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JOURNAL ARTICLE
Leyllane Rafael Moreira, Ana Carla Silva, Cíntia Nascimento da Costa Oliveira, Claudeir Dias da Silva Júnior, Amanda Vasconcelos Nascimento, Kamila Kássia Dos Santos Oliveira, Ana Karine de Araújo Soares, Karina Lidianne Alcântara Saraiva, Milena de Paiva Cavalcanti, Virginia Maria Barros de Lorena
BACKGROUND: Trypanosoma cruzi, which causes Chagas disease (CD), is a versatile haemoparasite that uses several strategies to evade the host's immune response, including adipose tissue (AT), used as a reservoir of infection. As it is an effective barrier to parasite evasion, the effectiveness of the drug recommended for treating CD, Benznidazole (BZ), may be questionable. OBJECTIVE: To this end, we evaluated the parasite load and immunomodulation caused by BZ treatment in the culture of adipocytes differentiated from human adipose tissue-derived stem cells (ADSC) infected with T...
2023: Memórias do Instituto Oswaldo Cruz
#22
JOURNAL ARTICLE
Paloma Rezende Corrêa, Marcos Gustavo Araujo Schwarz, Renata Monteiro Maia, Fátima Maria Figueroa Vergara, Milton Ozório Moraes, Leila Mendonça-Lima
BACKGROUND: The Bacille Calmette-Guérin (BCG) vaccine comprises a family of strains with variable protective efficacy against pulmonary tuberculosis (TB) and leprosy, partly due to genetic differences between strains. OBJECTIVES: Previous data highlighting differences between the genomes and proteomic profiles of BCG strains Moreau and Pasteur led us to evaluate their behaviour in the macrophage microenvironment, capable of stimulating molecular responses that can impact the protective effect of the vaccine...
2023: Memórias do Instituto Oswaldo Cruz
#23
JOURNAL ARTICLE
Otávio Espíndola, Paola C Resende, Lusiele Guaraldo, Guilherme Amaral Calvet, Trevon L Fuller, Stephanie Lema Suarez Penetra, Heloisa Ferreira Pinto Santos, Anielle Pina-Costa, Michele Fernanda Borges da Silva, Isabella Campos Vargas Moraes, Fernando Medeiros, Jimmy Whitworth, Christopher Smith, Karin Nielsen-Saines, Marilda M Siqueira, Patrícia Brasil
BACKGROUND: There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES: The aim of this case report was to characterize the clinical features of acute XBB...
2023: Memórias do Instituto Oswaldo Cruz
#24
JOURNAL ARTICLE
Suelen Silva Gomes Dias, Tamires Cunha-Fernandes, Vinicius Cardoso Soares, Cecília Jg de Almeida, Patricia T Bozza
Lipid droplets (LD) are evolutionarily conserved lipid-enriched organelles with a diverse array of cell- and stimulus-regulated proteins. Accumulating evidence demonstrates that intracellular pathogens exploit LD as energy sources, replication sites, and part of the mechanisms of immune evasion. Nevertheless, LD can also favor the host as part of the immune and inflammatory response to pathogens. The functions of LD in the central nervous system have gained great interest due to their presence in various cell types in the brain and for their suggested involvement in neurodevelopment and neurodegenerative diseases...
2023: Memórias do Instituto Oswaldo Cruz
#25
JOURNAL ARTICLE
Felipe Dutra Rêgo, Eduardo Sérgio da Silva, Valeriana Valadares Lopes, Rafael Gonçalves Teixeira-Neto, Vinícius Silva Belo, Antônio Augusto Fonseca Júnior, Diego Andrade Pereira, Heber Paulino Pena, Márcia Dalastra Laurenti, Gabriela V Araújo, Vânia Lúcia Ribeiro da Matta, Islam Hussein Chouman, Thainá Bergantin Burrin, Carmen M Sandoval, Stella Maria Barrouin-Melo, Flaviane Alves de Pinho, Hélida Monteiro de Andrade, Ramon Vieira Nunes, Célia Maria Ferreira Gontijo, Vanete Thomaz Soccol, Donnamae Klocek, Danyil Grybchuk, Diego Henrique Macedo, Rubens Lima do Monte-Neto, Vyacheslav Yurchenko, Rodrigo Pedro Soares
BACKGROUND: Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES: In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions...
2023: Memórias do Instituto Oswaldo Cruz
#26
JOURNAL ARTICLE
Tatiana Prado, Maithê Gaspar Pontes Magalhães, Daniel Andrade Moreira, Martha Lima Brandão, Tulio Machado Fumian, Fernando Cesar Ferreira, Marcia Chame, Luciana Leomil, Wim Maurits Sylvain Degrave, José Paulo Gagliardi Leite, Marize Pereira Miagostovich
BACKGROUND: Few studies have focused on microbial diversity in indoor environments of ships, as well as the role of the microbiome and its ecological interconnections. In this study, we investigated the microbiome and virome present on the internal surfaces of a polar ship in different stages (beginning, during, and at the end) of the Brazilian Antarctic expedition in order to evaluate abundance of microorganisms in different periods. OBJECTIVES AND METHODS: We used shotgun metagenomic analysis on pooled samples from sampling surfaces in the ship's interior to track the microbial diversity...
