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Journal of Rheumatology

Karine Toupin April, Jennifer L Barton, Liana Fraenkel, Alexa Meara, Linda C Li, Peter Brooks, Maarten de Wit, Dawn Stacey, France Légaré, Beverley Shea, Anne Lyddiatt, Cathie Hofstetter, Robin Christensen, Marieke Scholte Voshaar, Maria E Suarez-Almazor, Annelies Boonen, Tanya Meade, Lyn March, Janet Elizabeth Jull, Willemina Campbell, Rieke Alten, Suvi Karuranga, Esi M Morgan, Ayano Kelly, Jessica Kaufman, Sophie Hill, Lara J Maxwell, Dorcas Beaton, Yasser El-Miedany, Shikha Mittoo, Susan J Bartlett, Jasvinder A Singh, Peter Tugwell
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) shared decision making (SDM) Working Group aims to determine the core outcome domain set for measuring the effectiveness of SDM interventions in rheumatology trials. METHODS: A white paper was developed to clarify the draft core domain set. It was then used to prepare stakeholders for interviews to explore reasons for lack of consensus on it and to suggest further improvements. RESULTS: OMERACT scientists/clinicians (n=13) and patients (n=10) suggested limiting the core domain set to outcome domains, removing process domains, and clarifying remaining domains...
February 1, 2019: Journal of Rheumatology
Cristina Macía Villa, Sandra Falcao, Marwin Gutierrez, Julio Medina, Hilde Berner Hammer, Eugenio De Miguel
OBJECTIVE: To analyse the association between enthesitis, synovitis and peritenon extensor tendon inflammation (PTI) in Psoriatic Arthritis (PsA). METHODS: PsA patients with swelling of metacarpophalangeal joints were included. Grey scale (GS) and power Doppler (PD) were used for synovitis and PTI ultrasound identification. Madrid Sonographic Enthesis Index (MASEI) was used for enthesitis assessment. PD activity was evaluated using PD item of MASEI and PD OMERACT definition...
February 1, 2019: Journal of Rheumatology
Ashish J Mathew, Simon Krabbe, Iris Eshed, Frédérique Gandjbakhch, Paul Bird, Susanne J Pedersen, Maria S Stoenoiu, Violaine Foltz, Daniel Glinatsi, Robert G Lambert, Kay Geert A Hermann, Walter P Maksymowych, Ida K Haugen, Jacob L Jaremko, René P Poggenborg, Joel Paschke, Jean-Denis Laredo, Philippe Carron, Philip G Conaghan, Mikkel Østergaard
OBJECTIVE: To develop and validate an enthesitis MRI-scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model. METHODS: Consensus definitions of key pathologies and three heel enthesitis multi-reader scoring exercises were done, separated by discussion, training and calibration. RESULTS: Definitions for bone and soft tissue pathologies were agreed. In final exercise, median pairwise single-measures intra-class correlation coefficients(ICCs; patient-level) for entheseal inflammation status/change scores were 0...
February 1, 2019: Journal of Rheumatology
Claire E Owen, Max Yates, Helen Twohig, Sara Muller, Lorna M Neill, Eileen Harrison, Beverley Shea, Lee S Simon, Catherine L Hill, Sarah L Mackie
OBJECTIVE: To report the progress of the OMERACT Polymyalgia Rheumatica (PMR) Working Group in selecting candidate instruments for a core outcome measurement set. METHODS: A systematic literature review identified outcomes measured and instruments used in PMR studies, and a respondent survey and raw data analysis assessed their domain match and feasibility. RESULTS: Candidate instruments were identified for pain (VAS/NRS), stiffness (VAS/NRS and duration) and physical function (HAQ-DI/MHAQ)...
