codes from administrative health data might be a valuable source to identify adverse drug events (ADEs), their ability to identify unintended harms remains unclear. We validated claims-based diagnosis codes for ADEs based on events identified in a prospective cohort study and assessed whether key attributes predicted their documentation in administrative data. METHODS: This was a retrospective analysis of 3 prospective cohorts in British Columbia, from 2008 to 2015 (n = 13 969)...
April 11, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38600727/a-10-year-retrospective-study-of-antibacterial-induced-thrombocytopenia-in-a-women-and-children-hospital-using-china-hospital-pharmacovigilance-system-and-visual-basic-for-applications
#9
JOURNAL ARTICLE
Jianhui Yang, Can Cai, Xiuming Pan, Weida Chen, Wei Zhuang, Wanlong Lin, Yao Chen
AIMS: We aimed to investigate antibacterial-induced thrombocytopenia using the China Hospital Pharmacovigilance System (CHPS) in conjunction with Visual Basic for Applications (VBA). METHODS: Between September 2011 and December 2022, a 2-phase workflow was employed to identify antibacterial-induced thrombocytopenia, including preliminary screening in phase (I) conducted by CHPS algorithms and causality assessment by trained pharmacists in phase (II) using VBA. The incidence of thrombocytopenia in each antibacterial was calculated, and comparisons were performed between paediatric and adult patients...
April 10, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38599659/a-case-report-highlighting-drug-drug-interactions-between-3-life-saving-treatments-feminizing-hormones-antiretrovirals-and-antituberculosis-drugs
#10
Tara Suchak, Margherita Bracchi, Maria Mercer, Frances Lander, Marta Boffito
We here present a case providing valuable insights for clinicians who deliver care to patients identifying as transgender or nonbinary. A 30-year-old trans woman presented to sexual health services requesting a routine sexual health screen and was subsequently diagnosed with HIV and syphilis. She started antiretrovirals for HIV (bictegravir/tenoforvir alafenamide/emtricitabine) 12 days later and was treated with benzathine penicillin G. The patient also had a positive tuberculosis (TB) ELIspot blood test result and further investigations proved the presence of active TB in the chest with mediastinal involvement...
April 10, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38599658/saliva-monitoring-of-prednisolone-in-children-with-first-onset-steroid-sensitive-nephrotic-syndrome-is-it-possible
#11
JOURNAL ARTICLE
Floor Veltkamp, Marcel C M Pistorius, Elske M Mak-Nienhuis, Michiel F Schreuder, Antonia H M Bouts, Ron A A Mathôt
AIMS: Prednisolone is the cornerstone of treatment for idiopathic nephrotic syndrome in children, but is associated with marked side-effects. Therapeutic drug monitoring using saliva would be a patient-friendly option to monitor prednisolone treatment. To assess the feasibility of saliva monitoring, we described the pharmacokinetics (PK) of unbound prednisolone in plasma and saliva of children with first onset steroid-sensitive nephrotic syndrome (SSNS). METHODS: Children (age 2-16 years) with SSNS participating in a randomized, placebo-controlled trial with levamisole were treated with an 18-week tapering schedule of prednisolone...
April 10, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38589944/opensafely-the-impact-of-covid-19-on-azathioprine-leflunomide-and-methotrexate-monitoring-and-factors-associated-with-change-in-monitoring-rate
#12
JOURNAL ARTICLE
Andrew D Brown, Louis Fisher, Helen J Curtis, Milan Wiedemann, William J Hulme, Victoria Speed, Lisa E M Hopcroft, Christine Cunningham, Ruth E Costello, James B Galloway, Mark D Russell, Katie Bechman, Zeyneb Kurt, Richard Croker, Chris Wood, Alex J Walker, Andrea L Schaffer, Seb C J Bacon, Amir Mehrkar, George Hickman, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ben Goldacre, Brian MacKenna
AIMS: The COVID-19 pandemic created unprecedented pressure on healthcare services. This study investigates whether disease-modifying antirheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic. METHODS: A population-based cohort study was conducted using the OpenSAFELY platform to access electronic health record data from 24.2 million patients registered at general practices using TPP's SystmOne software. Patients were included for further analysis if prescribed azathioprine, leflunomide or methotrexate between November 2019 and July 2022...
April 8, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38586907/correction-to-naltrexone-bupropion-mysimba-in-management-of-obesity-a-systematic-review-and-meta-analysis-of-unpublished-clinical-study-reports
#13
Igho J Onakpoya
No abstract text is available yet for this article.
April 8, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38583490/association-between-reversal-agents-sugammadex-vs-neostigmine-for-neuromuscular-block-and-postoperative-pulmonary-complications-a-retrospective-analysis
#14
JOURNAL ARTICLE
Aolin Ren, Meihan Fan, Zhen Gu, Xiao Liang, Liuhang Xu, Chengjun Liu, Dutian Wang, Hanxuan Chang, Minmin Zhu
AIMS: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with neostigmine. METHODS: This retrospective cohort study was conducted in a tertiary academic medical center. Patients ≥18 year of age undergoing noncardiac surgical procedures with general anesthesia and mechanical ventilation were enrolled between January 2019 and September 2021...