2023: Memórias do Instituto Oswaldo Cruz
#27
JOURNAL ARTICLE
Bárbara Figueira Gomes, Mario Roberto Senger, José Teófilo Moreira-Filho, Fabio Jorge de Vasconcellos Junior, Rafael Ferreira Dantas, Raymond Owens, Carolina Horta Andrade, Bruno Junior Neves, Floriano Paes Silva-Junior
BACKGROUND: Schistosomiasis is a neglected tropical disease caused by trematodes of the genus Schistosoma, with a limited treatment, mainly based on the use of praziquantel (PZQ). Currently, several aspartic proteases genes have already been identified within the genome of Schistosoma species. At least one enzyme encoded from this gene family (SmAP), named SmCD1, has been validated for the development of schistosomicidal drugs, since it has a key role in haemoglobin digestion by worms...
2023: Memórias do Instituto Oswaldo Cruz
#28
JOURNAL ARTICLE
Milene Dias Miranda, Gabriela Cardoso Caldas, Vivian Neuza Ferreira, Ortrud Monika Barth, Aline de Paula Dias da Silva, Mayara Secco Torres Silva, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso, Thiago Moreno Souza, Edson Elias da Silva, Debora Ferreira Barreto-Vieira
BACKGROUND: According to the last 2023 Monkeypox (Mpox) Outbreak Global Map from the Centres for Disease Control and Prevention (CDC), more than 100 countries with no Mpox infection report cases. Brazil stands out in this group and is the second country with the highest number of cases in the last outbreak. OBJECTIVE: To contribute to knowledge of the virus infection effects in a cellular model, which is important for diagnosis infections not yet included in a provider´s differential diagnosis and for developing viral inhibition strategies...
2023: Memórias do Instituto Oswaldo Cruz
#29
JOURNAL ARTICLE
Giardia lamblia-infected preschoolers present growth delays independent of the assemblage A, B or E.
Maria Fantinatti, Tiara Cascais-Figueredo, Phelipe Austriaco-Teixeira, Filipe Anibal Carvalho-Costa, Alda Maria Da-Cruz
BACKGROUND: Intestinal parasite Giardia can affect children's physical development mainly stunting even in asymptomatic cases. The protozoa G. lamblia is divided into assemblages A-H. However, it is still unclear whether clinical manifestations and pathogenesis may vary according to the infecting assemblage. OBJECTIVES: To investigate whether G. lamblia assemblages influence differently the physical development of preschoolers from a community of Rio de Janeiro, Brazil...
2023: Memórias do Instituto Oswaldo Cruz
#30
JOURNAL ARTICLE
Veronica Sandra Valentinuzzi/, Luciana Beatriz Abrahan
BACKGROUND: Triatoma infestans (Kissing bug) is the main vector of the parasite causative of Chagas disease in Latin-America. This species shows clear activity rhythms easily synchronised to day-night cycles (photic cycle). The haematophagous nature of these insects lead us to think that they may temporally adapt to the particular activity rhythms of potential hosts (non-photic cycle). Our previous data showed that kissing bugs were weakly affected by the activity-inactivity rhythm of a single host...
2023: Memórias do Instituto Oswaldo Cruz
#31
JOURNAL ARTICLE
Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau
BACKGROUND: Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS: We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021...
2023: Memórias do Instituto Oswaldo Cruz
#32
JOURNAL ARTICLE
Alexandre S Moura, André Luis Costa-da-Silva, Pedro S Peixoto, Ceres Maciel, André F Cardoso
BACKGROUND: Culex quinquefasciatus, a cosmopolitan, domestic, and highly anthropophilic mosquito, is a vector of pathogenic arboviruses such as West Nile virus and Rift Valley virus, as well as lymphatic filariasis. The current knowledge on its reproductive physiology regarding vitellogenin expression in different tissues is still limited. OBJECTIVES: In this study, we analysed the transcriptional profiles of vitellogenin genes in the fat body and ovaries of C. quinquefasciatus females during the first gonotrophic cycle...
2023: Memórias do Instituto Oswaldo Cruz
#33
JOURNAL ARTICLE
Desiree Dos Santos Nunes, Luiza M Higa, Régis Linhares Oliveira, Lendel Correia da Costa, Larissa Maciel Bomfim, Cássia Cristina Alves Gonçalves, Diana Mariani, Dennis E Hruby, Carolina Moreira Voloch, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Clarissa R Damaso
BACKGROUND: In 2022, an outbreak of mpox that started in European countries spread worldwide through human-to-human transmission. Cases have been mostly mild, but severe clinical presentations have been reported. In these cases, tecovirimat has been the drug of choice to treat patients with aggravated disease. OBJECTIVES: Here we investigated the tecovirimat susceptibility of 18 clinical isolates of monkeypox virus (MPXV) obtained from different regions of Brazil...