February 1, 2019: Journal of Rheumatology
Maryam Buni, Joyce Joseph, Claudia Pedroza, Sam Theodore, Deepthi Nair, Terry A McNearney, Hilda T Draeger, John D Reveille, Shervin Assassi, Maureen D Mayes
OBJECTIVE: To identify baseline features that predict progression of hand contractures and to assess the effect of contractures on functional status in the prospective GENISOS cohort. METHODS: Rate of decline in hand extension, as an indicator of hand contracture, was the primary outcome. We assessed longitudinal hand extension measurements, modified Health Assessment Questionnaire (MHAQ) score, SF36 physical function score, demographic, clinical, serological variables...
February 1, 2019: Journal of Rheumatology
Karen Hambardzumyan, Rebecca J Bolce, Johan K Wallman, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVE: To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). METHODS: In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on the 28-joint count Disease Activity Score (DAS28) after 3 months of MTX monotherapy using uni-/multivariate logistic regression...
February 1, 2019: Journal of Rheumatology
Ruben Queiro, Juan D Cañete, Carlos Montilla, Miguel Angel Abad, María Montoro, Susana Gómez, Ana Cábez
OBJECTIVE: To examine the grade of agreement between very low disease activity (VLDA) and Disease Activity Index for Psoriatic Arthritis (DAPSA) remission, as well as their association with the effect of the disease as assessed by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire in patients with psoriatic arthritis in routine clinical practice. METHODS: Posthoc analysis of data from a cross-sectional multicenter study. Patients were included who fulfilled the Classification for Psoriatic Arthritis (CASPAR) criteria with at least 1 year of disease duration and were treated with biological and/or conventional synthetic disease-modifying antirheumatic drugs according to routine clinical practice in Spain...
February 1, 2019: Journal of Rheumatology
Jyoti Panwar, Shirley M L Tse, Lillian Lim, Mirkamal A Tolend, Shilpa Radhakrishnan, Muayad Salman, Rahim Moineddin, Andrea S Doria, Jennifer Stimec
OBJECTIVE: Intra- and interreader reliability, construct validity, and responsiveness of the Spondyloarthritis Research Consortium of Canada (SPARCC) magnetic resonance imaging (MRI) scoring system were investigated for scoring sacroiliitis in patients with juvenile spondyloarthritis (JSpA)/enthesitis-related arthritis (ERA) who have received biologic and/or nonbiologic treatment. METHODS: Ninety whole-body MRI examinations with dedicated oblique coronal planes of the sacroiliac joints in 46 patients were independently reviewed and scored by 2 pediatric musculoskeletal radiologists, blinded to clinical details, using the SPARCC system...
February 1, 2019: Journal of Rheumatology
Ashish J Mathew, Simon Krabbe, Richard Kirubakaran, Andrew J Barr, Philip G Conaghan, Paul Bird, Mikkel Østergaard
OBJECTIVE: A systematic literature review was performed to document published MRI lesion definitions and scoring systems for enthesitis in SpA. METHODS: PubMed, EMBase and Cochrane library databases were searched for original publications involving adult SpA patients undergoing MRI of axial/peripheral joints. Selected articles were assessed for quality using a standardised assessment tool and metric indices. RESULTS: Considering the heterogeneous nature, quality and outcome measures of studies, statistical data pooling was considered inappropriate...
February 1, 2019: Journal of Rheumatology
Gergely Toldi, Patrizia Batel, Sándor Baráth, Péter Szerémy, András Apjok, Kata Filkor, Sándor Szántó, Gabriella Szűcs, Szilvia Szamosi, Thomas Häupl, Andreas Grützkau, Zoltán Szekanecz
OBJECTIVE: Multidrug resistance (MDR) transporters may be used as biomarkers to monitor disease progression in RA and as a predictive tool to establish responsiveness to biological therapy. In this multicenter clinical trial, we aimed to assess the predictive value of MDR1, MRP1 and BCRP activity measurement for biological therapeutic response in RA before as well as 4 to 6 and 12 weeks after the initiation of biological therapy. METHODS: Peripheral blood samples were collected from 27 bDMARD Responders and 12 Non-responders at the indicated time points as well as from 35 healthy controls...