April 7, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38571341/oxycodone-initiation-in-australia-2014-2018-sociodemographic-factors-and-preceding-health-service-use
#15
JOURNAL ARTICLE
Malcolm B Gillies, Ximena Camacho, Chrianna Bharat, Luke Buizen, Fiona Blyth, David Currow, Andrew Wilson, Louisa Degenhardt, Natasa Gisev, Sallie-Anne Pearson
AIMS: Oxycodone is the most commonly prescribed strong opioid in Australia. This study describes health service antecedents and sociodemographic factors associated with oxycodone initiation. METHODS: Population-based new user cohort study linking medicine dispensings, hospitalizations, emergency department visits, medical services and cancer notifications from New South Wales (NSW) for 2014-2018. New users had no dispensings of any opioid in the preceding year. We analysed health service use in the 5 days preceding initiation and proportion of people on treatment over 1 year and fitted an area-based, multivariable initiation model with sociodemographic covariates...
April 3, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38570720/the-association-between-proton-pump-inhibitor-use-and-systemic-anti-tumour-therapy-on-survival-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#16
(no author information available yet)
No abstract text is available yet for this article.
April 3, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38570184/model-based-precision-dosing-and-remedial-dosing-recommendations-for-delayed-or-missed-doses-of-isoniazid-in-chinese-patients-with-tuberculosis
#17
JOURNAL ARTICLE
Jin-Meng Li, Ruo-Ying Zhang, Gao-Yi Yang, Qing-Shan Cai, Ya-Zhen Lang, Fang-Ming Zhong, Jin-Peng Huang, Yuan-Yuan Chen, Yao Qin, Li-Kui Fang, Bo Ye, Li-Hua Lin, Hui-Hong Lin, Xin-Jun Cai, Kan Xu
AIMS: Isoniazid (INH) has been used as a first-line drug to treat tuberculosis (TB) for more than 50 years. However, large interindividual variability was found in its pharmacokinetics, and effects of nonadherence to INH treatment and corresponding remedy regime remain unclear. This study aimed to develop a population pharmacokinetic (PPK) model of INH in Chinese patients with TB to provide model-informed precision dosing and explore appropriate remedial dosing regimens for nonadherent patients...
April 3, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38566392/development-of-a-generalized-pharmacokinetic-model-to-characterize-clinical-pharmacokinetics-of-monomethyl-auristatin-e-based-antibody-drug-conjugates
#18
JOURNAL ARTICLE
Hsuan-Ping Chang, Yuen Kiu Cheung, Shufang Liu, Dhaval K Shah
AIMS: This study aims to develop a generalized pharmacokinetic (PK) model for monomethyl auristatin E (MMAE)-based antibody-drug conjugates (ADCs) that can simultaneously capture the PK of multiple ADC analytes commonly measured in the clinic. METHODS: A comprehensive literature review was conducted to collect PK data on MMAE-based ADCs from clinical trials. From each study, PK profiles of total antibody, the ADC, conjugated MMAE, and unconjugated MMAE, were extracted...
April 2, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38565322/ema-commentary-on-the-guideline-on-quality-nonclinical-and-clinical-aspects-of-medicinal-products-containing-genetically-modified-cells
#19
JOURNAL ARTICLE
Patrick Celis, Giada Farinelli, Ana Hidalgo-Simon, Pauline Meij, Mara Tihaya, Martina Schüssler-Lenz, Marcos Timón
Great advances have been made in the knowledge of development and regulatory approval of medicinal product containing genetically modified cells. Although a guideline has been available in the EU since 2012, the current updated version provides a useful guide to developers and professionals involved in the regulatory process of these medicines. This article presents the main issues communicated in that guidance, the regulators' insights and a commentary from the academic developers' point of view.
April 2, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38556851/assessing-pain-in-persons-with-opioid-use-disorder-approaches-techniques-and-special-considerations
#20
REVIEW
Julio C Nunes, Gabriel P A Costa, Jeremy Weleff, Michael Rogan, Peggy Compton, Joao P De Aquino
Pain and opioid use disorder (OUD) are inextricably linked, as the former can be a risk factor for the development of the latter, and over a third of persons with OUD suffer concomitant chronic pain. Assessing pain among people with OUD is challenging, because ongoing opioid use brings changes in pain responses and most pain assessment tools have not been validated for this population. In this narrative review, we discuss the fundamentals of pain assessment for populations with OUD. First, we describe the biological, psychological and social aspects of the pain experience among people with OUD, as well as how opioid-related phenomena may contribute to the pain experience in this population...
March 31, 2024: British Journal of Clinical Pharmacology
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