2023: Memórias do Instituto Oswaldo Cruz
#34
JOURNAL ARTICLE
Aline Cordeiro Loureiro, Alejandra Saori Araki, Rafaela Vieira Bruno, José Bento Pereira Lima, Simone Ladeia-Andrade, Liliana Santacoloma, Ademir Jesus Martins
BACKGROUND: Malaria is a public health concern in the Amazonian Region, where Anopheles darlingi is the main vector of Plasmodium spp. Several studies hypothesised the existence of cryptic species in An. darlingi, considering variations in behaviour, morphological and genetic aspects. Determining their overall genetic background for vector competence, insecticide resistance, and other elements is essential to better guide strategies for malaria control. OBJECTIVES: This study aimed to evaluate the molecular diversity in genes related to behaviour and insecticide resistance, estimating genetic differentiation in An...
2023: Memórias do Instituto Oswaldo Cruz
#35
JOURNAL ARTICLE
Adriana A Marin, Annette Juillard, Alejandro M Katzin, Leonardo Jm Carvalho, Georges Er Grau
BACKGROUND: Cerebral malaria (CM) is a severe immunovasculopathy caused for Plasmodium falciparum infection, which is characterised by the sequestration of parasitised red blood cells (pRBCs) in brain microvessels. Previous studies have shown that some terpenes, such as perillyl alcohol (POH), exhibit a marked efficacy in preventing cerebrovascular inflammation, breakdown of the brain-blood barrier (BBB) and brain leucocyte accumulation in experimental CM models. OBJECTIVE: To analyse the effects of POH on the endothelium using human brain endothelial cell (HBEC) monolayers co-cultured with pRBCs...
2023: Memórias do Instituto Oswaldo Cruz
#36
JOURNAL ARTICLE
Yasmin Rubio-Palis, Nicole Dzuris, Christopher Sandi, Rita Lucrecia Vizcaino-Cabarrus, Claudia Corredor-Medina, Jesús Alberto González, Audrey E Lenhart
BACKGROUND: The massive use of insecticides in public health has exerted selective pressure resulting in the development of resistance in Aedes aegypti to different insecticides in Venezuela. Between 2010 and 2020, the only insecticides available for vector control were the organophosphates (Ops) fenitrothion and temephos which were focally applied. OBJECTIVES: To determine the state of insecticide resistance and to identify the possible biochemical and molecular mechanisms involved in three populations of Ae...
2023: Memórias do Instituto Oswaldo Cruz
#37
EDITORIAL
Adeilton Alves Brandão
No abstract text is available yet for this article.
2023: Memórias do Instituto Oswaldo Cruz
#38
JOURNAL ARTICLE
Suwellen Sardinha Dias de Azevedo, Fernanda Heloise Côrtes, Larissa M Villela, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalvez Veloso, Mariza G Morgado, Gonzalo Bello
BACKGROUND: Elite controllers (EC) are human immunodeficiency virus (HIV)-positive individuals who can maintain low viral loads for extended periods without antiretroviral therapy due to multifactorial and individual characteristics. Most have a small HIV-1 reservoir composed of identical proviral sequences maintained by clonal expansion of infected CD4+ T cells. However, some have a more diverse peripheral blood mononuclear cell (PBMC)-associated HIV-1 reservoir with unique sequences...
2023: Memórias do Instituto Oswaldo Cruz
#39
JOURNAL ARTICLE
Enrique Hector Weir, Jorge Eduardo Rabinovich
BACKGROUND: Physical factors can determine the level of triatomine abundance, but do not regulate their population densities, and neither do natural enemies. OBJECTIVES: To identify the processes associated with density-dependent triatomine population regulation. METHODS: We set-up a laboratory experiment with four interconnected boxes; the central box harbored Rhodnius prolixus bugs and one hamster. Stage 5 and adult densities of 10, 20, 30, 40, and 60 bugs per hamster, were replicated four times (except the density of 60 bugs)...
2023: Memórias do Instituto Oswaldo Cruz
#40
JOURNAL ARTICLE
María Elisa Vázquez, Andrea Cecilia Mesías, Leonardo Acuña, Joseph Spangler, Brenda Zabala, Cecilia Parodi, Meghna Thakur, Eunkeu Oh, Scott Allan Walper, Cecilia Pérez Brandán
BACKGROUND: Vaccine development is a laborious craftwork in which at least two main components must be defined: a highly immunogenic antigen and a suitable delivery method. Hence, the interplay of these elements could elicit the required immune response to cope with the targeted pathogen with a long-lasting protective capacity. OBJECTIVES: Here we evaluate the properties of Escherichia coli spherical proteoliposomes - known as outer membrane vesicles (OMVs) - as particles with natural adjuvant capacities and as antigen-carrier structures to assemble an innovative prophylactic vaccine for Chagas disease...
2023: Memórias do Instituto Oswaldo Cruz
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