February 1, 2019: Journal of Rheumatology
Ariane Barbacki, Michelle Petri, Antonio Aviña-Zubieta, Graciela S Alarcón, Sasha Bernatsky
OBJECTIVE: Fatigue is a frequent, disabling issue in SLE. It is, however, difficult to quantify. The Ad Hoc Committee on SLE Response Criteria for Fatigue in 2007 recommended using the Krupp Fatigue Severity Scale (FSS). Since then, the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue scale has also been validated in SLE. We performed a review of instruments used to measure fatigue in adult SLE patients from 2007 onward. METHODS: We searched PubMed, Medline and EMBase (Jan...
February 1, 2019: Journal of Rheumatology
Dorcas E Beaton, Lara J Maxwell, Beverley J Shea, George A Wells, Maarten Boers, Shawna Grosskleg, Clifton O Bingham, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten de Wit, Laure Gossec, Lyn M March, Lee S Simon, Jasvinder A Singh, Vibeke Strand, Peter Tugwell
OBJECTIVE: Outcome Measures in Rheumatology (OMERACT) Filter 2.1 revised the process used for core outcome measurement set selection to add rigour and transparency in decision making. This paper describes OMERACT's methodology for instrument selection. METHODS: We presented instrument selection processes, tools, and reporting templates at OMERACT 2018, introducing the concept of "3 pillars, 4 questions, 7 measurement properties, 1 answer". Truth, Discrimination and Feasibility are the three original OMERACT pillars...
February 1, 2019: Journal of Rheumatology
Nataliya Milman, Eilish McConville, Joanna C Robson, Annelies Boonen, Peter Tugwell, George A Wells, Dipayan Chaudhuri, Jill Dawson, Gunnar Tomasson, Susan Ashdown, Don Gebhart, Georgia Lanier, Jacqueline Peck, Carol A McAlear, Katherine S Kellom, Peter F Cronholm, Peter A Merkel
OBJECTIVE: Aspects of ANCA-associated vasculitis (AAV) prioritized by patients with AAV were described using the International Classification of Function, Disability, and Health. METHODS: Items identified during 14 individual interviews were incorporated into ICF-based questionnaire administered to participants of 2 vasculitis patient symposia, 36 in UK and 63 in USA. RESULTS: Categories identified as at least "moderately relevant" by ≥ 5% of subjects included 44 body functions, 14 body structures, 35 activities and participation, 31 environmental factors, and 38 personal factors...
February 1, 2019: Journal of Rheumatology
Murray B Urowitz, Jiandong Su, Dafna D Gladman
OBJECTIVE: Atherosclerotic vascular events (AVEs) are a major cause of mortality and morbidity in systemic lupus erythematosus (SLE). We aimed to determine the impact of early recognition and therapy for both classic risk factors for AVE and for SLE on the burden of AVEs in lupus in recent decades. METHODS: Inception patients who entered the University of Toronto lupus Clinic between 1975 and 1987 followed to 1992 (Cohort 1) and between 1999 and 2011 followed to 2016 (Cohort 2) were studied...
February 1, 2019: Journal of Rheumatology
Lucy H Liu, Helene B Fevrier, Robert Goldfien, Anke Hemmerling, Lisa J Herrinton
OBJECTIVE: Hydroxychloroquine (HCQ) is a cornerstone to managing systemic lupus erythematosus (SLE), yet adherence to medication is poor. We sought to measure the association of adherence with five 'dimensions of adherence' as articulated by the World Health Organization for chronic conditions: the patient's socioeconomic status, and patient-, condition-, therapy-, and healthcare-system-related factors. Our long-term goal is to generate evidence in order to design effective interventions to increase adherence...
February 1, 2019: Journal of Rheumatology
Kristina Forslind, Kerstin Eberhardt, Björn Svensson
OBJECTIVE: The aim of this study was to examine the occurrence of repair in a cohort of conventionally treated patients with early rheumatoid arthritis over 8 years. METHODS: There were 395 patients included in the BARFOT study having radiographs of hands and feet at inclusion, and at 1, 2, 5, and 8 years, which were chronologically scored for erosions by the Sharp/van der Heijde method. An erosion with repair was defined as an erosion that has become partially or totally filled, with or without sclerosis...
February 1, 2019: Journal of Rheumatology
Sofia Ramiro, Matthew J Page, Samuel L Whittle, Hsiaomin Huang, Arianne P Verhagen, Dorcas Beaton, Pamela Richards, Marieke Scholte-Voshaar, Beverley Shea, Danielle van der Windt, Christian Kopkow, Mario Lenza, Nitin Jain, Bethan Richards, Catherine L Hill, Tiffany K Gill, Bart Koes, Nadine Foster, Philip G Conaghan, Toby O Smith, Peter Malliaras, Yngve Roe, Joel J Gagnier, Rachelle Buchbinder
OBJECTIVE: To reach consensus on the core domains to be included in a core domain set for clinical trials of shoulder disorders using the OMERACT Filter 2.1 Core Domain Set process. METHODS: At OMERACT 2018, the Outcome Measures in Rheumatology (OMERACT) Shoulder Working Group conducted a workshop that presented the OMERACT 2016 preliminary core domain set and its rationale based upon a systematic review of domains measured in shoulder trials and an international Delphi involving patients, clinicians and researchers, as well as a new systematic review of qualitative studies on the experiences of people with shoulder disorders...
February 1, 2019: Journal of Rheumatology
George A Bruyn, Annamaria Iagnocco, Esperanza Naredo, Peter V Balint, Marwin Gutierrez, Hilde B Hammer, Paz Collado, Georgios Filippou, Wolfgang A Schmidt, Sandrine Jousse-Joulin, Peter Mandl, Philip Conaghan, Richard J Wakefield, Helen I Keen, Lene Terslev, Maria Antonietta D'Agostino
The Outcome Measures in Rheumatology (OMERACT) ultrasound (US) working group (WG) operates research activities for the validation of US as an outcome measurement instrument according to the Filter 2.0 framework METHODS: From the onset of the WG research in 2005 through now, original publications on definitions and scoring systems for pathophysiological manifestations and elementary lesions of various rheumatic disorders were reviewed RESULTS: Definitions and scoring systems according to new terminology are provided CONCLUSION: We have redefined OMERACT definitions of US pathology and elementary lesions as well as scoring systems which are now proposed for OMERACT approval for application in clinical trials...
February 1, 2019: Journal of Rheumatology
Kim A Papp, Boulos Haraoui, Deepali Kumar, John K Marshall, Robert Bissonnette, Alain Bitton, Brian Bressler, Melinda Gooderham, Vincent Ho, Shahin Jamal, Janet E Pope, A Hillary Steinhart, Donald C Vinh, John Wade
The use of immunosuppressive therapies for immune-mediated disease is associated with an elevated risk of infections and related comorbidities. While many infectious diseases can generally be prevented by vaccines, immunization rates in this specific patient population remain suboptimal, due in part to uncertainty about their efficacy or safety under these clinical situations. To address this concern, a multidisciplinary group of Canadian physicians with expertise in dermatology, gastroenterology, infectious diseases, and rheumatology developed evidence-based clinical guidelines on vaccinations featuring 13 statements that are aimed at reducing the risk of preventable infections in individuals exposed to immunosuppressive and immunomodulatory agents...
February 1, 2019: Journal of Rheumatology
Jean W Liew, Gregory C Gardner
OBJECTIVE: In this retrospective observational study, we assess the efficacy and safety of the interleukin-1 receptor antagonist anakinra in medically complex, hospitalized patients with acute gout and calcium pyrophosphate crystal arthritis. METHODS: Adult inpatients patients treated with anakinra from 2014-2017 were identified for inclusion. Charts were reviewed for demographics, comorbidities, laboratory data, pain scores, joint involvement, prior treatment, dosing and response to anakinra, concurrent infections, and surgical interventions...
January 15, 2019: Journal of Rheumatology
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